Sequential Correlated Sampling Methods for Some Transport Problems. this volume
SIRS标准、qSOFA评分、qPitt评分对细菌性血流感染患者死亡风险的预测价值分析
Vol. 27, No. 2Mar. 2021122第27卷2期2021年3月天津医科大学学报Journal of Tianjin Medical University文章编号 1006-8147(2021)02-0122-05 亠 _SIRS 标准、qSOFA 评分、qPitt 评分对细菌性血流感染患者死亡风险的预测价值分析张安然,陈倩倩,田彬,李静,胡志东(天津医科大学总医院医学检验科,天津300052)摘要 目的:比较全身炎症反应综合征(SIRS )标准、快速序贯器官衰竭(qSOFA )评分及快速皮塔菌血症(qPitt )评分对细菌性血 流感染患者死亡风险的预测价值。
方法:回顾性分析2018年1月一2020年9月天津医科大学总医院急诊医学科110例发生细菌性血流感染患者的病例资料,以血培养阳性作为血流感染的诊断依据,计算血流感染发生24 h 内SIR 标准、qPitt 评分、qSOFA 评分,以28d 内患者预后作为依据分为存活组(81例)及死亡组(29例),应用受试者工作特征(ROC )曲线下面积(AUC ) 评估不同评分系统对患者预后的预测价值,Logistic 回归分析不同评分系统与血流感染患者死亡风险的关系,Pearson 相关分析不同评价系统之间的相关性。
结果:死亡组SIRS 标准、qSOFA 评分、qPitt 评分分别为(2.76±1.12)、(1.59±0.87)、(1.52±0.87),与存活组的差异具有统计学意义(均P <0.05); ROC 曲线显示qSOFA 评分对血流感染患者预后的预测价值最大(AUC 二0.866),SIRS 标准、qSOFA 评分、qPitt 评分的最佳截断值分别为3分、1分、1分;通过Logistic 回归分析发现SIRS 标准!3(00二3.673,95%C2:1.213〜11.126)、qSOFA 评分! 1(03=5.864,95%C4: 1.205〜28.549)、qPitt 评分! 1(O0=4.456,95%C4: 1.035+19.190)与 细菌性 血流感染患者的死亡风险显著相关;Pearson 相关分析显示qPitt 评分与qSOFA 评分相关性最好(r=0.835,P <0.01 )o 结论:SIRS标准、qPitt 评分和qSOFA 评分均能有效地预测细菌性血流感染患者的死亡风险,其中qSOFA 评分对患者预后的预测价值最大。
取样分离法的英文缩写
取样分离法的英文缩写The Abbreviation of Sampling Separation MethodIntroduction:Sampling separation is a crucial process in various scientific fields, aiming to isolate and extract specific components from a mixture for further analysis or application. In order to simplify its usage, an abbreviation, also known as an acronym or initialism, is often assigned to represent the sampling separation method. This article explores the significance of abbreviations for sampling separation methods in the English language.Abbreviations in Sampling Separation Methods:Abbreviations play a vital role in simplifying complex terminologies, especially in scientific research. By condensing a long and technical name into a shorter form, abbreviations make it easier for researchers, professionals, and even general readers to refer to a particular sampling separation method efficiently. These abbreviations are widely accepted and recognized across the scientific community and help in creating a standardized language for communication.Importance of Abbreviations:1. Enhanced Communication:Abbreviations act as effective communication tools, as they facilitate easy and precise exchange of information between researchers and experts. The use of abbreviations enables efficient and concise communication in scientific journals, research papers, and conferences. Additionally,abbreviations assist in the dissemination of knowledge, allowing researchers to present their work without the cumbersome repetition of lengthy methodologies.2. Time-Saving:The utilization of abbreviations saves valuable time for both the writer and the reader. Instead of repeatedly writing the complete name of a sampling separation method, researchers can use the respective abbreviation, reducing the overall length of the text. This time-saving benefit enables authors to focus on explaining the nuances of the method rather than wasting words on repetitive instances of its name.3. Standardization:Standardization plays a pivotal role in establishing a common platform for sharing and understanding scientific concepts. Abbreviations ensure uniformity and consistency in scientific literature and research, as the same abbreviation is used for a specific sampling separation method by different scientists and researchers. This standardization eliminates confusion and ambiguity that may arise due to variations in the nomenclature of different techniques.Examples of Abbreviations:1. Liquid-Liquid Extraction (LLE): LLE is a widely used method for extracting a compound of interest from a liquid mixture by partitioning it between two immiscible liquids.2. Solid Phase Extraction (SPE): SPE is a technique that involves the use of a solid adsorbent to extract and isolate specific analytes from a sample matrix.3. Gas Chromatography (GC): GC is an analytical method used to separate and analyze volatile compounds in a gaseous mixture.4. High-Performance Liquid Chromatography (HPLC): HPLC is a technique that utilizes high-pressure pumps to separate and identify components in a liquid mixture.Conclusion:Sampling separation methods are pivotal in various scientific fields for accurate analysis and understanding of mixtures. Abbreviations associated with these methods have become essential tools for efficient communication, time-saving writing practices, and standardization of terminologies in scientific literature. It is crucial for scientists and researchers to utilize these abbreviations accurately and consistently, ensuring effective knowledge dissemination across the scientific community.。
测绘类英语词汇(T-Z)_地质专业英语词汇
塔尔科特测纬度法 talcott method of latitude determination台链 station chain太阳辐射波谱 solar radiation spectrum太阳光压摄动 solar radiation pressure perturbation太阳同步卫星 sun-synchronous satellite态势地图 posture map特殊水深 special depth特征 feature特征编码 feature coding特征码 feature codes特征码清单 feature codes menu特征提取 feature extraction特征选择 feature selection特种地图 particular map体素 voxel天波干扰 sky-wave interference天波修正 sky-wave correction天顶距 zenith angle天顶距 zenith distance天球坐标系 celestial coordinate system天球坐标系 celestial coordinate system天文大地垂线偏差 astro-geodetic deflection of the vertical 天文大地网 astro-geodetic network天文大地网平差 adjustment of astrogeodetic network天文点 astronomical point天文定位系统 astronomical positioning system天文方位角 astronomical azimuth天文经度 astronomical longitude天文经纬仪 astronomical theodolite天文年历 astronomical almanac天文年历 astronomical ephemeris天文水准 astronomical leveling天文纬度 astronomical latitude天文重力水准 astro-gravimetric leveling天文坐标测量仪astronomical coordinate measuring instrument天线高度 antenna height田谐系数 coefficient of tesseral harmonics田谐系数 coefficient of tesseral harmonics条幅[航带]摄影机 continuous strip camera条幅[航带]摄影机 continuous strip camera条幅[航带]摄影机 strip camera条件方程 condition equation条件方程 condition equation条件平差 condition adjustment条件平差 condition adjustment铁路工程测量 railroad engineering survey通用横墨尔卡投影 universal transverse mercator projection通用极球面投影 universal polar stereographic projection通用极球面投影 ups通用墨卡尔投影 utm同步观测 simultaneous observation同步验潮 tidal synobservation同名光线 corresponding image rays同名光线 corresponding image rays同名核线 corresponding epipolar line同名核线 corresponding epipolar line同名像点 corresponding image points同名像点 corresponding image points同名像点 homologous image points统计地图 statistic map投影变换 projection transformation投影差 height displacement投影差 relied displacement投影方程 projection equation投影器 projector投影器主距 principal distance of projector投影晒印 projection printing透光率 transmittance透明负片 transparent negative透明正片 transparent positive透明注记 stick-up lettering透视截面法 perspective traces透视投影 perspective projection透视旋转定律,*沙尔定律 