小剂量阿司匹林治疗子痫前期高危孕妇的疗效观察

小剂量阿司匹林治疗子痫前期高危孕妇的疗效观察
牛锦华
【期刊名称】《中国医院用药评价与分析》
【年(卷),期】2016(016)003
【摘要】目的：探讨小剂量阿司匹林治疗子痫前期高危孕妇的临床效果。

方法：
选取解放军第463医院2012年5月—2015年5月收治的子痫前期高危风险的孕妇119例，按随机数字表法分为观察组59例，对照组60例。

观察组患者给予阿司匹林治疗，1日1次，1次100 mg，对照组患者给予安慰剂治疗，均睡前服药，2周为1疗程，2～3疗程结束后，对2组患者妊娠演化（平均出生孕期、新生儿
出生体质量、重度子痫前期、轻度子痫前期、早发子痫前期、妊娠诱发高血压、胎儿宫内发育迟缓、流产）结果进行比较。

结果：观察组患者平均出生孕期
（36.81±2.01）周、新生儿出生体质量（2890.20±340.12） g，均较对照组的（35.04±3.12）周、（2611.40±479.25）g低，差异有统计学意义（P＜0.05）。

观察组患者重度子痫前期2例（3.38％），轻度子痫前期11例（18.64％），早
发子痫前期7例（11.86％），妊娠诱发高血压病2例（3.38％），胎儿宫内发育迟缓8例（13.56％）、流产1例（1.69％），均低于对照组的9例（15.00％），31例（51.67％），16例（26.67％），10例（16.67％），18例（30.00％），7例（11.67％），差异有统计学意义（P＜0.05）。

治疗期间对2组患者的凝血、纤溶功能进行检测，均未见血小板计数异常，无妊娠期及围产期母儿出血等情况，观察组患者出现1例轻度胃肠道症状，对照组无胃肠道症状出现，2组的差异无统计学意义（ t＝1.026，P＝0.311）。

结论：小剂量阿司匹林治疗子痫前期高危孕妇，能有效预防子痫前期的发生，改善母儿结局，值得临床借
鉴。

%OBJECTIVE:To probe into the clinical efficacy of low-dose aspirin in treatment of high-risk pregnant women in preeclampsia .METHODS:119 cases of high-risk pregnant women in preeclampsia admitted into Hospital 463 of PLA from May 2012 to May 2015 were selected to be divided into observation group ( 59 cases ) and control group(60 cases) via the random number table.The observation group were treated with aspirin, once a day with 100mg;the control group received placebo;drugs were took before bedtime , two weeks as one treatment course .After two to three treatment course , the outcome of evolution of pregnancy ( the average birth pregnancy , neonatal birth weights, severe preeclampsia, mild preeclampsia, early preeclampsia, pregnancy induced hypertension , intrauterine growth retardation and abortion ) in two group of patients were compared .RESULTS:The average birth pregnancy and neonatal birth weights of observation group were ( 36.81 ±2.01 ) weeks and ( 2 890.20
±340.12 ) g, significantly lower than that of control group ( 35.04 ±3.12 ) weeks and ( 2 611.40 ±479.25 ) g, with statistically significant difference (P<0.05).In observation group, there were 2 cases of severe preeclampsia (3.38%), 11 cases of mild preeclampsia ( 18.64%) , 7 cases of early preeclampsia ( 11.86%) , 2 cases of pregnancy induced hypertension (3.38%), 8 cases of intrauterine growth retardation (13.56%) and 1 cases of abortion(1.69%), all of which were significantly lower than that of control group 9 cases ( 15.00%) , 31 cases ( 51.67%) , 16 cases ( 26.67%) , 10 cases (16.67%) , 18 cases ( 30.00%) and 7 cases ( 11.67%) , with no significant difference ( P <0.05 ) . During the treatment , the coagulation and
fibrinolysis function of two group of patients were determined , no abnormal platelet count and no bleeding of mothers and infants in pregnancy and perinatal period were observed ; there was 1 case with mild gastrointestinal symptoms in observation group , yet no symptom in control group , the difference was not statistically significant ( t =1.026, P =0.311 ).CONCLUSIONS: Low-dose aspirin in treatment of high-risk pregnant women in preeclampsia can effectively prevent the occurrence of preeclampsia and improve the maternal and neonatal outcome , which is worthy of clinical reference .
【总页数】3页(P297-298,299)
【作者】牛锦华
【作者单位】解放军第463医院妇产科，辽宁沈阳 110042
【正文语种】中文
【中图分类】R984
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