右美托咪定对甲状腺手术患者呛咳反应的影响

右美托咪定对甲状腺手术患者呛咳反应的影响
张艳萍;闵苏;任力;郝学超
【期刊名称】《临床麻醉学杂志》
【年(卷),期】2017(33)4
【摘要】Objective To evaluate the effect of dexmedetomidine on postoperative cough and the postoperative bleeding in patients undergoing thyroid surgery.Methods A total of 118 aged 18-65 years,BMI 18-30 kg/m2,ASA physical status Ⅰ or Ⅱ patients,scheduled for elective thyroid surgery,were randomly divided into 2 groups (n=59 each): dexmedetomidine group (group D) and control group (group C).At the beginning of the operation,patients in group D were infused with dexmedetomidine at a rate of 0.4 μg·kg-1·h-1until the end of
surgery.Meanwhile,the equal volume of normal saline was infused in group C.The incidence and severity of coughing during recovery,the volume of drainage at first and second 24 h after surgery,the occurrence of adverse events were recorded.Results Compared with group C,the incidence of coughing were lower in group D (10.1% vs 30.5%,P<0.05).The volume of drainage at first 24 h [(62.3±26.8) ml vs (78.6±30.1) ml,P<0.05] and secon d 24 h after surgery were less in group D than those in group pared with group C,the dosage of propofol and remifentanil were lower in group D (P<0.05).Compared with group C,the incidence of tachycardia during recovery decreased in group D (3.4% vs 23.7%,P<0.05).Conclusion
Continuous infusion of dexmedetomidine at a rate of 0.4 μg·kg-1·h-1 in patients undergoing thyroid surgery with general anesthesia can relieve cough reflex,reduce the risk of the postoperative bleeding.%目的探讨右美托咪定对甲状腺手术患者呛咳反应的影响.方法择期全麻下甲状腺肿瘤手术患者118例,男43例,女75例,年龄18~65岁,BMI 18~30 kg/m2,ASA Ⅰ或Ⅱ级,采用随机数字表法分为两组,每组59例.D组在手术开始时持续静脉泵注右美托咪定0.4 μg·kg-1·h-1至手术结束,C组在手术开始时持续静脉泵注等容量生理盐水至手术结束.观察患者全麻恢复期间呛咳发生情况,记录患者术后24、48 h引流量,以及心动过速、低血压、高血压、心动过缓等不良反应的发生情况.结果 D组全麻恢复期间呛咳发生率明显低于C组(10.1% vs 30.5%,P<0.05),D组术后第1个24
h[(62.3±26.8)ml vs (78.6±30.1)ml,P<0.05]、第2个24 h[(28.0±12.5)ml vs (37.5±18.6)ml,P<0.05]引流量明显少于C组;D组围术期心动过速发生率明显低于C组(3.4% vs 23.7%,P<0.05).结论术中持续输注右美托咪定0.4 μg·kg-1·h-1能够有效减轻甲状腺手术患者全麻恢复期间的呛咳反应,降低患者术后出血的风险.【总页数】4页(P349-352)
【作者】张艳萍;闵苏;任力;郝学超
【作者单位】400016 重庆医科大学附属第一医院麻醉科;400016 重庆医科大学附属第一医院麻醉科;400016 重庆医科大学附属第一医院麻醉科;400016 重庆医科大学附属第一医院麻醉科
【正文语种】中文
【相关文献】
1.右美托咪定对全身麻醉下甲状腺手术患者呛咳反应的影响 [J], 孙晶;赵怀金
2.右美托咪定对甲状腺手术患者平均动脉压、呛咳反应的作用分析 [J], 张晓; 杨向霞; 杨付明; 周晓刚; 鲁纯
3.右美托咪定对术毕瑞芬太尼抑制拔管期间呛咳反应半数有效效应室浓度的影响[J], 张俊峰;池国睿;钟岳
4.右美托咪定对甲状腺肿瘤手术患者全麻恢复期间呛咳反应的影响 [J], 陈美荣;邓壮;谢欣欣;董梦婷
5.术前输注右美托咪定对行甲状腺手术患者术后拔除气管导管时呛咳反应的抑制效果 [J], 胡湘;沈亮;陆志俊;陈蕾
因版权原因，仅展示原文概要，查看原文内容请购买。