chasles theorem透视旋转定律,*沙尔定律 chasles theorem透视旋转定律,*沙尔定律 rotation axiom of the perspective 透视旋转定律,*沙尔定律 rotational theorem图幅 mapsheet图幅编号 sheet designation图幅编号 sheet number图幅接边 edge matching图幅接合表 index diagram图幅接合表 sheet index图根点 mapping control point图根控制 mapping control图解纠正 graphical rectification图解图根点 graphic mapping control point图廓 edge of the format图廓 map border图历簿 mapping recorded file图例 legend图面配置 map layout图象 picture图像编码 image coding图像变换 image transformation图像处理 image processing图像分割 image segmentation图像分析 image analysis图像复合 image overlaying图像几何纠正 geometric rectification of imagery 图像几何配准 geometric registration of imagery 图像理解 image understanding图像描述 image description图像识别 image recognition图像数字化 image digitization图像增强 image enhancement图形 graphics图形-背景辨别 f-g discrimination图形-背景辨别 figure-ground discrimination图形符号 graphic symbol图形记号 graphic sign图形权倒数 weight reciprocal figure图形元素 graphic elements土地规划测量 land planning survey土地利用现状图 present landuse map土地信息系统 land information system土地信息系统 lis推荐航线 recommended route托帕可斯卫星 t/p托帕克斯卫星 topex/poseidon拖底扫海 aground sweeping陀螺定向光电测距导线 gyrophic edm traverse陀螺方位角 gyro azimuth陀螺经纬仪 gyro theodolite陀螺经纬仪 gyroscopic theodolite陀螺仪定向测量 gyrostatic orientation survey椭球扁率 flattening of ellipsoid椭球长半轴,*地球长半轴 semimajor axis of ellipsoid 椭球短半轴,*地球短半轴 semiminor axis of ellipsoid 椭球面大地测量学 ellipsoidal geodesy椭球偏心率 eccentricity of ellipsoid拓扑地图 topological map拓扑关系 topological relation拓扑检索 topological retrieval外部定向 exterior orientation网点 stipple网格地图 grid map网格法 grid method网格结构 grid structure网屏 screen网纹片 transparent foil网线 ruling危险界限 limiting danger line微波测距仪 microwave distance measuring instrument 微波辐射 microwave radiation微波辐射计 microwave radiometer微波图像 microwave imagery微波遥感 microwave remote sensing微波遥感器 microwave remote sensor微重力测量 microgravimetry维纳频谱 winer spectrum维宁?曼尼斯公式 vening-meinesz formula伪彩色图像 pseudo-color image伪等值线地图 pseudo-isoline map伪距测量 pseudo-range measurement卫星测高 satellite altimetry卫星大地测量 satellite geodesy卫星定位 satellite positioning卫星多普勒[频移]测量 satellite doppler shift measurement卫星多普勒定位 satellite doppler positioning卫星高度 satellite altitude卫星跟踪卫星技术 satellite-to-satellite tracking卫星跟踪卫星技术 sst卫星跟踪站 satellite tracking station卫星共振分析 analysis of satellite resonance卫星构形 satellite configuration卫星-惯导组合定位系统satellite-inertial guidance integrated positioning sy卫星轨道改进 improvement of satellite orbit卫星激光测距 satellite laser ranging卫星激光测距,侧视雷达 slr卫星激光测距仪 satellite laser ranger卫星-声学组合定位系统satellite-acoustics integrated positioning system卫星受摄运动 perturbed motion of satellite卫星像片图 satellite photo map卫星星下点 sub-satellite point卫星运动方程 equation of satellite motion卫星重力梯度测量 satellite gradiometry卫星姿态 satellite attitude位置[线交]角 intersection angle of lop位置函数,*坐标函数 position function位置精度 positional accuracy位置线 line of position位置线 lop位置线方程 equation of lop文化地图 cultural map文化地图 cultural map纹理分析 texture analysis纹理增强 texture enhancement沃尔什变换 walsh transformation无线电定位 radio positioning无线电航行警告 radio navigational warning无线电指向标,*电指向 radio beacon无线电指向标表 list of radio beacon五角棱镜 pentaprism物镜分辨力 resolving power of lens物理大地测量学,*大地重力学 physical geodesy 误差检验 error test误差理论 theory of errors误差椭圆 error ellipse雾[信]号 fog signal系列地图 series maps系统集成 system integration系统误差 systematic error弦线支距法 chord off-set method弦线支距法 chord off-set method显微摄影 photomicrography现势地图 up-to-data map线路平面图 route plan线路水准测量 route leveling线路中线测量 center line survey线路中线测量 center line survey线路中线测量 location of route线纹米尺,*日内瓦尺 standard meter线形锁 linear triangulation chain线形网 linear triangulation network线性调频脉冲 chirp线性调频脉冲 chirp线阵遥感器 linear array sensor线阵遥感器 pushbroom sensor线状符号 line symbol限差 tolerance限航区 restricted area乡村规划测量 rural planning survey相对定位 relative positioning相对定向 relative orientation相对定向元素 element of relative orientation相对航高 relative flying height相对论改正 relativistic correction相对误差 relative error相对重力测量 relative gravity measurement相干声呐测深系统 interferometric seabed inspection sonar 相关平差 adjustment of correlated observation相关器 correlator相关器 correlator相位传递函数 phase transfer function相位传递函数 ptf相位多值性 phase ambiguity相位模糊度解算 phase ambiguity resolution相位漂移 phase drift相位稳定性 phase stability相位周,*巷 lane相位周,*巷 phase cycle相位周值,*巷宽 lane width相位周值,*巷宽 phase cycle value镶嵌索引图 index mosaic巷道验收测量 footage measurement of workings象限仪 quadrant象形符号 replicative symbol像场角 angular field of view像等角点 isocenter of photograph像底点 photo nadir point像地平线,*合线 horizon trace像地平线,*合线 image horizon像地平线,*合线 vanishing line像幅 picture format像空间坐标系 image space coordinate system像片 photo像片 photograph像片比例尺 photo scale像片地质判读,*像片地质解译geological interpretation of photograph像片方位角 azimuth of photograph像片方位元素 photo orientation elements像片基线 photo base像片纠正 photo rectification像片内方位元素 elements of interior orientation像片判读 photo interpretation像片平面图 photoplan像片倾角 tilt angle of photograph像片外方位元素 elements of exterior orientation 像片镶嵌 photo mosaic像片旋角 swing angle像片旋角 yaw像片主距 principal distance of photo像平面坐标系 photo coordinate system像移补偿 image motion compensation像移补偿 imc像元 pixel像主点 principal point of photograph像主纵线 principal line [of photograph]销钉定位法 stud registration小潮升 neap rise小潮升 neap rise小角度法 minor angle method小像幅航空摄影 sfap小像幅航空摄影 small format aerial photography 协调世界时 coordinate universal time协调世界时 coordinate universal time协调世界时 utc协调世界时时号 time signal in utc协方差函数 covariance function协方差函数 covariance function心象地图 mental map新版海图 new edition of chart新版海图 new edition of chart信号杆 signal pole信息量 contents of information信息量 contents of information信息提取 information extraction信息属性 information attribute星载遥感器 satellite-borne sensor行差 run error行星大地测量学 planetary geodesy行政区划图 administrative map修版 retouching虚地图 virtual map虚拟地景 virtual landscape序惯平差 sequential adjustment悬式经纬仪 hanging theodolite旋转参数 rotation parameters选取限额 norm for selection选取限额 norm for selection选取指标 index for selection选权迭代法 iteration method with variable weights寻北器 north-finding instrument寻北器 north-finding instrument寻北器 polar finder压力验潮仪 pressure gauge亚太区域地理信息系统基础设施常设委员会 pcgiap亚太区域地理信息系统基础设施常设委员会permanent committee on gis infrastructure for asia and the pacific 严密平差 rigorous adjustment沿海测量 coastwise survey沿海测量 coastwise survey颜色空间 color space颜色空间 color space验潮 tidal observation验潮仪 tide-meter验潮站 tidal station验潮站零点 zero point of the tidal阳像 positive image遥感 remote sensing遥感测深 remote sensing sounding遥感模式识别 pattern recognition of remote sensing 遥感平台 remote sensing platform遥感数据获取 remote sensing data acquisition遥感制图 remote sensing mapping野外地质图 field geological map野外填图 field mapping因瓦基线尺 invar baseline wire阴像 negative image阴像 negative image引潮力 tide-generating force引潮位 tide-generating potential引航图集 pilot atlas引力 gravitation引力位 gravitational potential引水锚地 pilot anchorage引张线法 method of tension wire alignment印刷版 printing plate荧光地图 fluorescent map影像 image影像 imagery影像地质图 geological