Use of TGF beta superfamily antagonists to make do
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专利名称：Use of TGF beta superfamily antagonists to make dopaminergic neurons from
embryonic stem cells
发明人：Melissa K. Carpenter,R. Scott Thies
申请号：US11010230
申请日：20041210
公开号：US20050158855A1
公开日：
20050721
专利内容由知识产权出版社提供
摘要：This invention provides a system for efficiently producing differentiated cells from pluripotent cells, such as human embryonic stem cells. Rather than permitting the cells to form embryoid bodies according to established techniques, differentiation is effected directly in monolayer culture on a suitable solid surface. The cells are either plated directly onto a differentiation-promoting surface, or grown initially on the solid surface in the absence of feeder cells and then exchanged into a medium that assists in the differentiation process. The solid surface and the culture medium can be chosen to direct differentiation down a particular pathway, generating a cell population that is remarkably uniform. The methodology is well adapted to bulk production of committed precursor and terminally differentiated cells for use in drug screening or regenerative medicine.
申请人：Melissa K. Carpenter,R. Scott Thies
地址：Castro Valley CA US,Pleasanton CA US
国籍：US,US
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