THK5351_COA_25145_MedChemExpress
慢性阻塞性肺疾病合并症——认知障碍
专家述评—认知障碍慢性阻塞性肺疾病合并症—常潇丹，黄丹辉，蔡绍曦基金项目：国家自然科学基金项目（编号=81970032）作者单位：510515广州，南方医科大学南方医院呼吸与危重症医学科,慢性气道疾病研究室作者简介：常潇丹（1998-），女，在读硕士研究生,研究方向:呼吸系统疾病护理。
*************************通讯作者；蔡绍曦（I960-），女，医学博士，主任医师，教授，博士研究生导师，研究方向:慢性气道炎症、呼吸机相关性肺损伤的临床与基础研究。
E-mail：hxkcai@126・com蔡绍曦，医学博士，主任医师，博士研究生导师，博士后合作导师，南方医科大学南方医院呼吸与危重症医学科主任,广东电预防医学会呼吸病预防与控制专业委员会主任委员，广东省医学会呼吸病学分会前任主任委员，广东塔医师协会呼吸\a k.,;B科医师分会副主任委员冲华医学会呼吸病学分会委员及慢阻肺学组委员，中国医厂/师协会变态反应医师分会副主任委员，中国医师协会呼吸医师分会常委，《中国呼I I'*吸与危重监护杂志》常务编委，《中华结核与呼吸杂志》《中华医学杂志》通讯编委，CHEST（中文版）杂志编委。
主要研究方向:慢性气道疾病临床与应用基础研究，肺部疑难危重症诊治。
主持承担国家自然科学基金项目6项,其他国家级基金项目2项，省级课题8项。
广东省“名医工程”首批专家之一，并获得专项基金资助。
拥有国家发明专利1项，实用新型专利4项。
获广东霜科技进步二等奖1项，广卿市科技进步三等奖1项，军队医疗成果三等奖2项，军队科技成果三等奖1项，发表学术论文200余篇，其中SCI收录论文50余篇。
已培养博士、硕士研究生80余人。
［摘要］慢性阻塞性肺疾病（COPD）合并认知障碍的发病率较高，目前被证实有发展为痴呆症的可能,并且对患者的生活和COPD的疾病管理造成障碍，值得关注。
基于其发病隐匿,易被临床医师及患者家属忽略，增加其诊治难度，现对其发病特点、影响、筛查和评估及治疗等方面的研究进展进行述评，为临床诊治提供参考。
Bedaquiline fumarate_845533-86-0_DataSheet_MedChemExpress
Product Name:Bedaquiline fumarate CAS No.:845533-86-0Cat. No.:HY-14881A Product Data SheetMWt:671.58Formula:C36H35BrN2O6Purity :>98%Solubility:DMSOMechanisms:Biological Activity:Bedaquiline fumarate(TMC207; R207910) is an anti-tuberculosis drug which selectively inhibit the Pathways:Anti-infection; Target:Antibacterial q (;)g y mycobacterial energy metabolism i.e. ATP synthesis and found to be effective against all states ofMycobacterium tuberculosis.IC50 value:Target: anti-TB Preclinical studies have shown the efficacy of bedaquiline in terms of reduction in bacterial load and treatment duration. Phase II clinical studies have established the safety, tolerability and earliersputum conversion time in patients with MDR-TB. In 2012 FDA approved bedaquiline for treatment of MDR-TB and XDR-TB [1]. Bedaquiline possesses a unique mechanism of action that disrupts the ti it f th b t i l d i t i h h t th Cli i l t i l h b d t d References:[1]. Lakshmanan M, et al. Bedaquiline - The first ATP synthase inhibitor against multi drug resistanttuberculosis. J Young Pharm. 2013 Dec;5(4):112-115.[2]Chahine EB et al Bedaquiline:a novel diarylquinoline for multidrug-resistant tuberculosis Ann activity of the mycobacterial adenosine triphosphate synthase. Clinical trials have been conducted evaluating the use of bedaquiline in combination with a background regimen for the treatment of adults with pulmonary MDR-TB. Bedaquilin...[2]. Chahine EB, et al. Bedaquiline: a novel diarylquinoline for multidrug-resistant tuberculosis. AnnPharmacother. 2014 Jan;48(1):107-15.Caution: Not fully tested. For research purposes onlyMedchemexpress LLC18 W i l k i n s o n W a y , P r i n c e t o n , N J 08540,U S AT E m a i l : i n f o @m e d c h e m e x p r e s s .c o m W e b : w w w .m e d c h e m e x p r e s s .c o m。
微生物屏障试验 DIN 58953-6_2010 Test report
Interlaboratory T est …Microbial barrier testing of packa ging materials for medical devices which are tobe ster ili ze d“according to DIN 58953-6:2010Test re portJanuary 2013Author: Daniel ZahnISEGA Forschungs- und Untersuchungsgesellschaft mbHTest report Page 2 / 15Table of contentsSeite1.General information on the Interlaboratory Test (3)1.1 Organization (3)1.2 Occasion and Objective (3)1.3 Time Schedule (3)1.4 Participants (4)2.Sample material (4)2.1 Sample Description and Execution of the Test (4)2.1.1 Materials for the Analysis of the Germ Proofness under Humidityaccording to DIN 58953-6, section 3 (5)2.1.2 Materials for the Analysis of the Germ Proofness with Air Permeanceaccording to DIN 58953-6, section 4 (5)2.2 Sample Preparation and Despatch (5)2.3 Additional Sample and Re-examination (6)3.Results (6)3.1 Preliminary Remark (6)3.2 Note on the Record of Test Results (6)3.3 Comment on the Statistical Evaluation (6)3.4 Outlier tests (7)3.5 Record of Test Results (7)3.5.1 Record of Test Results Sample F1 (8)3.5.2 Record of Test Results Sample F2 (9)3.5.3 Record of Test Results Sample F3 (10)3.5.4 Record of Test Results Sample L1 (11)3.5.5 Record of Test Results Sample L2 (12)3.5.6 Record of Test Results Sample L3 (13)3.5.7 Record of Test Results Sample L4 (14)4.Overview and Summary (15)Test report Page 3 / 15 1. General Information on the Interlaboratory Test1.1 OrganizationOrganizer of the Interlaboratory Test:Sterile Barrier Association (SBA)Mr. David Harding (director.general@)Pennygate House, St WeonardsHerfordshire HR2 8PT / Great BritainRealization of the Interlaboratory Test:Verein zur Förderung der Forschung und Ausbildung fürFaserstoff- und Verpackungschemie e. V. (VFV)vfv@isega.dePostfach 10 11 0963707 Aschaffenburg / GermanyTechnical support:ISEGA Forschungs- u. Untersuchungsgesellschaft mbHDr. Julia Riedlinger / Mr. Daniel Zahn (info@isega.de)Zeppelinstraße 3 – 563741 Aschaffenburg / Germany1.2 Occasion and ObjectiveIn order to demonstrate compliance with the requirements of the ISO 11607-1:2006 …Packaging for terminally sterilized medical devices -- Part 1: Requirements for materials, sterile barrier systems and packaging systems“ validated test methods are to be preferably utilized.For the confirmation of the microbial barrier properties of porous materials demanded in the ISO 11607-1, the DIN 58953-6:2010 …Sterilization – Sterile supply – Part 6: Microbial barrier testing of packaging materials for medical devices which are to be sterilized“ represents a conclusive method which can be performed without the need for extensive equipment.However, since momentarily no validation data on DIN 58953-6 is at hand concerns emerged that the method may lose importance against validated methods in a revision of the ISO 11607-1 or may even not be considered at all.Within the framework of this interlaboratory test, data on the reproducibility of the results obtained by means of the analysis according to DIN 58953-6 shall be gathered.1.3 Time ScheduleSeptember 2010:The Sterile Barrier Association queried ISEGA Forschungs- und Unter-suchungsgesellschaft about the technical support for the interlaboratory test.For the realization, the Verein zur Förderung der Forschung und Ausbildungfür Faserstoff- und Verpackungschemie e. V. (VFV) was won over.November 2010: Preliminary announcement of the interlaboratory test / Seach for interested laboratoriesTest report Page 4 / 15 January toDecember 2011: Search for suitable sample material / Carrying out of numerous pre-trials on various materialsJanuary 2012:Renewed contact or search for additional interested laboratories, respectively February 2012: Sending out of registration forms / preparation of sample materialMarch 2012: Registration deadline / sample despatchMay / June 2012: Results come in / statistical evaluationJuly 2012: Despatch of samples for the re-examinationSeptember 2012: Results of the re-examination come in / statistical evaluationNovember 2012: Results are sent to the participantsDecember 2012/January 2013: Compilation of the test report1.4 ParticipantsFive different German laboratories participated in the interlaboratory test. In one laboratory, the analyses were performed by two testers working independently so that six valid results overall were received which can be taken into consideration in the evaluation.To ensure an anonymous evaluation of the results, each participant was assigned a laboratory number (laboratory 1 to laboratory 6) in random order, which was disclosed only to the laboratory in question. The complete laboratory number breakdown was known solely by the ISEGA staff supporting the proficiency test.2. Sample Material2.1 Sample Description and Execution of the TestUtmost care in the selection of suitable sample material was taken to include different materials used in the manufacture of packaging for terminally sterilized medical devices.With the help of numerous pre-trials the materials were chosen covering a wide range of results from mostly germ-proof samples to germ permeable materials.Test report Page 5 / 15 2.1.1 Materials for the Analysis of Germ Proofness under Humidity according to DIN 58953-6, section 3:The participants were advised to perform the analysis on the samples according to DIN 58953-6, section 3, and to protocol their findings on the provided result sheets.The only deviation from the norm was that in case of the growth of 1 -5 colony-forming units (in the following abbreviated as CFU) per sample, no re-examination 20 test pieces was performed.2.1.2 Materials for the Analysis of Germ Proofness with Air Permeance according to DIN 58953-6, section 4:The participants were advised to perform the analysis on the samples according to DIN 58953-6, section 4, and to protocol their findings on the provided result sheets.2.2 Sample Preparation and DespatchFor the analysis of the germ proofness under humidity, 10 test pieces in the size of 50 x 50 mm were cut out of each sample and heat-sealed into a sterilization pouch with the side to be tested up.Out of the 10 test pieces, 5 were intended for the testing and one each for the two controls according to DIN 58953-6, sections 3.6.2 and 3.6.3. The rest should remain as replacements (e.g. in case of the dropping of a test piece on the floor etc.).For the analysis of the germ proofness with air permeance, 15 circular test pieces with a diameter of 40 mm were punched out of each sample and heat-sealed into a sterilization pouch with the side to be tested up.Test report Page 6 / 15 Out of the 15 test pieces, 10 were intended for the testing and one each for the two controls according to DIN 58953-6, section 4.9. The rest should remain as replacements (e.g. in case of the dropping of a test piece on the floor etc.).The sterilization pouches with the test pieces were steam-sterilized in an autoclave for 15 minutes at 121 °C and stored in an climatic room at 23 °C and 50 % relative humidity until despatch.2.3 Additional Sample and Re-examinationFor the analysis of the germ proofness under humidity another test round was performed in July / August 2012. For this, an additional sample (sample L4) was sent to the laboratories and analysed (see 2.1.2). The results were considered in the evaluation.For validation or confirmation of non-plausible results, occasional samples for re-examination were sent out to the laboratories. The results of these re-examinations (July / August 2012) were not taken into consideration in the evaluation.3. Results3.1 Preliminary RemarkSince the analysis of germ proofness is designed to be a pass / fail – test, the statistical values and precision data were meant only to serve informative purposes.The evaluation of the materials according to DIN58953-6,sections 3.7and 4.7.6by the laboratories should be the most decisive criterion for the evaluation of reproducibility of the interlaboratory test results. Based on this, the classification of a sample as “sufficiently germ-proof” or “not sufficiently germ-proof” is carried out.3.2 Note on the Record of Test Results:The exact counting of individual CFUs is not possible with the required precision if the values turn out to be very high. Thus, an upper limit of 100 CFU per agar plate or per test pieces, respectively, was defined. Individual values above this limit and values which were stated with “> 100” by the laboratories, are listed as 100 CFU per agar plate or per test piece, respectively, in the evaluation.Test report Page 7 / 153.3 Comment on the Statistical EvaluationThe statistical evaluation was done based on the series of standards DIN ISO 5725-1ff.The arithmetic laboratory mean X i and the laboratory standard deviation s i were calculated from the individual measurement values obtained by the laboratories.The overall mean X of the laboratory means as well as the precision data of the method (reproducibility and repeatability) were determined for each sample3.4 Outlier testsThe Mandel's h-statistics test was utilised as outlier test for differences between the laboratory means of the participants.A laboratory was identified as a “statistical outlier” as soon as an exceedance of Mandel's h test statistic at the 1 % significance level was detected.The respective results of the laboratories identified as outliers were not considered in the statistical evaluation.3.5 Record of Test ResultsOn the following pages, the records of the test results for each interlaboratory test sample with the statistical evaluation and the evaluation according to DIN 58953-6 are compiled.Test report Page 8 / 153.5.1 Record of Test Results Sample F1Individual Measurement values:Statistical Evaluation:Comment:Laboratory 4, as an outlier, has not been taken into consideration in the statistical Evaluation.Outlier criterion: Mandel's h-statistics (1 % level of significance)Overall mean X:91.0CFU / agar plateRepeatability standard deviation s r:17.9CFU / agar plateReproducibility standard deviation s R:19.8CFU / agar plateRepeatability r:50.0CFU / agar plateRepeatability coefficient of variation:19.6%Reproducibility R:55.5CFU / agar plateReproducibility coefficient of variation:21.8%Evaluation according to DIN 58953-6, Section 3.7:Lab. 1 - 6:Number of CFU > 5, i.e. the material is classified as not sufficiently germ-proof.Conclusion:All of the participants, even the Laboratory 4 which was identified as an outlier, came to the same results and would classify the sample material as “not sufficiently germ-proof”Test report Page 9 / 153.5.2 Record of Test Results Sample F2Individual Measurement values:Statistical Evaluation:Comment:Laboratory 4, as an outlier, has not been taken into consideration in the statistical Evaluation.Outlier criterion: Mandel's h-statistics (1 % level of significance)Overall mean X:0CFU / agar plateRepeatability standard deviation s r:0CFU / agar plateReproducibility standard deviation s R:0CFU / agar plateRepeatability r:0CFU / agar plateRepeatability coefficient of variation:0%Reproducibility R:0CFU / agar plateReproducibility coefficient of variation:0%Evaluation according to DIN 58953-6, Section 3.7:Lab. 1 – 3:Number of CFU = 0, i.e. the material is classified as sufficiently germ-proofLab. 