EX VIVO ANTIGEN AND ADJUVANT PULSED PERI
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专利名称：EX VIVO ANTIGEN AND ADJUVANT PULSED PERIPHERAL BLOOD MONONUCLEAR CELLS
AS A SCREENING PLATFORM FOR
CANDIDATE NOVEL VACCINES AND
CANDIDATE ANTIGENS
发明人：GOSSELIN, Edmund J.,KUMAR,
Sudeep,NALIN, David
申请号：US2017/064989
申请日：20171207
公开号：WO2018/106849A1
公开日：
20180614
专利内容由知识产权出版社提供专利附图：
摘要：Peripheral blood mononuclear cells (PBMCs) can be used in place of DCs when pulsing with antigens, or antigen and adjuvant combination, and then administered to a subject as a vaccine to induce a protective immune response. The PBMC-based vaccine strategy provides a more marked and enduring protective immune response and is also capable of serving as a multi-organism prophylactic vaccine platform. The vaccine platform may be used to screen vaccine and adjuvant combinations and may also be used to allow for adjuvants that are otherwise unsafe for use in humans as the adjuvant may be removed prior to prophylactic administration of the pulsed PBMCs.
申请人：ALBANY MEDICAL COLLEGE
地址：47 New Scotland Avenue Albany, NY 12208 US
国籍：US
代理人：NOCILLY, David L. et al.
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