photomap影像分辨力 image resolution影像分辨力 resolving power of image影像复原 image restoration影像金字塔 image pyramid影像匹配 image matching影像融合 image fusion影像数据库 image database影像相关 image correlation影像镶嵌 image mosaic影像质量 image quality游艇用图 smallcraft chart游艇用图 yacht chart渔礁 fishing rock渔堰 fishing haven渔业用图 fishing chart渔栅 fishing stake宇宙制图 cosmic mapping宇宙制图 cosmic mapping预报地图 prognostic map预打样图 pre-press proof预制符号 preprinted symbol预制感光板,*ps 版 presensitized plate原子钟 atomic clock圆曲线测设 circular curve location圆曲线测设 circular curve location圆-圆定位,*距离-距离定位 range-range positioning 圆柱投影 cylindrical projection圆柱投影 cylindrical projection圆锥投影 conic projection圆锥投影 conic projection远程定位系统 long-range positioning system远海测量 pelagic survey月平均海面 monthly mean sea level月球轨道飞行器 lunar orbiter运动方程分析解 analytical solution of motion equation 运动方程数值解 numerical solution of motion equation 运动方程数值解 numerical solution of motion equation 运动线法 arrowhead method晕滃法 hachuring晕渲法 hill shading载波相位测量 carrier phase measurement载波相位测量 carrier phase measurement再分结构 subdivisional organization凿井施工测量 construction survey for shaft sinking凿井施工测量 construction survey for shaft sinking栅格绘图 raster plotting栅格数据 raster data站心坐标系 topocentric coordinate system章动 nutation章动 nutation照相排字机 phototypesetter照相制版镜头 printer lens照相制版镜头 process lens照准点 sighting point照准点归心 sighting centring真地平线,*真水平线 true horizon真实孔径雷达 real-aperture radar真误差 true error真子午线 true meridian整体大地测量 integrated geodesy整体感 associative perception整体结构 extensional organization正常高 normal height正常高 normal height正常水椭球,*水准椭球 normal level ellipsoid 正常水椭球,*水准椭球 normal level ellipsoid 正常引力位 normal gravitation potential正常引力位 normal gravitation potential正常重力 normal gravity正常重力 normal gravity正常重力场 normal gravity field正常重力场 normal gravity field正常重力公式 normal gravity formula正常重力公式 normal gravity formula正常重力位 normal gravity potential正常重力位 normal gravity potential正常重力线 normal gravity line正常重力线 normal gravity line正方形分幅 square mapsubdivision正片 positive正象 right-reading正直摄影 normal case photography正直摄影 normal case photography正轴投影 normal projection正轴投影 normal projection郑和航海图 zheng he's nautical chart政治地图 political map支水准路线 spur leveling line直方图规格化 histogram specification直方图均衡 histogram equalization直角坐标网 rectangular grid志田数 shida'a number制图分级 cartographic hierarchy制图分级 cartographic hierarchy制图简化 cartographic simplification制图简化 cartographic simplification制图精度 mapping accuracy制图夸大 cartographic exaggeration制图夸大 cartographic exaggeration制图专家系统 cartographic expert system制图专家系统 cartographic expert system制图资料 cartographic document制图资料 cartographic document制图资料 source material质底法 quality base method质量感 qualitative perception秩亏平差 rank defect adjustment置信度 confidence置信度 confidence中程定位系统 medium-range positioning system中国测绘学会chinese society of geodesy, photogrammetry and cartog中国测绘学会 csgpc中国测绘学会chinese society of geodesy, photogrammetry and cartog中国测绘学会 csgpc中国大地测量星表 cgsc中国大地测量星表 chinese geodetic stars catalogue中国大地测量星表 cgsc中国大地测量星表 chinese geodetic stars catalogue中华人民共和国测绘法surveying and mapping law of the people's republic of中天法 transit method中误差 rmse中误差 root mean square error中心式快门 between-the-lens shutter中心式快门 lens shutter中星仪 transit instrument中性色调,*灰色调 middle tone中央子午线 central meridian中央子午线 central meridian钟偏 clock offset钟偏 clock offset钟速 clock rate钟速 clock rate重采样 resampling重力 gravity重力测量 gravity measurement重力场 gravity field重力潮汐改正 correction of gravity measurement for tide 重力潮汐改正 correction of gravity measurement for tide 重力垂线偏差 gravimetric deflection of the vertical重力垂直梯度 vertical gradient of gravity重力点 gravimetric point重力固体潮观测 gravity observation of earth tide重力归算 gravity reduction重力基线 gravimetric baseline重力基准 gravity datum重力数据库 gravimetric database重力水平梯度 horizontal gradient of gravity重力梯度测量 gradiometry重力梯度测量 gravity gradient measurement重力梯度仪 gradiometer重力位 gravity potential重力仪 gravimeter重力异常 gravity anomaly周期误差 periodic error周跳 cycle slip周跳 cycle slip轴颈误差 error of pivot主垂面 principal plane [of photograph]主垂面 principal vertical plane主动式遥感 active remote sensing主分量变换 principal component transformation 主合点 principal vanishing point主核面 principal epipolar plane主核线 principal epipolar line主检比对 main/check comparison主台 main station主轴线测设 setting-out of main axis属性精度 attribute accuracy助曲线,*辅助等高线 extra contour专题测图仪 thematic mapper专题测图仪 tm专题层 thematic overlap专题地图 thematic map专题地图集 thematic atlas专题地图学 thematic cartography专题海图 thematic chart专用地图 special use map转点仪,*制点仪 point transfer device转绘仪 sketchmaster状态向量 state vector准确度 accuracy姿态 attitude姿态参数 attitude parameter姿态测量遥感器 attitude-measuring sensor资源与环境遥感remote sensing for natural resources and environment子午面 meridian plane子午圈 meridian子午圈曲率半径 radius of curvature in meridian自动安平水准仪 automatic level自动安平水准仪 compensator level自动安平水准仪 compensator level自动化地图制图 automatic cartography自动绘图 automatic plotting自动空中三角测量 automatic triangulation自动坐标展点仪 automatic coordinate plotter自检校 self-calibration自然地图 physical map自准直目镜 autocollimating eyepiece综合测绘系统 general surveying system综合地图 comprehensive map综合地图 comprehensive map综合地图集 comprehensive atlas综合地图集 comprehensive atlas综合法测量photo planimetric method of photogrammetric mapping纵断面测量 profiles survey纵断面图 profile纵断面图 profile diagram组合地图 homeotheric map组合定位 integrated positioning钻孔位置测量 bore-hole position survey最大似然分类 maximum likelihood classification最小二乘法 least square method最小二乘配置法,*最小二乘拟合推估法least squares collocation最小二乘相关 least squares correlation最小距离分类 minimum distance classification左右视差 horizontal parallax左右视差 x-parallax坐标地籍 coordinate cadastre坐标地籍 coordinate cadastre坐标方位角 grid bearing坐标格网 coordinate grid坐标格网 coordinate grid坐标量测仪 coordinate measuring instrument坐标量测仪 coordinate measuring instrument坐标增量 increment of coordinate坐标增值闭合差 closing error in coordinate increment坐标增值闭合差 closing error in coordinate increment坐标中误差 mean square error of coordinate。
sequential relationship analysis method
sequential relationship analysis method全文共四篇示例,供读者参考第一篇示例:序贯关系分析方法(sequential relationship analysis method)是一种用于研究变量之间的时间序列关系的统计方法。
这种方法可以帮助研究者确定变量之间的因果关系或影响关系,从而揭示变量之间的复杂交互作用。
序贯关系分析方法在许多领域中都有广泛的应用,包括经济学、社会科学、生物学等。
在经济学中,序贯关系分析方法被用来研究不同经济变量之间的时间序列关系,从而预测未来的经济走势。
在社会科学中,这种方法可以帮助研究者理解社会现象的演变过程,揭示其中的规律和因果关系。
序贯关系分析方法的基本思想是通过统计分析来确定变量之间的时间序列关系。
研究者需要收集各个变量的时间序列数据,并对这些数据进行预处理,以确保数据的准确性和可靠性。
然后,研究者可以利用统计方法如相关分析、回归分析等来确定变量之间的关系,从而找出其中的因果关系或影响关系。
序贯关系分析方法有许多优点。
这种方法能够帮助研究者理解变量之间的动态关系,揭示变量之间的内在联系。
序贯关系分析方法能够帮助研究者预测未来的趋势和发展方向,为决策提供参考依据。
这种方法还可以帮助研究者发现变量之间的隐藏关系,为进一步研究提供新的思路和方法。
在使用序贯关系分析方法时,研究者需要注意一些问题。
要选择适当的统计方法来进行分析,以确保分析结果的可靠性和有效性。
要考虑变量之间可能存在的复杂关系,避免简单化和片面化的解释。
要注意数据的准确性和完整性,以避免分析结果的偏差和误导。
序贯关系分析方法是一种有用的工具,可以帮助研究者揭示变量之间的时间序列关系,发现其中的规律和因果关系。
通过适当的分析和解释,研究者可以更好地理解复杂系统的运行机制,为未来的研究和决策提供有益的参考。
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第二篇示例:序列关系分析方法(Sequential Relationship Analysis Method)是一种用于研究事物之间相互关系的方法。