4:Number of CFU ≤ 5, i.e. a re-examination on 20 test pieces would have to be done Lab. 5 – 6:Number of CFU = 0, i.e. the material is classified as sufficiently germ-proofConclusion:All of the participants, except for the Laboratory 4 which was identified as an outlier, came to the same results and would classify the sample material as “sufficiently germ-proof”.Test report Page 10 / 153.5.3 Record of Test Results Sample F3Individual Measurement values:Statistical Evaluation:Overall mean X:30.1CFU / agar plateRepeatability standard deviation s r:17.2CFU / agar plateReproducibility standard deviation s R:30.9CFU / agar plateRepeatability r:48.2CFU / agar plateRepeatability coefficient of variation:57.1%Reproducibility R:86.5CFU / agar plateReproducibility coefficient of variation:103%Evaluation according to DIN 58953-6, Section 3.7:Lab. 1 - 4:Number of CFU > 5, i.e. the material is classified as not sufficiently germ-proof. Lab. 5:Number of CFU = 0, i.e. the material is classified as sufficiently germ-proof. Lab. 6:Number of CFU > 5, i.e. the material is classified as not sufficiently germ-proof.Conclusion:Five of the six participants came to the same result and would classify the sample as “not sufficiently germ-proof”. Only laboratory 5 would classify the sample material as “sufficiently germ-proof”.Test report Page 11 / 153.5.4 Record of Test Results Sample L1Individual Measurement values:Statistical Evaluation:Overall mean X:0.09CFU / test pieceRepeatability standard deviation s r:0.32CFU / test pieceReproducibility standard deviation s R:0.33CFU / test pieceRepeatability r:0.91CFU / test pieceRepeatability coefficient of variation:357%Reproducibility R:0.93CFU / test pieceReproducibility coefficient of variation:366%Evaluation according to DIN 58953-6, Section 4.7:Lab. 1 - 6:Number of CFU < 15, i.e. the material is classified as sufficiently germ-proof.Conclusion:All participants came to the same result and would classify the sample as “sufficiently germ-proof”.Test report Page 12 / 153.5.5 Record of Test Results Sample L2Individual Measurement values:Statistical Evaluation:Overall mean X:0.73CFU / test pieceRepeatability standard deviation s r: 1.10CFU / test pieceReproducibility standard deviation s R: 1.18CFU / test pieceRepeatability r: 3.07CFU / test pieceRepeatability coefficient of variation:151%Reproducibility R: 3.32CFU / test pieceReproducibility coefficient of variation:163%Evaluation according to DIN 58953-6, Section 4.7:Lab. 1:Number of CFU > 15, i.e. the material is classified as not sufficiently germ-proof. Lab. 2 - 6:Number of CFU < 15, i.e. the material is classified as sufficiently germ-proof.Conclusion:Five of the six participants came to the same result and would classify the sample as “sufficiently germ-proof”. Only laboratory 1 exceeds the limit value slightly by 1 CFU, so that the sample would be classified as “not sufficiently germ-proof”.Test report Page 13 / 153.5.6 Record of Test Results Sample L3Individual Measurement values:Statistical Evaluation:Overall mean X:0.36CFU / test pieceRepeatability standard deviation s r: 1.00CFU / test pieceReproducibility standard deviation s R: 1.06CFU / test pieceRepeatability r: 2.79CFU / test pieceRepeatability coefficient of variation:274%Reproducibility R: 2.98CFU / test pieceReproducibility coefficient of variation:293%Evaluation according to DIN 58953-6, Section 4.7:Lab. 1 - 6:Number of CFU < 15, i.e. the material is classified as sufficiently germ-proof.Conclusion:All participants came to the same result and would classify the sample as “sufficiently germ-proof”.Test report Page 14 / 153.5.7 Record of Test Results Sample L4Individual Measurement values:Statistical Evaluation:Overall mean X:35.1CFU / test pieceRepeatability standard deviation s r:18.8CFU / test pieceReproducibility standard deviation s R:42.6CFU / test pieceRepeatability r:52.7CFU / test pieceRepeatability coefficient of variation:53.7%Reproducibility R:119CFU / test pieceReproducibility coefficient of variation:122%Evaluation according to DIN 58953-6, Section 4.7:Lab. 1 - 3:Number of CFU > 15, i.e. the material is classified as not sufficiently germ-proof. Lab. 4:Number of CFU < 15, i.e. the material is classified as sufficiently germ-proof. Lab. 5 - 6:Number of CFU > 15, i.e. the material is classified as not sufficiently germ-proof.Conclusion:Five of the six participants came to the same result and would classify the sample as“not sufficiently germ-proof”.Test report Page 15 / 15 4. Overview and SummarySummary:In case of four of the overall seven tested materials, a 100 % consensus was reached regarding the evaluation as“sufficiently germ-proof”and“not sufficiently germ-proof”according to DIN 58 953-6.As for the other three tested materials, there were always 5 concurrent participants out of 6 (83 %). In each case, only one laboratory would have evaluated the sample differently.It is noteworthy that the materials about the evaluation of which a 100 % consensus was reached were the smooth sterilization papers. The differences with one deviating laboratory each occurred with the slightly less homogeneous materials, such as with the creped paper and the nonwoven materials.。
华中科技大学学术期刊分类目录(T-D)_最新权威版
24.755 23.917 23.654 23.565 23.333 23.194 22.929 22.864 22.864 22.864 22.490 22.345 22.333 21.757 21.543 21.543 20.833 20.761 20.614 19.966 19.795 19.547 19.352 18.571 18.571 18.038 17.983 17.983 17.949 17.689 17.689 17.689 17.436 17.313 17.215 16.417 16.238 16.179 16.008 16.008 15.766 15.575 15.518 15.389 15.389 15.389 15.333 15.333 15.280 15.280 15.265 15.253 15.251 15.202
ONCOLOGY CLINICAL NEUROLOGY PLANT SCIENCES BIOCHEMICAL RESEARCH METHODS ASTRONOMY & ASTROPHYSICS MATERIALS SCIENCE, MULTIDISCIPLINARY PHYSICS, MULTIDISCIPLINARY BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY MEDICINE, RESEARCH & EXPERIMENTAL MICROBIOLOGY PHARMACOLOGY & PHARMACY PHYSICS, PARTICLES & FIELDS CHEMISTRY, MULTIDISCIPLINARY PHARMACOLOGY & PHARMACY TOXICOLOGY CHEMISTRY, MULTIDISCIPLINARY CELL BIOLOGY NEUROSCIENCES INFECTIOUS DISEASES IMMUNOLOGY PHYSIOLOGY PHYSICS, MULTIDISCIPLINARY BEHAVIORAL SCIENCES NEUROSCIENCES ONCOLOGY CELL BIOLOGY DEVELOPMENTAL BIOLOGY ECOLOGY CHEMISTRY, MULTIDISCIPLINARY MAபைடு நூலகம்ERIALS SCIENCE, MULTIDISCIPLINARY NANOSCIENCE & NANOTECHNOLOGY GENETICS & HEREDITY MICROBIOLOGY MEDICINE, GENERAL & INTERNAL MICROBIOLOGY ASTRONOMY & ASTROPHYSICS MATERIALS SCIENCE, MULTIDISCIPLINARY BEHAVIORAL SCIENCES NEUROSCIENCES NEUROSCIENCES PSYCHOLOGY CLINICAL NEUROLOGY ECOLOGY EVOLUTIONARY BIOLOGY GENETICS & HEREDITY CHEMISTRY, PHYSICAL PHYSICS, CONDENSED MATTER BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY PSYCHOLOGY MEDICINE, GENERAL & INTERNAL NEUROSCIENCES CARDIAC & CARDIOVASCULAR SYSTEMS
化学治疗chemotherapy对病原体微生物9955
内酰胺环
内酰胺酶
-内酰胺类抗生素的共性
• 药动学 • 吸收后广泛分布于全身组织,关节
、胸腔、心包液和胆汁中含量较 高,容易达到治疗浓度 • 在前列腺液、脑和眼组织液中浓 度低 • 在体内不被代谢, 以原形迅速由 肾小管分泌排出, t1/2较短
药理作用和机制
• 属于快速杀菌药 • 敏感菌
–大多数G＋球菌(链、葡) –G＋杆菌(炭、白、破) –G－球菌(脑、淋) –G－杆菌(伤寒,副伤寒,百,肠,痢) –螺旋体(梅,幽)，放线菌
LD50/ED50或LD5/ED95 值越大表明药物疗效毒性 比越大
临床应用价值可能较高
抗微生物药物作用机制
1. 抑制细胞壁合成 –-LAs类
2. 增加胞浆膜通透性 – 氨基糖苷类通过离子吸附 – 制霉菌素结合真菌胞膜麦角固 醇 – 多粘菌素结合胞浆磷脂
-LAs类 转肽酶
3. 抑制细菌蛋白合成 –氯霉素、林可霉素和大环内酯 类作用于50S亚单位 –四环素和氨基糖苷类作用于30S 亚单位
机体、药物及病原体相互作用关系
抗菌药物发展简史
• Pasteur 和 Joubert 最先认识到 微生物的产物有可能抗菌
• 1928年,Fleming发现青霉素 • 1939年Florey置备成功青霉素,
1941年治疗感染, 开辟了抗生素 化疗的新纪元
• 1935年,Domagk合成磺胺药
• 抗生素(antibiotics): 由各种微 生物(包括细菌真菌放线菌)产生 的, 能抑制其它微生物的物质
3. 螺旋体所致感染 钩端螺旋体、梅毒(大剂量) 、 回归热等
4. G＋杆菌所致感染 破伤风、白喉、炭疽病,应与相 应的抗毒素合用
药动学
• 易被胃酸及消化酶破坏,不宜 口服
影响因子_Chem2012
Mark Rank Abbreviated Journal Title ISSN JCR Data More Information (linked to journal information)Total Cites Impact5-YearFactor ImpactFactor NATURE0028-0836********.2836.235SCIENCE0036-807548083631.20132.452P NATL ACAD SCI USA0027-84245042439.68110.4721CHEM REV0009-266510370240.19742.0542NAT MATER1476-11223924232.84136.7323CHEM SOC REV0306-00123591828.7628.0984ACCOUNTS CHEM RES0001-48423966421.6422.5075NAT CHEM1755-4330526020.52420.5336ALDRICHIM ACTA0002-5100110016.09116.8827NANO TODAY1748-0132217015.35516.0788ANNU REV PHYS CHEM0066-426X665714.1317.489ADV MATER0935-96487986013.87712.81310ANGEW CHEM INT EDIT1433-785120986213.45513.19511NANO LETT1530-69847528713.19813.84312COORDIN CHEM REV0010-85452506212.1112.74413SURF SCI REP0167-5729370211.69618.09514ACS NANO1936-0851*******.77411.17115MED RES REV0198-6325309610.710.0316J PHOTOCH PHOTOBIO C1389-5567165410.3612.45817ADV FUNCT MATER1616-301X2850310.1799.9218J AM CHEM SOC0002-78634083079.9079.76619NAT PROD REP0265-056857749.799.67120ENERG ENVIRON SCI1754-569250879.6110.81321PROG INORG CHEM0079-637914959.3338.33322ANNU REV ANAL CHEM1936-13278769.04811.80623PROG SURF SCI0079-681617288.6368.08824SMALL1613-6810151818.3498.26225ADV COLLOID INTERFAC0001-868664148.128.37226CURR OPIN COLLOID IN1359-029444788.017.83727ADV CARBOHYD CHEM BI0065-23188517.643 5.5628CHEM SCI2041-652016977.5257.54529CATAL REV0161-494027377.59.92730ANNU REV CHEM BIOMOL1947-54381587.2947.29431CHEM MATER0897-4756699267.286 6.94932ADV ORGANOMET CHEM0065-30559517 6.63633NANO RES1998-01242017 6.977.46134CHEMSUSCHEM1864-56313040 6.8277.17135GREEN CHEM1463-926212023 6.32 6.76136TRAC-TREND ANAL CHEM0165-99366620 6.273 6.87337J PHYS CHEM LETT1948-71854695 6.213 6.217 38CHEM COMMUN1359-7345105562 6.169 6.082 39ADV SYNTH CATAL1615-415014629 6.048 5.904 40J CATAL0021-951733570 6.002 6.201 41J MATER CHEM0959-942846166 5.968 5.992 42INT REV PHYS CHEM0144-235X1533 5.967 6.977 43CHEM-EUR J0947-653954127 5.925 5.866 44NANOSCALE2040-33643187 5.914 5.914 45ORG LETT1523-706068838 5.862 5.558 46ANAL CHEM0003-270095262 5.856 5.983 47J CONTROL RELEASE0168-365926071 5.7327.112 48LAB CHIP1473-019713729 5.67 6.497 49APPL CATAL B-ENVIRON0926-337320525 5.625 6.052 50BIOSENS BIOELECTRON0956-566320029 5.602 5.637 51BIOMACROMOLECULES1525-779721280 5.479 5.646 52CARBON0008-622327798 5.378 6.008 53J MED CHEM0022-262356481 5.248 5.321 54J CHEM THEORY COMPUT1549-96188327 5.215 5.673 55PROG NUCL MAG RES SP0079-65651765 5.214 6.296 56CHEMCATCHEM1867-38801502 5.207 5.207 57FARADAY DISCUSS1364-549853725 4.687 58BIOCONJUGATE CHEM1043-180213657 4.93 5.224 59CURR MED CHEM0929-867311387 4.859 4.806 60J PHYS CHEM C1932-744760782 4.805 5.049 61CRYST GROWTH DES1528-748319082 4.72 4.877 62J CHEM INF MODEL1549-959611209 4.675 4.305 63INORG CHEM0020-166982190 4.601 4.553 64J COMPUT CHEM0192-865122334 4.583 4.795 65ANAL CHIM ACTA0003-267038343 4.555 4.144 66J CHROMATOGR A0021-967360179 4.531 4.362 67CHEM-ASIAN J1861-47284472 4.5 4.461 67ELECTROANAL CHEM0070-9778451 4.56 69J ORG CHEM0022-326398614 4.45 4.204 70SOFT MATTER1744-683X10988 4.39 4.998 71CHEM REC1527-89991256 4.377 4.161 72ANALYST0003-265414243 4.23 4.119 73PROG SOLID STATE CH0079-67861516 4.188 3.551 74LANGMUIR0743-7463103776 4.186 4.514 75CURR TOP MED CHEM1568-02664646 4.174 4.417 76PHARM RES-DORDR0724-874117160 4.093 4.668 77INT J HYDROGEN ENERG0360-319926939 4.054 4.402 78J AM SOC MASS SPECTR1044-03058794 4.002 3.746 79ORGANOMETALLICS0276-733339562 3.963 3.78680CHEMBIOCHEM1439-42279059 3.944 3.719 81APPL CATAL A-GEN0926-860X26533 3.903 3.961 82CRIT REV ANAL CHEM1040-8347849 3.902 3.956 83SENSOR ACTUAT B-CHEM0925-400527323 3.898 3.751 84MAR DRUGS1660-33971161 3.854 3.704 85CRYSTENGCOMM1466-80339036 3.842 4.023 86DALTON T1477-922637605 3.838 3.887 87TALANTA0039-914024981 3.794 3.747 88CHEM RES TOXICOL0893-228X10444 3.779 3.969 89ANAL BIOANAL CHEM1618-264218911 3.778 3.733 90J PHYS CHEM B1520-6106118812 3.696 4.061 90ORG BIOMOL CHEM1477-052015667 3.696 3.652 92ACS CHEM NEUROSCI1948-7193310 3.676 3.676 93ADV CATAL0360-05641395 3.667 5.04 94FOOD CHEM0308-814636842 3.655 4.268 95CARBOHYD POLYM0144-861715055 3.628 3.987 96PHYS CHEM CHEM PHYS1463-907631819 3.573 3.931 97EXPERT OPIN THER PAT1354-37761563 3.571 2.122 98ULTRASON SONOCHEM1350-41774594 3.567 3.83 99GOLD BULL0017-15571139 3.517 3.162 100STRUCT BOND0081-59931940 3.475 6.315 101FOOD HYDROCOLLOID0268-005X5607 3.473 3.46 102COLLOID SURFACE B0927-77658715 3.456 3.354 103CURR ORG SYNTH1570-1794665 3.434 3.842 104J CHEMINFORMATICS1758-2946179 3.419 3.419 105CHEMPHYSCHEM1439-423510354 3.412 3.553 106J COMB CHEM1520-47663046 3.408 2.893 107CATAL TODAY0920-586122303 3.407 3.584 108ACS MED CHEM LETT1948-5875511 3.355 3.355 109J INORG BIOCHEM0162-01349265 3.354 3.495 110EUR J MED CHEM0223-523411332 3.346 3.509 111EUR J ORG CHEM1434-193X18591 3.329 3.289 112ELECTROPHORESIS0173-083517540 3.303 2.917 113J BIOL INORG CHEM0949-82573803 3.289 3.488 114J NANOPART RES1388-07644770 3.287 3.574 115MICROPOR MESOPOR MAT1387-181113858 3.285 3.254 116CHEM CENT J1752-153X292 3.281 3.033 117J MASS SPECTROM1076-51745549 3.268 3.301 117PHYTOMEDICINE0944-71134731 3.268 3.3 119BIOANALYSIS1757-6180829 3.223 3.223 120J ANAL ATOM SPECTROM0267-94776969 3.22 2.966 121J PHYS CHEM REF DATA0047-26894693 3.172 3.804 122MOL DIVERS1381-19911114 3.153 3.236123CHEMMEDCHEM1860-71793364 3.151 3.445 124J NAT PROD0163-386418661 3.128 3.164 125DYES PIGMENTS0143-72086586 3.126 3.28 126MAR CHEM0304-42036836 3.074 3.551 127J COLLOID INTERF SCI0021-979742700 3.07 3.263 128CURR ORG CHEM1385-27283649 3.064 3.468 129J PHARM SCI-US0022-354916617 3.055 3.324 130EUR J INORG CHEM1434-194815553 3.049 2.904 131ADV INORG CHEM0898-******** 3.048 3.049 131MICROCHEM J0026-265X3125 3.048 2.878 133MICROCHIM ACTA0026-36724182 3.033 2.508 134TETRAHEDRON0040-402053591 3.025 3.06 135J ETHNOPHARMACOL0378-874121075 3.014 3.728 136ANAL BIOCHEM0003-269740002 2.996 3.247 137PLASMONICS1557-1955654 2.989 4.026 138CATAL COMMUN1566-73677950 2.986 3.299 139J PHARMACEUT BIOMED0731-708514454 2.967 2.979 140J MOL CATAL A-CHEM1381-116917457 2.947 3.336 141J PHYS CHEM A1089-563953462 2.946 2.941 142FUEL PROCESS TECHNOL0378-******** 2.945 3.131 143BIOORGAN MED CHEM0968-089622584 2.921 3.157 144J ELECTROANAL CHEM1572-665722586 2.905 2.731 145J CHROMATOGR B1570-023221252 2.888 3.057 146DRUG DES DEV THER1177-8881203 2.877147ELECTROANAL1040-039710069 2.872 2.856 148ANTI-CANCER AGENT ME1871-52061203 2.862149J SUPERCRIT FLUID0896-84465365 2.86 3.145 150J AGR FOOD CHEM0021-856171104 2.823 3.239 151MEDCHEMCOMM2040-2503223 2.8 2.8 152RAPID COMMUN MASS SP0951-419813453 2.79 2.782 153PURE APPL CHEM0033-454512669 2.789 2.987 154J MOL CATAL B-ENZYM1381-11774576 2.735 2.701 155J SEP SCI1615-93067275 2.733 2.725 156SYNLETT0936-521417866 2.71 2.567 157TETRAHEDRON LETT0040-403976620 2.683 2.588 158TETRAHEDRON-ASYMMETR0957-416613382 2.652 2.652 159SOLID STATE IONICS0167-273822111 2.646 3.097 160RUSS CHEM REV+0036-021X3090 2.644 2.941 161PHYTOCHEM ANALYSIS0958-03441883 2.633 2.32 162TOP CATAL1022-55284801 2.624 2.973 163SEP PURIF REV1542-2119175 2.615 3.629 164NEW J CHEM1144-05469359 2.605 2.775 165INT J MOL SCI1661-65962744 2.598 2.617166PHOTOCH PHOTOBIO SCI1474-905X3988 2.584 2.688 167ENVIRON CHEM1448-25171188 2.57 2.694 168BIOORG MED CHEM LETT0960-894X31475 2.554 2.539 169MINI-REV MED CHEM1389-55752649 2.528 2.772 170FUTURE MED CHEM1756-8919616 2.522 2.522 171BEILSTEIN J ORG CHEM1860-5397812 2.517 2.078 172PLANT FOOD HUM NUTR0921-96681448 2.505 2.889 173J ANAL APPL PYROL0165-23704356 2.487 2.687 174REACT FUNCT POLYM1381-51484207 2.479 2.727 175APPL CLAY SCI0169-13175168 2.474 3.06 176SYNTHESIS-STUTTGART0039-788118726 2.466 2.448 177J CHEM THERMODYN0021-96145451 2.422 2.173 178J PHOTOCH PHOTOBIO A1010-603012665 2.421 2.925 179MINI-REV ORG CHEM1570-193X460 2.406 2.283 180ORG PROCESS RES DEV1083-61603609 2.391 2.38 181MOL INFORM1868-1743171 2.39 2.407 182MOLECULES1420-30495118 2.386 2.411 183J ORGANOMET CHEM0022-328X22966 2.384 2.085 184CHIRALITY0899-******** 2.35 2.232 185AUST J CHEM0004-94255762 2.342 2.258 186CHEM PHYS LETT0009-261455511 2.337 2.215 187CARBOHYD RES0008-621514992 2.332 2.386 188COLLOID POLYM SCI0303-402X5510 2.331 2.077 189J ALLOY COMPD0925-838836296 2.289 2.104 190CHEM BIOL DRUG DES1747-02771504 2.282 2.477 191ADV QUANTUM CHEM0065-3276754 2.275 1.356 192CATAL LETT1011-372X9443 2.242 2.314 193COLLOID SURFACE A0927-775717780 2.236 2.359 194BIOPHYS CHEM0301-46224908 2.203 2.163 195J CHEM TECHNOL BIOT0268-25756388 2.168 2.27 196THEOR CHEM ACC1432-881X4587 2.162 2.909 197MATCH-COMMUN MATH CO0340-62531420 2.161 1.826 198J SOLID STATE CHEM0022-459617779 2.159 2.412 199PLANTA MED0032-094311107 2.153 2.338 200SUPRAMOL CHEM1061-02782323 2.145 2.021 201FLUID PHASE EQUILIBR0378-******** 2.139 2.225 202J FLUORESC1053-05092486 2.107 2.197 203APPL SURF SCI0169-433228315 2.103 2.032 204PHYTOTHER RES0951-418X7721 2.086 2.469 204SAR QSAR ENVIRON RES1062-936X715 2.086 1.874 206J FOOD COMPOS ANAL0889-15753582 2.079 3.257 207APPL ORGANOMET CHEM0268-26052774 2.061 1.849 208POLYHEDRON0277-538713245 2.057 2.118209J BIOMOL SCREEN1087-05712131 2.049 2.066 210J FLUORINE CHEM0022-11394628 2.033 1.95 211SOLVENT EXTR ION EXC0736-******** 2.024 1.81 212J ANAL TOXICOL0146-47602651 2.022 1.994 213ADSORPTION0929-560713282 2.215 214SURF SCI0039-602823707 1.994 1.661 215J ENVIRON MONITOR1464-03253800 1.991 2.245 216J IND ENG CHEM1226-086X1844 1.977 1.647 216PROG ORG COAT0300-94404252 1.977 2.167 218INORG CHEM COMMUN1387-70036187 1.972 1.975 219BIOMED CHROMATOGR0269-38792728 1.966 1.88 220J PHYS ORG CHEM0894-32302668 1.963 1.648Eigenfactor® MetricsMore Information Immediacy Articles Cited Eigenfactor®Article Influence®Index Half-life Score Score9.698419.4 1.6565820.3536.0758719.4 1.4128217.5081.87436147.8 1.6033 4.8927.1581967.90.2146413.3056.246134 4.70.2208917.8915.471314 3.20.13678.0693.4612670.10127.2865.308120 1.80.032847.94472 5.70.00328 5.2462.32437 2.80.0121 5.1443.267309.70.016877.4672.15578950.26226 4.0612.8982002 5.40.513933.372.082955 4.20.34576 5.0592.1791517.70.04173.2063.2588.70.009037.8051.631114120.12069 3.5842.12524 6.80.00678 2.7330.37516 6.60.00367 3.3871.51453340.112652.9391.86531767.50.816772.7922.61172 5.70.01594 2.9722.049548 1.90.01802 2.6940>10.00.00081 2.9341.0520 3.10.0052 3.930.51290.00413 3.9451.221430 3.20.072332.5070.633797.80.01312 2.3720.829707.40.00919 2.2640.3336>10.00.00074 1.6142.8483280.90.00453 2.4890.4297>10.00.00219 2.9011.41724 1.40.000932.9691.637673 6.40.15823 1.910.52>10.00.00074 1.8340.918122 2.30.01112 2.3841.1142012.40.01339 1.8641.09442 4.20.03184 1.4971.022138 5.60.01667 1.8071.405529 1.40.024172.072 1.5033408 5.50.24077 1.547 1.003398 4.10.04809 1.4850.842389.60.04417 1.5691.0882527 4.30.12631 1.571 1.75127.10.004032.549 1.29416973.90.1688 1.527 1.187653 1.40.01164 1.561 1.48516804.90.18767 1.411 0.93313287.70.17541 