新生儿25-羟维生素d及钙、磷、镁、碱性磷酸酶水平观察

Observation of levels of 25-hydroxyvitamin D, calcium, phosphorus, magnesium and alkaline phosphatase in neonates
YU Jinqian, ZHAO Tianjiao, ZHAO Hui, ZHANG Qian, WANG Xiaoxia (Maternal and Child Health Hospital of Shunyi District, Beijing 101300, China)
【Abstract】 Objective: To study levels of 25-hydroxyvitamin D and serum calcium, phosphorus, magnesium and alkaline phosphatase in neonates with different gestational ages and birth body weights. Methods: 984 hospitalized neonates were selected as the research objects. They were divided into three groups according to the gestational age: <34 weeks group, 34-37 week group, and ≥37 week group. Also, they were divided into three groups according to the birth body weight: very low birth body weight group (<1500 g, VLBW group), low birth weight group (≥1500 and <2500 g, LBW group) and normal birth body weight group (2500-3999 g, NBW group). The levels of 25-hydroxyvitamin D and serum calcium, phosphorus, magnesium and alkaline phosphatase in the neonates with different gestational ages and different birth weights were compared. Results: The levels of 25-hydroxyvitamin D, blood calcium and blood phosphorus in the <34 week group and 34-37 week group were significantly lower than those in the ≥37 week group, the ALP levels were significantly higher than that in the ≥37 week group, and the differences were statistically significant (P<0.05). There was no significant difference in the serum magnesium levels among the neonates of different gestational ages (P>0.05). The levels of 25-hydroxyvitamin D and blood calcium in the LBW group were significantly higher than those in the NBW group, the levels of 25-hydroxyvitamin D and blood calcium in the NBW group were significantly higher than those in the VLBW group, and the differences were statistically significant (P<0.05). The blood phosphorus level in the NBW group was significantly higher than those in the LBW group and the VLBW group, and the differences were statistically significant (P<0.05). There were no significant differences in the serum magnesium and alkaline phosphatase levels among the different body weight groups (P>0.05). Conclusions: The levels of serum 25-hydroxyvitamin D, calcium, and phosphorus increase with the gestational age. The levels of 25-hydroxyvitamin D and calcium are the highest in the neonates with low body weight, the phosphorus level is the highest in those with normal body weight, and the serum ALP level is the highest in those with full-term gestational age and normal body weight. Further, there are no correlations among serum magnesium level and gestational age as well as body weight.
足月胎龄和正常体质量新生儿中最高 , 血清镁水平与胎龄及体质量无相关性。
【关键词】 新生儿；25- 羟维生素 D；钙；磷；镁；碱性磷酸酶
doi: 10. 3969 / j. issn. 1672-0369. 2020. 02. 004
中图分类号： R722.1
文献标识码： B
文章编号： 1672-0369（2020）02-0010-03
生儿作为研究对象。按照不同胎龄将其划分为三组：<34 周组、34~37 周组和≥ 37 周组；另按照出生体质量将其划分为三组：极低出生体
质量新生儿组（<1500 g，VLBW 组）、低出生体质量组（≥ 1500 且 <2500 g，LBW 组）和正常出生体质量组（2500~3999 g，NBW 组）。
25- 羟维生素 D、血钙水平明显高于 VLBW 组，差异有统计学意义（P<0.05）；NBW 组血磷水平明显高于 LBW 组和 VLBW 组，差异均有
统计学意义（P<0.05）；不同体质量各组血清镁及碱性磷酸酶水平差异无统计学意义（P>0.05）。结论：血清 25- 羟维生素 D、钙、磷水
平随胎龄增加而增高，而 25- 羟维生素 D、钙在低体质量新生儿中水平最高 , 磷水平在正常体质量新生儿中最高 , 血清hly No.2
揖临床研究铱
新生儿 25- 羟维生素 D 及钙、磷、镁、碱性磷酸酶 水平观察
尉进茜，赵天娇，赵 辉，张 倩，王晓霞
（北京市顺义区妇幼保健院，北京 101300） 【摘要】 目的：观察不同胎龄、出生体质量的新生儿 25- 羟维生素 D 及钙、磷、镁、碱性磷酸酶水平。方法：选取 984 例住院新
比较不同胎龄、不同出生体质量的新生儿 25- 羟维生素 D 与钙、磷、镁、碱性磷酸酶水平。结果：胎龄 <34 周及胎龄 34~37 周新生儿的
25- 羟维生素 D、血钙、血磷水平明显低于胎龄≥ 37 周的新生儿，碱性磷酸酶水平明显高于胎龄≥ 37 周的新生儿，差异有统计学意义
（P<0.05）；不同胎龄新生儿血清镁水平差异无统计学意义（P>0.05）；LBW 组 25- 羟维生素 D、血钙水平明显高于 NBW 组，NBW 组
2020 年 1 月 中国民康医学 Jan.，2020
第 32 卷 半月刊 第 2 期摇 摇 摇 摇 摇
Medical Journal of Chinese People's Health