经济社会调查中的空间平衡抽样设计
摘要:在经济社会调查中,总体单元之间的空间相关性普遍存在,对传统抽样设计提出了挑战。针对这 一问题,提出了使用经纬度坐标作为空间辅助信息,借助空间平衡抽样算法获取样本的设计思路。该种算法 利用总体单元之间的空间距离设计抽样算法更新包含概率,使空间上距离较近的单元倾向于不同时进入样 本,从而使样本单元在空间上均匀覆盖。实证研究结果表明,随着样本量连续增加,空间平衡抽样设计的估 计量标准差在合理的抽样比范围内总是优于传统抽样设计,能够显著提高估计效率。
金勇进(通讯作者),男,北京人,教授,博士生导师,研究方向:抽样技术。
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统计与信息论坛
Hale Waihona Puke 地理学中的空间平衡抽样设计进行抽样,利用总体 单元的空间位置信息对抽样设计进行改进,解决传 统抽样设计面对空间总体时所面临的难题。
学者们关于空间平衡抽样方法的研究取得了一 些 成 果,Stevens 等 提 出 广 义 随 机 棋 盘 分 层 法 (GRTS),并将其应用到自然资源的调查当中,其思 路是利用一个函数将二维空间的坐标投影到一维空 间并基于一些限制条件加以随机排序,然后使用系 统πPS抽样对一维空间上的样本进行样本点选择, 进而使 入 样 单 元 在 空 间 上 尽 可 能 地 分 散[1]。 姜 成 晟、王劲峰等总结了几种主流的地理学空间抽样中 的样本点选择方法,并认为 GRTS抽样并不是一种 严格的样本点布局方法,因为该种方法改造了样本 空间的结构[2]。Dickson等认为 GRTS方法并不完 美,因为空间重构会导致一维空间中的样本次序存 在不确定性,样本点排列次序的不同会对二阶包含 概率产生影响[3]。基于 GRTS法存在的缺陷,学者 们 提 出 了 空 间 平 衡 抽 样 设 计 的 改 进 方 法。 Grafstrm 提出 了 空 间 相 关 泊 松 抽 样 法 (Spatially CorrelatedPoissonSampling),该 种 方 法 利 用 预 设 的距离函数对包含概率进行更新,使空间上距离较 近的单元倾向于不同时进入样本,进而抽取到在空 间上具有 平 衡 性 的 样 本[4]。Grafstrm等 介 绍 了 局 部枢轴法(LocalPivotalMethods)在空间平衡抽样 设计中的应用,在实际应用中有 LPM1和 LPM2两 种算法[5],前者抽取的样本点分布更加均衡,后者计 算速度更快。Grafstrm 等将局部枢轴法的思想与立 方体法(CubeMethod)进行结合,提出了空间双重平 衡抽样法(DoublyBalancedSpatialSampling),又称局 部立方体法(LocalCubeMethod)[6]。其思路是在总 体空间中抽取一系列空间子集,在子集内部使用立方 体法 的 起 飞 步 (Flightphase)和 着 陆 步 (Landing phase)进行抽样。
ICU脓毒症患者应用哌拉西林
ICU 脓毒症患者应用哌拉西林/他唑巴坦药物浓度的影响因素分析洪曦菲 林雪 朱忠华 郑绍鹏[摘 要] 目的 探究影响重症医学科(ICU )内脓毒症患者应用哌拉西林/他唑巴坦治疗后血浆哌拉西林浓度的因素。
方法 回顾性收集2020年8月至2022年3月黄山市人民医院ICU 患有脓毒症,并接受哌拉西林/他唑巴坦常规剂量4.5 g (哌拉西林4 g/他唑巴坦0.5 g )静脉滴注,每8小时输注1次,同时监测哌拉西林浓度的患者82例,根据治疗药物监测(TDM )情况分为达标组(n =34)与未达标组(n =48),采用多因素logisitic 回归分析筛选哌拉西林浓度不足的影响因素,通过受试者工作特征(ROC )曲线分析危险因素对血药浓度不足的预测价值。
结果 单因素分析显示,年龄、身体质量指数(BMI )、外伤、手术、急性生理学与慢性健康状况评分Ⅱ(APACHE Ⅱ)、序贯器官衰竭(SOFA )评分、肌酐清除率(CrCl )与哌拉西林药物浓度不足差异均有统计学意义(P <0.05)。
多因素lo⁃gistic 回归显示:BMI (OR =1.611,95%CI :1.069~2.427)、CrCl (OR =1.249,95%CI :1.059~1.474)是哌拉西林浓度不足的独立危险因素(均P <0.05)。
BMI 预测哌拉西林浓度不足的曲线下面积(AUC )为0.784,最佳截断值为20.78 kg/m 2,灵敏度为83.3%,特异度为73.5%;CrCl 的AUC 为0.975,最佳截断值为41.62 mL/min ,灵敏度为97.9%,特异度为88.2%。
结论 对于ICU 脓毒症患者,BMI 和CrCl 是哌拉西林药物浓度不足的独立危险因素,二者与药物浓度呈负相关,都有很好的预测价值,而CrCl 对哌拉西林药物浓度不足的预测价值更高。
[关键词]哌拉西林/他唑巴坦;脓毒症;血浆药物浓度;肌酐清除率;危险因素doi:10.3969/j.issn.1000-0399.2023.11.007Impact factors associated with drug concentration of piperacillin/tazobactam in patients with sepsis in ICU HONG Xifei 1,LIN Xue 1,ZHU Zhonghua 2,ZHENG Shaopeng 11.Department of Critical Care Medicine,Huangshan City People's Hospital,Huangshan 245000,China2.Department of Pharmacy,Huangshan City People'sHospital,Huangshan 245000,ChinaFunding project:Anhui Province 2021 Key Medical and Health Specialty Construction Project (No.2021),the fifth batch of Huangshan City "Special Branch Plan" Innovation Leading Talents Research Fund Project (No.Huang Talent Office [2020] No.3)Correspondingauthor:ZHENGShaopeng,********************[Abstract ] Objective To explore the factors affecting the plasma concentration of piperacillin obtained after piperacillin/tazobactamtreatment in patients with sepsis within the Intensive Care Unit (ICU). Methods The clinical data of 82 patients with sepsisadmitted to the ICU of Huangshan Hospital from August 2020 to March 2022 were retrospectively analyzed, and the patients received a regular dose of piper⁃acillin/tazobactam of 4.5g (piperacillin 4 g/ tazobactam 0.5 g), with simultaneous monitoring of piperacillin concentrations.The 82 cases met the inclusion criteria.According to the therapeutic drug monitoring(TDM),they were divided into standard group(n =34) and substandard group(n =48).Multiple logistic regression analysis was conducted to screen the influencing factors of insufficient piperacillin concentration in blood, and the predictive value of risk factors was analyzed by the receiver operating characteristic curve(ROC) of the subjects. Results The univariate analysis revealed that age,body mass index (BMI),trauma, surgery,acute physiology and chronic health score Ⅱ (APACHE Ⅱ), sequential organ failure (sofa) score,creatinine clearance rate(CrCl) were statistically significant(all P <0.05).Multiple logistic regression showed that BMI(OR = 1.611,95% CI: 1.069~2.427) and CrCl (OR =1.249,95% CI: 1.059~1.474) were independent risk factors for insufficient piperacillin concentra⁃tion(all P <0.05).The area under the curve (AUC) of BMI predicting insufficient piperacillin concentration was 0.784,the optimal cut-off value was 20.78 kg/m 2,the sensitivity was 83.3% and thespecificity was 73.5%. The AUC of CrCl was 0.975 and the best cut-off value was 41.62 mL/min,the sensitivity was 97.9%,and the specificity was 88.2%. Conclusions For ICU patients with sepsis,BMI and CrCl are independent risk· 临床医学 ·基金项目:安徽省2021医疗卫生重点专科建设项目(编号:2021),黄山市第五批市“特支计划”创新领军人才科研基金项目(编号:黄人才办[2020]3号)作者单位:245000 安徽黄山 黄山市人民医院重症医学科(洪曦菲,林雪,郑绍鹏),药剂科(朱忠华)通信作者:郑绍鹏,********************本文引用格式:洪曦菲,林雪,朱忠华,等.ICU 脓毒症患者应用哌拉西林/他唑巴坦药物浓度的影响因素分析[J ].安徽医学,2023,44(11):1309-1313.DOI :10.3969/j.issn.1000-0399.2023.11.007factors for piperacillin drug concentration,and both are inversely correlated with drug concentration and have good predictive value,while CrCl has a higher predictive value for piperacillin drug concentration.[Key words] Piperacillin/tazobactam;Sepsis;Plasma drug concentration;Creatinine clearance;Risk factors脓毒症是重症医学科(intensive care unit,ICU)常见病,其治疗不仅需要选择合适的抗菌药物,更需要结合抗菌药物的药物代谢动力学/药物效应动力学(Phar⁃macokinetics/pharmacodynamic, PK/PD)特点来优化给药方案,提高临床治愈率[1-2]。
脓毒症合并急性肺损伤患者SOFA评分、APACHE_Ⅱ评分、炎症因子水平变化及临床意义
脓毒症合并急性肺损伤患者SOFA 评分、APACHE Ⅱ评分、炎症因子水平变化及临床意义杨晓英,庞秀峰,朱玉琴,樊锐,冯忠强上海市杨浦区中心医院(同济大学附属杨浦医院)急诊科,上海200090【摘要】目的探讨脓毒症合并急性肺损伤(ALI)患者序贯性器官衰竭评分(SOFA)、急性生理与慢性健康状况评分Ⅱ(APACHE Ⅱ)、炎症因子水平的变化及其临床意义。
方法回顾性分析2020年1月至2022年5月期间上海市杨浦区中心医院收治的100例脓毒症合并ALI 患者(观察组)临床资料,选择本院同期单纯脓毒症患者80例作为研究组,在我院行体检的80例健康者作为对照组。
依据观察组患者病情严重程度分为低危组32例[急性生理与慢性健康状况评分(APACHE Ⅱ)<10分)]、中危组30例(APACHE Ⅱ评分10~20分)和高危组38例(APACHE Ⅱ评分>20分)。
依据观察组患者的临床结局分为存活组59例和死亡组41例。
比较观察组、研究组和对照组及不同病情不同严重程度、不同预后患者的SOFA 评分、APACHE Ⅱ评分及白细胞介素-22(IL -22)、肿瘤坏死因子-α(TNF -α)、C 反应蛋白(CRP)、降钙素原(PCT)水平,采用Pearson 相关性分析法分析炎症因子与SOFA 评分、APACHE Ⅱ评分的相关性。
结果观察组患者的SOFA 评分、APACHE Ⅱ评分、IL -22、TNF -α、CRP 、PCT 水平明显高于研究组和对照组,而研究组患者的上述指标明显高于对照组,差异均有统计学意义(P <0.05);随着观察组患者病情严重程度的加重,SOFA 评分、APACHE Ⅱ评分、IL -22、TNF -α、CRP 、PCT 水平也随之升高,其中高危组明显高于中危组,而中危组明显高于低危组,差异均有统计学意义(P <0.05);死亡组患者的SOFA 评分、APACHE Ⅱ评分、IL -22、TNF -α、CRP 、PCT 明显高于存活组,差异均有统计学意义(P <0.05);经Pearson 相关性分析结果显示,PCT 、IL -22、TNF -α、CRP 水平与SOFA 评分、APACHE Ⅱ评分均呈正相关性(P <0.05)。
Sampling Methods and the Central Limit Theorem
When a population can be clearly divided into groups based on some characteristic, we may use stratified random sampling. It guarantees each group is represented in the sample. The groups are also called strata. Once the strata are defined, we can apply simple random sampling within each group or stratum to collect the sample.
