SPE-1987-29-PEH-P
SPE固相萃取(类型的选择以及行业应用)

Florisil (硅酸镁) ,1g/6mL
• 活化及平衡:0.5mL 异辛烷
•上
样:0.2g 废弃变压器油
•洗
脱:5×2mL 异辛烷
注:杂质被吸附到小柱上,而PCBs被异辛烷直接洗脱下来。
上海安谱
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PCBs in Used Transformer Oil(SPE/GC)
上海安谱
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血浆中的儿茶酚胺类药物(SPE/LC)
• 色谱柱:SUPELCOSIL LC-18-DB,15cm×4.6mm, 5um
• 流动相:0.025M 柠檬酸/Na2HPO4, 0.005mM Na2EDTA,
34mg/L辛烷磺酸钠,85%H2PO4调节pH3.4
选择: SCX, MCX, SAX, MAX
选择: WCX, PRS, NH2, PSA
选择: Florisil ,氧化铝 PSA,Si, NH2, Diol, CN
上海安谱
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类型及规格选择指南
Anpelclean SPE方法开发包含有不同的化学固定相,或者不同大小和填料 的小柱,方便在方法开发时选择最合适的SPE小柱
• 柱 温:室温
流 速:1.5mL/min
• 检测器:ECD
进样量:100uL
上海安谱
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SPE在环境监测中的应用
废弃变压器油中的多氯联苯 PCBs in Used Transformer Oil
上海安谱
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PCBs in Used Transformer Oil(SPE/GC)
营养成份,
上海安谱
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概要 1. SPE填料类型及选择 2. SPE的应用
上海安谱
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SPE在药物检测中的应用
甘薯蛋白抗癌作用研究进展

荧光显微镜观察细胞凋亡( Hoechst 33258 核染色):将细胞接种到24孔板 上(1.2x105/孔),托血清16-24 h后用不同浓度SPP处理细胞48 h ,吸去培养基,用PBS洗细胞3 次。然后用2.5% 的戊二醛固定细胞4 h,置摇床上用0.9% NaCL洗细胞3次。除去上清液后,用1μg/ml Hoechst 33258溶液在冰上避光处理细胞30min,然后用0.9% NaCL漂洗3次,甘油封闭后立即于荧光显微镜下(Olymus IX71)紫外光 (360 nm)激发,观察细胞核染色情况。
结果
结果
结果
结果
Fig 1 . Sporamin inhibited the wound closure of HT-29 cells in the presence of PMA. *, P<0.05 vs. PMA alone; #, P<0.05 vs. vehicle
划痕愈合实验
Fig 3. Sporamin suppressed the PMA-induced secretion of uPA in HT-29 cells after 16 h
Fig 2. Sporamin decreases adhesion of colorectal carcinoma HT-29 cells to the substrate in the presence of PMA in HT-29 cells after 16 h
Fig 4. Gelatin zymogram of conditioned medium from HT-29 cancer cells treated with 100 ng/ml PMA and various concentrations of sporamin during 4-h incubation period showing direct inhibitory effect of sporamin on MMP-9 and MMP-2 activity.
赛普替尼 分子量

赛普替尼(Selpercatinib),其化学名为LOXO-292,是一种选择性RET抑制剂,用于治疗RET融合阳性的非小细胞肺癌和甲状腺癌等类型的癌症。
赛普替尼的分子式为C29H31N7O3,根据分子式计算其分子量如下:
碳(C)的原子量约为12.01,因此C29 = 29 * 12.01
氢(H)的原子量约为1.008,因此H31 = 31 * 1.008
氮(N)的原子量约为14.01,因此N7 = 7 * 14.01
氧(O)的原子量约为16.00,因此O3 = 3 * 16.00
分子量的计算公式为:
分子量= (C的数量×C的原子量) + (H的数量×H的原子量) + (N的数量×N的原子量) + (O的数量×O的原子量)
将上述数值代入计算:
分子量= (29 ×12.01) + (31 ×1.008) + (7 ×14.01) + (3 ×16.00)
分子量≈348.29 + 31.248 + 98.07 + 48.00
分子量≈525.608
所以,赛普替尼的分子量大约是525.61 g/mol。
这个计算是基于分子式中每种元素的原子量的标准值,实际分子量可能会有极小的变化,这取决于原子量的精确值。
专用SPE萃取小柱介绍