1.5470.915331 6.70.04644 1.6491.143538 3.60.05012 1.7050.858471 5.40.04732 1.4211.102704 4.20.05043 1.2040.752509 4.90.06046 1.3951.081641 6.30.06074 1.595 1.0497097.40.09638 1.3 1.145413 3.10.04017 1.716 1.55207.60.004652.345 1.049224 1.60.00601 1.352 1.3771389.20.01265 1.752 0.577300 5.50.03426 1.347 0.474403 5.20.03177 1.297 0.723166 2.90.28453 1.339 0.7237333.50.053380.912 0.595289 6.30.017020.7660.82814997.40.127630.9641.0763438.40.03476 1.516 0.597626 6.80.070850.9630.622110470.09860.9211.0453772.70.02083 1.243>10.00.00011 1.506 1.09912429.90.13784 1.05 0.8981353 2.50.05461 1.584 0.3182260.0032 1.1690.75869480.0249 1.0571.25>10.00.00172 1.053 0.711936 6.50.22306 1.179 0.706201 4.70.01384 1.168 0.7392618.50.02793 1.196 0.5911753 3.30.059170.7180.711228 5.80.02249 1.0541.013827 6.90.067680.830.819337 4.30.03418 1.204 0.5245527.10.045390.929 0.235177.20.001430.864 0.355904 5.50.057310.801 0.404171 1.90.004220.839 0.8441018 2.90.021720.749 0.831492 5.50.077660.883 0.447854 5.10.05450.81 0.68921970.02114 1.039 0.702967 4.10.062970.967 0.7151689 6.70.2465 1.159 0.8941061 3.90.051860.961 0.69669 1.40.00158 1.21405>10.00.00072 1.57 0.7321483 4.70.079720.839 0.64835 4.90.028380.744 0.91231440.11162 1.241 0.70896 2.90.005410.609 0.964197 4.70.009170.739 0.28257.30.002590.91611980.00341 1.67 0.825234 5.40.011580.756 0.716524 4.20.021180.7390.43848 4.40.002050.9771.4250 1.50.000460.805 0.71410 4.50.04139 1.1870 4.50.008370.668 0.45566870.04130.919 0.793179 1.30.00205 1.044 0.635222 6.80.015560.791 0.484672 3.50.026580.705 0.766789 4.80.049630.8180.424413 6.90.029650.6261.018111 5.60.01044 1.028 0.287669 3.80.015170.929 0.796368 5.20.03430.799 0.20986 3.20.001390.839 0.58143 6.50.013621 0.441195 5.40.009240.65 0.795171 1.60.001670.422 0.6142647.70.010820.673 0.21414>10.00.004512.295 0.734943.90.002830.6860.765226 3.30.014480.8530.4644018.60.025550.6821.052213 4.90.013750.659 0.5487>10.00.01419 1.433 0.6410467.80.070860.835 0.47215 5.80.008280.868 0.6764449.50.023950.793 0.605583 5.20.036290.663 0.310>10.00.00060.798 0.686185 5.30.005860.592 0.5226 4.60.008520.479 0.588119180.085760.724 0.344756 6.80.024870.586 0.475524>10.00.034330.912 0.276105 3.30.00338 1.185 0.46378 3.80.026420.746 0.602487 5.90.028250.647 0.496280 6.20.034720.765 0.5991610 6.30.124690.81 0.402326 5.90.013060.799 0.52978550.057240.716 0.526409>10.00.020090.672 0.3015487.20.038990.75 0.64937 1.90.000820.528362 5.80.018750.583 0.495103 3.30.005940.555200 4.80.011950.645 0.36816487.70.106370.722 0.591164 1.10.000580.7 0.56342660.032820.763 0.928139>10.00.014250.916 0.574183 5.70.0090.576 0.26453 3.80.026470.7 0.59358360.04060.66 0.51817349.50.098910.574 0.33328870.023130.591 0.29421100.028010.852 0.14854>10.00.004550.917 0.533757.10.00310.519 0.237152 5.20.014030.848 0.3339 4.70.000610.947 0.684358 6.80.01790.68 0.205611 2.60.01090.6360.62216 4.70.011730.744 0.56760 5.20.00460.935 0.5051516 5.10.073520.5710.402102 4.70.008450.7241.286112 1.70.002350.689 0.491962.10.002940.478 0.311617.50.00190.52 0.2641407.50.007770.652 0.623151 5.60.009150.618 0.30427650.011510.675 0.5575198.10.032360.622 0.531271 6.80.01050.542 0.3713267.50.020820.69 0.1503.90.001480.557 0.6211774.90.008970.574 0.37777 1.40.000560.519 0.325756 2.80.015320.517 0.658584>10.00.024370.447 0.4051265.80.006880.602 0.6922089.50.008880.572 0.451010>10.00.078030.694 0.401404>10.00.017360.539 0.51319590.007720.464 0.7552050 3.80.097330.507 0.376165 3.30.006880.645 0.66712>10.00.00110.509 0.4782497.40.017690.585 0.3366606.60.036250.587 0.5871098.60.00970.678 0.3982017.80.010420.532 0.974265 5.60.011680.86 0.575120 3.70.005470.581 0.3184918.50.029120.67 0.328274>10.00.010820.469 0.26411090.003750.484 0.4863257.70.015030.544 0.237257 5.10.005680.505 0.3831811 5.30.077130.549 0.29290 6.70.012010.475 0.2563950.001450.383 0.448163 5.60.008040.74 0.4131267.20.004260.402 0.4064617.20.019290.3870.46126 5.50.006040.602 0.2781807.30.008730.496 0.15645>10.00.001770.415 0.2139480.004840.536 0.29100 5.90.003030.562 0.511319>10.00.034280.619 0.318371 5.40.010620.649 0.2145 3.70.005160.354 0.275204 6.70.007280.481 0.454476 4.80.011950.353 0.422161 4.80.006940.423 0.466146 6.60.004980.398。
HPLC_法测定阿瑞匹坦中基因毒性杂质3-氯甲基-1,2,4-三唑啉-5-酮
第52卷第9期 辽 宁 化 工 Vol.52，No. 9 2023年9月 Liaoning Chemical Industry September，2023收稿日期： 2022-09-12HPLC 法测定阿瑞匹坦中基因毒性杂质3-氯甲基-1,2,4-三唑啉-5-酮常月赏，兰公剑*，王阔，陶蕾（南京正大天晴制药有限公司，江苏 南京 210046）摘 要：建立了液相色谱法测定阿瑞匹坦基因毒性杂质3-氯甲基-1,2,4-三唑啉-5-酮的分析方法。
采用安捷伦Poroshell 120系列EC -C18柱为色谱柱，0.1%磷酸溶液为流动相A，乙腈为流动相B，进行线性梯度洗脱，流速为1.0 mL ·min -1，柱温为30 ℃；检测波长为210 nm。
结果表明：溶剂空白及主峰不干扰该杂质的测定；该杂质在限度浓度20%~200%的范围内线性关系良好；该杂质的回收率在99.3%~101.0%范围内，RSD 小于5.0%；对照品溶液及供试液在室温放置18 h 内稳定；重复性和中间精密度RSD 均小于5.0%。
本方法专属性及精密度好，准确度高，可以用于本品中基因毒性杂质3-氯甲 基-1,2,4-三唑啉-5-酮的检测。
关 键 词：阿瑞匹坦；基因毒性杂质；3-氯甲基-1,2,4-三唑啉-5-酮；液相色谱法（HPLC） 中图分类号：TQ460.7 文献标识码： A 文章编号： 1004-0935（2023）09-1399-04阿瑞匹坦与其他止吐药物联合用药，适用于预防高度致吐性抗肿瘤化疗的初次和重复治疗过程中出现的急性和迟发性恶心和呕吐[1-6]。
阿瑞匹坦具有全新的药理作用机制，其作为首个神经激肽-1（NK -1）受体拮抗剂为预防和治疗癌症患者化疗引起的恶心呕吐提供了更多的药物治疗选择[7-9]。
3-氯甲基-1,2,4-三唑啉-5-酮是合成阿瑞匹坦的关键物料，属三唑啉酮类衍生物[10]。
3-氯甲基-1,2, 4-三唑啉-5-酮为单卤代烷烃化合物[11-12]，依据ICH M7，该化合物具有基因警示结构。
2013年最新SCI期刊影响因子
1619-4500 0891-0162 0149-1423 1550-7416 1530-9932 1532-8813 0942-8925 0025-5858 1085-3375 1069-6563 1040-2446 1876-2859 1076-6332 0898-9621 0001-4842 0949-1775 0889-325X 0889-3241 0360-0300 1550-4832 0362-1340 1549-6325 1544-3558 1544-3566 1556-4665 1529-3785 0734-2071 1073-0516 0362-5915 1084-4309 1539-9087 0730-0301 1046-8188 1094-9224 1533-5399 1556-4681 0098-3500 1049-3301 1551-6857 0164-0925 1936-7406 1550-4859 1049-331X 1553-3077 1559-1131 0814-6039 1063-7710 1944-8244 2155-5435 1554-8929
4OR-Q J OPER RES AAOHN J AAPG BULL AAPS J AAPS PHARMSCITECH AATCC REV ABDOM IMAGING ABH MATH SEM HAMBURG ABSTR APPL ANAL ACAD EMERG MED ACAD MED ACAD PEDIATR ACAD RADIOL ACCOUNT RES ACCOUNTS CHEM RES ACCREDIT QUAL ASSUR ACI MATER J ACI STRUCT J ACM COMPUT SURV ACM J EMERG TECH COM ACM SIGPLAN NOTICES ACM T ALGORITHMS ACM T APPL PERCEPT ACM T ARCHIT CODE OP ACM T AUTON ADAP SYS ACM T COMPUT LOG ACM T COMPUT SYST ACM T COMPUT-HUM INT ACM T DATABASE SYST ACM T DES AUTOMAT EL ACM T EMBED COMPUT S ACM T GRAPHIC ACM T INFORM SYST ACM T INFORM SYST SE ACM T INTERNET TECHN ACM T KNOWL DISCOV D ACM T MATH SOFTWARE ACM T MODEL COMPUT S ACM T MULTIM COMPUT ACM T PROGR LANG SYS ACM T RECONFIG TECHN ACM T SENSOR NETWORK ACM T SOFTW ENG METH ACM T STORAGE ACM T WEB ACOUST AUST ACOUST PHYS+ ACS APPL MATER INTER ACS CATAL ACS CHEM BIOL
THK5351 1707147-26-9 GlpBio
Peptides, Inhibitors, AgonistsProduct Data SheetProduct Name: THK5351Cat. No.:GC30814Chemical Name:CHEMICAL PROPERTIESCas No.: 1707147-26-9Molecular Formula: C18H18FN3O2Molecular Weight: 327.35Storage: PowderSolubility: Soluble in DMSOChemical Structure:BackgroundTHK5351 can be radiolabeled and used as a radiotracer for in vivo imaging of tau pathology in the brain.Aggregated tau protein is a major neuropathological substrate central to the pathophysiology of neurodegenerative diseases such as Alzheimer's disease (AD). 18F−THK5351 binds to Alzheimer disease hippocampal homogenates with hi gh affinity (Kd=2.9 nM; maximum number of binding sites=368.3 pmol/g tissue). It has fast dissociation from white−matter tissue. The THK5351 binding amount correlates with the amount of tau deposits in tissue[1].THK5351 exhibits favorable pharmacokinetics and no defluorination in mice. 18F−THK5351 enters the brain immediately after intravenous injection and shows a fast washout from the brain. At 0.1 and 1 mg/kg, no animals died and no treatment−related c hanges in any animal are noted in clinical observations, body weight measurement, and pathologic examination[1]. Autoradiography in the brain sections of patients with PSP demonstrates [3H]THK−5351 binding to tau deposits with a high selectivity. Although patie nts with PSP exhibits no remarkable [18F]THK−5351 retention in the temporal cortex, significantly higher tracer retention is observed in the globus pallidus and midbrain[2].References:[1]. Harada R, et al. 18F-THK5351: A Novel PET Radiotracer for Imaging Neurofibrillary Pathology in Alzheimer Disease. J Nucl Med. 2016 Feb;57(2):208-14.[2]. Ishiki A, et al. Tau imaging with [18 F]THK-5351 in progressive supranuclear palsy. Eur J Neurol. 2017 Jan;24(1):130-136.Research Update1. Effect of Hydrofluoric Acid Concentration and Etching Time on Bond Strength to Lithium Disilicate Glass Ceramic. Oper Dent. 2017 Nov/Dec;42(6):606-615. doi: 10.2341/16-215-L. Epub 2017 Jul 14. PMID:28708007AbstractThe aim of this study was to evaluate the influence of different concentrations of hydrofluoric acid (HF) associated with varied etching times on the microshear bond strength (μSBS) of a resin cement to a lithium disilicate glass ceramic. Two hundred seventy-five ceramic blocks (IPS e.max Press [EMX], Ivoclar Vivadent), measuring 8 mm × 3 mm thickness, were randomly distributed into five groups according to the HF concentrations (n=50): 1%, 2.5%, 5%, 7.5%, and 10%.2. Does acid etching morphologically and chemically affect lithium disilicate glass ceramic surfaces? J Appl Biomater Funct Mater. 2017 Jan 26;15(1):e93-e100. doi: 10.5301/jabfm.5000303. PMID:27647389AbstractBACKGROUND: This study evaluated the surface morphology, chemical composition and adhesiveness of lithium disilicate glass ceramic after acid etching with hydrofluoric acid or phosphoric acid.METHODS: Lithium disilicate glass ceramic specimens polished by 600-grit silicon carbide paper were subjected to one or a combination of these surface treatments: airborne particle abrasion with 50-μm alumina (AA), etching with 5% h ydrofluoric acid (HF) or 36% phosphoric acid (Phos), and application of silane coupling agent (Si).3. Fatigue failure load of feldspathic ceramic crowns after hydrofluoric acid etching at different concentrations. J Prosthet Dent. 2018 Feb;119(2):278-285. doi: 10.1016/j.prosdent.2017.03.021. Epub 2017 May 26. PMID:28552291AbstractSTATEMENT OF PROBLEM: Hydrofluoric acid etching modifies the cementation surface of ceramic restorations, which is the same surface where failure is initiated. Information regarding the influence of hydrofluoric acid etching on the cyclic loads to failure of ceramic crowns is lacking.PURPOSE: The purpose of this in vitro study was to evaluate the influence of different hydrofluoric acid concentrations on the fatigue failure loads of feldspathic ceramic crowns.。
一种p53自身抗体检测试剂盒及其应用[发明专利]
![一种p53自身抗体检测试剂盒及其应用[发明专利]](https://img.taocdn.com/s3/m/7e0022ffdb38376baf1ffc4ffe4733687e21fcc5.png)
(19)中华人民共和国国家知识产权局(12)发明专利申请(10)申请公布号 (43)申请公布日 (21)申请号 202010017406.6(22)申请日 2020.01.08(71)申请人 浙江省肿瘤医院地址 310022 浙江省杭州市拱墅区半山东路1号(72)发明人 凌志强 (74)专利代理机构 广州市越秀区哲力专利商标事务所(普通合伙) 44288代理人 杨艳(51)Int.Cl.G01N 33/574(2006.01)(54)发明名称一种p53自身抗体检测试剂盒及其应用(57)摘要本发明公开了一种p53自身抗体检测试剂盒，包括辣根过氧化物酶标记多肽、蛋白AGL琼脂糖磁珠、血清稀释液、TBST缓冲液、50％二甲基亚砜水溶液、3,3’,5,5’-四甲基联苯胺底物溶液、反应终止液；多肽的氨基酸序列如SEQ ID No.1所示。
采用辣根过氧化物酶标记特异性强的多肽抗原，可与血清中自身抗体充分、有效结合，并采用蛋白AGL琼脂糖磁珠俘获、定量自身抗体，检测灵敏度高，非特异性本底弱，便于自动化检测，特别适用于肿瘤早期自身抗体筛查。
本发明还公开了一种上述试剂盒在肺癌p53自身抗体检测中的应用，检测特异性强，灵敏度高、假阴性率低，成本低廉，操作简便，更有利于自动化、大样本筛查技术的实现。
权利要求书1页 说明书7页序列表1页 附图2页CN 111175505 A 2020.05.19C N 111175505A1.一种p53自身抗体检测试剂盒，其特征在于，包括：辣根过氧化物酶标记多肽、蛋白AGL琼脂糖磁珠、血清稀释液、TBST缓冲液、50％二甲基亚砜水溶液、3,3’,5,5’-四甲基联苯胺底物溶液、反应终止液；所述多肽的氨基酸序列如SEQ ID No.1所示。
2.根据权利要求1所述的p53自身抗体检测试剂盒，其特征在于，所述辣根过氧化物酶标记多肽是通过碘酸钠法制备而得的。
3.根据权利要求1所述的p53自身抗体检测试剂盒，其特征在于，所述血清稀释液为含1％脱脂奶粉的TBST缓冲液；所述反应终止液为2mol/L的硫酸溶液。
安捷伦产品目录
15
Real-Time PCR
16
Mx3000P QPCR System
17
Brilliant III Ultra-Fast SYBR Green QPCR and QRT-PCR Reagents
18
Brilliant III Ultra-Fast QPCR and QRT-PCR Reagents
Agilent / STRATAGENE
Agilent website: /genomics
Welgene | Agilent Stratagene
威健股份有限公司 | Stratagene 總代理
Table of Content
Table of Contents
/ XL1-Red Competent Cells SoloPack Gold Supercompetent Cells
/ TK Competent Cells Specialty Cells
/ Classic Cells / Fine Chemicals For Competent Cells
適用於 UNG 去汙染或 bisulphite
sequencing
適用於 TA Cloning
最高敏感性
取代傳統 Taq 的好選擇
-
2
威健股份有限公司 | Stratagene 總代理
PCR Enzyme & Instrument
Agilent SureCycler 8800
市場上領先的 cycling 速度和 sample 體積 10 ～ 100 μL 簡易快速可以選擇 96 well 和 384 well 操作盤 優秀的溫控設備讓各個 well 都能保持溫度的穩定 七吋的高解析度觸控螢幕讓操作上更為簡便 可以透過網路遠端操控儀器及監控儀器 Agilent 專業的技術支援可以幫助您應對各種 PCR 的問題
CHIR-99021_DataSheet_MedChemExpress
Inhibitors, Agonists, Screening Libraries Data SheetBIOLOGICAL ACTIVITY:CHIR–99021 is a GSK–3α/β inhibitor with IC 50 of 10 nM/6.7 nM; > 500–fold selectivity for GSK–3 versus its closest homologs CDC2 and ERK2, as well as other protein kinases.IC50 & Target: IC50: 10 nM/6.7 nM (GSK–3α/β)[1]In Vitro: CHIR 99021inhibits human GSK–3β with K i values of 9.8 nM [1]. CHIR 99021 is a small organic molecule that inhibits GSK3α and GSK3β by competing for their ATP–binding sites.In vitro kinase assays reveal that CHIR 99021 specifically inhibits GSK3β (IC 50=~5 nM) and GSK3α (IC 50=~10 nM), with little effect on other kinases [2]. In the presence of CHIR–99021 the viability of the ES–D3 cells is reduced by 24.7% at 2.5 μM, 56.3% at 5 μM, 61.9% at 7.5 μM and 69.2% at 10 μM CHIR–99021 with an IC 50 of 4.9μM [3].In Vivo: In ZDF rats, a single oral dose of CHIR 99021 (16 mg/kg or 48 mg/kg) rapidly lowers plasma glucose, with a maximal reduction of nearly 150 mg/dl 3–4 h after administration [1]. CHIR99021 (2 mg/kg) given once, 4 h before irradiation, significantly improves survival after 14.5 Gy abdominal irradiation (ABI). CHIR99021 treatment significantly blocks crypt apoptosis andaccumulation of p–H2AX + cells, and improves crypt regeneration and villus height. CHIR99021 treatment increases Lgr5+ cellsurvival by blocking apoptosis, and effectively prevents the reduction of Olfm4, Lgr5 and CD44 as early as 4 h [4].PROTOCOL (Extracted from published papers and Only for reference)Kinase Assay:[2]Kinases are purified from SF9 cells through use of their His or Glu tag. Glu–tagged proteins are purified, and His–tagged proteins are purified. Kinase assays are performed in 96–well plates with appropriate peptide substrates in a 300–μL reaction buffer (variations on 50 mM Tris–HCl, pH 7.5, 10 mM MgCl 2, 1 mM EGTA, 1 mMdithiothreitol, 25 mMβ–glycerophosphate, 1mM NaF, and 0.01% bovine serum albumin). Peptides has K m values from 1 to 100 μM. CHIR 99021 or CHIR GSKIA is added in 3.5μL of Me 2SO, followed by ATP to a final concentration of 1 μM. After incubation, triplicate 100–μL aliquots are transferred to Combiplate 8 plates containing 100 μL/well of 50 μM ATP and 20 mM EDTA. After 1 hour, the wells are rinsed five times with phosphate–buffered saline, filled with 200 μL of scintillation fluid, sealed, and counted in a scintillation counter 30 min later. All of the steps are at room temperature. The percentage of inhibition is calculated as 100×(inhibitor–no enzyme control)/(Me 2SO control–no enzyme control)[2].Cell Assay: CHIR 99021 is dissolved in DMSO and stored, and then diluted with appropriate media before use [3].[3]The viability of the mouse ES cells is determined after exposure to different concentrations of GSK3 inhibitors for three days using the MTT assay.The decrease of MTT activity is a reliable metabolism–based test for quantifying cell viability; this decrease correlates with the loss of cell viability. 2,000 cells are seeded overnight on gelatine–coated 96–well plates in LIF–containing ES cell medium. On the next day the medium is changed to medium devoid of LIF and with reduced serum and supplemented with 0.1–1 μM BIO, or 1–10 μM SB–216763, CHIR–99021 or CHIR–98014. Basal medium without GSK3 inhibitors or DMSO is used as control. All tested conditions are analyzed in triplicates [3].Product Name:CHIR–99021Cat. No.:HY-10182CAS No.:252917-06-9Molecular Formula:C 22H 18Cl 2N 8Molecular Weight:465.34Target:GSK–3; GSK–3; Autophagy Pathway:Stem Cell/Wnt; PI3K/Akt/mTOR; Autophagy Solubility:DMSO: ≥ 5.1 mg/mLAnimal Administration: CHIR 99021 is formulated as solutions in 20 mM citrate–buffered 15% Captisol or as fine suspensions in0.5% carboxymethylcellulose (Rat)[1].CHIR 99021 is prepared in DMSO and diluted (Mice)[4].[1][4]Rat[1]Primary hepatocytes from male Sprague Dawley rats that weighed <140 g are prepared and used 1–3 h after isolation. Aliquotsof 1×106cells in 1 mL of DMEM/F12 medium plus 0.2% BSA and CHIR 99021(orally at 16 or 48 mg/kg) or controls are incubated in 12–well plates on a low–speed shaker for 30 min at 37°C in a CO2–enriched atmosphere, collected by centrifugation and lysed by freeze/thaw in buffer A plus 0.01% NP40; the GS assay is again performed.Mice[4]Mice 6–10 weeks old are used. The PUMA+/+ and PUMA–/– littermates on C57BL/6 background (F10) and Lgr5–EGFP(Lgr5–EGFP–IRES–creERT2) mice are subjected to whole body irradiation (TBI), or abdominal irradiation (ABI). Mice are injected intraperitoneally (i.p.) with 2 mg/kg of CHIR99021 4 h before radiation or 1 mg/kg of SB415286 28 h and 4 h before radiation. Mice are sacrificed to collect small intestines for histology analysis and western blotting. All mice are injected i.p. with 100 mg/kg of BrdU before sacrifice.References:[1]. Ring DB, et al. Selective glycogen synthase kinase 3 inhibitors potentiate insulin activation of glucose transport and utilization in vitro and in vivo. Diabetes. 2003 Mar;52(3):588–95.[2]. Bennett CN, et al. Regulation of Wnt signaling during adipogenesis. J Biol Chem. 2002 Aug 23;277(34):30998–1004.[3]. Naujok O, et al. Cytotoxicity and activation of the Wnt/beta–catenin pathway in mouse embryonic stem cells treated with four GSK3 inhibitors.BMC Res Notes. 2014 Apr 29;7:273.[4]. Wang X, et al. Pharmacologically blocking p53–dependent apoptosis protects intestinal stem cells and mice from radiation. Sci Rep. 2015 Apr 10;5:8566.Caution: Product has not been fully validated for medical applications. For research use only.Tel: 609-228-6898 Fax: 609-228-5909 E-mail: tech@Address: 1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USA。
