精子DNA碎片率与AIH或IVF-ET临床妊娠率的相关性

精子DNA碎片率与AIH或IVF-ET临床妊娠率的相关性马刚;李路;冀雪霞;苗艳梅;苏辉;乔志成
【期刊名称】《中国性科学》
【年(卷),期】2017(26)12
【摘要】目的:探讨精子DNA碎片率与因常见男性因素为主行夫精人工授精术(AIH)或体外受精-胚胎移植术(IVF-ET)治疗夫妇临床妊娠率的相关性.方法:筛选因常见男性因素为主行AIH的患者64例及IVF-ET的患者46例,其中女方的促排方案相同,男女年龄均在40岁以下,平均年龄(31±9)岁,基本排除女方常见不孕因素.根据术中精子DNA碎片率的高低,分为五组:组1:术前3个月内精子DNA碎片检查结果正常组,24例(AIH,16例);组2:术前精子DNA碎片检查结果异常,经治疗后好转组,44例(AIH,30例);组3:术前精子DNA碎片检查结果异常,经治疗后未见明显好转或拒绝治疗组,22例(AIH,10例);组4:术前未做精子DNA碎片率检查,术中留取精液检测结果异常组,10例(AIH,4例);组5:术前未做精子DNA碎片率检查,术中留取精液检测结果正常组,10例(AIH,4例);分别统计各组AIH及IVF-ET的临床妊娠率,计算两者均值,并比较各组差异.结果:组1、组2、组3、组4、组5妊娠率分别为37.5％、31.8％、31.8％、20.0％、45.5％.结论:精子DNA碎片率会显著影响以男性因素为主的AIH或IVF-ET的妊娠结局.%Objectives:To investigate the correlation of clinical pregnancy rate and sperm DNA fragmentation rate for artificial insemination by husband (AIH) or in vitro fertilization-embryo transfer (IVF-ET) treatment couples with primarily male infertility factors.Methods:The records of couples with common male factors primarily for AIH (64 cases) and IVF-ET (46 cases),assisted reproductive
technology (ART) treatment were screened,with the same protocols of the wife's ovulation induction.All the men and women were all aged under 40 years old (average age 31 ± 9).The women common infertihty factors were basically ruled out.According to the rate of sperm DNA fragmentation,all cases were divided into 5 groups:group 1 with normal sperm DNA fragmentation rate three months before treatment including 24 cases (AIH,16 cases);group 2 with abnormal sperm DNA fragmentation rate before treatment but improvement after treatment including 44 cases (AIH,30 cases);group 3 with abnormal sperm DNA fragmentation rate before treatment and no obvious improvement after treatment or treatment rejection including 22 cases (AIH,10 cases);group 4 without sperm DNA fragmentation rate test before treatment,and abnormal sperm test results after treatment including 10 cases (AIH,4 cases);Group 5 without sperm DNA fragmentation rate test before treatment and with normal sperm test results after treatment including 10 cases (AIH,4 cases).The clinical pregnancy rates of each group of AIH and IVF-ET were recorded and compared.Results:The average clinical pregnancy rate were 43.8％,40.0％,30％,16.5％ and 45.0％ for group 1-5
respectively.Conclusion:Sperm DNA fragmentation rate significantly affects the clinical pregnancy outcome of AIH and IVF-ET for couples with primarily male infertility factors.
【总页数】3页(P94-96)
【作者】马刚;李路;冀雪霞;苗艳梅;苏辉;乔志成
【作者单位】衡水市哈励逊国际和平医院生殖中心,河北衡水053000;衡水市枣强
县人民医院妇产科,河北衡水053000;衡水市哈励逊国际和平医院生殖中心,河北衡水053000;衡水市哈励逊国际和平医院生殖中心,河北衡水053000;衡水市哈励逊
国际和平医院生殖中心,河北衡水053000;衡水市哈励逊国际和平医院生殖中心,河北衡水053000
【正文语种】中文
【中图分类】R698+.2
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