专用SPE固相萃取小柱介绍DVB Extract-Clean™固相萃取小柱•吸附样品的容量比C18大•提升从水相中萃取极性有机物的效率•颗粒度小,比XAD-2效率高•100%二乙烯基苯降低了溶胀•应用范围广泛Extract-Clean™DVB萃取小柱由高纯度,100%二乙烯基苯树脂填充到SPE小柱管中,配合20um 聚乙烯筛板组成。
Extract-Clean™ DVB萃取小柱无需调节就可直接萃取混合物,并且比C18的上样容量大(见表1)。
它从水相中萃取极性有机化合物的效率高。
较小的柱床体积萃取效果可等同于较大的C18柱床体积。
树脂的平均颗粒度为40um,因而比那些颗粒度较大的SPE小柱如XAD-2等,有更好的萃取效率。
Extract-Clean™DVB萃取小柱(100%二乙烯基苯)比苯乙烯-二乙烯基苯树脂的小柱有几个优势:溶胀小,当流动相从水相切换到有机相时流速保持稳定,并且二乙烯基苯是强路易斯碱,提高了树脂的吸附容量。
Extract-Clean™ DVB萃取小柱有着广泛的应用范围,比如从环境样品中抽提苯酚和酸性农药,并且可用于药物代谢产物中的极性成分和核酸的提纯制备。
自由乙烯基团的存在也使得DVB树脂可用于固相合成的载体。
表1:分别采用未调节的C18和DVB小柱,从水中萃取苯酚,比较它们的吸附容量D D V V B BE E x x t t r r a a c c t t--C C l l e e a a n n™™萃萃取取小小柱柱柱床重量管子体积数量货号价格25mg 1.5mL 100 220025 140450mg 1.5mL 100 220050 1566100mg 1.5mL 100 220100 1944500mg 4.0mL 50 220500 2808 EPA方法SW-846固相萃取小柱•弗罗里硅土,氧化铝,和硅胶SPE萃取小柱用于EPA方法•Extrcat-Clean, Ultra-Clean, Extrcat-Clean RC, 三种形式的固相萃取小柱供选择•聚乙烯,不锈钢,特氟陇,三种筛板供选择Alltech提供符合EPA方法3610,3620,3630的萃取小柱。
EN779中文版

EN779:2002
2/62
过滤器标准译文
目录
目 录 .................................................................................................................................................. 2 前 言 .................................................................................................................................................. 5 介 绍 .................................................................................................................................................. 6 1 范围.................................................................................................................................................. 7 2 规范性引用文件.............................................................................................................................. 7 3 术语和定义...................................................................................................................................... 7 4 符号和缩略语................................................................................................................................ 10 5 要求................................................................................................................................................ 11 6 分级................................................................................................................................................ 12 7 试验台和相关设备........................................................................................................................ 12
The machine of the plural stations in order depend

专利名称:The machine of the plural stations in order depends on washing lap with the jet ofdirection of the compressed gas, to cleanthe container发明人:スィレット、ダミアン,フレイル、ディアズ・フィリップ申请号:JP2007521935申请日:20050708公开号:JP2008506524A公开日:20080306专利内容由知识产权出版社提供专利附图:摘要:A machine for cleaning the inner walls (66, 75) of a receptacle (12), includes several cleaning stations of which one is fitted with an insufflation tube (36) that is connected to a source of pressurized gas and that is provided with a nozzle (38) insufflating the gas towards the inner walls (66, 75) of the receptacle (12) during a cleaning cycle including an ascending phase and a descending phase (Pd) of the insufflation tube (36), the nozzle (38) having an annular peripheral slot (64) that is capable of forming a peripheral jet (f2) of gas of generally frustoconical shape directed towards the inner side walls (66) of the receptacle (12) and towards the bottom, and the peripheral jet (f2) being triggered for at least a part of the descending phase (Pd).申请人:スィデル・パルティスィパスィヨン地址:フランス国、エフ-76930 オクトゥビル・スュール・メール、アブニュ・ドゥ・ラ・パトルイユ・ドゥ・フランス(番地なし)国籍:FR代理人:鈴江 武彦,河野 哲,中村 誠,蔵田 昌俊,峰 隆司,福原 淑弘,白根 俊郎,村松 貞男,野河 信久,砂川 克,橋本 良郎,風間 鉄也更多信息请下载全文后查看。
Sensata 29PS 手动复位压力开关说明书