基于网络药理及分子对接探讨薏苡仁—浙贝母药对治疗慢性萎缩性胃炎的作用机制
1118 环球中医药2023年6月第16卷第6期 Global Traditional Chinese Medicine,June 2023,Vol.16,No.6㊃数据挖掘㊃基金项目:江苏省自然科学基金(BK20210687)作者单位:210023 南京中医药大学中医学院㊃中西医结合学院(周明㊁刘敏)作者简介:周明(1987-),博士,主治医师,讲师㊂研究方向:方药功效理论及中医药现代化研究㊂E⁃mail:290508@基于网络药理及分子对接探讨薏苡仁 浙贝母药对治疗慢性萎缩性胃炎的作用机制周明 刘敏【摘要】 目的 基于网络药理学方法配合分子对接验证,探讨薏苡仁 浙贝母治疗慢性萎缩性胃炎的可能机制㊂方法 利用TCMSP 数据库获取薏苡仁㊁浙贝母的主要活性成分及其对应靶点,通过5个疾病数据库,包括GeneCards㊁OMIM㊁PharmGkb㊁TTD 和DrugBank,收集慢性萎缩性胃炎疾病相关靶点,将药物对应靶点与疾病相关靶点取交集,得到薏苡仁 浙贝母治疗慢性萎缩性胃炎的作用靶点㊂Cytoscape 软件用于成分与靶点间的网络构建与分析㊂作用靶点的GO 功能富集与KEGG 通路富集分析使用R 语言完成㊂靶蛋白间的相互作用网络使用STRING 数据库平台构建,并筛选核心靶点㊂Autodock Vina 软件用于分子对接,对核心靶点进行进一步验证㊂结果 筛选出薏苡仁 浙贝母活性成分7个,对应作用靶点12个,进一步经拓扑分析筛选出CASP3㊁CASP8㊁PTGS2㊁JUN㊁PPARG 共5个核心靶点㊂KEGG 分析显示作用靶点主要富集在白细胞介素⁃17㊁P53㊁肿瘤坏死因子信号通路㊂通过分子对接证实,核心靶点与对应活性成分间均有较好的结合稳定性㊂结论 薏苡仁 浙贝母主要通过炎症及肿瘤相关的信号通路实现对慢性萎缩性胃炎的治疗作用㊂【关键词】 薏苡仁; 浙贝母; 慢性萎缩性胃炎; 网络药理学; 分子对接【中图分类号】 R573 【文献标识码】 A doi:10.3969/j.issn.1674⁃1749.2023.06.008Mechanism of Coicis Semen⁃Fritillariae Thunbergii Drug Pair on Intervention of Chronic Atrophic Gastritis based on Network Pharmacology⁃Molecular Docking ZHOU Ming ,LIU MinSchool of Traditional Chinese Medicine and School of Integrated Chinese and Western Medicine ,Nanjing University of Chinese Medicine ,Nanjing 210023,ChinaCorresponding author :ZHOU Ming ,E⁃mail :290508@【Abstract 】 Objective To explore the possible mechanism of Coix seed⁃Fritillaria thunbergii in the treatment of chronic atrophic gastritis based on the methods of network pharmacology and the verification ofmolecular docking.Methods The TCMSP database was used to obtain the active components and potential targets.The disease targets related to chronic atrophic gastritis were collected through GeneCards,OMIM,PharmGKB,TTD and DrugBank databases.The potential drug targets and disease⁃related targets wereintersected to obtain the predicted targets.The component⁃target interaction network was constructed by Cy⁃toscape software,and R language was used for GO and KEGG analysis.Then the predicted targets were analyzed by protein⁃protein interaction using STRING database,and the core targets were screened.Autodock Vina software was used for molecular docking.Results 7active ingredients and 12corresponding action targets were screened,and 5core targets were screened through topological analysis,which were CASP3,CASP8,PTGS2,JUN and PPARG respectively.The enrichment of KEGG pathway isdominated by IL⁃17,P53,TNF pathways.The results of molecular docking showed that the active环球中医药2023年6月第16卷第6期 Global Traditional Chinese Medicine,June2023,Vol.16,No.61119 ingredients had good binding ability with the core targets.Conclusion Coix seed and Fritillaria thunbergiican treat chronic atrophic gastritis mainly through inflammation and tumor related signal pathways.【Key words】 Coicis Semen; Fritillariae Thunbergii; Chronic atrophic gastritis; Network phar⁃macology; Molecular docking 慢性萎缩性胃炎(Chronic Atrophic Gastritis, CAG)是以不典型消化道症状为主要临床表现的慢性消化系统疾病[1],随着病情发展,常伴肠上皮化生或不典型增生[2⁃3],被视为胃癌的癌前疾病[4]㊂中医药在减轻患者临床症状,延缓或逆转病理进展方面有确切效果[5⁃6]㊂薏苡仁㊁浙贝母为中医临床治疗脾胃病的常用药㊂根据‘中华人民共和国药典(2020版)“记载,薏苡仁具有健脾渗湿㊁解毒散结等功效[7]㊂用于慢性萎缩性胃炎的治疗符合CAG本虚标实的病机共识[8⁃9]㊂现代药理研究发现,薏苡仁除有调节肠道菌群㊁增强免疫㊁镇痛抗炎㊁调节代谢㊁抗氧化等作用外,还有明确抗肿瘤效果,以其为原料药开发的康莱特系列药物已广泛用于多种癌症的临床治疗[10]㊂浙贝母是一味化痰药,传统认为其具有清热化痰㊁解毒散结等功效㊂而‘景岳全书本草正“谓其 善开郁结,止疼痛,消胀满”[11],可见浙贝母也能理中焦之气,可用来缓解CAG常见的脘腹胀满㊂此外, 百病多由痰作祟”,对于脾胃病中疑难者,国医大师徐景藩先生临证常配浙贝母,往往都有不错疗效[12⁃13]㊂现代药理研究发现,浙贝母具有祛痰㊁抗炎㊁抗菌㊁抗溃疡作用,同时也常用于肿瘤治疗[14]㊂两药配伍,在缓解CAG临床症状㊁减轻炎症反应㊁抑制 炎癌转化”等方面有可预期的效果㊂目前,单独针对薏苡仁或浙贝母的基础研究较为普遍,而对于薏苡仁 浙贝母药对及其治疗CAG的药效物质基础及分子作用机制研究相对较少,值得进一步探究㊂网络药理学基于生物学㊁药理学㊁计算机技术等多学科交叉融合的系统生物学理论,构建 药物 成分 靶点 通路”的相互作用网络,符合中药研究的需求,能够系统的揭示药物起效的作用机制[15⁃16]㊂本研究基于网络药理学理论和方法,筛选薏苡仁 浙贝母药对治疗CAG的活性成分及对应作用靶点[17],探寻其可能的作用机制,以期为CAG 治疗用药的进一步开发和应用奠定基础㊂1 资料与方法1.1 薏苡仁 浙贝母活性成分及对应靶点筛选以 薏苡仁” 浙贝母”为关键词,运用TCMSP 平台(https:///tcmsp.php)[18]检索两药的化学成分㊂根据药物代谢动力学特性,以口服生物利用度(oral bioavailability,OB)及类药性(drug⁃likeness,DL)[19]分别大于等于30%和0.18为条件,筛选薏苡仁 浙贝母药对的候选活性成分㊂以 薏苡仁” 浙贝母”为关键词,在TCMSP数据库中查找药对所有靶点,并利用Perl语言脚本及候选活性成分数据筛选对应靶点㊂进一步在UniProt数据库(/)下载人类基因注释文件[20],将靶点名称转换为标准基因名,用于后续分析处理㊂1.2 慢性萎缩性胃炎疾病相关靶点筛选以 atrophic gastritis”或 gastritis”为关键词,检索在线疾病数据库GeneCards(https://www. /)㊁OMIM(https:///)㊁DrugBank(https://www.drugbank.ca/)㊁PharmGkb (https:///)及TTD(http://db. /ttd/)[21],分别下载CAG相关疾病靶点,利用R语言 venn”程序包进行筛选㊁整理,获取疾病相关靶点数据㊂1.3 薏苡仁 浙贝母治疗CAG作用靶点预测及中药 活性成分 作用靶点网络构建将薏苡仁 浙贝母药对候选活性成分对应靶点基因与CAG疾病相关靶点基因进行匹配,获得的两者共同基因,即为薏苡仁 浙贝母治疗CAG的作用靶点㊂同时利用以上数据,通过Perl语言脚本建立 中药 活性成分 作用靶点”映射关系,使用Cytoscape3.9软件进行网络绘制及相应分析[22]㊂1.4 蛋白互作网络构建与核心靶点筛选使用预测出的作用靶点,在STRING(https:// string⁃/cgi/input.pl)网站,选择物种为人(Homo sapiens),设置置信度≥0.4,构建蛋白互作网络(Protein⁃Protein Interaction,PPI)[23],保存网络图及TSV格式分析结果㊂使用Cytoscape及其插件CytoNCA对PPI网络进行拓扑分析,计算网络中各节点的介度中心性(betweenness centrality,BC)㊁接近中心性(closeness centrality,CC)㊁度中心性(degree centrality,DC)㊁特征向量中心性(eigenvector centrality,EC)㊁局部边连通性(local1120 环球中医药2023年6月第16卷第6期 Global Traditional Chinese Medicine,June2023,Vol.16,No.6average connectivity⁃based method centrality,LAC)和网络中心性(network centrality,NC)[24],选出5个筛选指标均大于相应中位数的节点,即为筛选出的核心靶点,并构建核心靶点间的网络关系㊂1.5 基因本体富集与京都基因与基因组百科全书通路富集分析使用R语言完成富集分析,涉及 clusterProfiler” org.Hs.eg.db” enrichplot” ggplot2” pathview”等相关程序包㊂薏苡仁 浙贝母治疗CAG作用靶点的基因本体(Gene Ontology, GO)富集分析具体包含生物过程(biological process, BP)㊁细胞组分(cell component,CC)㊁分子功能(molecular function,MF)三部分[25],在结果中选择各部分显著富集的前10项绘制柱状图㊂京都基因与基因组百科全书(Kyoto Encyclopedia of Genes and Genomes,KEGG)通路富集分析用来搜索作用靶点涉及的主要信号通路[26],选择显著富集的前30项通路条目绘制气泡图㊂两富集分析均以P值及矫正P值小于0.05为筛选标准㊂1.6 分子对接验证在Pubchem数据库(https://pubchem.ncbi. /)中搜索下载核心靶点对应活性成分的2D数据,利用ChemOffice14.0软件构建3D结构,以mol2格式保存㊂核心靶点的3D结构数据通过PDB数据库(https://)获取,靶蛋白3D结构中包含的水分子和小分子配体均由PyMOL⁃2.4.0软件去除㊂蛋白加氢㊁活性成分及靶蛋白的格式转换及活性口袋的预设置,均在AutoDockTools⁃1.5.7软件平台处理㊂分子对接使用Autodock Vina软件完成,通过结合能计算验证活性成分与靶蛋白的结合能力㊂PyMOL⁃2.4.0软件用于对接结果的可视化㊂2 结果2.1药对活性成分及对应靶点在TCMSP数据库中,对薏苡仁㊁浙贝母分别进行成分搜索,以OB≥30%,DL≥0.18为筛选条件,共得到16个候选活性成分,其中薏苡仁9个㊁浙贝母7个,活性成分相关信息见表1㊂通过检索,获得薏苡仁 浙贝母药对所有靶基因共356个,其中薏苡仁246个,浙贝母110个㊂利用UniProt数据库下载的人类基因数据以及Perl语言脚本,将查询到的靶基因进行去重㊁筛选㊁规范基因名称,最终获得候选活性成分对应的靶基因数据98条㊂2.2 慢性萎缩性胃炎疾病相关靶点通过1.2中所述五个疾病数据库下载有关CAG的疾病相关靶点㊂利用R语言 venn”程序包进行分析,去除重复基因,取并集,合计获得769个疾病靶点,其中DrugBank18个,GeneCards449个, OMIM197个,PharmGkb159个,TTD1个,绘制韦恩图,结果见图1㊂表1 TCMSP数据库中薏苡仁 浙贝母药对活性成分相关信息中药名分子编号活性成分名称OB(%)DL 薏苡仁MOL001323Sitosterol alpha143.280.78薏苡仁MOL001494Mandenol420.19薏苡仁MOL002372(6Z,10E,14E,18E)⁃2,6,10,15,19,23⁃hexamethyltetracosa⁃2,6,10,14,18,22⁃hexaene33.550.42薏苡仁MOL002882[(2R)⁃2,3⁃dihydroxypropyl] (Z)⁃octadec⁃9⁃enoate34.130.3薏苡仁MOL000359sitosterol36.910.75薏苡仁MOL000449Stigmasterol43.830.76薏苡仁MOL008118Coixenolide32.40.43薏苡仁MOL0081212⁃Monoolein34.230.29薏苡仁MOL000953CLR37.870.68浙贝母MOL001004pelargonidin37.990.21浙贝母MOL000358beta⁃sitosterol36.910.75浙贝母MOL004440Peimisine57.40.81浙贝母MOL004443Zhebeiresinol58.720.19浙贝母MOL004444Ziebeimine64.250.7浙贝母MOL0044466⁃Methoxyl⁃2⁃acetyl⁃3⁃methyl⁃1,4⁃naphthoquinone⁃8⁃O⁃beta⁃D⁃glucopyranoside33.310.57浙贝母MOL004450Chaksine65.630.66环球中医药2023年6月第16卷第6期 Global Traditional Chinese Medicine,June 2023,Vol.16,No.61121 图1 5个疾病数据库所得慢性萎缩性胃炎相关靶点取并集之韦恩图2.3 薏苡仁 浙贝母治疗CAG 作用靶点及中药 活性成分 作用靶点网络图分析通过Perl 语言脚本,对药对候选活性成分对应靶基因与CAG 疾病相关靶点进行整理后取交集,得到12个共有靶点,即为预测出的薏苡仁 浙贝母治疗CAG 的作用靶点,对应7个活性成分,准备网络构建及分析的关系文件㊂将关系文件导入Cytoscape 3.9软件,生成中药 活性成分 作用靶点相互作用网络图,如图2所示,节点代表活性成分或作用靶点,节点连线说明成分与靶点之间产生相互联系㊂图中节点越大其关联的活性成分或作用靶点越多,此节点在网络中越重要㊂结果显示,7个活性成分中degree 值>3的有MOL000358(β⁃谷甾醇,beta⁃sitosterol,degree 值为8)㊁MOL001004(天竺葵素,pelargonidin,degree 值为5)㊁MOL000449(豆甾醇,Stigmasterol,degree 值为3)㊂β⁃谷甾醇和天竺葵素来自浙贝母,豆甾醇为薏苡仁的活性成分㊂β⁃谷甾醇degree 值为8,表示其与12个靶基因中的8个发生联系㊂2.4 PPI 网络构建与关键靶点筛选蛋白相互作用分析显示,薏苡仁 浙贝母治疗CAG 的12个作用靶点间共产生34条相互作用关系㊂进一步采用CytoNCA 对网络的拓扑属性进行分析,筛选大于所有指标中位值的节点,得到5个核心靶点,分别为PTGS2㊁CASP3㊁CASP8㊁JUN㊁PPARG,如图3所示,进一步建立核心靶点间的互作关系网络㊂ 注:图中紫色节点代表来自浙贝母的活性成分,绿色节点代表来自薏苡仁的活性成分,蓝色节点表示药对活性成分调控慢性萎缩性胃炎的作用靶点㊂图2 薏苡仁 浙贝母治疗慢性萎缩性胃炎 中药 活性成分 作用靶点”网路图注:图中黄色节点为经拓扑分析筛选出的核心靶点图3 薏苡仁 浙贝母药对治疗慢性萎缩性胃炎靶点蛋白相互作用网络图2.5 GO 富集及KEGG 通路富集分析12个作用靶点的 gene symbol(基因名)”通过R 语言 org.Hs.eg.db”程序包转换为 entrezID”, enrichplot”程序包用于GO 富集分析㊂分别选取在BP㊁MF㊁CC 上显著富集的前10个条目绘制柱状图,如图4所示㊂分析结果显示,薏苡仁 浙贝母治疗CAG 的作用靶点在生物过程方面主要与脂多糖㊁细菌来源分子及氧水平降低等反应相关;在细胞组成上主要位于细胞器外膜㊁线粒体外膜㊁膜微域等;在分子功能方面主要包括血红素结合㊁DNA 结合转录因子结合㊁四吡咯结合等㊂作用靶点的KEGG 通路富集分析使用 enrichplot”和 pathview”程序包,以P 值及矫正P1122 环球中医药2023年6月第16卷第6期 Global Traditional Chinese Medicine,June 2023,Vol.16,No.6值均小于0.05进行筛选,结果得到87条富集的信号通路㊂选择前30条通路绘制气泡图,见图5㊂分析显示,薏苡仁 浙贝母治疗CAG 的作用靶点主要富集在白细胞介素⁃17(interleukin⁃17,IL⁃17)信号通路㊁P53信号通路㊁肿瘤坏死因子(tumor necrosis factor,TNF)信号通路等㊂以IL⁃17信号通路为例,通路中主要富集了PTGS2㊁JUN㊁CASP3㊁CASP8等靶基因,见图6㊂ 注:纵坐标表示富集到的GO 条目名称,横坐标表示富集到的基因数目㊂图4 薏苡仁 浙贝母药对治疗慢性萎缩性胃炎作用靶点的GO富集分析 注:纵坐标为富集到的通路名称,横坐标为参与该通路的靶点占总靶点的比例㊂图5 薏苡仁 浙贝母药对治疗慢性萎缩性胃炎作用靶点的KEGG 通路富集分析环球中医药2023年6月第16卷第6期 Global Traditional Chinese Medicine,June 2023,Vol.16,No.61123 图6 薏苡仁 浙贝母药对治疗慢性萎缩性胃炎作用靶点在IL⁃17信号通路上的富集图2.6 活性成分及核心靶点的分子对接验证根据 中药 活性成分 作用靶点”网络图中活性成分degree 值排名,将薏苡仁 浙贝母药对治疗CAG 的核心靶点PTGS2㊁CASP3㊁CASP8㊁JUN㊁PPARG 与对应的活性成分进行分子对接㊂配体与受体的结合能越低,说明两者形成的复合物结构越稳定,也预示着两者有较大的可能发生相互作用㊂一般情况下以结合能小于-5.0kcal /mol 作为稳定结合的评判标准[27]㊂结果显示,5个核心靶点与对应活性成分的结合能均小于-5.0kcal /mol,表明核心靶点与活性成分有较好的结合能力,对接结果见表2㊂利用PyMOL 软件对结果进行可视化,以PTGS2蛋白分子对接结果为例进行展示,对接模式图见图7㊂表2 薏苡仁 浙贝母药对核心作用靶点与对应活性成分分子对接结果核心靶点活性成分成分来源结合能(kcal /mol)CASP3β⁃谷甾醇(beta⁃sitosterol)浙贝母-7.6CASP8β⁃谷甾醇(beta⁃sitosterol)浙贝母-7.2JUNβ⁃谷甾醇(beta⁃sitosterol)浙贝母-7.1PPARG 天竺葵素(pelargonidin)浙贝母-8.9PTGS2β⁃谷甾醇(beta⁃sitosterol)浙贝母-8.6天竺葵素(pelargonidin)浙贝母-9.4豆甾醇(Stigmasterol)薏苡仁-8.6图7 薏苡仁 浙贝母药对活性成分与PTGS2蛋白分子对接模式图3 讨论上世纪90年代,有学者提出胃炎的 炎癌转化”路径,即慢性非萎缩性胃炎 慢性萎缩性胃炎 肠上皮化生 异型增生 胃癌,被医学界广泛认可[28]㊂有研究表明,我国萎缩性胃炎发病率在2014年已约占受检人群的25%,并且呈逐年上升趋势[29]㊂目前,常规治疗CAG 多用于缓解临床症状,1124 环球中医药2023年6月第16卷第6期 Global Traditional Chinese Medicine,June2023,Vol.16,No.6尚不能满足临床治愈的需求,且长期使用质子泵抑制剂等药物对胃肠道有明显副作用[30⁃31]㊂中药副作用小,其协同起效特征在复杂疾病的治疗中具有一定优势[32]㊂近年来越来越多的临床医生和患者开始关注并使用中医药来预防和治疗CAG[33],寻找治疗CAG效果确切的中药,并明确其作用机制具有重要的社会意义㊂本研究基于网络药理学理论和方法,筛选出薏苡仁 浙贝母药对治疗CAG的7个主要生物活性成分,映射12个CAG作用靶点㊂其中β⁃谷甾醇(beta⁃sitosterol)与核心靶点有着广泛的结合作用㊂β⁃谷甾醇作为甾醇类化合物,有明确的抗炎作用,其可通过抑制表皮细胞㊁巨噬细胞中炎症小体NOD样受体热蛋白结构域相关蛋白3,最终抑制丝裂原活化蛋白激酶(mitogen⁃activated protein kinase, MAPK)信号通路的激活,使得细胞中的白细胞介素⁃6㊁白细胞介素⁃8等炎症因子生成减少而起效[34]㊂同时,有研究表明,β⁃谷甾醇能够缓解阿司匹林导致的胃黏膜损伤,促进愈合,有一定的保护胃黏膜效果[35]㊂此外,β⁃谷甾醇具有抗菌作用,动物实验显示β⁃谷甾醇可使结肠炎模型小鼠肠上皮细胞㊁巨噬细胞上抗菌肽的表达显著增加,降低肠道菌的存活率,并且对肺炎链球菌㊁金黄葡萄球菌等均有抑制效果[36⁃38],或对控制CAG相关的幽门螺杆菌感染有一定作用㊂另有研究表明β⁃谷甾醇对胃癌有治疗效果,可抑制肿瘤细胞增值及诱导其凋亡[39⁃40],可见其或可延缓或逆转CAG的 炎癌转化”过程㊂本研究通过PPI网络拓扑分析,进一步筛选到5个核心靶点,包括PTGS2㊁CASP3㊁CASP8㊁JUN㊁PPARG,其中PTGS2与多个活性成分关联㊂PTGS2又称环氧酶⁃2(cyclooxygenase⁃2,COX⁃2),是前列腺素E2(prostaglandin E2,PGE2)形成的关键酶,后者有强烈的促炎作用,因此PTGS2与抗炎功效关系密切,一直是非甾体类抗炎药的重要靶点㊂此外, PTGS2是一种诱导型蛋白,正常组织或细胞中极少表达,当机体受到炎症因子㊁肿瘤促进剂㊁生长因子等因素刺激时表达上升[41],参与炎症反应㊁免疫调节㊁细胞增殖与凋亡等多种病理过程,并且与多种癌肿的发生密切相关[42⁃43]㊂本研究KEGG通路分析结果中涉及到的IL⁃17㊁TNF㊁核转录因子⁃κB (nuclear factor⁃kappa B,NF⁃κB)等炎症㊁肿瘤相关信号通路均与PTGS2基因有密切联系,表明PTGS2在薏苡仁 浙贝母药对治疗CAG中,通过抗炎㊁抗肿瘤机制起着重要作用㊂KEGG通路富集分析结果显示,大多数靶标蛋白的编码基因富集在与CAG 炎癌转化”相关的IL⁃17信号通路㊁P53信号通路和TNF信号通路上㊂研究证实IL⁃17信号通路在急慢性炎症反应中扮演着重要角色,IL17家族有6个成员(IL⁃17A⁃F),可通过与相应受体结合,激活下游MAPK,NF⁃κB和CCAAT/增强子结合蛋白通路中的抗细胞因子㊁趋化因子和抗菌肽,与CAG的发生发展显著相关[44⁃45]㊂P53信号通路是一经典的肿瘤相关通路, P53蛋白可促细胞凋亡,在肿瘤抑制中具有重要作用,其失活会促进肿瘤发生或发展,大量基因组测序证实,约一半的肿瘤伴有P53基因突变[46]㊂有研究发现,随着慢性胃炎程度的加重,患者胃黏膜中突变型P53基因表达明显升高[47],可见薏苡仁 浙贝母通过对P53通路的调控,或可减缓CAG病情恶化㊂TNF通路是与肿瘤和炎症均有关的信号通路, TNF⁃α可直接杀伤肿瘤细胞,同时参与全身炎症反应,其与相应受体结合后可激活下游,包括NF⁃κB 和MAPK途径,实现细胞毒性㊁免疫调节和细胞凋亡等生物学功能[48]㊂相关研究也发现,中药治疗CAG的起效机制与TNF信号通路相关[49]㊂综上所述,本研究以薏苡仁 浙贝母为研究对象,使用网络药理学相关理论与方法,探讨了薏苡仁 浙贝母药对治疗CAG的物质基础㊁作用靶点及相关起效机制,并通过分子对接实验,验证核心靶蛋白与对应活性成分均有较好结合能力,预测结果有一定可靠性㊂研究方法先进合理,研究结果体现了中药多成分协同起效的独特优势,为临床运用薏苡仁 浙贝母治疗CAG提供了理论支持,为后续新药研发及推广临床应用提供了相对可靠依据㊂然而,各平台数据㊁相应分析算法及软件功能存在一定局限性,所得结论还可以通过进一步实验加以验证㊂参考文献[1] LI Y F,XIA R,ZHANG B,et al.Chronic Atrophic Gastritis:AReview[J].J Environ Pathol Toxicol Oncol,2018,37(3):241⁃259.[2] FANN C Y,CHIANG T H,YEN M F,et al.Personalized risk as⁃sessment for dynamic transition of gastric neoplasms[J].Journalof Biomedical Science,2018,25(5):2654⁃2664.[3] PARK Y H,KIM N.Review of atrophic gastritis and intestinalmetaplasia as a premalignant lesion of gastric cancer[J].Journal环球中医药2023年6月第16卷第6期 Global Traditional Chinese Medicine,June2023,Vol.16,No.61125of cancer prevention,2015,20(1):25⁃40.[4] YOKOYAMA A,OMORI T,YOKOYAMA T,et al.Chronicatrophic gastritis and metachronous gastric cancer in Japanesealcoholic men with esophageal squamous cell carcinoma[J].Alcohol Clin Exp Res,2009,33(5):898⁃905.[5] 于莹,张功,韩涛,等.临床常用中成药辅助治疗慢性萎缩性胃炎的网状Meta分析[J].中草药,2022,53(6):1790⁃1800.[6] 吉跃进,沈洪,朱磊.中药治疗慢性萎缩性胃炎研究进展[J].中华中医药学刊,2021,39(5):166⁃170,289.[7] 国家药典委员会.中华人民共和国药典(一部)[S].北京:中国医药科技出版社,2020:393⁃394,304⁃305.[8] 张声生,李乾构,唐旭东,等.慢性萎缩性胃炎中医诊疗共识意见(2009,深圳)[J].中国中西医结合消化杂志,2010,18(5):345⁃349.[9] 赵欢,杨巧芳.名中医治疗慢性萎缩性胃炎病因病机思路与用药规律[J].时珍国医国药,2018,29(6):1518⁃1520. [10] 李晓凯,顾坤,梁慕文,等.薏苡仁化学成分及药理作用研究进展[J].中草药,2020,51(21):5645⁃5657. [11] 邱玏.川贝母㊁浙贝母功效沿革考辨[J].安徽中医药大学学报,2018,37(6):1⁃3.[12] 刘妍彤,吕晓东,庞立健,等.慢性复杂性疾病中医共性证治探究[J].时珍国医国药,2016,27(3):669⁃671. [13] 徐景藩.呕吐痰饮利小便胃脘胀痛用贝母[J].上海中医药杂志,1990,36(6):32⁃33.[14] 赵金凯,杜伟锋,应泽茜,等.浙贝母的现代研究进展[J].时珍国医国药,2019,30(1):177⁃180.[15] 申凤霞,李倩,聂宗恒,等.基于网络药理学与分子对接探讨防己 黄芪药对治疗糖尿病肾病的作用机制[J].环球中医药,2022,15(3):408⁃416.[16] YUAN Z Z,PAN Y Y,LENG T,et al.Progress and Prospects ofResearch Ideas and Methods in the Network Pharmacology ofTraditional Chinese Medicine[J].J Pharm Pharm Sci,2022,25:218⁃226.[17] 林嫚婷,谢地,胡汉昆.基于网络药理学和分子对接研究冬虫夏草治疗糖尿病肾病的作用机制[J].中国药师,2021,24(6):1057⁃1063.[18] RU J L,LI P,WANG J,et al.TCMSP:a database of systemspharmacology for drug discovery from herbal medicines[J].Journal of Cheminformatics,2014,6:13.[19] 石雅馨,王新,张乘源,等.经方桂枝茯苓丸 异病同治”任脉癥瘕类疾病的网络药理学研究[J].世界科学技术⁃中医药现代化,2021,23(6):1867⁃1877.[20] 李嘉丽,杨泽虹,杨良俊,等.黄芪⁃莪术对胃癌前病变作用机制的网络药理学分析[J].中药新药与临床药理,2019,30(12):1434⁃1441.[21] 李家合.基于网络药理学探讨 健脾利湿化瘀方”治疗前列腺癌的分子机理[D].天津:天津中医药大学,2020. [22] SHANNON P,MARKIEL A,OZIER O,et al.Cytoscape:asoftware environment for integrated models of biomolecularinteraction networks[J].Genome Res,2003,13(11):2498⁃2504.[23] 韩霜,常鑫鑫,汤爽,等.整合化学物质组学和网络生物学分析鬼箭羽治疗肾炎的潜在药效物质基础[J].中国中药杂志,2020,45(18):4429⁃4439.[24] 高世勇,李婉秋,王帅,等.基于网络药理学的小陷胸汤治疗大肠癌的机制研究[J].中草药,2022,53(3):773⁃782. [25] 徐瑞杰,薛蓉,梅茜,等.基于指纹图谱和网络药理学的枳实薤白桂枝汤质量标志物预测[J].中草药,2022,53(2):372⁃381.[26] 马迪,马桂琴.基于网络药理学探讨四妙勇安汤治疗银屑病关节炎的作用机制预测研究[J].中国中药杂志,2020,45(11):2611⁃2618.[27] HSIN K Y,GHOSH S,KITANO H,et bining machinelearning systems and multiple docking simulation packages toimprove docking prediction reliability for network pharmacology[J].PLoS ONE,2013,8(12):e83922.[28] CORREA P.A human model of gastric carcinogenesis[J].CancerRes,1988,48(13):3554⁃3560.[29] DU Y Q,BAI Y,XIE P,et al.Chronic gastritis in China:anational multi⁃center survey[J].BMC Gastroenterol,2014,14:21.[30] WEI Y,MA L X,YIN S J,et al.Huangqi Jianzhong Tang forTreatment of Chronic Gastritis:A Systematic Review ofRandomized Clinical Trials[J].Evid Based Complement AlternatMed,2015:878164.[31] SONG H,ZHU J W,LU D H.Long⁃term proton pump inhibitor(PPI)use and the development of gastric pre⁃malignant lesions[J].Cochrane Database Syst Rev,2014,12:CD010623. [32] 董雅倩,张佳幸,龚琳娜,等.白花蛇舌草环烯醚萜的鉴定及基于网络药理学的抗肾纤维化作用的机制研究[J].药学学报,2020,55(12):2934⁃2941.[33] DAI Y K,ZHANG Y Z,LI D Y,et al.The efficacy of Jianpi Yiqitherapy for chronic atrophic gastritis:A systematic review andmetaanalysis[J].PLoS One,2017,12(7):e0181906. [34] LIAO P C,LAI M H,HSU K P,et al.Identification ofβ⁃Sitosterolas in Vitro Anti⁃Inflammatory Constituent in Moringa oleifera[J].J Agric Food Chem,2018,66(41):10748⁃10759. [35] 肖志彬,刘小雷,成日青,等.β⁃谷甾醇对阿司匹林致胃黏膜损伤副作用及其药理作用的影响[J].中国实验方剂学杂志,2016,22(1):148⁃152.[36] DING K,TAN Y Y,DING Y,et al.β⁃Sitosterol improvesexperimental colitis in mice with a target against pathogenicbacteria[J].J Cell Biochem,2019,120(4):5687⁃5694. [37] 赵小然.β⁃谷甾醇和毛蕊花糖苷对肺炎链球菌溶血素的抑制作用及机制[D].吉林:吉林大学,2017.[38] ODODO M M,CHOUDHURY M K,DEKEBO A H,et al.Structure elucidation ofβ⁃sitosterol with antibacterial activity fromthe root bark of Malva parviflora[J].Springer Plus,2016,5(1):1210.[39] SHIN E J,CHOI H K,SUNG M J,et al.Anti⁃tumour effects ofbeta⁃sitosterol are mediated by AMPK/PTEN/HSP90axis in AGShuman gastric adenocarcinoma cells and xenograft mouse models[J].Biochem Pharmacol,2018,152:60⁃70.[40] 孙玉成,刘晓巍,片光哲.β⁃谷甾醇诱导人胃癌细胞自噬与凋1126 环球中医药2023年6月第16卷第6期 Global Traditional Chinese Medicine,June2023,Vol.16,No.6亡的作用及机制研究[J].中国医师杂志,2019,21(6):866⁃871.[41] CHEN Y,ZHU L,JI L,et al.Silencing the acat1gene in humansh⁃sy5y neuroblastoma cells inhibits the expression of cyclo⁃oxygenase2(cox2)and reducesβ⁃amyloid⁃induced toxicity dueto activation of protein kinase c(pkc)and erk[J].Med SciMonit,2018,24:9007⁃9018.[42] XIE Y,LIU L.Analysis of correlation between HP infection andactivation of PI3K/Akt pathway in mucosal tissues of gastriccancer and precancerous lesions[J].Oncology letters,2018,16(5):5615⁃5620.[43] 王霞.COX⁃2与VEGF在皮肤鳞状细胞癌(SCC)及基底细胞癌(BCC)中的表达分析[J].当代医学,2018,24(16):119⁃121.[44] SONG X Y,QIAN Y C.The activation and regulation of IL⁃17receptor mediated signaling[J].Cytokine,2013,62(2):175⁃182.[45] LUO Y,GUO H,BIAN W,et al.IL⁃17polymorphism is associatedwith chronic atrophic gastritis[J].J Third Mil Med Univ,2010,32:525⁃528.[46] 李超,伏圣博,刘华玲,等.细胞凋亡研究进展[J].世界科技研究与发展,2007,29(3):45⁃53.[47] 崔轶霞,王海军,惠起源,等.胃黏膜不同病变组织中突变型P53蛋白表达的研究[J].延安大学学报(医学科学版),2008,6(3):3⁃4.[48] 王文珊,傅冷西,叶君健.TNF⁃α信号传导通路的研究进展[J].福建医科大学学报,2005,47(S1):27⁃31. [49] 李萍,李园,李可歆,等.基于生物分子网络探讨胃复春片治疗慢性萎缩性胃炎的作用机制研究[J].世界中西医结合杂志,2020,15(1):48⁃53.(收稿日期:2022⁃07⁃04)(本文编辑:王馨瑶)。
