LDN-27219_312946-37-5_DataSheet_MedChemExpress
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Product Name:
LDN-27219CAS No.:
312946-37-5Product Data Sheet
Cat. No.:
HY-16693MWt:
408.50Formula:
C20H16N4O2S2Purity :
>98%
Solubility:Mechanisms:
Biological Activity:
Pathways:Others; Target:Others DMSO
g y LDN-27219 is a potent inhibitor of hTGase(Tissue transglutaminase) with an IC50 of 0.6 uM.
IC50 value: 0.6 uM [1]
Target: hTGase inhibitor LDN-27219 is a potent inhibitor of the enzyme(hTGase), producing 100% inhibition at the screening concentration of 10 uM. To examine the enzyme selectivity of LDN-27219, it was tested as an inhibitor of coagulation Factor XIIIa and caspase 3. At concentrations as high as 50 íM, the
compound had no effect on the activities of either of these enzymes. LDN-27219 was found to be nontoxic at concentrations as high as 100 íM in an assay that measures the viability of HT1080 cells,References:
[1]. Case A, et al. Kinetic analysis of the interaction of tissue transglutaminase with a nonpeptidic
slow-binding inhibitor. Biochemistry. 2007 Jan 30;46(4):1106-15.g y y
a fibrosarcoma tumor cell line....
Caution: Not fully tested. For research purposes only
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18 W i l k i n s o n W a y , P r i n c e t o n , N J 08540,U S A
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