奥硝唑在正常和重症急性胰腺炎小鼠的药动学研究

奥硝唑在正常和重症急性胰腺炎小鼠的药动学研究
谢云芬;蒋军;夏宗玲
【期刊名称】《药学与临床研究》
【年(卷),期】2013(021)001
【摘要】目的:研究奥硝唑(ONZ)在重症急性胰腺炎(SAP)小鼠的药动学过程及胰腺分布.方法:以20％L-精氨酸200 mg/100 g体重腹腔注射方法复制SAP模型.给予正常对照组和SAP模型组小鼠尾静脉注射奥硝唑8.25 mg·kg-1,在规定时间点取样,用高效液相色谱法(HPLC)测定血清和胰腺组织中药物的浓度.结果:奥硝唑在两组血浆和胰腺中的处置均符合一室模型,对血胰屏障的穿透率均＞1.正常对照组药物在血浆中t1/2为1.63 h,C0为61.86 mg·L-1,AUC0-∞为145.76 mg·h·L-1；在胰腺组织中t1/2为1.41 h,C0为124.76 mg·kg-1,AUC0-∞为254.61 mg·h·kg-1.SAP模型组药物在血浆和胰腺组织中t1/2与正常组相近,但是C0及AUC0-∞下降明显.结论:奥硝唑在正常组和SAP模型组小鼠胰腺中均有良好的分布,值得向临床推荐用于预防和治疗胰腺感染.%Objective: To investigate the pharmacokinetics and pancreas distributions of ornidazole (ONZ) after intravenous injection in sever acute pancreatitis (SAP) mice. Methods: Ornidazole (8.25 mg#kg~' body weight) were intravenously injected to mice after abdominally injected L-arginine to induce SAP while injected normal saline as control. At given time points, serum and pancreatic samples were collected. The concentrations of ornidazole in the samples were measured by HPLC. Results: The disposition of ornidazole in both groups fitted one compartment model, and the penetration ratios of the
drug through the blood -pancreas barrier were greater than 1. In normal control group, the pharmacokinetic parameters in plasma were as follows: t1/2 was 1.63 h, C0 was 61.86 mg·L-1, AUC0-∞ was 145.76 mg·h ·L-1; and those in tissue were as follows: t1/2 was 1.41 h, C0 was 124.76 mg·kg-1, AUC0-∞ was 254.61 mg·h·kg-1. In SAP group, the half-life of ONZ in plasma and tissue were similar to that of control group. But the C0 and AUC0-∞ of SAP group were lower than those of control group. Conclusion: Ornidazole has a fairly, high distribution in pancreas of the normal and SAP mice. It is therefore proposed that ornidazole may be used clinically for the prevention and treatment of pancreatic infection.
【总页数】4页(P17-20)
【作者】谢云芬;蒋军;夏宗玲
【作者单位】江苏省常州市第一人民医院药剂科,常州213003
【正文语种】中文
【中图分类】R965.1
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