冠状动脉支架置入患者术后炎症反应（以连续测量C-反应蛋白评估）与再狭窄相关

冠状动脉支架置入患者术后炎症反应（以连续测量C-反应蛋
白评估）与再狭窄相关
Dibra; A.; Mehilli; J.; Braun; S.; 王亭忠（译）; 杜媛（校）
【期刊名称】《《世界核心医学期刊文摘：心脏病学分册》》
【年(卷),期】2006(002)001
【摘要】Objectives: We hypothesized that a higher degree of inflammatory response to coronary stenting, as measured by the change in C-reactive protein(CRP) levels after intervention in patients with stable or unstable angina, would be related to a higher risk of in-stent restenosis. Methods: We studied 1800 consecutive patients with stable or unstable angina treated with coronary stenting. C-reactive protein levels were serially measured before and after the intervention. The difference(Δ) between highest CRP values after intervention and CRP values before intervention was calculated. Patients were grouped into tertiles according to ΔCRP values. The primary end point was angiographic
restenosis(diameter stenosis ≥50%at 6-month angiography). The secondary end point was clinical restenosis, defined as target vessel revascularization performed in the presence of angiographic restenosis and symptoms or signs of ischemia. Results: No relationship was found between CRP values at baseline and angiographic restenosis(P=.88). On the other hand, the change between baseline and peak postintervention CRP values strongly correlated with angiographic restenosis(30.5%in the
upper tertile with ΔCRP values >11.8 mg/L, 25.3%in the middle tertile with ΔCRP values 3.0-11.8 mg/L, and 21.5%in the lower tertile with ΔCRP values< 3.0 mg/L, P=.002) as well as with clinical restenosis(P=.01). Patients in the upper tertile had the highest risk of restenosis even after adjustment for other covariates. Conclusions: The inflammatory response to coronary stenting as assessed by the change in CRP correlates with the development of in-stent restenosis. These findings provide strong support for the role of inflammation in restenosis.
【总页数】1页(P30)
【作者】Dibra; A.; Mehilli; J.; Braun; S.; 王亭忠（译）; 杜媛（校）
【作者单位】
【正文语种】中文
【中图分类】R375.2
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