瑞舒伐他汀对急性心肌梗死患者PCI术后血管内皮功能和炎性因子水平的影响

瑞舒伐他汀对急性心肌梗死患者PCI术后血管内皮功能和炎
性因子水平的影响
张辉;王茜
【期刊名称】《中国生化药物杂志》
【年(卷),期】2016(036)011
【摘要】Objective To investigate the effect of rosuvastatin on vascular endothelial function and inflammatory factors in patients with acute myocardial infarction ( AMI) after PCI.Methods A total of 217 patients from May 2014 to May 2016 in The Second Hospital of Baoding were randomly divided into the observation group 109 cases and the control group 108 cases.Two groups were treated with conventional basic therapy,and the control group was treated with atorvastatin,while the observation group was treated with rosuvastatin.The clinical efficacy,the levels of FMD and NMD,vascular endothelial function and inflammatory factors were compared between the two groups,and adverse reactions were recorded.Results The effective rate of the observation group was
95.41%,significantly higher than that of 86.11% in the control group
(P<0.05);the levels of FMD and NMD in the two groups were significantly higher than before treatment,and the observation group was higher than the control group(P <0.05);the level of ET-1 was significantly decreased,and the levels of NO and NOS were significantly higher in the two groups,and the changes in the observation group were more
significant(P<0.05);the levels of hs-CRP,TNF-α,IL-8,IL-6 was significantly decreased,the observation group was significantly lower than the control group( P <0.05 );and no serious adverse reactions were
observed.Conclusion Rosuvastatin can improve the vascular endothelial function and inflammatory factor level of AMI patients after PCI,improve the curative effect and improve the quality of life of patients.%目的：探讨瑞舒伐他汀对急性心肌梗死（ acute myocardial infarction ， AMI ）患者经皮冠
状动脉介入术（ percutaneous coronary intervention ，PCI）术后血管内皮功
能和炎性因子水平的影响。

方法选择保定市第二医院2014年5月～2016年5月收治的217例患者，采用随机数字法分为观察组109例和对照组108例。

2组均进行常规基础治疗，对照组采用阿托伐他汀治疗，观察组采用瑞舒伐他汀治疗。

观察比较2组临床疗效、血流介导的血管扩张功能（ flow mediated dilation ，FMD ）及非内皮依赖性舒张功能（nitroglycerin－mediated dilation，NMD）水平、血管内皮功能及炎性因子水平的变化，记录不良反应情况。

结果观察组有效率为95．41％，明显高于对照组的86．11％（P＜0．05）。

治疗后，2组FMD 和NMD水平与治疗前比较均显著升高，且观察组明显高于对照组（P＜0．05）；2组血浆内皮素－1（endothelin－1，ET－1）水平显著降低，一氧化氮（NO）
和一氧化氮合酶（NOS）水平均显著升高，且观察组变化更为显著（P＜0．05）；2组超敏C反应蛋白（hypersensitive C－reactive protein，hs－CRP）、肿瘤
坏死因子－α（tumor necrosis factor， TNF－α）、白细胞介素－8（interleukin－8，IL－8）、白细胞介素－6（interleukin－6，IL－6）水平均显著降低，同时观察组显著低于对照组（P＜0．05）；患者均未出现严重不良反应。

结论瑞舒伐他汀可以有效改善AMI患者PCI术后的血管内皮功能及炎性因子水平，提高疗效，从而改善患者的生活质量。

【总页数】4页(P124-126,130)
【作者】张辉;王茜
【作者单位】保定市第二医院心内科，河北保定 071051;保定市第二医院心内科，河北保定 071051
【正文语种】中文
【中图分类】R541.4
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