瑞舒伐他汀强化治疗对ACS患者PCI术后血脂代谢、脂肪细胞因子、斑块稳定性的影响

瑞舒伐他汀强化治疗对ACS患者PCI术后血脂代谢、脂肪细
胞因子、斑块稳定性的影响
孙秀全;李彦芳;孟英杰;石桂芳
【期刊名称】《海南医学院学报》
【年(卷),期】2017(023)019
【摘要】目的:探讨瑞舒伐他汀强化治疗对ACS患者PCI术后血脂代谢、脂肪细胞因子、斑块稳定性的影响.方法:选择在本院接受PCI治疗的106例ACS患者,回顾治疗方案并分为接受PCI术后瑞舒伐他汀常规剂量治疗的常规剂量组60例、接受PCI术后瑞舒伐他汀强化治疗的强化治疗组46例.对比两组患者治疗前后血脂代谢、脂肪细胞因子、斑块稳定性的差异.结果:PCI术前,两组患者的血脂代谢、脂肪细胞因子、斑块稳定性差异无统计学意义(P>00.5);PCI术后1月,强化治疗组患者外周血中脂质代谢指标HDL-C、ApoA1的含量高于常规剂量组,LDL-C、ApoB的含量低于常规剂量组;血清中脂肪细胞因子A PN、Leptin的含量高于常规剂量组,Resistin的含量低于常规剂量组;斑块稳定性相关指标ICAM-1、MMP-1、TIMP-1的含量低于常规剂量组(P<00.5).结论:ACS患者PCI术后接受瑞舒伐他汀强化治疗,可有效调节机体脂质代谢并增加斑块稳定性.%Objective:To explore the effect of rosuvastatin intensification therapy on blood lipid metabolism ,adipocyto-kines and plaque stability after PCI in ACS patients .Methods:ACS patients who received PCI in the hospital between July 2015 and January 2017were reviewed and divided into the routine dose group (n=60) who received rosuvastatin routine dose therapy after PCI and the intensification therapy group (n=46) who received rosuvastatin
intensification therapy after PCI .The differ-ences in blood lipid metabolism ,adipocytokines and plaque stability were compared between the two groups before and after treatment .Results:Before PCI ,the differences in blood lipid metabolism ,adipocytokines and plaque stability were not statisti-cally significant between the two groups (P>00.5) .1 month after PCI ,lipid metabolism indexes HDL-C and ApoA1 levels in peripheral blood of intensification therapy group were higher than those of routine dose group while LDL-C and ApoB levels were lower than those of routine dose group ;adipocytokines APN and Leptin levels in serum were higher than those of routine dose group while Resistin level was lower than that of routine dose group ;plaque stability-related indexes ICAM-1 ,MMP-1 and TIMP-1 levels were lower than those of routine dose group (P<00.5) .Conclusion:Rosuvastatin intensification therapy af-ter PCI could effectively regulate the lipid metabolism and increase the plaque stability in ACS patients .
【总页数】4页(P2652-2655)
【作者】孙秀全;李彦芳;孟英杰;石桂芳
【作者单位】河北邯郸峰峰矿区冀中能源峰峰集团总医院心内二科,河北邯郸056200;河北邯郸峰峰矿区冀中能源峰峰集团总医院心内二科,河北邯郸 056200;河北邯郸峰峰矿区冀中能源峰峰集团总医院心内二科,河北邯郸 056200;河北邯郸峰峰矿区冀中能源峰峰集团总医院心内二科,河北邯郸 056200
【正文语种】中文
【中图分类】R541.4
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