Page 129PS SERIES | MANUAL RESET PRESSURE SWITCHESFeaturesIntroductionApplicationsOperationProduct Features• Manual Reset • Snap-acting, trip free mechanism • Single-pole, single-throw switch, normally closed • Factory calibrated pressure setpoints from 200 to 750 psig (14 to 52 bar)• Tamper resistantThe 29PS Series is a manual reset, single pole, single throw, snap acting pressure switch. The 29PS is based on Sensata Technologies’ 20PS pressure switch, long recognized as an industry standard control device. Features of this switch include manual reset, a broad assortment of port fittings and electrical connections, and the option of a panel mount or line mount design.Sensata Technologies has been a leading global supplier of pressure sensors and switches for over 50 years.The Model 29PS pressure switch is primarily applied as an upper limit control on unitary and central air conditioning systems, heat pumps, roof top units, and refrigeration systems.This hermetic pressure switch employs a trip-free manual reset function, providing high reliability in an environmentally sealed, low-cost package.The 29PS utilizes a snap-acting stainless steel Klixon ® disc that reverses its curvature when pressurized above a customer specified actuation pressure. When the disc snaps, it opens a set of electrical contacts by means of a transfer pin. Resetting of the switch must be accomplished manually by pressing the integrated reset button.The unique latching mechanism in the 29PS design assures safe electrical cutout even if the reset button is held firmly depressed.This “trip-free” design prevents the consumer from restarting the equipment until the line pressure has dropped below the release setpoint. Without this “trip-free” mechanism, the equipment could be restarted by simply holding the reset button in the depressed position, while an overpressure condition remains.The welded, hermetic design of the 29PS provides increased reliability and maintenance-free operation for the lifetime of the switch. The actuation and release pressures of the disc are factory calibrated, simplifying installation and making the 29PS tamper resistant.The epoxy potting and rubber boot provide an environmental seal for the switch mechanism, protecting it from dust, oil and moisture. The 29PS is built into a vibration resistant package.Its compact size coupled with a wide variety of threaded and brazed pressure connections allows the 29PS to be mounted wherever is most appropriate for the application; inside a control box or out in the elements. Panel-mounted devices are typically provided with capillary tubes to allow for convenient access to the reset button. A variety of line-mounted fittings are available to simplify installation. Many different lead termination options are available for maximumflexibility.DESIGN SPECIFICATIONS All dimensions in millimeters [Inches].TYPICAL DIMENSIONAL DRAWINGSPage 2Page 3CONTACT US Americas +1 (877) 502 5500 – Option 2************************Europe, Middle East & Africa +44 (1202) 416170***********************Asia Pacific *************************.com China +86 (21) 2306 1500Japan +81 (45) 277 7117Korea +82 (31) 601 2004India +91 (80) 67920890Rest of Asia +886 (2) 27602006 ext 2808Rev:04/19/18Sensata Technologies, Inc. (“Sensata”) data sheets are solely intended to assist designers (“Buyers”) who are developing systems that incorporate Sensata products (also referred to herein as “components”). Buyer understands and agrees that Buyer remains responsible for using its independent analysis, evaluation and judgment in designing Buyer’s systems and products. Sensata data sheets have been created using standard laboratory conditions and engineering practices. Sensata has not conducted any testing other than that specifically described in the published documentation for a particular data sheet. Sensata may make corrections, enhancements, improvements and other changes to its data sheets or components without notice.Buyers are authorized to use Sensata data sheets with the Sensata component(s) identified in each particular data sheet. HOWEVER, NO OTHER LICENSE, EXPRESS OR IMPLIED, BY ESTOPPEL OR OTHERWISE TO ANY OTHER SENSATA INTELLECTUAL PROPERTY RIGHT, AND NO LICENSE TO ANY THIRD PARTY TECHNOLOGY OR INTELLECTUAL PROPERTY RIGHT, IS GRANTED HEREIN. SENSATA DATA SHEETS ARE PROVIDED “AS IS”. SENSATA MAKES NO WARRANTIES OR REPRESENTATIONS WITH REGARD TO THE DATA SHEETS OR USE OF THE DATA SHEETS, EXPRESS, IMPLIED OR STATUTORY, INCLUDING ACCURACY OR COMPLETENESS. SENSATA DISCLAIMS ANY WARRANTY OF TITLE AND ANY IMPLIED WARRANTIES OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE, QUIET ENJOYMENT, QUIET POSSESSION, AND NON-INFRINGEMENT OF ANY THIRD PARTY INTELLECTUAL PROPERTY RIGHTS WITH REGARD TO SENSATA DATA SHEETS OR USE THEREOF.All products are sold subject to Sensata’s terms and conditions of sale supplied at SENSATA ASSUMES NO LIABILITY FOR APPLICATIONS ASSISTANCE OR THE DESIGN OF BUYERS’ PRODUCTS. BUYER ACKNOWLEDGES AND AGREES THAT IT IS SOLELY RESPONSIBLE FOR COMPLIANCE WITH ALL LEGAL, REGULATORY AND SAFETY-RELATED REQUIREMENTS CONCERNING ITS PRODUCTS, AND ANY USE OF SENSATA COMPONENTS IN ITS APPLICATIONS, NOTWITHSTANDING ANY APPLICATIONS-RELATED INFORMATION OR SUPPORT THAT MAY BE PROVIDED BY SENSATA.Mailing Address: Sensata Technologies, Inc., 529 Pleasant Street, Attleboro, MA 02703, USA.AGENCY APPROVALS AND CERTIFICATIONSWARNINGSHAZARD OF ELECTRIC SHOCK, EXPLOSION OR ARC FLASH • Disconnect all power before installing or working with this equipment • Verify all connections and replace all covers before turning on powerFailure to follow these instructions will result in death or serious injury。
