抗血小板药物致上消化道出血临床分析及泮托拉唑的预防作用

抗血小板药物致上消化道出血临床分析及泮托拉唑的预防作用吕龙;董建新
【期刊名称】《中国医院用药评价与分析》
【年(卷),期】2015(000)006
【摘要】OBJECTIVE:To analyze the causes of antiplatelet drug-induced upper digestive tract hemorrhage in&nbsp;order to provide reference for clinical antiplatelet treatment.METHODS: A retrospective analysis was performed on patients with antiplatelet drug-induced upper digestive tract hemorrhage, meanwhile, the patient history was obtained and gastroscopy was performed, the causes of digestive tract hemorrhage was analyzed and pantoprazole was used for preventing hemorrhage.RESULTS: Acute gastric mucosal lesion and peptic ulcer disease were the leading cause for antiplatelet drug-induced upper digestive tract hemorrhage.The clinical manifestation of antiplatelet drug-induced upper digestive tract hemorrhage varied.The recurrence rate of digestive tract hemorrhage in patients after preventive treatment with pantoprazole for one year was significantly lower than in those without receiving pantoprazole therapy ( P<0.05 ) .CONCLUSIONS: Rational use of antiplatelet drugs plus use of appropriate amount of proton pump inhibitor pantoprazole is of importance for the prevention of upper digestive tract hemorrhage and presence of serious complications.%目的：探讨抗血小板药物引起上消化道出血的原因，以期为临床抗血小板治疗提供参考。

方法：对使用抗血小板药物并发上
消化道出血患者资料进行回顾性分析，询问患者病史，进行胃镜检查，分析其消化道出血的原因，并给予泮托拉唑预防出血。

结果：抗血小板药物引起上消化道出血的最常见病因为急性胃黏膜病变，消化性溃疡病史亦是常见病因。

抗血小板药物引起上消化道出血的临床表现多样；使用泮托拉唑组患者预防性治疗1年后，其消化道出血复发率明显低于不使用泮托拉唑组，差异有统计学意义（P＜0．05）。

结论：合理应用抗血小板药物，适量加用质子泵抑制剂泮托拉唑，对预防上消化道出血、防止严重并发症有积极的意义。

【总页数】3页(P815-817)
【作者】吕龙;董建新
【作者单位】嘉应学院医学院附属医院消化内科，广东梅州 514031;嘉应学院医学院附属医院心血管内科，广东梅州 514031
【正文语种】中文
【中图分类】R973
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