8-20
Example- Stratified Random Sampling
8-21
Example- Stratified Random Sampling
stratified random sampling will guarantee that at least one firm in strata 1 and 5 are represented in the sample. In this case, the number of firms sampled from each stratum is proportional to the stratum’s relative frequency in the population.
8-14
Example- Systematic Random Sampling
First, k is calculated as the population size divided by the sample size. For Computer Graphic, Inc., we would select every 20th invoice from the file drawers; in so doing the numbering process is avoided. If k is not a whole number, then round down.
Grey_2010_Food-Chemistry
Antiproliferative effects of sea buckthorn (Hippophae rhamnoides L.)extracts on human colon and liver cancer cell linesCarl Grey a,*,Cecilia Widén b ,Patrick Adlercreutz a ,Kimmo Rumpunen b ,Rui-Dong Duan caDepartment of Biotechnology,Lund University,P.O.Box 124,SE-22100Lund,SwedenbDepartment of Plant Breeding and Biotechnology Balsgård,Swedish University of Agricultural Sciences,Fjälkestadsvägen 459,SE-29194Kristianstad,Sweden cGastroenterology and Nutrition Laboratory,Biomedical Center,B11,Lund University,SE-22184Lund,Swedena r t i c l e i n f o Article history:Received 11August 2009Received in revised form 6October 2009Accepted 20November 2009Keywords:Antiproliferation Apoptosis Caco-2cells Cell culture Hep G2cells Isorhamnetin PhenolsProanthocyanidin RutinSea buckthorn Ursolic acida b s t r a c tSea buckthorn berries contain many bioactive compounds that have anticancer properties.To investigate whether the antiproliferative effects could be associated with the presence of certain compounds,a sequential extraction was performed.The extraction started with heptane followed by ethyl acetate,eth-anol,and water.A second protocol using ethanol:water (1:1)was also used.The contents of the extracts were determined and their effects on cell proliferation were investigated in both Caco-2and Hep G2cells.The ethyl acetate fraction was exclusively found to contain high levels of ursolic acid,together with low amounts of phenolics.The ethanol:water extracts contained high levels of phenolic compounds and pro-anthyocyanidin,but little ursolic acid.When the antiproliferative effects were examined,the strongest inhibitory effect was found in the ethyl acetate extract for the Caco-2cells and in the ethanol:water extract for the Hep G2cells.The antiproliferative effects were in both cases dose-dependent and were in the case of the ethyl acetate extract associated with an increase in apoptosis.The results obtained show that the choice of extraction solvent is of considerable importance and that ursolic acid might be more important than the polyphenols in inhibiting the cancer cell proliferation.Ó2009Elsevier Ltd.All rights reserved.1.IntroductionSea buckthorn (Hippophae L.)is a small Eurasian genus with species of great economic potential due to the possible use of dif-ferent parts of the plants:as nutritious food and fodder,as pharma-ceutical and cosmetic ingredients,as a soil enhancer,and as a source of energy.Today,there are seven recognized species in the genus,of which Hippophae rhamnoides has the widest distribu-tion (Swenson &Bartish,2002).Thanks to Russian and European plant breeders,domestication efforts based on native H.rhamno-ides subsp.mongolica and H.rhamnoides subsp.rhamnoides have re-sulted in access to several cultivars with both wide and specific adaptation.This plant material forms the basis of the growing pro-duction of sea buckthorn berries in Western Europe,especially in the countries around the Baltic Sea.Sea buckthorn berries are a rich source of many different bioac-tive compounds that may contribute to the claimed and proven health benefits of sea buckthorn juice and oil.Major bioactive com-pounds that have already been identified in the berries are ascorbicacid (Tiitinen,Hakala,&Kallio,2005;Tiitinen,Yang,Haraldsson,Jonsdottir,&Kallio,2006),carotenoids (Andersson,Olsson,Johans-son,&Rumpunen,2009),lipids (Kallio,Yang,Peippo,Tahvonen,&Pan,2002;Yang &Kallio,2001,2006),phenols (Arimboor,Kumar,&Arumughan,2008;Rosch,Bergmann,Knorr,&Kroh,2003;Shar-ma et al.,2008),phytoestrogens (Yang,Linko,Adlercreutz,&Kallio,2006),phytosterols (Li,Beveridge,&Drover,2007;Yang,Karlsson,Oksman,&Kallio,2001),tocopherols (Andersson,Rumpunen,Johansson,&Olsson,2008;Kallio,Yang,&Peippo,2002),and triter-penes (Cossuta,Simandi,Hohmann,Doleschall,&Keve,2007),all in significant amounts.Sea buckthorn was used in medicine as much as 1000years ago as an effective herb to treat various conditions such as arthritis,wounds,fever,pain,cough,stomach discomfort,and gynecological diseases in India,China,Mongolia,Russia and the Middle East.Re-cently,several biological effects of extracts of sea buckthorn have been identified and some of them have been tested in clinical trials.Oral administration of sea buckthorn oil in patients with atopic dermatitis was found to improve the inflammation,and the effects were correlated with the reduced formation of 4-leukotrienes and increased formation of 5-leukotrienes from arachidonic acid (Yang et al.,1999).Both animal studies and clinical trials have shown0308-8146/$-see front matter Ó2009Elsevier Ltd.All rights reserved.doi:10.1016/j.foodchem.2009.11.039*Corresponding author.Tel.:+46462220858;fax:+46462224713.E-mail address:carl.grey@biotek.lu.se (C.Grey).Food Chemistry 120(2010)1004–1010Contents lists available at ScienceDirectFood Chemistryj o u r n a l ho m e p a g e :w w w.e l s e v i e r.c o m /l o c ate/foodchemthat seed oil of sea buckthorn has a protective effect against tissue injury.It has been found to inhibit liver damage induced by CCl4in rats(Gao,Gu,Cheng,&Jiang,2003)and to increase the survival rate of mice treated with irradiation(Agrawala&Goel,2002;Ku-mar,Namita,&Goel,2002).Cell culture studies have shown that extract of sea buckthorn can inhibit cell proliferation or promote apoptosis in cancer cells such as HT29colon cancer cells,MCF-7 breast cancer cells,and HL-60leukemia cells(Hibasami et al., 2005;Olsson,Gustavsson,Andersson,Nilsson,&Duan,2004).In addition,sea buckthorn may also affect lipid metabolism,resulting in decreasing LDL levels,increasing HDL levels,and decreasing platelet aggregation,thus having an influence on the pathogenesis of cardiovascular diseases(Eccleston et al.,2002;Johansson,Korte, Yang,Stanley,&Kallio,2000;Yang&Kallio,2002).Apart from their effects on mammalian cells,extracts from sea buckthorn inhibit the growth of several strains of bacteria,particularly those that col-onize the gastrointestinal tract including Helicobacter pylori(Li,Xu, Zhang,Liu Jun,&Tan Ren,2005).While several biological effects of sea buckthorn have been re-ported,the effects vary significantly depending on the type of ex-tract used,i.e.on the composition of sea buckthorn extracts (Yang&Kallio,2002).Many bioactive compounds with possible anticarcinogenic effects may be found within the groups of poly-phenols and triterpens.Anticarcinogenic effects have previously been demonstrated for isorhamnetin(Teng,Lu,Wang,Tao,& Wei,2006)and ursolic acid(Andersson,Liu,Nilsson,&Duan, 2003;Pathak et al.,2007).The objective of the present study was (1)to compare the antiproliferative and apoptotic effects of differ-ent sea buckthorn extracts on human colon cancer cells(the Caco-2cell line)and human liver cancer cells(the Hep G2cell line),and (2)to determine whether the antiproliferative activities of sea buckthorn extracts are associated with the content of different bio-active compounds.2.Materials and methods2.1.Chemicals and cellsCaco-2and Hep G2cells were purchased from the American Tis-sue Culture Collection(Rockville,MD,USA).The Cell Death Detec-tion kit and the Cell Proliferation Reagent,4-[3-(4-lodophenyl)-2-(4-nitrophenyl)-2H-5-tetrazoliol]-1,3-benzene disulfonate(WST-1),were obtained from Roche Diagnostics GmbH(Mannheim,Ger-many).The Folin–Ciocalteau reagent(85%ortho-phosphoric acid, DMSO,methanol,acetonitrile and acetic acid)was obtained from Merck(Darmstadt,Germany).Gallic acid,sodium carbonate,and ursolic acid were from Sigma–Aldrich(Seelze,Germany).The stan-dards used for HPLC analysis(procyanidin B2,isorhamnetin-3-O-rutinoside,kaempferol-3-glucoside,isorhamnetin-3-O-rutinoside, and rutin were purchased from Extrasynthese(Genay,France). 