IDENTIFICATION OF NOVEL GENES CODING FOR SMALL TEM
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专利名称：IDENTIFICATION OF NOVEL GENES CODING FOR SMALL TEMPORAL RNAS
发明人：Thomas Tuschl,Mariana Lagos-
Quintana,Winfried Lendeckel,Jutta
Meyer,Reinhard Rauhut
申请号：US13472826
申请日：20120516
公开号：US20130245090A1
公开日：
20130919
专利内容由知识产权出版社提供
摘要：In , lin-4 and let-7 enclode 22- and 21-nucleotide RNAs, respectively, that function as key regulators of developmental timing. Because the appearance of these short RNAs is regulated during development, they are also referred to as “small temporal RNAs” (stRNAs). We show that many more 21- and 22-nt expressed RNAs, termed microRNAs, (miRNAs), exist in invertebrates and vertebrates, and that some of these novel RNAs, similar to let-7 stRAN, are also highly conserved. This suggests that sequence-specific post-transcriptional regulatory mechanisms mediated by small RNAs are more general than previously appreciated.
申请人：Thomas Tuschl,Mariana Lagos-Quintana,Winfried Lendeckel,Jutta Meyer,Reinhard Rauhut
地址：New York NY US,Berlin DE,Hohengandern DE,Vienna AT,Goettingen DE
国籍：US,DE,DE,AT,DE
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