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Petroleum Reservoir Traps
Raymond T. Skirvin, J.R. Butler and Co Brian E. Ausbum, J.R. Butler and CO.*
Introduction
A reservoir trap is a combination of physical conditions that will cause hydrocarbon liquids and/or gases and water to accumulate in porous and permeable rock and prevent them from escaping either laterally or vertically because of differences in specific gravity, pressure, fluid/gas characteristics, and/or lithology. It has the capability of collecting, holding, and yielding hydrocarbon fluids and water. The portion of the trap that contains oil and/or gas accumulations is the petroleum reservoir. It generally occupies a limited portion of the trap capacity, the remainder being occupied by formation waters that underlie and are interspersed within the petroleum accumulation. Traps are formed by an infinite variety of structural and stratigraphic conditions of rock formations combined with pressure differentials among the various fluids within the reservoir rock. A trap consists of an impervious cover or roof rock overlying a porous and permeable rock. Reservoir pressure gradients and fluid flow within the reservoir rock can create traps that do not have structural closure. The boundary between oil and water or between gas and water need not be flat or level when these pressure gradients are present. Generally. however, traps do have structural closure, and as viewed from below, the impervious cover is concave, preventing the oil and gas, if present. from escaping vertically or laterally. The water underlying the oil and gas exerts a buoyant force on the oil/water boundary or contact, lifting and holding the oil and gas to the crest of the structure or area of minimum hydrostatic pressure. made by geologists attempting to include all factors and conditions that account for petroleum reservoirs. Many reservoirs have unique features that cause the oil to accumulate at a given location. The purpose of this chapter is to illustrate the more common geological conditions that cause traps and to point out a few of the infinite variety of minor variations that help create and hold petroleum accumulations in place. Structural Traps Structure implies some form of rock deformation, commonly expressed as a positive uplift, which may result in four-way dip closure. With the proper stratigraphy, structural traps may be present. Domes, anticlines, and folds are common structures. Fault-related features also may be classified as structural traps if closure is present. Structural traps are the easiest to locate by surface and subsurface geological and geophysical studies. They are the most numerous among traps and have received a greater amount of attention in the search for oil than all other types of traps. In new areas of exploration the prime search is for potential reservoir rock, source beds for hydrocarbons, and structural deformation. This structural deformation provides opportunities for several types of structural traps. Domes, Anticlines, and Folds. Domes, anticlines, and folds in general must have structural closure to become effective traps. The reservoir rock must dip away in all directions from the crest of the structure. If there is not dip in all directions away from the crest but hydrocarbons are present, there are other contnbuting physical factors that helped complete the trap. Domes, anticlines, and folds caused by structural deformation of sedimentary rocks generally create many potential traps because the deformation extends vertically through potential reservoirs. Thus a single well can reveal many possible pay zones when drilled on the crest of a domal structure.
Fig. 29.2-Example oilfield.
of anticlinal folds creating structural and stratographic traps: Midway
1
3.000
SANTA
FE SPRINGS
FIELD, CALIFORNIA
Fig. 29.3-Example of anticlinal folds creating many separate reservoirs: Santa Fe Springs field.
29-2
PETROLEUM ENGINEERING
HANDBOOK
KREYENHAGEN HILLS
KETTLEMAN PLAINS
KETHiXl-;AN
SANvJL$+J’ N
TEMBLOR
SANDSTONE SHALE CRETACEOUS -UNDIFF
REEF R’ KETTLEMAN DGE HILLS
Trap Classification
Classification of traps logically falls into three broad general groups: (I) structural, (2) stratigraphic, and (3) combination. More detailed classifications have been
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