2.2.Plant materialsTo evaluate the effects of different extraction solvents,whole berries from the sea buckthorn cultivar H.rhamnoides‘BHi 10726’were coarsely ground while still frozen and then lyophilised before extraction.To screen cultivars for ursolic acid content and to evaluate the effects,berries from twenty-four cultivars and ad-vanced selections of sea buckthorn were lyophilised.The seeds were removed and theflesh with skin was ground in a laboratory mill(Yellow line,A10;IKA-Werke,Staufen,Germany)before extraction.Three cultivars of sea buckthorn with different ursolic acid content in the berries were then chosen for further tests on cell cultures:low(H.rhamnoides‘BHi10941’),medium(H.rhamno-ides‘BHi10726’),and high ursolic acid content(H.rhamnoides ‘Podaruk Sadu’).2.3.Preparation of extractsTwo protocols were used to extract the sea buckthorn berries. Thefirst protocol was a sequential extraction using four different solvents of different polarity,starting with the most unpolar.The solvents were used in the following order:n-heptane,ethyl ace-tate,96%ethanol,and water.The second protocol contained one solvent mixture,ethanol:acidified water(1:1),the water phase containing50mM H3PO4.Lyophilised sea buckthorn berries with or without seeds(5g)were put in a500ml E-bottle.Solvent (50ml)was added,the bottle was capped,and the extraction was carried out at ambient temperature in the dark,with gentle shaking for24h.The extract wasfiltered,the solvent of thefiltrate was removed using a rotary evaporator and the remainingfiltrate was stored atÀ20°C.Before the proliferation and apoptosis exper-iments,the concentrated extracts were dissolved in2ml DMSO, except the heptane and water fractions.The concentrated heptane extract was already liquid and therefore used as it was.The dried water extract was dissolved in water andfilter-sterilised before it was used in the cell experiments.In thefirst protocol,the berries (on thefilter)were returned to theflask before the next solvent was added and the extraction proceeded in the same manner as just described.2.4.Analysis of phenolsThe content of total phenols was determined according to the Folin–Ciocalteau method(Singleton,Orthofer,&Lamuela-Raven-tos,1999).The extracts were mixed with Folin–Ciocalteau reagent, 15%Na2CO3,and water.The absorbance was measured at765nm after120min using a Shimadzu spectrophotometer(UV-2101PC). Gallic acid was used as a standard and the total amount of pheno-lics was expressed as l g of gallic acid equivalents per gramme dry weight.Selected phenolic compounds were analysed on a Shimadzu HPLC system equipped with a diode-array detector according to a method slightly modified from Schieber,Keller,and Carle (2001)and Tsao,Yang,Christopher,Zhu,and Zhu(2003).The elu-ent consisted of solvent A(0.952%acetic acid,4.76%acetonitrile) and solvent B(95%acetonitrile,5%methanol).The binary gradient was as follows:2%B(0–2min),15%B(2–8min),21%B(8–28min), 80%B(28–37min),and2%B(37–40min).A Phenomenex Synergi 4l Hydro-RP80A column(250Â4.6mm)and a guard C18precol-umn were used.Evaluation of data was carried out with Shimadzu Class-VP software(version6.13SP2).Retention times and spectral data were obtained and compared with those of the external stan-dards rutin,isorhamnetin-3-O-rutinoside,kaempferol-3-glucoside, and isorhamnetin-3-O-rutinoside.Detection was carried out at 350nm,the injection volume was10l l,and theflow rate was1.0ml/min.2.5.Analysis of proanthocyanidinsProanthocyanidins were analysed according to the method pub-lished by Salminen et al.(2005).The eluent consisted of solvent A (0.05M H3PO4)and solvent B(acetonitrile).The binary gradient was as follows:2%B(0–3.5min),70%B(3.5–6min),95%B(6–8.5min),and0%B(8.5–15min).As the stationary phase a Super-spher100RP-18(75Â4mm)column and a C18precolumn were used.Detection was carried out at240and510nm,and data were compared with those of procyanidin B2as a standard.The injection volume was5l l and theflow rate was1.0ml/min.C.Grey et al./Food Chemistry120(2010)1004–101010052.6.Analysis of ursolic acidThe ursolic acid content of the samples was determined by the method described by(Cui et al.,2006).The isocratic eluent con-sisted of92%methanol and0.03%H3PO4.The separation was per-formed using a Phenomenex Synergi4l Hydro-RP80A (250Â4.6mm)column and a guard C18precolumn.The injection volume was10l l and theflow rate was0.8ml/min.Detection was carried out at210nm against a standard of ursolic acid.Each sam-ple was analysed in triplicate.2.7.Cell cultureMonolayer cultures of Caco-2cells were grown in Dulbecco’s modified Eagle’s medium(DMEM)with1mM sodium pyruvate, and Hep G2cells were cultured in RMPI-1640medium with L-glu-tamine.Both media contained100IU/ml penicillin,10l g/mL streptomycin,and10%heat-inactivated FBS.The cells were grown and maintained at37°C in an incubator containing95%air and5% CO2.The cells were harvested with0.05%trypsin/0.02%EDTA at about80%confluence,and subcultured in their respective media before use.After24h incubation for attachment,the cells were treated with medium containing sea buckthorn extracts or ursolic acid,used as a positive control,at various concentrations for48h. Sea buckthorn extracts and ursolic acid stock solution(80mM) were dissolved in DMSO.Medium containing0–2%DMSO(depend-ing on the experiment)was used as control.2.8.Assay of cell viabilityThe cell viability was assayed by determination of the cleavage of tetrazodium salt(WST-1)to formazan by mitochondrial dehy-drogenases as described previously by(Olsson et al.,2004).The amount of formazan formed is proportional to the number of via-ble cells.Briefly,2Â104cells in200l l medium were incubated with sea buckthorn extracts or ursolic acid in a microtiter plate as described above.The medium was then removed and the cells were incubated with110l l medium containing10l l WST-1re-agent for about1h.The production of formazan was determined spectrophotometrically at415nm against655nm as a back-ground.The results were expressed as a percentage of the control. The sample size for each concentration was six wells and most experiments were repeated at least twice.2.9.Assay of apoptosisApoptosis was detected using the Cell Death Detection ELISA kit,which is based on a semiquantitative determination of the enrichment of mono-and oligonucleosomes in the cytoplasm (Liu et al.,2002).Briefly,1Â104cells were seeded in a96-well microplate and incubated with sea buckthorn extracts or ursolic acid for either24h for the Caco-2cells or48h for the Hep G2cells. The cells were then lysed and centrifuged.The supernatant con-taining the cytoplasmic histone-associated DNA fragments was re-acted with the anti-histone antibodies labelled with biotin,and anti-DNA antibodies coupled to peroxidase,for2h.The substrates of the peroxidase were added and color development was mea-sured with a microplate reader(Bio-Rad,Stockholm,Sweden)at 415nm against490nm as background.The specific enrichment of mono-and oligonucleosomes released into the cytoplasm was expressed as enrichment factor relative to the control.In both the apoptosis and the proliferation assay,ursolic acid at80l M was used as a positive control.Our previous study have shown that at this concentration ursolic acid significantly inhibited cell prolif-eration and induced apoptosis(Andersson et al.,2003).2.10.Statistical analysisThe results of the proliferation experiments were expressed as the mean±the95%confidential interval.Each observation was re-peated in six wells in one tofive separate experiments.Confiden-tial intervals were calculated using the Student’s-t distribution and the two tailed t-test was used to determine significant results. Outliers were rejected if they were found positive in Grubbs’test ata significance level of5%.3.Results and discussionThe levels of phenolic compounds and ursolic acid of different extracts is given in Table1.The heptane extract had the lowest concentration of total phenols,and an initial