2010年中科院公布SCI影响因子及大小类分区表
刊名简称刊名全称ISSN小类名称PLOS PATHOG PLoS Patho1553-7366病毒学REV MED VIROL REVIEWS IN1052-9276病毒学ADV VIRUS RES ADVANCES I0065-3527病毒学AIDS AIDS0269-9370病毒学ANTIVIR THER ANTIVIRAL 1359-6535病毒学J VIROL JOURNAL OF0022-538X病毒学RETROVIROLOGY Retrovirol1742-4690病毒学ANTIVIR RES ANTIVIRAL 0166-3542病毒学INFLUENZA OTHER RESP Influenza 1750-2640病毒学INT J MED MICROBIOL INTERNATIO1438-4221病毒学J CLIN VIROL JOURNAL OF1386-6532病毒学J GEN VIROL JOURNAL OF0022-1317病毒学J MED VIROL JOURNAL OF0146-6615病毒学J VIRAL HEPATITIS JOURNAL OF1352-0504病毒学MICROBES INFECT MICROBES A1286-4579病毒学VIROLOGY VIROLOGY0042-6822病毒学ACTA VIROL ACTA VIROL0001-723X病毒学AIDS RES HUM RETROV AIDS RESEA0889-2229病毒学ARCH VIROL ARCHIVES O0304-8608病毒学CURR HIV RES CURRENT HI1570-162X病毒学FOOD ENVIRON VIROL Food and E1867-0334病毒学FUTURE VIROL Future Vir1746-0794病毒学INDIAN J VIROL Indian Jou0970-2822病毒学INTERVIROLOGY INTERVIROL0300-5526病毒学J NEUROVIROL JOURNAL OF1355-0284病毒学J VIROL METHODS JOURNAL OF0166-0934病毒学S AFR J HIV MED SOUTHERN A1608-9693病毒学VIRAL IMMUNOL VIRAL IMMU0882-8245病毒学VIROL J Virology J1743-422X病毒学VIROLOGIE VIROLOGIE1267-8694病毒学VIRUS GENES VIRUS GENE0920-8569病毒学VIRUS RES VIRUS RESE0168-1702病毒学VIRUSES-BASEL Viruses-Ba1999-4915病毒学ACTA NEUROPATHOL ACTA NEURO0001-6322病理学AM J PATHOL AMERICAN J0002-9440病理学ANNU REV PATHOL-MECH Annual Rev1553-4006病理学J PATHOL JOURNAL OF0022-3417病理学AM J SURG PATHOL AMERICAN J0147-5185病理学BRAIN PATHOL BRAIN PATH1015-6305病理学DIS MODEL MECH Disease Mo1754-8403病理学EXPERT REV MOL DIAGN EXPERT REV1473-7159病理学HISTOPATHOLOGY HISTOPATHO0309-0167病理学J MOL DIAGN JOURNAL OF1525-1578病理学J NEUROPATH EXP NEUR JOURNAL OF0022-3069病理学LAB INVEST LABORATORY0023-6837病理学MODERN PATHOL MODERN PAT0893-3952病理学NEUROPATH APPL NEURO NEUROPATHO0305-1846病理学SEMIN IMMUNOPATHOL Seminars i1863-2297病理学ADV ANAT PATHOL ADVANCES I1072-4109病理学ALZ DIS ASSOC DIS ALZHEIMER 0893-0341病理学AM J CLIN PATHOL AMERICAN J0002-9173病理学ANAL CELL PATHOL Analytical2210-7177病理学ARCH PATHOL LAB MED ARCHIVES O0003-9985病理学CANCER CYTOPATHOL CANCER CYT1934-662X病理学CYTOM PART B-CLIN CY CYTOMETRY 1552-4949病理学DIS MARKERS DISEASE MA0278-0240病理学EXP MOL PATHOL EXPERIMENT0014-4800病理学HISTOL HISTOPATHOL HISTOLOGY 0213-3911病理学HUM PATHOL HUMAN PATH0046-8177病理学INT J EXP PATHOL INTERNATIO0959-9673病理学INT J IMMUNOPATH PH INTERNATIO0394-6320病理学J CLIN PATHOL JOURNAL OF0021-9746病理学PATHOBIOLOGY PATHOBIOLO1015-2008病理学PATHOLOGY PATHOLOGY0031-3025病理学TISSUE ANTIGENS TISSUE ANT0001-2815病理学TOXICOL PATHOL TOXICOLOGI0192-6233病理学VIRCHOWS ARCH VIRCHOWS A0945-6317病理学ACTA CYTOL ACTA CYTOL0001-5547病理学AM J FOREN MED PATH AMERICAN J0195-7910病理学ANN DIAGN PATHOL Annals of 1092-9134病理学ANN PATHOL ANNALES DE0242-6498病理学APMIS APMIS0903-4641病理学APPL IMMUNOHISTO M M APPLIED IM1062-3345病理学BRAIN TUMOR PATHOL Brain Tumo1433-7398病理学CARDIOVASC PATHOL CARDIOVASC1054-8807病理学CLIN NEUROPATHOL CLINICAL N0722-5091病理学CYTOPATHOLOGY CYTOPATHOL0956-5507病理学DIAGN CYTOPATHOL DIAGNOSTIC8755-1039病理学DIAGN MOL PATHOL DIAGNOSTIC1052-9551病理学DIAGN PATHOL Diagnostic1746-1596病理学ENDOCR PATHOL ENDOCRINE 1046-3976病理学EXP TOXICOL PATHOL EXPERIMENT0940-2993病理学FETAL PEDIATR PATHOL Fetal and 1551-3815病理学FOLIA NEUROPATHOL FOLIA NEUR1641-4640病理学FORENSIC SCI MED PAT Forensic S1547-769X病理学INDIAN J PATHOL MICR Indian Jou0377-4929病理学INT J GYNECOL PATHOL INTERNATIO0277-1691病理学INT J SURG PATHOL INTERNATIO1066-8969病理学J COMP PATHOL JOURNAL OF0021-9975病理学J CUTAN PATHOL JOURNAL OF0303-6987病理学J ORAL PATHOL MED JOURNAL OF0904-2512病理学J TOXICOL PATHOL Journal of0914-9198病理学KOREAN J PATHOL Korean Jou1738-1843病理学LEPROSY REV LEPROSY RE0305-7518病理学MED MOL MORPHOL Medical Mo1860-1480病理学MED NUCL Medecine N0928-1258病理学NEUROPATHOLOGY NEUROPATHO0919-6544病理学PATHOL BIOL PATHOLOGIE0369-8114病理学PATHOL INT PATHOLOGY 1320-5463病理学PATHOL ONCOL RES PATHOLOGY 1219-4956病理学PATHOL RES PRACT PATHOLOGY 0344-0338病理学PATHOLOGE PATHOLOGE0172-8113病理学PEDIATR DEVEL PATHOL PEDIATRIC 1093-5266病理学POL J PATHOL POLISH JOU1233-9687病理学SCI JUSTICE SCIENCE & 1355-0306病理学SEMIN DIAGN PATHOL SEMINARS I0740-2570病理学ULTRASTRUCT PATHOL ULTRASTRUC0191-3123病理学VET PATHOL VETERINARY0300-9858病理学POLYM TEST POLYMER TE0142-9418材料科学：表征与测试PROG CRYST GROWTH CH PROGRESS I0960-8974材料科学：表征与测试EXP MECH EXPERIMENT0014-4851材料科学：表征与测试MATER CHARACT MATERIALS 1044-5803材料科学：表征与测试NANOSC MICROSC THERM Nanoscale 1556-7265材料科学：表征与测试NDT&E INT NDT & E IN0963-8695材料科学：表征与测试ENG FAIL ANAL ENGINEERIN1350-6307材料科学：表征与测试J NONDESTRUCT EVAL JOURNAL OF0195-9298材料科学：表征与测试J SANDW STRUCT MATER JOURNAL OF1099-6362材料科学：表征与测试J STRAIN ANAL ENG JOURNAL OF0309-3247材料科学：表征与测试MECH ADV MATER STRUC MECHANICS 1537-6494材料科学：表征与测试MECH TIME-DEPEND MAT MECHANICS 1385-2000材料科学：表征与测试RES NONDESTRUCT EVAL RESEARCH I0934-9847材料科学：表征与测试STRAIN STRAIN0039-2103材料科学：表征与测试ADV STEEL CONSTR Advanced S1816-112X材料科学：表征与测试ARCH MECH ARCHIVES O0373-2029材料科学：表征与测试BETON- STAHLBETONBAU Beton- und0005-9900材料科学：表征与测试COMPUT CONCRETE Computers 1598-8198材料科学：表征与测试EXP TECHNIQUES EXPERIMENT0732-8818材料科学：表征与测试INSIGHT INSIGHT1354-2575材料科学：表征与测试J TEST EVAL JOURNAL OF0090-3973材料科学：表征与测试MATER EVAL MATERIALS 0025-5327材料科学：表征与测试MATER PERFORMANCE MATERIALS 0094-1492材料科学：表征与测试MATER TEST Materials 0025-5300材料科学：表征与测试NONDESTRUCT TEST EVA Nondestruc1058-9759材料科学：表征与测试PART PART SYST CHAR PARTICLE &0934-0866材料科学：表征与测试POLYM POLYM COMPOS POLYMERS &0967-3911材料科学：表征与测试POWDER DIFFR POWDER DIF0885-7156材料科学：表征与测试QIRT J QIRT Journ1768-6733材料科学：表征与测试RUSS J NONDESTRUCT+RUSSIAN JO1061-8309材料科学：表征与测试STRENGTH MATER+STRENGTH O0039-2316材料科学：表征与测试DYES PIGMENTS DYES AND P0143-7208材料科学：纺织CELLULOSE CELLULOSE0969-0239材料科学：纺织COLOR TECHNOL COLORATION1472-3581材料科学：纺织TEXT RES J TEXTILE RE0040-5175材料科学：纺织FIBER POLYM FIBERS AND1229-9197材料科学：纺织IND TEXTILA Industria 1222-5347材料科学：纺织J AM LEATHER CHEM AS JOURNAL OF0002-9726材料科学：纺织J ENG FIBER FABR Journal of1558-9250材料科学：纺织J IND TEXT Journal of1528-0837材料科学：纺织WOOD FIBER SCI WOOD AND F0735-6161材料科学：纺织AATCC REV AATCC REVI1532-8813材料科学：纺织FIBRE CHEM+FIBRE CHEM0015-0541材料科学：纺织FIBRES TEXT EAST EUR FIBRES & T1230-3666材料科学：纺织INT J CLOTH SCI TECH Internatio0955-6222材料科学：纺织J NAT FIBERS Journal of1544-0478材料科学：纺织J SOC LEATH TECH CH JOURNAL OF0144-0322材料科学：纺织J TEXT I JOURNAL OF0040-5000材料科学：纺织J VINYL ADDIT TECHN JOURNAL OF1083-5601材料科学：纺织SEN-I GAKKAISHI SEN-I GAKK0037-9875材料科学：纺织TEKST KONFEKSIYON Tekstil ve1300-3356材料科学：纺织TEKSTIL TEKSTIL0492-5882材料科学：纺织COMPOS SCI TECHNOL COMPOSITES0266-3538材料科学：复合COMPOS PART A-APPL S COMPOSITES1359-835X材料科学：复合COMPOS PART B-ENG COMPOSITES1359-8368材料科学：复合COMPOS STRUCT COMPOSITE 0263-8223材料科学：复合APPL COMPOS MATER APPLIED CO0929-189X材料科学：复合CEMENT CONCRETE COMP CEMENT & C0958-9465材料科学：复合J COMPOS CONSTR JOURNAL OF1090-0268材料科学：复合J COMPOS MATER JOURNAL OF0021-9983材料科学：复合MECH ADV MATER STRUC MECHANICS 1537-6494材料科学：复合POLYM COMPOSITE POLYMER CO0272-8397材料科学：复合ADV COMPOS LETT ADVANCED C0963-6935材料科学：复合ADV COMPOS MATER ADVANCED C0924-3046材料科学：复合BETON- STAHLBETONBAU Beton- und0005-9900材料科学：复合CEM WAPNO BETON Cement Wap1425-8129材料科学：复合COMPOS INTERFACE COMPOSITE 0927-6440材料科学：复合J REINF PLAST COMP JOURNAL OF0731-6844材料科学：复合J SANDW STRUCT MATER JOURNAL OF1099-6362材料科学：复合J THERMOPLAST COMPOS JOURNAL OF0892-7057材料科学：复合MECH COMPOS MATER MECHANICS 0191-5665材料科学：复合PLAST RUBBER COMPOS PLASTICS R1465-8011材料科学：复合POLYM POLYM COMPOS POLYMERS &0967-3911材料科学：复合PROG RUBBER PLAST RE Progress i1477-7606材料科学：复合SCI ENG COMPOS MATER SCIENCE AN0334-181X材料科学：复合STEEL COMPOS STRUCT STEEL AND 1229-9367材料科学：复合J EUR CERAM SOC JOURNAL OF0955-2219材料科学：硅酸盐CERAM INT CERAMICS I0272-8842材料科学：硅酸盐INT J APPL CERAM TEC Internatio1546-542X材料科学：硅酸盐J AM CERAM SOC JOURNAL OF0002-7820材料科学：硅酸盐ADV APPL CERAM Advances i1743-6753材料科学：硅酸盐J CERAM SOC JPN JOURNAL OF1882-0743材料科学：硅酸盐J ELECTROCERAM JOURNAL OF1385-3449材料科学：硅酸盐J NON-CRYST SOLIDS JOURNAL OF0022-3093材料科学：硅酸盐J SOL-GEL SCI TECHN JOURNAL OF0928-0707材料科学：硅酸盐AM CERAM SOC BULL AMERICAN C0002-7812材料科学：硅酸盐BOL SOC ESP CERAM V BOLETIN DE0366-3175材料科学：硅酸盐CERAM-SILIKATY CERAMICS-S0862-5468材料科学：硅酸盐CFI-CERAM FORUM INT CFI-CERAMI0173-9913材料科学：硅酸盐GLASS CERAM+GLASS AND 0361-7610材料科学：硅酸盐GLASS PHYS CHEM+GLASS PHYS1087-6596材料科学：硅酸盐GLASS TECHNOL-PART A GLASS TECH1753-3546材料科学：硅酸盐IND CERAM INDUSTRIAL1121-7588材料科学：硅酸盐J CERAM PROCESS RES JOURNAL OF1229-9162材料科学：硅酸盐J INORG MATER JOURNAL OF1000-324X材料科学：硅酸盐MATER WORLD MATERIALS 0967-8638材料科学：硅酸盐PHYS CHEM GLASSES-B Physics an1753-3562材料科学：硅酸盐POWDER METALL MET C+POWDER MET1068-1302材料科学：硅酸盐REFRACT IND CERAM+REFRACTORI1083-4877材料科学：硅酸盐SCI SINTER SCIENCE OF0350-820X材料科学：硅酸盐T INDIAN CERAM SOC Transactio0371-750X材料科学：硅酸盐J ELECTROCHEM SOC JOURNAL OF0013-4651材料科学：膜CHEM VAPOR DEPOS CHEMICAL V0948-1907材料科学：膜SURF COAT TECH SURFACE & 0257-8972材料科学：膜THIN SOLID FILMS THIN SOLID0040-6090材料科学：膜APPL SURF SCI APPLIED SU0169-4332材料科学：膜J THERM SPRAY TECHN JOURNAL OF1059-9630材料科学：膜J VAC SCI TECHNOL A JOURNAL OF0734-2101材料科学：膜PROG ORG COAT PROGRESS I0300-9440材料科学：膜CORROS REV CORROSION 0334-6005材料科学：膜INT J SURF SCI ENG Internatio1749-785X材料科学：膜J COAT TECHNOL RES Journal of1547-0091材料科学：膜J PLAST FILM SHEET JOURNAL OF8756-0879材料科学：膜JCT COATINGSTECH JCT COATIN1547-0083材料科学：膜KORROZ FIGY Korrozios 0133-2546材料科学：膜PIGM RESIN TECHNOL Pigment & 0369-9420材料科学：膜SURF COAT INT SURFACE CO1754-0925材料科学：膜SURF ENG SURFACE EN0267-0844材料科学：膜T I MET FINISH TRANSACTIO0020-2967材料科学：膜BIOMATERIALS BIOMATERIA0142-9612材料科学：生物材料ACTA BIOMATER Acta Bioma1742-7061材料科学：生物材料EUR CELLS MATER EUROPEAN C1473-2262材料科学：生物材料J MECH BEHAV BIOMED Journal of1751-6161材料科学：生物材料MACROMOL BIOSCI MACROMOLEC1616-5187材料科学：生物材料BIOINTERPHASES Biointerph1559-4106材料科学：生物材料COLLOID SURFACE B COLLOIDS A0927-7765材料科学：生物材料DENT MATER DENTAL MAT0109-5641材料科学：生物材料J BIOACT COMPAT POL JOURNAL OF0883-9115材料科学：生物材料J BIOMAT SCI-POLYM E JOURNAL OF0920-5063材料科学：生物材料J BIOMED MATER RES A JOURNAL OF1549-3296材料科学：生物材料J BIOMED MATER RES B JOURNAL OF1552-4973材料科学：生物材料ARTIF CELL BLOOD SUB ARTIFICIAL1073-1199材料科学：生物材料BIOFABRICATION Biofabrica1758-5082材料科学：生物材料BIOINSPIR BIOMIM Bioinspira1748-3182材料科学：生物材料BIOMED MATER Biomedical1748-6041材料科学：生物材料BIO-MED MATER ENG BIO-MEDICA0959-2989材料科学：生物材料CELL POLYM CELLULAR P0262-4893材料科学：生物材料DENT MATER J DENTAL MAT0287-4547材料科学：生物材料J APPL BIOMATER BIOM Journal of1722-6899材料科学：生物材料J BIOBASED MATER BIO Journal of1556-6560材料科学：生物材料J BIOMATER APPL JOURNAL OF0885-3282材料科学：生物材料J BIONIC ENG Journal of1672-6529材料科学：生物材料J MATER SCI-MATER M JOURNAL OF0957-4530材料科学：生物材料MAT SCI ENG C-MATER Materials 0928-4931材料科学：生物材料CELLULOSE CELLULOSE0969-0239材料科学：纸与木材BIORESOURCES BioResourc1930-2126材料科学：纸与木材HOLZFORSCHUNG HOLZFORSCH0018-3830材料科学：纸与木材WOOD SCI TECHNOL WOOD SCIEN0043-7719材料科学：纸与木材EUR J WOOD WOOD PROD European J0018-3768材料科学：纸与木材J WOOD CHEM TECHNOL JOURNAL OF0277-3813材料科学：纸与木材J WOOD SCI JOURNAL OF1435-0211材料科学：纸与木材NORD PULP PAP RES J NORDIC PUL0283-2631材料科学：纸与木材TAPPI J TAPPI JOUR0734-1415材料科学：纸与木材APPITA J APPITA JOU1038-6807材料科学：纸与木材CELL CHEM TECHNOL CELLULOSE 0576-9787材料科学：纸与木材DREWNO Drewno1644-3985材料科学：纸与木材DRVNA IND Drvna Indu0012-6772材料科学：纸与木材FOREST PROD J FOREST PRO0015-7473材料科学：纸与木材J PULP PAP SCI JOURNAL OF0826-6220材料科学：纸与木材MADERAS-CIENC TECNOL Maderas-Ci0717-3644材料科学：纸与木材MOKUZAI GAKKAISHI MOKUZAI GA0021-4795材料科学：纸与木材PAP PUU-PAP TIM PAPERI JA 0031-1243材料科学：纸与木材PULP PAP-CANADA PULP & PAP0316-4004材料科学：纸与木材WOCHENBL PAPIERFABR WOCHENBLAT0043-7131材料科学：纸与木材WOOD FIBER SCI WOOD AND F0735-6161材料科学：纸与木材WOOD RES-SLOVAKIA WOOD RESEA1336-4561材料科学：纸与木材ACS NANO ACS Nano 1936-0851材料科学：综合ADV FUNCT MATER ADVANCED F1616-301X材料科学：综合ADV MATER ADVANCED M0935-9648材料科学：综合ANNU REV MATER RES ANNUAL REV1531-7331材料科学：综合MAT SCI ENG R MATERIALS 0927-796X材料科学：综合MATER TODAY Materials 1369-7021材料科学：综合NANO LETT NANO LETTE1530-6984材料科学：综合NANO TODAY Nano Today1748-0132材料科学：综合NAT MATER NATURE MAT1476-1122材料科学：综合NAT NANOTECHNOL Nature Nan1748-3387材料科学：综合PROG MATER SCI PROGRESS I0079-6425材料科学：综合ACTA MATER ACTA MATER1359-6454材料科学：综合CARBON CARBON0008-6223材料科学：综合CHEM MATER CHEMISTRY 0897-4756材料科学：综合CRIT REV SOLID STATE CRITICAL R1040-8436材料科学：综合CRYST GROWTH DES CRYSTAL GR1528-7483材料科学：综合CURR OPIN SOLID ST M CURRENT OP1359-0286材料科学：综合INT J PLASTICITY INTERNATIO0749-6419材料科学：综合INT MATER REV INTERNATIO0950-6608材料科学：综合J MATER CHEM JOURNAL OF0959-9428材料科学：综合J MECH PHYS SOLIDS JOURNAL OF0022-5096材料科学：综合J PHYS CHEM C Journal of1932-7447材料科学：综合LANGMUIR LANGMUIR0743-7463材料科学：综合MICROSC MICROANAL MICROSCOPY1431-9276材料科学：综合MRS BULL MRS BULLET0883-7694材料科学：综合NANO RES Nano Resea1998-0124材料科学：综合NANOSCALE Nanoscale2040-3364材料科学：综合NANOTECHNOLOGY NANOTECHNO0957-4484材料科学：综合ORG ELECTRON ORGANIC EL1566-1199材料科学：综合PLASMONICS Plasmonics1557-1955材料科学：综合SMALL SMALL1613-6810材料科学：综合SOFT MATTER Soft Matte1744-683X材料科学：综合SOL ENERG MAT SOL C SOLAR ENER0927-0248材料科学：综合ACS APPL MATER INTER ACS Applie1944-8244材料科学：综合ADV ENG MATER ADVANCED E1438-1656材料科学：综合APPL PHYS A-MATER APPLIED PH0947-8396材料科学：综合CEMENT CONCRETE RES CEMENT AND0008-8846材料科学：综合CMC-COMPUT MATER CON CMC-Comput1546-2218材料科学：综合COMP MATER SCI COMPUTATIO0927-0256材料科学：综合CORROS SCI CORROSION 0010-938X材料科学：综合CURR APPL PHYS CURRENT AP1567-1739材料科学：综合CURR NANOSCI Current Na1573-4137材料科学：综合DIAM RELAT MATER DIAMOND AN0925-9635材料科学：综合DIG J NANOMATER BIOS Digest Jou1842-3582材料科学：综合ELECTROCHEM SOLID ST ELECTROCHE1099-0062材料科学：综合EUR PHYS J E EUROPEAN P1292-8941材料科学：综合EXP MECH EXPERIMENT0014-4851材料科学：综合FUNCT MATER LETT Functional1793-6047材料科学：综合GOLD BULL GOLD BULLE0017-1557材料科学：综合IEEE T NANOTECHNOL IEEE TRANS1536-125X材料科学：综合INT J ADHES ADHES INTERNATIO0143-7496材料科学：综合INT J DAMAGE MECH INTERNATIO1056-7895材料科学：综合INT J FATIGUE INTERNATIO0142-1123材料科学：综合INTERMETALLICS INTERMETAL0966-9795材料科学：综合J ALLOY COMPD JOURNAL OF0925-8388材料科学：综合J MATER RES JOURNAL OF0884-2914材料科学：综合J MATER SCI JOURNAL OF0022-2461材料科学：综合J MICROMECH MICROENG JOURNAL OF0960-1317材料科学：综合J NANOPART RES JOURNAL OF1388-0764材料科学：综合J NANOSCI NANOTECHNO JOURNAL OF1533-4880材料科学：综合J NUCL MATER JOURNAL OF0022-3115材料科学：综合MACROMOL MATER ENG MACROMOLEC1438-7492材料科学：综合MAT SCI ENG A-STRUCT MATERIALS 0921-5093材料科学：综合MATER CHEM PHYS MATERIALS 0254-0584材料科学：综合MATER LETT MATERIALS 0167-577X材料科学：综合MATER RES BULL MATERIALS 0025-5408材料科学：综合MATER SCI ENG