细胞凋亡抑制蛋白 Livin 和 Survivin 检测在胃癌诊断中的价值

细胞凋亡抑制蛋白 Livin 和 Survivin 检测在胃癌诊断中的价
值
杨少蓉;马国卫
【期刊名称】《检验医学与临床》
【年(卷),期】2015(000)003
【摘要】目的：探讨细胞凋亡抑制蛋白Livin和Survivin检测在胃癌诊断中的作用。

方法选择170例天门市第一人民医院手术或内镜病检标本作为研究对象，其中胃癌组织标本45例，萎缩性胃炎37例，浅表性胃炎29例，异型增生胃黏膜33例，26例正常胃部组织。

比较各组组织中Livin、Survivin表达阳性率，并分析胃癌组织中Livin与Survivin表达的相关性。

结果胃癌组织 Livin、Survivin阳性率显著高于其他组织，差异有统计学意义（P＜0．05），其中萎缩性胃炎、异型增生胃黏膜Livin阳性率显著高于正常组织，萎缩性胃炎、浅表性胃炎、异型增生胃黏膜Survivin阳性率显著高于正常组织，差异有统计学意义（P＜0．05）。

Livin阳性表达与组织分化程度和TNM分期有关（P＜0．05）；Survivin阳性表达与组织浸润程度和 TNM 分期有关（P＜0．05）。

Livin阳性率为57．78％，Survivin阳性率为64．44％，二者均为阳性21例，二者表达无明显相关性（χ2＝1．076，P＞0．05）。

结论细胞凋亡抑制蛋白Livin和Survivin在胃癌组织中表达显著上升，两种蛋白因子检测可作为胃癌辅助诊断的指标之一。

%Objective To explore the diagnosis value of apoptosis inhibition protein Livin and Survivin in gas‐tric cancer .Methods Totally 170 cases of operation or endoscopic biopsy specimens in our hospital were selected as the object ,including 45 cases of gastric cancer tissues ,37 cases of atrophic
gastritis ,29 cases of superficial gastritis , 33 cases of gastric mucosa dysplasia ,26 cases of normal gastric tissue .Compared the expression positive rate of Livin ,Survivin of each group ,and analysised the relationship between the Livin and Survivin in gastric cancer . Results The positive rate of Livin and Survivin of gastric carcinoma tissues was significantly higher than other groups (P<0 .05);wherein the atrophic gastritis ,gastric mucosa dysplasia ,Livin positive rate was significantly high‐er than that of normal tissue ,atrophic gastritis ,superficial gastritis with dysplasia of gastric mucosa ,positive rate of Survivin was significantly higher than that in normal tissue (P<0 .05) .The positive expression of Livin related with tissue differentiation ,TNM stage (P<0 .05);the positive expression of Survivin related with the degree of tissue in‐filtration ,TNM stage (P<0 .05) .The positive rate of Livin was 57 .78% ,the positive rate of Survivin was 64 .44% , both were positive in 21 cases ,the expression had no obvious correlation (χ2 =1 .076 ,P<0 .05) .Conclusion Apop‐tosis inhibition protein Livin and Survivin expression in gastric cancer tissue increased significantly ,two kinds of ge‐netic testing c an be used as one of indexes of gastric cancer screening .
【总页数】3页(P355-357)
【作者】杨少蓉;马国卫
【作者单位】湖北省天门市第一人民医院普外科2区 431700;湖北省天门市第一人民医院普外科2区 431700
【正文语种】中文
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