screening also re-vealed a very low content of ursolic acid(close to the detection limit).Also,the water extract contained low amounts of the com-pounds analysed.As expected,the extracts using ethanol were generally rich in phenolic compounds.The ethanol:water extracts (1and2)had consistently higher concentrations of phenolics than the other extracts;finely ground berries were used in the second extract protocol,which contained higher levels of most compounds analysed than thefirst extraction method.The ethyl acetate extract clearly had the highest level of ursolic acid–about ten times the amount of the ethanol extract–but,on the other hand,quite low concentrations of most phenolic compounds compared to the ethanol extracts.DMSO was used to dissolve all the extracts(except the water and heptane fractions).In order to dissolve as much solids of the evaporated extract as possible,a relatively high amount of DMSO had to be used.Therefore,the effect on cell proliferation of DMSO alone was investigated,before examining the biological effects of the extracts.A slight inhibition by DMSO occurred in the Caco-2 cell line(p<0.05above1%),whereas a significant(p<0.05)in-crease in the proliferation was observed in the Hep G2cells (Fig.1).Thus,when DMSO concentrations above0.5%are used,it is also necessary to consider the effect of DMSO alone.The inhibi-tion of cell proliferation found in Caco-2cells by DMSO is in agree-ment with the toxic properties of DMSO(Crawford&Braunwald, 1991).The stimulation of the Hep G2cell proliferation might beTable1The levels of phenolic compounds and ursolic acid of24sea buckthorn cultivars,given as l g/g d.w.±SD.Extract a TP PC RT IH-3R IH-3G KF-3G UAHeptane362±9––––––Ethyl acetate1234±50998±5318.3±0.4149±3126±2 4.5±0.1946±17 Ethanol2632±182365±6879.6±2.8490±16250±88.9±0.392±2 Water456±20683±50 6.2±0.131±0.46±50.6±0.024±2 Ethanol:water(1)3737±562342±14879.8±4.1498±24282±139.9±0.543±6 Ethanol:water(2)4213±426836±52596.2±13.6549±29300±1611.8±2.220±16a TP=total phenolics;PC=proanthocyanidine;RT=rutin;IH-3R=isorhamnetin-3-O-rutinoside;IH-3G=isorhamnetin-3-O-glucoside;KF-3G=kaempferol-3-glucoside; UA=ursolic acid.1006 C.Grey et al./Food Chemistry120(2010)1004–1010connected to an upregulated detoxifying function of the liver cells induced by DMSO.Also,DMSO has previously been shown to stim-ulate proliferation in fetal liver cells (Koyama,Ehashi,Ohshima,&Miyoshi,2009).The effect of the different sea buckthorn extracts was first eval-uated by measuring Caco-2cell proliferation.As shown in Fig.2,the extracts were found to inhibit cell proliferation in the concen-tration range of 0.25–2%(v/v),whereas no effect was observed be-low 0.1%for any extracts (data not shown).In the sequential extraction,the ethyl acetate fraction stood out as the most effec-tive one,showing a clear dose-dependent inhibition.The degree of the inhibition was much higher than that induced by DMSO alone (Fig.1),indicating a true positive effect that reflects the com-position of the extract.The heptane and pure ethanol fractions also showed inhibitory effects,but both were much weaker and less dependent on the dose.The water fraction was the only extract not found to have any significant ing the second extrac-tion protocol,the ethanol:water extracts were also found to inhibitthe proliferation to a higher degree than the effect of DMSO alone at 1%and 2%.The second extract (ethanol:water (2))using fine ground berries was found to be more effective.However,the dose dependency was quite different compared to that of the ethyl ace-tate extract,since the effect was rather sudden and no concentra-tion giving an intermediate inhibition was found.In addition,pure ursolic acid used as positive control at 80l M was found to strongly suppress the cell proliferation to about 3%of the control (data not shown);this was comparable to the effects of the 2%ethyl acetate extracts that contained approximately 100l M ursolic acid.At this stage it was decided to continue with the extracts show-ing the strongest inhibitory effects,the ethyl acetate fraction and the two ethanol:water extracts.As shown in Fig.3,these extracts were tested on Hep G2cells,a different cancer cell line In contrast to the results with Caco-2cells,the ethanol:water extracts inhib-ited the proliferation more efficiently than the ethyl acetate frac-tion,especially the second ethanol:water extract.Also,a more clear dose-dependant response was found for the ethanol:water extract up to 1%.But at 2%all of the extracts increased cell prolif-eration.The reason for the weak effect of the ethyl acetate extracts in Hep G2cells may indicate that hepatic cells,which are glandular cells,are less sensitive than the epithelial Caco-2cells.The less effective inhibition in cell proliferation induced by the etha-nol:water extracts at 2%was probably due to the increase in cell proliferation caused by the relatively high DMSO concentration (see Fig.1).Ursolic acid was also included in these experiments,and a concentration of 80l M inhibited cell proliferation to about 7%.The results obtained above showed a strong inhibition of cell proliferation for the ethyl acetate and ethanol:water extracts.The results are consistent with a previous study in which etha-nol:water-derived sea buckthorn extracts were also found to inhi-bit proliferation of HT29and MCF-7cells,although the inhibition was reached at higher concentrations of extract (Olsson et al.,2004).The antiproliferation results for ursolic acid obtained here for both Caco-2and Hep G2are also similar to the effects reported in a previous study using 40and 80l M ursolic acid on HT29cells (Andersson et al.,2003).To confirm whether the observed inhibition of cell proliferation was associated with an apoptotic effect,the ethyl acetate and the-200204060801001201401600.250.512Extract concentration % (v/v)C e l l p r o l i f e r a t i o n (%)Hep EtAc EtOH H 2OEtOH:H 20 (1)EtOH:H 2O (2)bcdadefabcbcbc facdeb bfbabdadefbdefacdebdefabcefabcdfabcdebdefacdabdefabcefacdfacdeFig. 2.Inhibition of proliferation of Caco-2cells using different extracts as indicated.Pure culture medium was used as control.The dried extracts from 5g (d.w.)of berries were dissolved in 2ml of DMSO and mixed with culture medium in different ratios,shown as volume %.The dried heptane extract was used directly and the water extract was dissolved in 2ml of water.Error bars represent the 95%confidence intervals and significant results within the same concentration are indicated as a p <0.05vs Hep,b p <0.05vs EtAc,c p <0.05vs EtOH,d p <0.05vs H 2O,ep <0.05vs EtOH:H 2O (1),f p <0.05vs EtOH:H 2O (2).C.Grey et al./Food Chemistry 120(2010)1004–10101007ethanol:water extracts were analysed with an ELISA-based Cell Death Detection assay,using Caco-2and Hep G2cells.The results of two repeated experiments are shown in Fig.4A and B.Ethyl ace-tate extracts induced apoptosis in both Caco-2and Hel G2cells. Pure ursolic acid(at80l M)was also effective(data not shown), which is in agreement with the results obtained by Andersson et ing HT29cells(Andersson et al.,2003).However,weaker effects were observed for the ethanol:water extract.The apoptosis results basically followed the proliferation results found for Caco-2,since a strong inhibition of proliferation was observed for the ethyl acetate extract and ursolic acid,whereas a concentration of ethanol:water extracts(ethanol:water(1))of1%or less did not in-hibit the growth.In contrast,the strong inhibition of proliferation using ethanol:water extracts at1%on Hep G2cells could not be correlated to an apoptotic effect.These results indicate that the ethyl acetate extract has a composition that gives both antiprolif-erative and proapoptotic effects,whereas the effects of the compo-sitions in ethanol:water extract are mainly antiproliferative.The major composition found in ethyl acetate fraction was urso-lic acid,which is a type of triterpenoids and its anticancer effects have been well documented(Pathak et al.,2007).Interestingly,in line with the results presented here,Teng et al.found that when fractioning sea buckthorn extracts,only the ethyl acetate fraction contained