B-ADV Materials 0921-5107材料科学：综合MECH MATER MECHANICS 0167-6636材料科学：综合METALL MATER TRANS A METALLURGI1073-5623材料科学：综合MICROPOR MESOPOR MAT MICROPOROU1387-1811材料科学：综合NANOSCALE RES LETT Nanoscale 1931-7573材料科学：综合OPT MATER OPTICAL MA0925-3467材料科学：综合PHOTONIC NANOSTRUCT Photonics 1569-4410材料科学：综合PHYS CHEM MINER PHYSICS AN0342-1791材料科学：综合PHYS STATUS SOLIDI-R Physica St1862-6254材料科学：综合SCI ADV MATER Science of1947-2935材料科学：综合SCI TECHNOL ADV MAT SCIENCE AN1468-6996材料科学：综合SCRIPTA MATER SCRIPTA MA1359-6462材料科学：综合SMART MATER STRUCT SMART MATE0964-1726材料科学：综合SOFT MATER SOFT MATER1539-445X材料科学：综合SYNTHETIC MET SYNTHETIC 0379-6779材料科学：综合THIN SOLID FILMS THIN SOLID0040-6090材料科学：综合WEAR WEAR0043-1648材料科学：综合ACI MATER J ACI MATERI0889-325X材料科学：综合ACI STRUCT J ACI STRUCT0889-3241材料科学：综合ACTA MECH SOLIDA SIN ACTA MECHA0894-9166材料科学：综合ADV CEM RES ADVANCES I0951-7197材料科学：综合ADV MATER PROCESS ADVANCED M0882-7958材料科学：综合ANN CHIM-SCI MAT ANNALES DE0151-9107材料科学：综合ARCH CIV MECH ENG Archives o1644-9665材料科学：综合ATOMIZATION SPRAY ATOMIZATIO1044-5110材料科学：综合B MATER SCI BULLETIN O0250-4707材料科学：综合CHALCOGENIDE LETT Chalcogeni1584-8663材料科学：综合CIRCUIT WORLD CIRCUIT WO0305-6120材料科学：综合COMBUST EXPLO SHOCK+COMBUSTION0010-5082材料科学：综合CONSTR BUILD MATER CONSTRUCTI0950-0618材料科学：综合CORROS ENG SCI TECHN CORROSION 1478-422X材料科学：综合CORROSION CORROSION0010-9312材料科学：综合ELECTRON MATER LETT Electronic1738-8090材料科学：综合FATIGUE FRACT ENG M FATIGUE & 8756-758X材料科学：综合FERROELECTRICS FERROELECT0015-0193材料科学：综合FIBRE CHEM+FIBRE CHEM0015-0541材料科学：综合FIRE MATER FIRE AND M0308-0501材料科学：综合FIRE SAFETY J FIRE SAFET0379-7112材料科学：综合FIRE TECHNOL FIRE TECHN0015-2684材料科学：综合FULLER NANOTUB CAR N FULLERENES1536-383X材料科学：综合GEOSYNTH INT GEOSYNTHET1072-6349材料科学：综合GRANUL MATTER GRANULAR M1434-5021材料科学：综合HIGH TEMP MAT PR-ISR HIGH TEMPE0334-6455材料科学：综合HIGH TEMP MATER P-US HIGH TEMPE1093-3611材料科学：综合IEEE T ADV PACKAGING IEEE TRANS1521-3323材料科学：综合IEEE T COMPON PACK T IEEE TRANS1521-3331材料科学：综合INDIAN J ENG MATER S INDIAN JOU0971-4588材料科学：综合INFORM MIDEM INFORMACIJ0352-9045材料科学：综合INORG MATER+INORGANIC 0020-1685材料科学：综合INT J FRACTURE INTERNATIO0376-9429材料科学：综合INT J MATER PROD TEC INTERNATIO0268-1900材料科学：综合INT J MIN MET MATER Internatio1674-4799材料科学：综合INT J NANOTECHNOL Internatio1475-7435材料科学：综合INT J NUMER ANAL MET INTERNATIO0363-9061材料科学：综合INT J REFRACT MET H INTERNATIO0263-4368材料科学：综合INT J SURF SCI ENG Internatio1749-785X材料科学：综合J ADHES SCI TECHNOL JOURNAL OF0169-4243材料科学：综合J ADHESION JOURNAL OF0021-8464材料科学：综合J ADV CONCR TECHNOL Journal of1346-8014材料科学：综合J ADV MATER-COVINA JOURNAL OF1070-9789材料科学：综合J COMPUT THEOR NANOS Journal of1546-1955材料科学：综合J CULT HERIT JOURNAL OF1296-2074材料科学：综合J ELASTICITY JOURNAL OF0374-3535材料科学：综合J ELASTOM PLAST JOURNAL OF0095-2443材料科学：综合J ELECTRON MATER JOURNAL OF0361-5235材料科学：综合J ENERG MATER Journal of0737-0652材料科学：综合J ENG MATER-T ASME JOURNAL OF0094-4289材料科学：综合J EXP NANOSCI Journal of1745-8080材料科学：综合J FIRE PROT ENG Journal of1042-3915材料科学：综合J FIRE SCI JOURNAL OF0734-9041材料科学：综合J FRICT WEAR+Journal of1068-3666材料科学：综合J INTEL MAT SYST STR JOURNAL OF1045-389X材料科学：综合J LASER MICRO NANOEN Journal of1880-0688材料科学：综合J MAGN MAGN MATER JOURNAL OF0304-8853材料科学：综合J MATER CIVIL ENG JOURNAL OF0899-1561材料科学：综合J MATER ENG PERFORM JOURNAL OF1059-9495材料科学：综合J MATER PROCESS TECH JOURNAL OF0924-0136材料科学：综合J MATER SCI TECHNOL JOURNAL OF1005-0302材料科学：综合J MATER SCI-MATER EL JOURNAL OF0957-4522材料科学：综合J MECH MATER STRUCT Journal of1559-3959材料科学：综合J MICRO-NANOLITH MEM Journal of1932-5150材料科学：综合J NANO RES-SW Journal of1662-5250材料科学：综合J NANOMATER Journal of1687-4110材料科学：综合J NEW MAT ELECTR SYS JOURNAL OF1480-2422材料科学：综合J NON-CRYST SOLIDS JOURNAL OF0022-3093材料科学：综合J OPTOELECTRON ADV M JOURNAL OF1454-4164材料科学：综合J OVONIC RES Journal of1584-9953材料科学：综合J PHASE EQUILIB DIFF JOURNAL OF1547-7037材料科学：综合J PHYS CHEM LETT Journal of1948-7185材料科学：综合J POROUS MAT JOURNAL OF1380-2224材料科学：综合J SOC INF DISPLAY Journal of1071-0922材料科学：综合J SUPERHARD MATER+Journal of1063-4576材料科学：综合J WUHAN UNIV TECHNOL JOURNAL OF1000-2413材料科学：综合JOM-US JOM-JOURNA1047-4838材料科学：综合KONA POWDER PART J KONA Powde0288-4534材料科学：综合KOREAN J MET MATER Korean Jou1738-8228材料科学：综合KOVOVE MATER KOVOVE MAT0023-432X材料科学：综合LASER ENG LASERS IN 0898-1507材料科学：综合MACH SCI TECHNOL MACHINING 1091-0344材料科学：综合MAG CONCRETE RES MAGAZINE O0024-9831材料科学：综合MAT SCI SEMICON PROC MATERIALS 1369-8001材料科学：综合MATER CONSTRUCC MATERIALES0465-2746材料科学：综合MATER CORROS MATERIALS 0947-5117材料科学：综合MATER DESIGN MATERIALS 0261-3069材料科学：综合MATER HIGH TEMP MATERIALS 0960-3409材料科学：综合MATER MANUF PROCESS MATERIALS 1042-6914材料科学：综合MATER RES INNOV MATERIALS 1432-8917材料科学：综合MATER RES-IBERO-AM J Materials 1516-1439材料科学：综合MATER SCI TECH-LOND MATERIALS 0267-0836材料科学：综合MATER SCI+MATERIALS 1068-820X材料科学：综合MATER SCI-MEDZG Materials 1392-1320材料科学：综合MATER SCI-POLAND MATERIALS 0137-1339材料科学：综合MATER STRUCT MATERIALS 1359-5997材料科学：综合MATER TECHNOL MATERIALS 1066-7857材料科学：综合MATER TEHNOL Materiali 1580-2949材料科学：综合MATER TRANS MATERIALS 1345-9678材料科学：综合MATER WORLD MATERIALS 0967-8638材料科学：综合MATERIA-BRAZIL Materia-Ri1517-7076材料科学：综合MATERIALWISS WERKST MATERIALWI0933-5137材料科学：综合MATH MECH SOLIDS MATHEMATIC1081-2865材料科学：综合MECH ADV MATER STRUC MECHANICS 1537-6494材料科学：综合MET MATER INT METALS AND1598-9623材料科学：综合METALL MATER TRANS B METALLURGI1073-5615材料科学：综合METALLOFIZ NOV TEKH+METALLOFIZ1024-1809材料科学：综合MICRO NANO LETT Micro & Na1750-0443材料科学：综合MICROELECTRON INT MICROELECT1356-5362材料科学：综合MICROSYST TECHNOL MICROSYSTE0946-7076材料科学：综合MODEL SIMUL MATER SC MODELLING 0965-0393材料科学：综合NANO NANO1793-2920材料科学：综合NEW CARBON MATER NEW CARBON1007-8827材料科学：综合OPTOELECTRON ADV MAT Optoelectr1842-6573材料科学：综合P I MECH ENG L-J MAT PROCEEDING1464-4207材料科学：综合PARTICUOLOGY Particuolo1674-2001材料科学：综合PHILOS MAG PHILOSOPHI1478-6435材料科学：综合PHYS STATUS SOLIDI A PHYSICA ST1862-6300材料科学：综合PLAST ENG PLASTICS E0091-9578材料科学：综合PROG NAT SCI PROGRESS I1002-0071材料科学：综合RAPID PROTOTYPING J RAPID PROT1355-2546材料科学：综合RARE METAL MAT ENG RARE METAL1002-185X材料科学：综合RARE METALS RARE METAL1001-0521材料科学：综合RECENT PAT NANOTECH Recent Pat1872-2105材料科学：综合REV ADV MATER SCI REVIEWS ON1606-5131材料科学：综合REV ROM MATER Revista Ro1583-3186材料科学：综合ROAD MATER PAVEMENT Road Mater1468-0629材料科学：综合SAMPE J SAMPE JOUR0091-1062材料科学：综合SCI CHINA TECHNOL SC Science Ch1674-7321材料科学：综合SCI MODEL SIMUL Scientific1874-8554材料科学：综合SCI TECHNOL ENERG MA Science an1347-9466材料科学：综合SCI TECHNOL WELD JOI SCIENCE AN1362-1718材料科学：综合SEMICOND SCI TECH SEMICONDUC0268-1242材料科学：综合SENSOR MATER SENSORS AN0914-4935材料科学：综合SOLDER SURF MT TECH SOLDERING 0954-0911材料科学：综合T FAMENA Transactio1333-1124材料科学：综合VACUUM VACUUM0042-207X材料科学：综合ZKG INT ZKG INTERN0949-0205材料科学：综合SIAM J IMAGING SCI SIAM Journ1936-4954成像科学与照相技术IEEE T MED IMAGING IEEE TRANS0278-0062成像科学与照相技术REMOTE SENS ENVIRON REMOTE SEN0034-4257成像科学与照相技术INT J REMOTE SENS INTERNATIO0143-1161成像科学与照相技术ISPRS J PHOTOGRAMM ISPRS JOUR0924-2716成像科学与照相技术PHOTOGRAMM ENG REM S PHOTOGRAMM0099-1112成像科学与照相技术PHOTOGRAMM REC PHOTOGRAMM0031-868X成像科学与照相技术EURASIP J IMAGE VIDE EURASIP Jo1687-5176成像科学与照相技术IEEE J-STARS IEEE Journ1939-1404成像科学与照相技术IMAGING SCI J IMAGING SC1368-2199成像科学与照相技术INT J IMAG SYST TECH INTERNATIO0899-9457成像科学与照相技术J APPL REMOTE SENS Journal of1931-3195成像科学与照相技术J ELECTRON IMAGING JOURNAL OF1017-9909成像科学与照相技术J IMAGING SCI TECHN JOURNAL OF1062-3701成像科学与照相技术J REAL-TIME IMAGE PR Journal of1861-8200成像科学与照相技术PHOTOGRAMM FERNERKUN Photogramm1432-8364成像科学与照相技术RIV ITAL TELERILEVAM Rivista It1129-8596成像科学与照相技术SIGNAL IMAGE VIDEO P Signal Ima1863-1703成像科学与照相技术SMPTE MOTION IMAG J SMPTE MOTI0036-1682成像科学与照相技术ANN FAM MED ANNALS OF 1544-1709初级卫生保健BRIT J GEN PRACT BRITISH JO0960-1643初级卫生保健J AM BOARD FAM MED Journal of1557-2625初级卫生保健SCAND J PRIM HEALTH SCANDINAVI0281-3432初级卫生保健AM FAM PHYSICIAN AMERICAN F0002-838X初级卫生保健BMC FAM PRACT BMC Family1471-2296初级卫生保健FAM PRACT FAMILY PRA0263-2136初级卫生保健ATEN PRIM Atencion P0212-6567初级卫生保健AUST FAM PHYSICIAN Australian0300-8495初级卫生保健AUST J PRIM HEALTH Australian1448-7527初级卫生保健CAN FAM PHYSICIAN CANADIAN F0008-350X初级卫生保健FAM MED FAMILY MED0742-3225初级卫生保健J FAM PRACTICE JOURNAL OF0094-3509初级卫生保健PRIMARY CARE PRIMARY CA0095-4543初级卫生保健CLIN INFECT DIS CLINICAL I1058-4838传染病学EMERG INFECT DIS EMERGING I1080-6040传染病学LANCET INFECT DIS LANCET INF1473-3099传染病学AIDS AIDS0269-9370传染病学AIDS REV AIDS REVIE1139-6121传染病学ANTIVIR THER ANTIVIRAL 1359-6535传染病学CLIN MICROBIOL INFEC CLINICAL M1198-743X传染病学CURR OPIN INFECT DIS CURRENT OP0951-7375传染病学INFECT IMMUN INFECTION 0019-9567传染病学J ANTIMICROB CHEMOTH JOURNAL OF0305-7453传染病学J INFECT DIS JOURNAL OF0022-1899传染病学J VIRAL HEPATITIS JOURNAL OF1352-0504传染病学JAIDS-J ACQ IMM DEF JAIDS-JOUR1525-4135传染病学AM J INFECT CONTROL AMERICAN J0196-6553传染病学BMC INFECT DIS BMC INFECT1471-2334传染病学EUR J CLIN MICROBIOL EUROPEAN J0934-9723传染病学HIV MED HIV MEDICI1464-2662传染病学INFECT CONT HOSP EP INFECTION 0899-823X传染病学INFECT GENET EVOL INFECTION 1567-1348传染病学INFLUENZA OTHER RESP Influenza 1750-2640传染病学INT J ANTIMICROB AG INTERNATIO0924-8579传染病学INT J HYG ENVIR HEAL INTERNATIO1438-4639传染病学INT J TUBERC LUNG D INTERNATIO1027-3719传染病学J HOSP INFECT JOURNAL OF0195-6701传染病学J INFECTION JOURNAL OF0163-4453传染病学PEDIATR INFECT DIS J PEDIATRIC 0891-3668传染病学SEX TRANSM DIS SEXUALLY T0148-5717传染病学SEX TRANSM INFECT SEXUALLY T1368-4973传染病学VECTOR-BORNE ZOONOT VECTOR-BOR1530-3667传染病学AIDS PATIENT CARE ST AIDS PATIE1087-2914传染病学AIDS RES HUM RETROV AIDS RESEA0889-2229传染病学B MALARIOL SALUD AMB Boletin de1690-4648传染病学BRAZ J INFECT DIS Brazilian 1413-8670传染病学CAN J INFECT DIS MED Canadian J1712-9532传染病学CLIN VACCINE IMMUNOL Clinical a1556-6811传染病学CURR HIV RES CURRENT HI1570-162X传染病学DIAGN MICR INFEC DIS DIAGNOSTIC0732-8893传染病学ENFERM EMERG Enfermedad1575-4723传染病学ENFERM INFEC MICR CL ENFERMEDAD0213-005X传染病学EPIDEMIOL INFECT EPIDEMIOLO0950-2688传染病学FEMS IMMUNOL MED MIC FEMS IMMUN0928-8244传染病学HIV CLIN TRIALS HIV CLINIC1528-4336传染病学INFECT DIS CLIN N AM INFECTIOUS0891-5520传染病学INFECTION INFECTION0300-8126传染病学INT J INFECT DIS INTERNATIO1201-9712传染病学INT J STD AIDS INTERNATIO0956-4624传染病学JPN J INFECT DIS JAPANESE J1344-6304传染病学LEPROSY REV LEPROSY RE0305-7518传染病学MED MALADIES INFECT MEDECINE E0399-077X传染病学MICROB DRUG RESIST MICROBIAL 1076-6294传染病学REV CHIL INFECTOL Revista Ch0716-1018传染病学S AFR J HIV MED SOUTHERN A1608-9693传染病学SCAND J INFECT DIS SCANDINAVI0036-5548传染病学SEX HEALTH Sexual Hea1448-5028传染病学TICKS TICK-BORNE DIS Ticks and 1877-959X传染病学TRANSBOUND EMERG DIS Transbound1865-1674传染病学TRANSPL INFECT DIS Transplant1398-2273传染病学ZOONOSES PUBLIC HLTH Zoonoses a1863-1959传染病学ANNU REV MAR SCI Annual Rev1941-1405地球化学与地球物理EARTH PLANET SC LETT EARTH AND 0012-821X地球化学与地球物理GEOCHIM COSMOCHIM AC GEOCHIMICA0016-7037地球化学与地球物理REV GEOPHYS REVIEWS OF8755-1209地球化学与地球物理CHEM GEOL CHEMICAL G0009-2541地球化学与地球物理CONTRIB MINERAL PETR CONTRIBUTI0010-7999地球化学与地球物理ELEMENTS Elements1811-5209地球化学与地球物理GEOCHEM GEOPHY GEOSY GEOCHEMIST1525-2027地球化学与地球物理IEEE T GEOSCI REMOTE IEEE TRANS0196-2892地球化学与地球物理J PETROL JOURNAL OF0022-3530地球化学与地球物理LITHOS LITHOS0024-4937地球化学与地球物理QUAT GEOCHRONOL Quaternary1871-1014地球化学与地球物理REV MINERAL GEOCHEM REVIEWS IN1529-6466地球化学与地球物理SURV GEOPHYS SURVEYS IN0169-3298地球化学与地球物理TECTONICS TECTONICS0278-7407地球化学与地球物理AM MINERAL AMERICAN M0003-004X地球化学与地球物理APPL GEOCHEM APPLIED GE0883-2927地球化学与地球物理B SEISMOL SOC AM BULLETIN O0037-1106地球化学与地球物理DYNAM ATMOS OCEANS DYNAMICS O0377-0265地球化学与地球物理GEOCHEM T GEOCHEMICA1467-4866地球化学与地球物理GEOPHYS J INT GEOPHYSICA0956-540X地球化学与地球物理J ATMOS SOL-TERR PHY JOURNAL OF1364-6826地球化学与地球物理J GEOCHEM EXPLOR JOURNAL OF0375-6742地球化学与地球物理J GEODESY JOURNAL OF0949-7714地球化学与地球物理LITHOSPHERE-US Lithospher1941-8264地球化学与地球物理METEORIT PLANET SCI METEORITIC1086-9379地球化学与地球物理MINER DEPOSITA MINERALIUM0026-4598地球化学与地球物理ORG GEOCHEM ORGANIC GE0146-6380地球化学与地球物理PHYS EARTH PLANET IN PHYSICS OF0031-9201地球化学与地球物理RADIOCARBON RADIOCARBO0033-8222地球化学与地球物理SEISMOL RES LETT SEISMOLOGI0895-0695地球化学与地球物理SPACE WEATHER SPACE WEAT1542-7390地球化学与地球物理TECTONOPHYSICS TECTONOPHY0040-1951地球化学与地球物理ACTA GEOD GEOPHYS HU Acta Geoda1217-8977地球化学与地球物理ACTA GEODYN GEOMATER Acta Geody1214-9705地球化学与地球物理ACTA GEOPHYS Acta Geoph1895-6572地球化学与地球物理ANN GEOPHYS-ITALY ANNALS OF 1593-5213地球化学与地球物理APPL GEOPHYS Applied Ge1672-7975地球化学与地球物理AQUAT GEOCHEM AQUATIC GE1380-6165地球化学与地球物理ASTRON GEOPHYS ASTRONOMY 1366-8781地球化学与地球物理B CIENC GEOD Boletim de1413-4853地球化学与地球物理B GEOFIS TEOR APPL Bollettino0006-6729地球化学与地球物理CHEM ERDE-GEOCHEM CHEMIE DER0009-2819地球化学与地球物理CHINESE J GEOPHYS-CH CHINESE JO0001-5733地球化学与地球物理ECON GEOL ECONOMIC G0361-0128地球化学与地球物理EXPLOR GEOPHYS Exploratio0812-3985地球化学与地球物理GEOCHEM INT+GEOCHEMIST0016-7029地球化学与地球物理GEOCHEM J GEOCHEMICA0016-7002地球化学与地球物理GEOCHEM-EXPLOR ENV A GEOCHEMIST1467-7873地球化学与地球物理GEOFIS INT Geofisica 0016-7169地球化学与地球物理GEOFIZIKA Geofizika 0352-3659地球化学与地球物理GEOFLUIDS GEOFLUIDS1468-8115地球化学与地球物理GEOPHYS ASTRO FLUID GEOPHYSICA0309-1929地球化学与地球物理GEOPHYS PROSPECT GEOPHYSICA0016-8025地球化学与地球物理GEOPHYSICS GEOPHYSICS0016-8033地球化学与地球物理GEOTECTONICS+GEOTECTONI0016-8521地球化学与地球物理IEEE GEOSCI REMOTE S IEEE Geosc1545-598X地球化学与地球物理IZV-PHYS SOLID EART+IZVESTIYA-1069-3513地球化学与地球物理J EARTHQ TSUNAMI Journal of1793-4311地球化学与地球物理J ENVIRON ENG GEOPH JOURNAL OF1083-1363地球化学与地球物理J GEODYN JOURNAL OF0264-3707地球化学与地球物理J GEOPHYS ENG Journal of1742-2132地球化学与地球物理J SEISM EXPLOR JOURNAL OF0963-0651地球化学与地球物理J SEISMOL JOURNAL OF1383-4649地球化学与地球物理J VOLCANOL SEISMOL+Journal of0742-0463地球化学与地球物理LITHOL MINER RESOUR+LITHOLOGY 0024-4902地球化学与地球物理MAR GEOD MARINE GEO0149-0419地球化学与地球物理MAR GEOPHYS RES MARINE GEO0025-3235地球化学与地球物理MINER PETROL MINERALOGY0930-0708地球化学与地球物理NEAR SURF GEOPHYS Near Surfa1569-4445地球化学与地球物理NONLINEAR PROC GEOPH NONLINEAR 1023-5809地球化学与地球物理PERIOD MINERAL Periodico 0369-8963地球化学与地球物理PETROL SCI Petroleum 1672-5107地球化学与地球物理PETROPHYSICS Petrophysi1529-9074地球化学与地球物理PURE APPL GEOPHYS PURE AND A0033-4553地球化学与地球物理RADIO SCI RADIO SCIE0048-6604地球化学与地球物理STUD GEOPHYS GEOD STUDIA GEO0039-3169地球化学与地球物理ANNU REV EARTH PL SC ANNUAL REV0084-6597地球科学综合EARTH-SCI REV EARTH-SCIE0012-8252地球科学综合GLOBAL BIOGEOCHEM CY GLOBAL BIO0886-6236地球科学综合GONDWANA RES GONDWANA R1342-937X地球科学综合NAT GEOSCI Nature Geo1752-0894地球科学综合PALEOCEANOGRAPHY PALEOCEANO0883-8305地球科学综合PRECAMBRIAN RES PRECAMBRIA0301-9268地球科学综合QUATERNARY SCI REV QUATERNARY0277-3791地球科学综合AM J SCI AMERICAN J0002-9599地球科学综合ASTROBIOLOGY ASTROBIOLO1531-1074地球科学综合B VOLCANOL BULLETIN O0258-8900地球科学综合BIOGEOCHEMISTRY BIOGEOCHEM0168-2563地球科学综合BIOGEOSCIENCES Biogeoscie1726-4170地球科学综合BOREAS BOREAS0300-9483地球科学综合CLIM PAST Climate of1814-9324地球科学综合CRYOSPHERE Cryosphere1994-0416地球科学综合GEOBIOLOGY GEOBIOLOGY1472-4677地球科学综合GEOL SOC AM BULL GEOLOGICAL0016-7606地球科学综合GEOPHYS RES LETT GEOPHYSICA0094-8276地球科学综合GEOSTAND GEOANAL RES GEOSTANDAR1639-4488地球科学综合GEOTEXT GEOMEMBRANES GEOTEXTILE0266-1144地球科学综合GLOBAL PLANET CHANGE GLOBAL AND0921-8181地球科学综合HOLOCENE HOLOCENE0959-6836地球科学综合HYDROL EARTH SYST SC HYDROLOGY 1027-5606地球科学综合J GEOL SOC LONDON JOURNAL OF0016-7649地球科学综合J GEOPHYS RES JOURNAL OF0148-0227地球科学综合J HYDROL JOURNAL OF0022-1694地球科学综合J QUATERNARY SCI JOURNAL OF0267-8179地球科学综合LANDSCAPE ECOL LANDSCAPE 0921-2973地球科学综合MAR GEOL MARINE GEO0025-3227地球科学综合PALAEOGEOGR PALAEOCL PALAEOGEOG0031-0182地球科学综合PROG PHYS GEOG PROGRESS I0309-1333地球科学综合QUATERNARY RES QUATERNARY0033-5894地球科学综合AAPG BULL AAPG BULLE0149-1423地球科学综合ACTA GEOL SIN-ENGL ACTA GEOLO1000-9515地球科学综合ANN GEOPHYS-GERMANY ANNALES GE0992-7689地球科学综合。
最新JCR分区表
