非诺贝特酯防治大鼠非酒精性脂肪肝实验研究

非诺贝特酯防治大鼠非酒精性脂肪肝实验研究
杨元十;岑国栋
【期刊名称】《中国药业》
【年(卷),期】2011(20)22
【摘要】目的观察非诺贝特酯对非酒精性脂肪肝大鼠模型的影响.方法以高脂乳液灌胃制备SD大鼠非酒精性脂肪肝模型,随机分为模型对照组、非诺贝特酯组和阳性对照(易善复)组,预防治疗8周后行血清、肝组织生化检测和病理学检查.结果非诺贝特酯能明显降低非酒精性脂肪肝大鼠模型肝组织中甘油三酯的水平,改善脂肪变性.结论非诺贝特酯对非酒精性脂肪肝大鼠有较好的治疗作用.%Objective To investigate the effect of fenofibrate ester ont rat model of nonalcoholic fatty liver disease (NAFLD). Methods SD rat model of NAFLD was established by gastric gavage with high fat diet. Then rats with NAFLD were divided into three groups at random: model control group, fenofibrate ester group and positive control group. The detections of serology, and biochemistry and pathology of liver tissues were performed after 8 - week preventive treatment. Results Fenofibrate ester obviously decreased the triglyceride level of liver tissues and improved steatosis in NAFLD rat model. Conclusion Fenofibrate ester has a better therapeutical effect on NAFLD rat model.
【总页数】3页(P35-37)
【作者】杨元十;岑国栋
【作者单位】四川省资中县人民医院,四川,内江,641200;成都地奥制药集团药物研究所,四川,成都,610041
【正文语种】中文
【中图分类】R965.1;R972+.6
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