游离脂肪酸与非酒精性脂肪性肝病的相关性

游离脂肪酸与非酒精性脂肪性肝病的相关性
汪明东;孙立山;郑慧雅;陆柳;范列英
【期刊名称】《同济大学学报（医学版）》
【年(卷),期】2012(033)004
【摘要】Objective To explore the correlation between serum free fatty acid ( FFA) and nonalcoholic fatty liver disease ( NAFLD ). Methods FFA, fasting blood glucose ( FBG ), triglyceride ( TG) , total cholesterol ( CHOL) , high density lipoprotein cholesterol ( HDL-C), low density lipoprotein cholesterol (LDL-C) , were measured in serum samples from 296 patients with NAFLD and 189 sex- and age-matched subjects (control group). Results Serum FFA levels were higher in NAFLD patients than those in controls [ (0. 82 ±0. 39) mmol /L vs. (0. 38 ±0. 17) mmol/ L, P<0.01) ]. Serum FFA was positively correlated with TG,GLU, CHOL, LDL-C, while it was negatively correlated with HDL-C in pearson correlation analysis. Conclusion Serum FFA levels are significantly associated with NAFLD, and associated with triglycerides, glucose and total cholesterol levels.%目的探讨游离脂肪酸(free fatty acid,FFA)与非酒精性脂肪性肝病(nonalcoholic fatty liver disease,NAFLD)发病的相关性.方法分别测定296例NAFLD患者和189例健康对照个体血清中的FFA、空腹血糖(fasting blood glucose,FBG)、三酰甘油(triglyceride,TG)、总胆固醇(cholesterol,CHOL)、高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)、低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)等指标.结果 NAFLD组血清FFA水平显著高于对
照组[(0.82±0.39)] mmol/L,(0.38±0.17) mmol/L,P＜0.01)].Pearson 相关分析提示血清FFA水平与TG,GLU,CHOL,LDL-C存在明显的正相关,与HDL-C存在明显的负相关.结论血清FFA水平与NAFLD患病显著相关,并且与TG,GLU,CHOL等指标相关.
【总页数】4页(P54-56,82)
【作者】汪明东;孙立山;郑慧雅;陆柳;范列英
【作者单位】同济大学附属东方医院检验科,上海200120;同济大学附属东方医院检验科,上海200120;同济大学附属东方医院检验科,上海200120;同济大学附属东方医院检验科,上海200120;同济大学附属东方医院检验科,上海200120
【正文语种】中文
【中图分类】R575.5
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