刊名简称刊名全称ISSN PLOS PATHOG PLoS Pathogens1553-7366 REV MED VIROL REVIEWS IN MEDICAL VIROLOGY1052-9276 ADV VIRUS RES ADVANCES IN VIRUS RESEARCH0065-3527 AIDS AIDS0269-9370 ANTIVIR THER ANTIVIRAL THERAPY1359-6535 J VIROL JOURNAL OF VIROLOGY0022-538X RETROVIROLOGY Retrovirology 1742-4690 ANTIVIR RES ANTIVIRAL RESEARCH0166-3542 INFLUENZA OTHER RESP Influenza and Other Respiratory Viruses1750-2640 INT J MED MICROBIOL INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY1438-4221 J CLIN VIROL JOURNAL OF CLINICAL VIROLOGY1386-6532 J GEN VIROL JOURNAL OF GENERAL VIROLOGY0022-1317 J MED VIROL JOURNAL OF MEDICAL VIROLOGY0146-6615 J VIRAL HEPATITIS JOURNAL OF VIRAL HEPATITIS1352-0504 MICROBES INFECT MICROBES AND INFECTION1286-4579 VIROLOGY VIROLOGY0042-6822 ACTA VIROL ACTA VIROLOGICA0001-723X AIDS RES HUM RETROV AIDS RESEARCH AND HUMAN RETROVIRUSES0889-2229 ARCH VIROL ARCHIVES OF VIROLOGY0304-8608 CURR HIV RES CURRENT HIV RESEARCH1570-162X FOOD ENVIRON VIROL Food and Environmental Virology1867-0334 FUTURE VIROL Future Virology1746-0794 INDIAN J VIROL Indian Journal of Virology 0970-2822 INTERVIROLOGY INTERVIROLOGY0300-5526 J NEUROVIROL JOURNAL OF NEUROVIROLOGY1355-0284 J VIROL METHODS JOURNAL OF VIROLOGICAL METHODS0166-0934 S AFR J HIV MED SOUTHERN AFRICAN JOURNAL OF HIV MEDICINE1608-9693 VIRAL IMMUNOL VIRAL IMMUNOLOGY0882-8245 VIROL J Virology Journal1743-422X VIROLOGIE VIROLOGIE1267-8694 VIRUS GENES VIRUS GENES0920-8569 VIRUS RES VIRUS RESEARCH0168-1702 VIRUSES-BASEL Viruses-Basel1999-4915 ACTA NEUROPATHOL ACTA NEUROPATHOLOGICA0001-6322 AM J PATHOL AMERICAN JOURNAL OF PATHOLOGY0002-9440 ANNU REV PATHOL-MECH Annual Review of Pathology-Mechanisms of Disease1553-4006 J PATHOL JOURNAL OF PATHOLOGY0022-3417 AM J SURG PATHOL AMERICAN JOURNAL OF SURGICAL PATHOLOGY0147-5185 BRAIN PATHOL BRAIN PATHOLOGY1015-6305 DIS MODEL MECH Disease Models & Mechanisms1754-8403 EXPERT REV MOL DIAGN EXPERT REVIEW OF MOLECULAR DIAGNOSTICS1473-7159 HISTOPATHOLOGY HISTOPATHOLOGY0309-0167 J MOL DIAGN JOURNAL OF MOLECULAR DIAGNOSTICS1525-1578 J NEUROPATH EXP NEUR JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEURO0022-3069 LAB INVEST LABORATORY INVESTIGATION0023-6837 MODERN PATHOL MODERN PATHOLOGY0893-3952 NEUROPATH APPL NEURO NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY0305-1846 SEMIN IMMUNOPATHOL Seminars in Immunopathology1863-2297 ADV ANAT PATHOL ADVANCES IN ANATOMIC PATHOLOGY1072-4109 ALZ DIS ASSOC DIS ALZHEIMER DISEASE & ASSOCIATED DISORDERS0893-0341 AM J CLIN PATHOL AMERICAN JOURNAL OF CLINICAL PATHOLOGY0002-9173ANAL CELL PATHOL Analytical Cellular Pathology-Cellular Oncology2210-7177 ARCH PATHOL LAB MED ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE0003-9985 CANCER CYTOPATHOL CANCER CYTOPATHOLOGY1934-662X CYTOM PART B-CLIN CY CYTOMETRY PART B-CLINICAL CYTOMETRY1552-4949 DIS MARKERS DISEASE MARKERS0278-0240 EXP MOL PATHOL EXPERIMENTAL AND MOLECULAR PATHOLOGY0014-4800 HISTOL HISTOPATHOL HISTOLOGY AND HISTOPATHOLOGY0213-3911 HUM PATHOL HUMAN PATHOLOGY0046-8177 INT J EXP PATHOL INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY0959-9673 INT J IMMUNOPATH PH INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHA0394-6320 J CLIN PATHOL JOURNAL OF CLINICAL PATHOLOGY0021-9746 PATHOBIOLOGY PATHOBIOLOGY1015-2008 PATHOLOGY PATHOLOGY0031-3025 TISSUE ANTIGENS TISSUE ANTIGENS0001-2815 TOXICOL PATHOL TOXICOLOGIC PATHOLOGY0192-6233 VIRCHOWS ARCH VIRCHOWS ARCHIV-AN INTERNATIONAL JOURNAL OF PATH0945-6317 ACTA CYTOL ACTA CYTOLOGICA0001-5547 AM J FOREN MED PATH AMERICAN JOURNAL OF FORENSIC MEDICINE AND PATHOL0195-7910 ANN DIAGN PATHOL Annals of Diagnostic Pathology 1092-9134 ANN PATHOL ANNALES DE PATHOLOGIE0242-6498 APMIS APMIS0903-4641 APPL IMMUNOHISTO M M APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOL1062-3345 BRAIN TUMOR PATHOL Brain Tumor Pathology1433-7398 CARDIOVASC PATHOL CARDIOVASCULAR PATHOLOGY1054-8807 CLIN NEUROPATHOL CLINICAL NEUROPATHOLOGY0722-5091 CYTOPATHOLOGY CYTOPATHOLOGY0956-5507 DIAGN CYTOPATHOL DIAGNOSTIC CYTOPATHOLOGY8755-1039 DIAGN MOL PATHOL DIAGNOSTIC MOLECULAR PATHOLOGY1052-9551 DIAGN PATHOL Diagnostic Pathology1746-1596 ENDOCR PATHOL ENDOCRINE PATHOLOGY1046-3976 EXP TOXICOL PATHOL EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY0940-2993 FETAL PEDIATR PATHOL Fetal and Pediatric Pathology1551-3815 FOLIA NEUROPATHOL FOLIA NEUROPATHOLOGICA1641-4640 FORENSIC SCI MED PAT Forensic Science Medicine and Pathology1547-769X INDIAN J PATHOL MICR Indian Journal of Pathology and Microbiology0377-4929 INT J GYNECOL PATHOL INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY0277-1691 INT J SURG PATHOL INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY1066-8969 J COMP PATHOL JOURNAL OF COMPARATIVE PATHOLOGY0021-9975 J CUTAN PATHOL JOURNAL OF CUTANEOUS PATHOLOGY0303-6987 J ORAL PATHOL MED JOURNAL OF ORAL PATHOLOGY & MEDICINE0904-2512 J TOXICOL PATHOL Journal of Toxicologic Pathology0914-9198 KOREAN J PATHOL Korean Journal of Pathology1738-1843 LEPROSY REV LEPROSY REVIEW0305-7518 MED MOL MORPHOL Medical Molecular Morphology1860-1480 MED NUCL Medecine Nucleaire-Imagerie Fonctionnelle et Met0928-1258 NEUROPATHOLOGY NEUROPATHOLOGY0919-6544 PATHOL BIOL PATHOLOGIE BIOLOGIE0369-8114 PATHOL INT PATHOLOGY INTERNATIONAL1320-5463 PATHOL ONCOL RES PATHOLOGY & ONCOLOGY RESEARCH1219-4956 PATHOL RES PRACT PATHOLOGY RESEARCH AND PRACTICE0344-0338 PATHOLOGE PATHOLOGE0172-8113 PEDIATR DEVEL PATHOL PEDIATRIC AND DEVELOPMENTAL PATHOLOGY1093-5266POL J PATHOL POLISH JOURNAL OF PATHOLOGY1233-9687 SCI JUSTICE SCIENCE & JUSTICE1355-0306 SEMIN DIAGN PATHOL SEMINARS IN DIAGNOSTIC PATHOLOGY0740-2570 ULTRASTRUCT PATHOL ULTRASTRUCTURAL PATHOLOGY0191-3123 VET PATHOL VETERINARY PATHOLOGY0300-9858 POLYM TEST POLYMER TESTING0142-9418 PROG CRYST GROWTH CH PROGRESS IN CRYSTAL GROWTH AND CHARACTERIZATION 0960-8974 EXP MECH EXPERIMENTAL MECHANICS0014-4851 MATER CHARACT MATERIALS CHARACTERIZATION1044-5803 NANOSC MICROSC THERM Nanoscale and Microscale Thermophysical Engineer1556-7265 NDT&E INT NDT & E INTERNATIONAL0963-8695 ENG FAIL ANAL ENGINEERING FAILURE ANALYSIS1350-6307 J NONDESTRUCT EVAL JOURNAL OF NONDESTRUCTIVE EVALUATION0195-9298 J SANDW STRUCT MATER JOURNAL OF SANDWICH STRUCTURES & MATERIALS1099-6362 J STRAIN ANAL ENG JOURNAL OF STRAIN ANALYSIS FOR ENGINEERING DESIG0309-3247 MECH ADV MATER STRUC MECHANICS OF ADVANCED MATERIALS AND STRUCTURES1537-6494 MECH TIME-DEPEND MAT MECHANICS OF TIME-DEPENDENT MATERIALS1385-2000 RES NONDESTRUCT EVAL RESEARCH IN NONDESTRUCTIVE EVALUATION0934-9847 STRAIN STRAIN0039-2103 ADV STEEL CONSTR Advanced Steel Construction1816-112X ARCH MECH ARCHIVES OF MECHANICS0373-2029 BETON- STAHLBETONBAU Beton- und Stahlbetonbau0005-9900 COMPUT CONCRETE Computers and Concrete 1598-8198 EXP TECHNIQUES EXPERIMENTAL TECHNIQUES0732-8818 INSIGHT INSIGHT1354-2575 J TEST EVAL JOURNAL OF TESTING AND EVALUATION0090-3973 MATER EVAL MATERIALS EVALUATION0025-5327 MATER PERFORMANCE MATERIALS PERFORMANCE0094-1492 MATER TEST Materials Testing-Materials and Components Techn0025-5300 NONDESTRUCT TEST EVA Nondestructive Testing and Evaluation1058-9759 PART PART SYST CHAR PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION0934-0866 POLYM POLYM COMPOS POLYMERS & POLYMER COMPOSITES0967-3911 POWDER DIFFR POWDER DIFFRACTION0885-7156 QIRT J QIRT Journal1768-6733 RUSS J NONDESTRUCT+RUSSIAN JOURNAL OF NONDESTRUCTIVE TESTING1061-8309 STRENGTH MATER+STRENGTH OF MATERIALS0039-2316 DYES PIGMENTS DYES AND PIGMENTS0143-7208 CELLULOSE CELLULOSE0969-0239 COLOR TECHNOL COLORATION TECHNOLOGY1472-3581 TEXT RES J TEXTILE RESEARCH JOURNAL0040-5175 FIBER POLYM FIBERS AND POLYMERS1229-9197 IND TEXTILA Industria Textila 1222-5347 J AM LEATHER CHEM AS JOURNAL OF THE AMERICAN LEATHER CHEMISTS ASSOCIA0002-9726 J ENG FIBER FABR Journal of Engineered Fibers and Fabrics 1558-9250 J IND TEXT Journal of Industrial Textiles1528-0837 WOOD FIBER SCI WOOD AND FIBER SCIENCE0735-6161 AATCC REV AATCC REVIEW1532-8813 FIBRE CHEM+FIBRE CHEMISTRY0015-0541 FIBRES TEXT EAST EUR FIBRES & TEXTILES IN EASTERN EUROPE1230-3666 INT J CLOTH SCI TECH International Journal of Clothing Science and Te0955-6222 J NAT FIBERS Journal of Natural Fibers1544-0478 J SOC LEATH TECH CH JOURNAL OF THE SOCIETY OF LEATHER TECHNOLOGISTS 0144-0322J TEXT I JOURNAL OF THE TEXTILE INSTITUTE0040-5000 J VINYL ADDIT TECHN JOURNAL OF VINYL & ADDITIVE TECHNOLOGY1083-5601 SEN-I GAKKAISHI SEN-I GAKKAISHI0037-9875 TEKST KONFEKSIYON Tekstil ve Konfeksiyon 1300-3356 TEKSTIL TEKSTIL0492-5882 COMPOS SCI TECHNOL COMPOSITES SCIENCE AND TECHNOLOGY0266-3538 COMPOS PART A-APPL S COMPOSITES PART A-APPLIED SCIENCE AND MANUFACTUR1359-835X COMPOS PART B-ENG COMPOSITES PART B-ENGINEERING1359-8368 COMPOS STRUCT COMPOSITE STRUCTURES0263-8223 APPL COMPOS MATER APPLIED COMPOSITE MATERIALS0929-189X CEMENT CONCRETE COMP CEMENT & CONCRETE COMPOSITES0958-9465 J COMPOS CONSTR JOURNAL OF COMPOSITES FOR CONSTRUCTION1090-0268 J COMPOS MATER JOURNAL OF COMPOSITE MATERIALS0021-9983 J SANDW STRUCT MATER JOURNAL OF SANDWICH STRUCTURES & MATERIALS1099-6362 MECH ADV MATER STRUC MECHANICS OF ADVANCED MATERIALS AND STRUCTURES1537-6494 POLYM COMPOSITE POLYMER COMPOSITES0272-8397 ADV COMPOS LETT ADVANCED COMPOSITES LETTERS0963-6935 ADV COMPOS MATER ADVANCED COMPOSITE MATERIALS0924-3046 BETON- STAHLBETONBAU Beton- und Stahlbetonbau0005-9900 CEM WAPNO BETON Cement Wapno Beton1425-8129 COMPOS INTERFACE COMPOSITE INTERFACES0927-6440 J REINF PLAST COMP JOURNAL OF REINFORCED PLASTICS AND COMPOSITES0731-6844 J THERMOPLAST COMPOS JOURNAL OF THERMOPLASTIC COMPOSITE MATERIALS0892-7057 MECH COMPOS MATER MECHANICS OF COMPOSITE MATERIALS0191-5665 PLAST RUBBER COMPOS PLASTICS RUBBER AND COMPOSITES1465-8011 POLYM POLYM COMPOS POLYMERS & POLYMER COMPOSITES0967-3911 PROG RUBBER PLAST RE Progress in Rubber Plastics and Recycling Techno1477-7606 SCI ENG COMPOS MATER SCIENCE AND ENGINEERING OF COMPOSITE MATERIALS0334-181X STEEL COMPOS STRUCT STEEL AND COMPOSITE STRUCTURES1229-9367 J EUR CERAM SOC JOURNAL OF THE EUROPEAN CERAMIC SOCIETY0955-2219 CERAM INT CERAMICS INTERNATIONAL0272-8842 INT J APPL CERAM TEC International Journal of Applied Ceramic Technol1546-542X J AM CERAM SOC JOURNAL OF THE AMERICAN CERAMIC SOCIETY0002-7820 ADV APPL CERAM Advances in Applied Ceramics1743-6753 J CERAM SOC JPN JOURNAL OF THE CERAMIC SOCIETY OF JAPAN1882-0743 J ELECTROCERAM JOURNAL OF ELECTROCERAMICS1385-3449 J NON-CRYST SOLIDS JOURNAL OF NON-CRYSTALLINE SOLIDS0022-3093 J SOL-GEL SCI TECHN JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY0928-0707 AM CERAM SOC BULL AMERICAN CERAMIC SOCIETY BULLETIN0002-7812 BOL SOC ESP CERAM V BOLETIN DE LA SOCIEDAD ESPANOLA DE CERAMICA Y VI0366-3175 CERAM-SILIKATY CERAMICS-SILIKATY0862-5468 CFI-CERAM FORUM INT CFI-CERAMIC FORUM INTERNATIONAL0173-9913 GLASS CERAM+GLASS AND CERAMICS0361-7610 GLASS PHYS CHEM+GLASS PHYSICS AND CHEMISTRY1087-6596 GLASS TECHNOL-PART A GLASS TECHNOLOGY1753-3546 IND CERAM INDUSTRIAL CERAMICS1121-7588 J CERAM PROCESS RES JOURNAL OF CERAMIC PROCESSING RESEARCH1229-9162 J INORG MATER JOURNAL OF INORGANIC MATERIALS1000-324X MATER WORLD MATERIALS WORLD0967-8638 PHYS CHEM GLASSES-B Physics and Chemistry of Glasses-European Journa1753-3562 POWDER METALL MET C+POWDER METALLURGY AND METAL CERAMICS1068-1302 REFRACT IND CERAM+REFRACTORIES AND INDUSTRIAL CERAMICS1083-4877SCI SINTER SCIENCE OF SINTERING0350-820X T INDIAN CERAM SOC Transactions of the Indian Ceramic Society 0371-750X J ELECTROCHEM SOC JOURNAL OF THE ELECTROCHEMICAL SOCIETY0013-4651 CHEM VAPOR DEPOS CHEMICAL VAPOR DEPOSITION0948-1907 SURF COAT TECH SURFACE & COATINGS TECHNOLOGY0257-8972 THIN SOLID FILMS THIN SOLID FILMS0040-6090 APPL SURF SCI APPLIED SURFACE SCIENCE0169-4332 J THERM SPRAY TECHN JOURNAL OF THERMAL SPRAY TECHNOLOGY1059-9630 J VAC SCI TECHNOL A JOURNAL OF VACUUM SCIENCE & TECHNOLOGY A-VACUUM 0734-2101 PROG ORG COAT PROGRESS IN ORGANIC COATINGS0300-9440 CORROS REV CORROSION REVIEWS0334-6005 INT J SURF SCI ENG International Journal of Surface Science and Eng1749-785X J COAT TECHNOL RES Journal of Coatings Technology and Research1547-0091 J PLAST FILM SHEET JOURNAL OF PLASTIC FILM & SHEETING8756-0879 JCT COATINGSTECH JCT COATINGSTECH1547-0083 KORROZ FIGY Korrozios Figyelo0133-2546 PIGM RESIN TECHNOL Pigment & Resin Technology0369-9420 SURF COAT INT SURFACE COATINGS INTERNATIONAL1754-0925 SURF ENG SURFACE ENGINEERING0267-0844 T I MET FINISH TRANSACTIONS OF THE INSTITUTE OF METAL FINISHING0020-2967 BIOMATERIALS BIOMATERIALS0142-9612 ACTA BIOMATER Acta Biomaterialia1742-7061 EUR CELLS MATER EUROPEAN CELLS & MATERIALS1473-2262 J MECH BEHAV BIOMED Journal of the Mechanical Behavior of Biomedical1751-6161 MACROMOL BIOSCI MACROMOLECULAR BIOSCIENCE1616-5187 BIOINTERPHASES Biointerphases 1559-4106 COLLOID SURFACE B COLLOIDS AND SURFACES B-BIOINTERFACES0927-7765 DENT MATER DENTAL MATERIALS0109-5641 J BIOACT COMPAT POL JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS0883-9115 J BIOMAT SCI-POLYM E JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION0920-5063 J BIOMED MATER RES A JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A1549-3296 J BIOMED MATER RES B JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-1552-4973 ARTIF CELL BLOOD SUB ARTIFICIAL CELLS BLOOD SUBSTITUTES AND IMMOBILIZ1073-1199 BIOFABRICATION Biofabrication1758-5082 BIOINSPIR BIOMIM Bioinspiration & Biomimetics1748-3182 BIOMED MATER Biomedical Materials1748-6041 BIO-MED MATER ENG BIO-MEDICAL MATERIALS AND ENGINEERING0959-2989 CELL POLYM CELLULAR POLYMERS0262-4893 DENT MATER J DENTAL MATERIALS JOURNAL0287-4547 J APPL BIOMATER BIOM Journal of Applied Biomaterials & Biomechanics1722-6899 J BIOBASED MATER BIO Journal of Biobased Materials and Bioenergy1556-6560 J BIOMATER APPL JOURNAL OF BIOMATERIALS APPLICATIONS0885-3282 J BIONIC ENG Journal of Bionic Engineering1672-6529 J MATER SCI-MATER M JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICI0957-4530 MAT SCI ENG C-MATER Materials Science & Engineering C-Materials for 0928-4931 BIORESOURCES BioResources1930-2126 CELLULOSE CELLULOSE0969-0239 HOLZFORSCHUNG HOLZFORSCHUNG0018-3830 WOOD SCI TECHNOL WOOD SCIENCE AND TECHNOLOGY0043-7719 EUR J WOOD WOOD PROD European Journal of Wood and Wood Products0018-3768 J WOOD CHEM TECHNOL JOURNAL OF WOOD CHEMISTRY AND TECHNOLOGY0277-3813 J WOOD SCI JOURNAL OF WOOD SCIENCE1435-0211NORD PULP PAP RES J NORDIC PULP & PAPER RESEARCH JOURNAL0283-2631 TAPPI J TAPPI JOURNAL0734-1415 WOOD FIBER SCI WOOD AND FIBER SCIENCE0735-6161 APPITA J APPITA JOURNAL1038-6807 CELL CHEM TECHNOL CELLULOSE CHEMISTRY AND TECHNOLOGY0576-9787 DREWNO Drewno1644-3985 DRVNA IND Drvna Industrija0012-6772 FOREST PROD J FOREST PRODUCTS JOURNAL0015-7473 J PULP PAP SCI JOURNAL OF PULP AND PAPER SCIENCE0826-6220 MADERAS-CIENC TECNOL Maderas-Ciencia y Tecnologia 0717-3644 MOKUZAI GAKKAISHI MOKUZAI GAKKAISHI0021-4795 PAP PUU-PAP TIM PAPERI JA PUU-PAPER AND TIMBER0031-1243 PULP PAP-CANADA PULP & PAPER-CANADA0316-4004 WOCHENBL PAPIERFABR WOCHENBLATT FUR PAPIERFABRIKATION0043-7131 WOOD RES-SLOVAKIA WOOD RESEARCH1336-4561 ACS NANO ACS Nano 1936-0851 ADV FUNCT MATER ADVANCED FUNCTIONAL MATERIALS1616-301X ADV MATER ADVANCED MATERIALS0935-9648 ANNU REV MATER RES ANNUAL REVIEW OF MATERIALS RESEARCH1531-7331 MAT SCI ENG R MATERIALS SCIENCE & ENGINEERING R-REPORTS0927-796X MATER TODAY Materials Today1369-7021 NANO LETT NANO LETTERS1530-6984 NANO TODAY Nano Today1748-0132 NAT MATER NATURE MATERIALS1476-1122 NAT NANOTECHNOL Nature Nanotechnology1748-3387 PROG MATER SCI PROGRESS IN MATERIALS SCIENCE0079-6425 ACTA MATER ACTA MATERIALIA1359-6454 CARBON CARBON0008-6223 CHEM MATER CHEMISTRY OF MATERIALS0897-4756 CRIT REV SOLID STATE CRITICAL REVIEWS IN SOLID STATE AND MATERIALS SC1040-8436 CRYST GROWTH DES CRYSTAL GROWTH & DESIGN1528-7483 CURR OPIN SOLID ST M CURRENT OPINION IN SOLID STATE & MATERIALS SCIEN1359-0286 EXP MECH EXPERIMENTAL MECHANICS0014-4851 INT J PLASTICITY INTERNATIONAL JOURNAL OF PLASTICITY0749-6419 INT MATER REV INTERNATIONAL MATERIALS REVIEWS0950-6608 J MATER CHEM JOURNAL OF MATERIALS CHEMISTRY0959-9428 J MECH PHYS SOLIDS JOURNAL OF THE MECHANICS AND PHYSICS OF SOLIDS0022-5096 J PHYS CHEM C Journal of Physical Chemistry C1932-7447 LANGMUIR LANGMUIR0743-7463 MICROSC MICROANAL MICROSCOPY AND MICROANALYSIS1431-9276 MRS BULL MRS BULLETIN0883-7694 NANO RES Nano Research1998-0124 NANOSCALE Nanoscale2040-3364 NANOTECHNOLOGY NANOTECHNOLOGY0957-4484 ORG ELECTRON ORGANIC ELECTRONICS1566-1199 PLASMONICS Plasmonics 1557-1955 SMALL SMALL1613-6810 SOFT MATTER Soft Matter1744-683X SOL ENERG MAT SOL C SOLAR ENERGY MATERIALS AND SOLAR CELLS0927-0248 THIN SOLID FILMS THIN SOLID FILMS0040-6090 ACS APPL MATER INTER ACS Applied Materials & Interfaces1944-8244 ADV ENG MATER ADVANCED ENGINEERING MATERIALS1438-1656APPL PHYS A-MATER APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING0947-8396 CEMENT CONCRETE RES CEMENT AND CONCRETE RESEARCH0008-8846 CMC-COMPUT MATER CON CMC-Computers Materials & Continua1546-2218 COMP MATER SCI COMPUTATIONAL MATERIALS SCIENCE0927-0256 CORROS SCI CORROSION SCIENCE0010-938X CURR APPL PHYS CURRENT APPLIED PHYSICS1567-1739 CURR NANOSCI Current Nanoscience1573-4137 DIAM RELAT MATER DIAMOND AND RELATED MATERIALS0925-9635 DIG J NANOMATER BIOS Digest Journal of Nanomaterials and Biostructure1842-3582 ELECTROCHEM SOLID ST ELECTROCHEMICAL AND SOLID STATE