喉癌中肝细胞再生磷酸酶-3的表达及与微血管密度的相关性

喉癌中肝细胞再生磷酸酶-3的表达及与微血管密度的相关性胡海丽;董雪蕾;田秀芬
【期刊名称】《天津医药》
【年(卷),期】2011(39)6
【摘要】目的:探讨在喉鳞状细胞癌中肝细胞再生磷酸酶-3(PRL-3)和微血管密度(MVD)的相关性.方法:采用免疫组化SABC法检测69例喉鳞状细胞癌组织和25例相应癌旁组织中PRL-3的表达情况,并用CD105标记MVD,研究PRL-3的表达及MVD计数与喉鳞癌临床病理特征的关系,采用Spearman等级相关分析PRL-3表达与MVD的相关性.结果:PRL-3在癌组织中的阳性表达率(65.22%)高于癌旁组织(8%),差异有统计学意义(P<0.01).癌组织中有淋巴结转移患者的PRL-3阳性率和MVD计数明显高于尤淋巴结转移患者,病理分期为Ⅲ～Ⅳ期的PRL-3和MVD高于Ⅰ～Ⅱ期,差异均有统计学意义(P<0.05).PRL-3的表达与MVD计数呈正相关
(r=0.811,P<0.01).结论:PRL-3可能作为一种新的肿瘤标志物来监控喉鳞状细胞癌的发生、浸润和转移.%Objective: To evaluate the role of phosphatase of regenerating liver-3(PRL-3) and Microvessel density (MVD) in laryngeal squamous cell carcinoma, and their relationship thereof. Methods: The expression level of PRL-3 was detected by immmuno-histochemical SABC method in tissue samples of 69 laryngeal carcinoma and 25 corresponding adjacent tissues. MVD was marked by CD105. The relationship between expression of PRL-3, the count of MVD and the clinicopathologic parameters of laiyngeal squamous cell carcinoma was investigated. Results: The positive rate of PRL-3 was significantly higher in laryngeal squamous
cell carcinoma (65.22％) than that of corresponding adj acent tissues (8％, P ＜ 0.01). The positive expression of PRL-3 and count of MVD were significantly higher in lymph-node metastasis group than those in no-metastasis group (P ＜ 0.05). The expression of PRL-3 and MVD were
sig nificantly higher in Ⅲ-Ⅳ pathological staging than those of stage Ⅰ - Ⅱ (P ＜ 0.05). The expression of PRL-3 was positively correlated with MVD (r = 0.811, P ＜ 0.01).Conclusion : PRL-3 may be used as a new tumor marker in ocCurrence, invasion and metastasis of laryngeal squamous cell carcmoma.
【总页数】3页(P496-498)
【作者】胡海丽;董雪蕾;田秀芬
【作者单位】450052,郑州大学第三附属医院耳鼻喉科;450052,郑州大学第三附属医院耳鼻喉科;郑州大学第一附属医院耳鼻喉科
【正文语种】中文
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