LETTERS1099-0062 EUR PHYS J E EUROPEAN PHYSICAL JOURNAL E1292-8941 FUNCT MATER LETT Functional Materials Letters1793-6047 GOLD BULL GOLD BULLETIN0017-1557 IEEE T NANOTECHNOL IEEE TRANSACTIONS ON NANOTECHNOLOGY1536-125X INT J ADHES ADHES INTERNATIONAL JOURNAL OF ADHESION AND ADHESIVES0143-7496 INT J DAMAGE MECH INTERNATIONAL JOURNAL OF DAMAGE MECHANICS1056-7895 INT J FATIGUE INTERNATIONAL JOURNAL OF FATIGUE0142-1123 INTERMETALLICS INTERMETALLICS0966-9795 J ALLOY COMPD JOURNAL OF ALLOYS AND COMPOUNDS0925-8388 J MATER RES JOURNAL OF MATERIALS RESEARCH0884-2914 J MATER SCI JOURNAL OF MATERIALS SCIENCE0022-2461 J MICROMECH MICROENG JOURNAL OF MICROMECHANICS AND MICROENGINEERING0960-1317 J NANOPART RES JOURNAL OF NANOPARTICLE RESEARCH1388-0764 J NANOSCI NANOTECHNO JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY1533-4880 J NON-CRYST SOLIDS JOURNAL OF NON-CRYSTALLINE SOLIDS0022-3093 J NUCL MATER JOURNAL OF NUCLEAR MATERIALS0022-3115 MACROMOL MATER ENG MACROMOLECULAR MATERIALS AND ENGINEERING1438-7492 MAT SCI ENG A-STRUCT MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL M0921-5093 MATER CHEM PHYS MATERIALS CHEMISTRY AND PHYSICS0254-0584 MATER LETT MATERIALS LETTERS0167-577X MATER RES BULL MATERIALS RESEARCH BULLETIN0025-5408 MATER SCI ENG B-ADV Materials Science and Engineering B-Advanced Fun0921-5107 MECH ADV MATER STRUC MECHANICS OF ADVANCED MATERIALS AND STRUCTURES1537-6494 MECH MATER MECHANICS OF MATERIALS0167-6636 METALL MATER TRANS A METALLURGICAL AND MATERIALS TRANSACTIONS A-PHYSI1073-5623 MICROPOR MESOPOR MAT MICROPOROUS AND MESOPOROUS MATERIALS1387-1811 NANOSCALE RES LETT Nanoscale Research Letters1931-7573 OPT MATER OPTICAL MATERIALS0925-3467 PHOTONIC NANOSTRUCT Photonics and Nanostructures-Fundamentals and Ap1569-4410 PHYS CHEM MINER PHYSICS AND CHEMISTRY OF MINERALS0342-1791 PHYS STATUS SOLIDI-R Physica Status Solidi-Rapid Research Letters1862-6254 SCI ADV MATER Science of Advanced Materials1947-2935 SCI TECHNOL ADV MAT SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS1468-6996 SCRIPTA MATER SCRIPTA MATERIALIA1359-6462 SMART MATER STRUCT SMART MATERIALS & STRUCTURES0964-1726 SOFT MATER SOFT MATERIALS1539-445X SYNTHETIC MET SYNTHETIC METALS0379-6779 WEAR WEAR0043-1648 ACI MATER J ACI MATERIALS JOURNAL0889-325X ACI STRUCT J ACI STRUCTURAL JOURNAL0889-3241 ACTA MECH SOLIDA SIN ACTA MECHANICA SOLIDA SINICA0894-9166 ADV CEM RES ADVANCES IN CEMENT RESEARCH0951-7197ADV MATER PROCESS ADVANCED MATERIALS & PROCESSES0882-7958 ANN CHIM-SCI MAT ANNALES DE CHIMIE-SCIENCE DES MATERIAUX0151-9107 ARCH CIV MECH ENG Archives of Civil and Mechanical Engineering1644-9665 ATOMIZATION SPRAY ATOMIZATION AND SPRAYS1044-5110 B MATER SCI BULLETIN OF MATERIALS SCIENCE0250-4707 CHALCOGENIDE LETT Chalcogenide Letters1584-8663 CIRCUIT WORLD CIRCUIT WORLD0305-6120 COMBUST EXPLO SHOCK+COMBUSTION EXPLOSION AND SHOCK WAVES0010-5082 CONSTR BUILD MATER CONSTRUCTION AND BUILDING MATERIALS0950-0618 CORROS ENG SCI TECHN CORROSION ENGINEERING SCIENCE AND TECHNOLOGY1478-422X CORROSION CORROSION0010-9312 ELECTRON MATER LETT Electronic Materials Letters1738-8090 FATIGUE FRACT ENG M FATIGUE & FRACTURE OF ENGINEERING MATERIALS & ST8756-758X FERROELECTRICS FERROELECTRICS0015-0193 FIBRE CHEM+FIBRE CHEMISTRY0015-0541 FIRE MATER FIRE AND MATERIALS0308-0501 FIRE SAFETY J FIRE SAFETY JOURNAL0379-7112 FIRE TECHNOL FIRE TECHNOLOGY0015-2684 FULLER NANOTUB CAR N FULLERENES NANOTUBES AND CARBON NANOSTRUCTURES1536-383X GEOSYNTH INT GEOSYNTHETICS INTERNATIONAL1072-6349 GRANUL MATTER GRANULAR MATTER1434-5021 HIGH TEMP MAT PR-ISR HIGH TEMPERATURE MATERIALS AND PROCESSES0334-6455 HIGH TEMP MATER P-US HIGH TEMPERATURE MATERIAL PROCESSES1093-3611 IEEE T ADV PACKAGING IEEE TRANSACTIONS ON ADVANCED PACKAGING1521-3323 IEEE T COMPON PACK T IEEE TRANSACTIONS ON COMPONENTS AND PACKAGING TE1521-3331 INDIAN J ENG MATER S INDIAN JOURNAL OF ENGINEERING AND MATERIALS SCIE0971-4588 INFORM MIDEM INFORMACIJE MIDEM-JOURNAL OF MICROELECTRONICS EL0352-9045 INORG MATER+INORGANIC MATERIALS0020-1685 INT J FRACTURE INTERNATIONAL JOURNAL OF FRACTURE0376-9429 INT J MATER PROD TEC INTERNATIONAL JOURNAL OF MATERIALS & PRODUCT TEC0268-1900 INT J MIN MET MATER International Journal of Minerals Metallurgy and1674-4799 INT J NANOTECHNOL International Journal of Nanotechnology1475-7435 INT J NUMER ANAL MET INTERNATIONAL JOURNAL FOR NUMERICAL AND ANALYTIC0363-9061 INT J REFRACT MET H INTERNATIONAL JOURNAL OF REFRACTORY METALS & HAR0263-4368 INT J SURF SCI ENG International Journal of Surface Science and Eng1749-785X J ADHES SCI TECHNOL JOURNAL OF ADHESION SCIENCE AND TECHNOLOGY0169-4243 J ADHESION JOURNAL OF ADHESION0021-8464 J ADV CONCR TECHNOL Journal of Advanced Concrete Technology 1346-8014 J ADV MATER-COVINA JOURNAL OF ADVANCED MATERIALS1070-9789 J COMPUT THEOR NANOS Journal of Computational and Theoretical Nanosci1546-1955 J CULT HERIT JOURNAL OF CULTURAL HERITAGE1296-2074 J ELASTICITY JOURNAL OF ELASTICITY0374-3535 J ELASTOM PLAST JOURNAL OF ELASTOMERS AND PLASTICS0095-2443 J ELECTRON MATER JOURNAL OF ELECTRONIC MATERIALS0361-5235 J ENERG MATER Journal of Energetic Materials 0737-0652 J ENG MATER-T ASME JOURNAL OF ENGINEERING MATERIALS AND TECHNOLOGY-0094-4289 J EXP NANOSCI Journal of Experimental Nanoscience1745-8080 J FIRE PROT ENG Journal of Fire Protection Engineering1042-3915 J FIRE SCI JOURNAL OF FIRE SCIENCES0734-9041 J FRICT WEAR+Journal of Friction and Wear1068-3666 J INTEL MAT SYST STR JOURNAL OF INTELLIGENT MATERIAL SYSTEMS AND STRU1045-389X J LASER MICRO NANOEN Journal of Laser Micro Nanoengineering1880-0688J MAGN MAGN MATER JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS0304-8853 J MATER CIVIL ENG JOURNAL OF MATERIALS IN CIVIL ENGINEERING0899-1561 J MATER ENG PERFORM JOURNAL OF MATERIALS ENGINEERING AND PERFORMANCE1059-9495 J MATER PROCESS TECH JOURNAL OF MATERIALS PROCESSING TECHNOLOGY0924-0136 J MATER SCI TECHNOL JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY1005-0302 J MATER SCI-MATER EL JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTR0957-4522 J MECH MATER STRUCT Journal of Mechanics of Materials and Structures1559-3959 J MICRO-NANOLITH MEM Journal of Micro-Nanolithography MEMS and MOEMS1932-5150 J NANO RES-SW Journal of Nano Research1662-5250 J NANOMATER Journal of Nanomaterials1687-4110 J NEW MAT ELECTR SYS JOURNAL OF NEW MATERIALS FOR ELECTROCHEMICAL SYS1480-2422 J OPTOELECTRON ADV M JOURNAL OF OPTOELECTRONICS AND ADVANCED MATERIAL1454-4164 J OVONIC RES Journal of Ovonic Research1584-9953 J PHASE EQUILIB DIFF JOURNAL OF PHASE EQUILIBRIA AND DIFFUSION1547-7037 J PHYS CHEM LETT Journal of Physical Chemistry Letters1948-7185 J POROUS MAT JOURNAL OF POROUS MATERIALS1380-2224 J SOC INF DISPLAY Journal of the Society for Information Display1071-0922 J SUPERHARD MATER+Journal of Superhard Materials 1063-4576 J WUHAN UNIV TECHNOL JOURNAL OF WUHAN UNIVERSITY OF TECHNOLOGY-MATERI1000-2413 JOM-US JOM-JOURNAL OF THE MINERALS METALS & MATERIALS S1047-4838 KONA POWDER PART J KONA Powder and Particle Journal0288-4534 KOREAN J MET MATER Korean Journal of Metals and Materials1738-8228 KOVOVE MATER KOVOVE MATERIALY-METALLIC MATERIALS0023-432X LASER ENG LASERS IN ENGINEERING0898-1507 MACH SCI TECHNOL MACHINING SCIENCE AND TECHNOLOGY1091-0344 MAG CONCRETE RES MAGAZINE OF CONCRETE RESEARCH0024-9831 MAT SCI SEMICON PROC MATERIALS SCIENCE IN SEMICONDUCTOR PROCESSING1369-8001 MATER CONSTRUCC MATERIALES DE CONSTRUCCION0465-2746 MATER CORROS MATERIALS AND CORROSION-WERKSTOFFE UND KORROSION0947-5117 MATER DESIGN MATERIALS & DESIGN0261-3069 MATER HIGH TEMP MATERIALS AT HIGH TEMPERATURES0960-3409 MATER MANUF PROCESS MATERIALS AND MANUFACTURING PROCESSES1042-6914 MATER RES INNOV MATERIALS RESEARCH INNOVATIONS1432-8917 MATER RES-IBERO-AM J Materials Research-Ibero-american Journal of Mat1516-1439 MATER SCI TECH-LOND MATERIALS SCIENCE AND TECHNOLOGY0267-0836 MATER SCI+MATERIALS SCIENCE1068-820X MATER SCI-MEDZG Materials Science-Medziagotyra 1392-1320 MATER SCI-POLAND MATERIALS SCIENCE-POLAND0137-1339 MATER STRUCT MATERIALS AND STRUCTURES1359-5997 MATER TECHNOL MATERIALS TECHNOLOGY1066-7857 MATER TEHNOL Materiali in Tehnologije 1580-2949 MATER TRANS MATERIALS TRANSACTIONS1345-9678 MATER WORLD MATERIALS WORLD0967-8638 MATERIA-BRAZIL Materia-Rio de Janeiro1517-7076 MATERIALWISS WERKST MATERIALWISSENSCHAFT UND WERKSTOFFTECHNIK0933-5137 MATH MECH SOLIDS MATHEMATICS AND MECHANICS OF SOLIDS1081-2865 MET MATER INT METALS AND MATERIALS INTERNATIONAL1598-9623 METALL MATER TRANS B METALLURGICAL AND MATERIALS TRANSACTIONS B-PROCE1073-5615 METALLOFIZ NOV TEKH+METALLOFIZIKA I NOVEISHIE TEKHNOLOGII1024-1809 MICRO NANO LETT Micro & Nano Letters1750-0443 MICROELECTRON INT MICROELECTRONICS INTERNATIONAL1356-5362 MICROSYST TECHNOL MICROSYSTEM TECHNOLOGIES0946-7076MODEL SIMUL MATER SC MODELLING AND SIMULATION IN MATERIALS SCIENCE AN0965-0393 NANO NANO1793-2920 NEW CARBON MATER NEW CARBON MATERIALS1007-8827 OPTOELECTRON ADV MAT Optoelectronics and Advanced Materials-Rapid Com1842-6573 P I MECH ENG L-J MAT PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENG1464-4207 PARTICUOLOGY Particuology1674-2001 PHILOS MAG PHILOSOPHICAL MAGAZINE1478-6435 PHYS STATUS SOLIDI A PHYSICA STATUS SOLIDI A-APPLICATIONS AND MATERIA1862-6300 PLAST ENG PLASTICS ENGINEERING0091-9578 PROG NAT SCI PROGRESS IN NATURAL SCIENCE1002-0071 RAPID PROTOTYPING J RAPID PROTOTYPING JOURNAL1355-2546 RARE METAL MAT ENG RARE METAL MATERIALS AND ENGINEERING1002-185X RARE METALS RARE METALS1001-0521 RECENT PAT NANOTECH Recent Patents on Nanotechnology1872-2105 REV ADV MATER SCI REVIEWS ON ADVANCED MATERIALS SCIENCE1606-5131 REV ROM MATER Revista Romana de Materiale-Romanian Journal of 1583-3186 ROAD MATER PAVEMENT Road Materials and Pavement Design1468-0629 SAMPE J SAMPE JOURNAL0091-1062 SCI CHINA TECHNOL SC Science China-Technological Sciences1674-7321 SCI MODEL SIMUL Scientific Modeling and Simulations1874-8554 SCI TECHNOL ENERG MA Science and Technology of Energetic Materials 1347-9466 SCI TECHNOL WELD JOI SCIENCE AND TECHNOLOGY OF WELDING AND JOINING1362-1718 SEMICOND SCI TECH SEMICONDUCTOR SCIENCE AND TECHNOLOGY0268-1242 SENSOR MATER SENSORS AND MATERIALS0914-4935 SOLDER SURF MT TECH SOLDERING & SURFACE MOUNT TECHNOLOGY0954-0911 T FAMENA Transactions of FAMENA 1333-1124 VACUUM VACUUM0042-207X ZKG INT ZKG INTERNATIONAL0949-0205 SIAM J IMAGING SCI SIAM Journal on Imaging Sciences1936-4954 IEEE T MED IMAGING IEEE TRANSACTIONS ON MEDICAL IMAGING0278-0062 REMOTE SENS ENVIRON REMOTE SENSING OF ENVIRONMENT0034-4257 INT J REMOTE SENS INTERNATIONAL JOURNAL OF REMOTE SENSING0143-1161 ISPRS J PHOTOGRAMM ISPRS JOURNAL OF PHOTOGRAMMETRY AND REMOTE SENSI0924-2716 PHOTOGRAMM ENG REM S PHOTOGRAMMETRIC ENGINEERING AND REMOTE SENSING0099-1112 PHOTOGRAMM REC PHOTOGRAMMETRIC RECORD0031-868X EURASIP J IMAGE VIDE EURASIP Journal on Image and Video Processing1687-5176 IEEE J-STARS IEEE Journal of Selected Topics in Applied Earth1939-1404 IMAGING SCI J IMAGING SCIENCE JOURNAL1368-2199 INT J IMAG SYST TECH INTERNATIONAL JOURNAL OF IMAGING SYSTEMS AND TEC0899-9457 J APPL REMOTE SENS Journal of Applied Remote Sensing1931-3195 J ELECTRON IMAGING JOURNAL OF ELECTRONIC IMAGING1017-9909 J IMAGING SCI TECHN JOURNAL OF IMAGING SCIENCE AND TECHNOLOGY1062-3701 J REAL-TIME IMAGE PR Journal of Real-Time Image Processing1861-8200 PHOTOGRAMM FERNERKUN Photogrammetrie Fernerkundung Geoinformation1432-8364 RIV ITAL TELERILEVAM Rivista Italiana di Telerilevamento1129-8596 SIGNAL IMAGE VIDEO P Signal Image and Video Processing1863-1703 SMPTE MOTION IMAG J SMPTE MOTION IMAGING JOURNAL0036-1682 ANN FAM MED ANNALS OF FAMILY MEDICINE1544-1709 BRIT J GEN PRACT BRITISH JOURNAL OF GENERAL PRACTICE0960-1643 J AM BOARD FAM MED Journal of the American Board of Family Medicine1557-2625 SCAND J PRIM HEALTH SCANDINAVIAN JOURNAL OF PRIMARY HEALTH CARE0281-3432 AM FAM PHYSICIAN AMERICAN FAMILY PHYSICIAN0002-838X。
中科院SCI分区目录
刊名简称 J AM CHEM SOC ANGEW CHEM INT EDIT ANAL CHEM CHEM REV ACCOUNTS CHEM RES COORDIN CHEM REV CHEM SOC REV ANNU REV PHYS CHEM PROG POLYM SCI TOP CURR CHEM ADV POLYM SCI SURF SCI REP CATAL REV CURR OPIN COLLOID IN ADV CATAL ADV ORGANOMET CHEM PROG SOLID STATE CH ALDRICHIM ACTA J ORG CHEM MACROMOLECULES CHEM COMMUN INORG CHEM J PHYS CHEM B LANGMUIR J CHROMATOGR A ORGANOMETALLICS DALTON T J CATAL ORG LETT CHEM-EUR J ELECTROPHORESIS J COMPUT CHEM CARBON RAPID COMMUN MASS SP CHEM RES TOXICOL J ANAL ATOM SPECTROM APPL CATAL B-ENVIRON MACROMOL RAPID COMM J AM SOC MASS SPECTR J PHYS CHEM REF DATA FARADAY DISCUSS J MASS SPECTROM ADV COLLOID INTERFAC BIOMACROMOLECULES TRAC-TREND ANAL CHEM ELECTROCHEM COMMUN J BIOL INORG CHEM ADV SYNTH CATAL ADV INORG CHEM CHEMPHYSCHEM GREEN CHEM J COMB CHEM PROG SURF SCI CRYST GROWTH DES
一株发孢甲基弯菌及其应用[发明专利]
![一株发孢甲基弯菌及其应用[发明专利]](https://img.taocdn.com/s3/m/26b8f019910ef12d2bf9e727.png)
专利名称：一株发孢甲基弯菌及其应用专利类型：发明专利
发明人：邢新会,吴昊,李和平,王立言申请号：CN200710175425.6
申请日：20070929
公开号：CN101397543A
公开日：
20090401
专利内容由知识产权出版社提供
摘要：本发明公开了一株发孢甲基弯菌及其应用。
本发明所提供的发孢甲基弯菌为发孢甲基弯菌(Methylosinus trichosporium)LEB－5，其保藏编号为CGMCC No.2173。
本发明还提供了一种生产甲烷单加氧酶的方法即发酵发孢甲基弯菌(Methylosinus trichosporium)LEB－5 CGMCC
No.2173得到甲烷单加氧酶。
本发明的发孢甲基弯菌(Methylosinus trichosporium)LEB－5 CGMCC No.2173生长速度快、遗传稳定性高，而且易于培养、培养效率高，能以甲烷为唯一碳源和能源产生具有高酶活的甲烷单加氧酶。
本发明用发孢甲基弯菌(Methylosinus trichosporium)LEB－5 CGMCC No.2173生产甲烷单加氧酶的方法，克服了目前甲烷氧化菌利用甲烷效率低、生长速度慢、含有的甲烷单加氧酶的催化活性不高等问题，在天然气利用、大宗化学品生产、生物材料开发、瓦斯气体治理、环境污染物的生物修复等方面将会有广阔的应用前景。
申请人：清华大学
地址：100084 北京市海淀区清华园
国籍：CN
代理机构：北京纪凯知识产权代理有限公司
更多信息请下载全文后查看。
德谷门冬双胰岛素注射液治疗2_型糖尿病的疗效及安全性研究
DOI：10.16658/ki.1672-4062.2023.19.084德谷门冬双胰岛素注射液治疗2型糖尿病的疗效及安全性研究戴卉，张开凤，朱凤丽江苏省镇江市丹徒区人民医院内分泌科，江苏镇江212000[摘要]目的探讨德谷门冬双胰岛素注射液在2型糖尿病中的效果以及安全性。
方法选取2022年1月—2023年7月江苏省镇江市丹徒区人民医院收治的62例2型糖尿病患者为研究对象，按随机数表法分为对照组（n=31）和观察组（n=31）。
对照组患者接受门冬胰岛素30注射液治疗，观察组患者接受德谷门冬双胰岛素注射治疗。
对比两组患者临床疗效、血糖变化和不良反应发生率。
结果观察组治疗有效为96.77%，高于对照组的77.42%，差异有统计学意义（χ2=5.167，P=0.023）。
治疗前，两组患者血糖水平比较，差异无统计学意义（P>0.05）；治疗后，两组患者血糖水平均改善，且观察组血糖指标低于对照组，差异有统计学意义（P< 0.05）。
观察组不良反应发生率低与对照组，差异有统计学意义（P<0.05）。
结论德谷门冬双胰岛素的应用可以明显改善2型糖尿病患者血糖水平，疗效更为确切，且安全性更高，不会增加用药后不良反应。
[关键词] 2型糖尿病；德谷门冬双胰岛素；门冬胰岛素30注射液；安全性[中图分类号] R587 [文献标识码] A [文章编号] 1672-4062（2023）10（a）-0084-04Study on the Efficacy and Safety of Insulin Degludec and Insulin Aspart Injection in the Treatment of Type 2 Diabetes MellitusDAI Hui, ZHANG Kaifeng, ZHU FengliDepartment of Endocrinology, Zhenjiang Dantu District People's Hospital, Zhenjiang, Jiangsu Province, 212000 China [Abstract] Objective To explore the effect and safety of insulin degludec and insulin aspart injection in type 2 diabe⁃tes mellitus.Methods 62 patients of type 2 diabetes mellitus patients admitted to Zhenjiang Dantu District People's Hospital, Jiangsu Province from January 2022 to July 2023 were selected as study objects and divided into the control group (n=31) and the observation group (n=31) by taking the random number table method. The patients in the control group were treated with insulin aspart 30 injection and the patients in the observation group were treated with insulin degludec and insulin aspart injection. Compared the clinical efficacy, the changes in blood glucose and the incidence of adverse reactions between the two groups of patients.Results The treatment effectiveness of the observation group was 96.77%, which was higher than that of the control group, which was 77.42%, and the difference was statistically significant (χ2=5.167, P=0.023). There was no statistically significant difference in blood glucose levels between the two groups before treatment (P>0.05). After treatment, blood glucose levels improved in both groups, and the level of blood glucose in the observation group were lower than those in the control group, and the difference was statistically significant (P<0.05). The incidence of adverse reactions in the observation group was lower than that in the control group, and the difference was statistically significant (P<0.05).Conclusion The application of insulin degludec and in⁃sulin aspart can significantly improve the blood glucose level of patients with type 2 diabetes mellitus, the efficacy is more accurate, and the safety is higher, and it will not increase the occurrence of adverse reactions after the use of medication.[作者简介]戴卉（1985-），女，本科，主治医师，研究方向为内分泌科。