active compounds that were responsible for cytotoxicity in BEL-7402cells(human hepatocellular carcinoma)(Teng et al.,2006).Since their ethyl acetate fraction was rich in polyphenols, they assumed that the polyphenols were responsible for the inhi-bition of proliferation.However,the ursolic acid content was not analysed in their study,and in the light of the results obtained here,the importance of ursolic acid may have been overlooked.Ursolic acid has been shown to have anticancer properties that are mediated by multiple signaling pathways,leading to apoptosis and inhibition of proliferation,invasion,and metastasis(Ikeda, Murakami,&Ohigashi,2008).It also inhibits STAT3proteins(sig-nal transducers and activators of transcription),which are impor-tant in tumor cell survival,proliferation,and angiogenesis (Aggarwal&Shishodia,2006;Pathak et al.,2007).Isorhamnetin, found in abundance in different glycosylated forms in sea buck-thorn,has been shown in vitro to have antitumour activity in BEL-7402cells,giving about50%inhibition of cell viability at 600l M when incubated for24h(Teng et al.,2006).The concentra-tions reached here were lower,where the combined concentration of the different forms of isorhamnetin reached about100l M in the 2%mixtures of ethanol:water extracts.Following screening of24cultivars,three sea buckthorn culti-vars(‘BHi10941’,‘Podaruk Sadu’and‘BHi10726’)were selected1008 C.Grey et al./Food Chemistry120(2010)1004–1010and extracted according to protocol1,in which the ethyl acetate fractions were used to investigate whether any genotype-depen-dent difference in cell proliferation could be detected.The extracts were tested on both the Caco-2and Hep G2cell lines in relatively low doses(up to0.5%)to avoid the interference of DMSO.As shown in Fig.5A and B,all the extracts showed dose-dependant inhibitory effect on the cell proliferation.The difference between the extracts of the different cultivars was quite small.The‘BHi10941’ethyl acetate extract inhibited the growth somewhat more than the oth-ers,whereas the‘Podaruk Sadu’extract was significantly(p<0.01) less effective than the‘BHi10726’and‘BHi10941’extracts on Hep G2cells.The content of these extracts is given in Table2.The ef-fects observed in Fig.5do not correlate with the concentrations of polyphenols or ursolic acid found.The most likely reason is that the content of ursolic acid was in the8–50l M range(calculated from data in Table2),and at these concentrations the effects of pure ursolic acid have been found to be rather weak(Andersson et al.,2003).Thus,the inhibitory effects at the relatively low ex-tract concentrations used in Fig.5were not,at least solely,caused by a single component,highlighting the potential advantage of using whole extracts rather than using isolated compounds when trying to assess the physiological relevance of fruits and berries (Coates Emma et al.,2007;Lee,Lee,Surh,&Lee,2003).Synergistic effects in which combinations of phytochemicals show a greater inhibition of proliferation of human cancer cells than purified sin-gle compounds have previously been reported for different groups of polyphenols(Mertens-Talcott,Talcott,&Percival,2003;Seeram, Adams,Hardy,&Heber,2004).4.ConclusionsBased on our results,it is worthy of note that when evaluating berry extracts,the effects of important compounds such as ursolic acid may not be apparent if only one extraction solvent,e.g.etha-nol,is used.So far,most in vitro cancer cell studies involving berry and fruit extracts have mostly focused on the polyphenols,which are effectively extracted with alcohols.If a more accurate evalua-tion of the potential health benefits is desired,several extracts with different solvents should be tested–and perhaps also combina-tions of them.In addition,the fact that the ethyl acetate fraction was far more effective than both the ethanol fraction and the eth-anol:water extract(protocol2)in the present study indicates that the phenolics are not the most potent antiproliferative compounds present in sea buckthorn,a role that ursolic acid may possess instead.AcknowledgementsThis project was supported by the Swedish Research Council for the Environment,Agricultural Sciences,and Spatial Planning and by the Albert Påhlsson Foundation.We thank Anders Ekholm, Department of Plant Breeding and Biotechnology Balsgård,the Swedish University of Agricultural Sciences,for providing skillful support with the HPLC analyses.ReferencesAggarwal,B.B.,&Shishodia,S.(2006).Molecular targets of dietary agents for prevention and therapy of cancer.Biochemical Pharmacology,71(10), 1397–1421.Agrawala,P.K.,&Goel,H.C.(2002).Protective effect of RH-3with special reference to radiation induced micronuclei in mouse bone marrow.Indian 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老年脓毒症患者血清氨基末端脑钠肽前体升高的影响因素分析
论著DOI:10.16662/ki.1674-0742.2023.17.001老年脓毒症患者血清氨基末端脑钠肽前体升高的影响因素分析李程锦,石松菁,陈湘平,陈凤朱福建医科大学教学医院福建省老年医院重症医学科,福建福州350000[摘要]目的探讨影响老年脓毒症患者NT-proBNP升高的影响因素。
方法采用回顾性研究分析2017年10月—2019年12月福建省老年医院收治的老年脓毒症患者114例的临床资料。
根据患者确诊入院时的血清NT-proBNP水平是否升高,将其分为观察组(NT-proBNP升高)60例和对照组(NT-proBNP正常)54例。
收集患者的人口学特征以及既往病史、BMI、是否有脓毒性休克及SOFA评分、APACHE Ⅱ评分等。
入院时采集患者外周静脉血,送检血清肌酐、NT-proBNP、心肌损伤标志物、炎症指标、心肌抑制因子、心肌自身免疫抗体等指标。
以单因素和多因素分析老年脓毒症患者NT-proBNP的影响因素。
结果与对照组比较,观察组的脓毒性休克占比、SOFA评分、APACHEⅡ评分、CK-MB、cTnI、PCT、CRP、IL-1β、TNF-α、β1-AAB、M2-AA显著较高,Ccr水平更低,差异有统计学意义(P<0.05)。
Logistic多因素回归分析结果表明老年脓毒症患者NT-proBNP水平的独立影响因素为PCT、IL-1β、BMI、Ccr(P<0.05)。
结论老年脓毒症患者NT-proBNP的升高与BMI、PCT、IL-1β、Ccr指标相关,上述指标是老年脓毒症患者NT-proBNP升高的影响因素,但这些发现需要样本量更大的前瞻性研究进一步验证。
[关键词]脓毒症;氨基末端脑钠肽前体;炎症因子;心肌损伤标志物;心肌自身免疫抗体[中图分类号]R5 [文献标识码]A [文章编号]1674-0742(2023)06(b)-0001-07Analysis of Factors Affecting Elevated Serum Amino-terminal Brain Natri⁃uretic Peptide Precursors in Elderly Patients with SepsisLI Chengjin, SHI Songjing, CHEN Xiangping, CHEN FengzhuDepartment of Critical Care Medicine, Fujian Provincial Geriatric Hospital, Fujian Medical University Teaching Hos⁃pital, Fuzhou, Fujian Province, 350000 China[Abstract] Objective To investigate the influencing factors affecting the elevation of NT-proBNP in elderly patients with sepsis. Methods A retrospective study was used to analyze the clinical data of 114 cases of geriatric sepsis pa⁃tients admitted to Fujian Provincial Geriatric Hospital from October 2017 to December 2019. The patients were di⁃vided into 60 cases in the observation group (elevated NT-proBNP) and 54 cases in the control group (normal NT-proBNP) according to whether their serum NT-proBNP levels were elevated at the time of confirmed admission. The patients' demographic characteristics as well as past medical history, BMI, presence of septic shock and SOFA score and APACHE Ⅱ score were collected. Peripheral venous blood was collected from patients on admission and sent for serum creatinine, NT-proBNP, myocardial injury markers, inflammatory indexes, myocardial inhibitory factors, and myocardial autoimmune antibodies. Analyzed the influencing factors of NT proBNP levels in elderly sepsis patients us⁃ing single and multiple factors. Results Compared with the control group, septic shock percentage, SOFA score, APACHEⅡ score, CK-MB, cTnI, PCT, CRP, IL-1β, TNF-α, β1-AAB, and M2-AA in the observation group were significantly higher, Ccr levels was lower, the difference was statistically significant (P<0.05). Logistic multi-factor re⁃[基金项目]福建省卫生计生科研人才培养项目青年科研课题(2017/2/19)。
On Sequential Monte Carlo Sampling Methods for Bayesian Filtering
methods, see (Akashi et al., 1975)(Handschin et. al, 1969)(Handschin 1970)(Zaritskii et al., 1975). Possibly owing to the severe computational limitations of the time these Monte Carlo algorithms have been largely neglected until recently. In the late 80’s, massive increases in computational power allowed the rebirth of numerical integration methods for Bayesian filtering (Kitagawa 1987). Current research has now focused on MC integration methods, which have the great advantage of not being subject to the assumption of linearity or Gaussianity in the model, and relevant work includes (M¨ uller 1992)(West, 1993)(Gordon et al., 1993)(Kong et al., 1994)(Liu et al., 1998). The main objective of this article is to include in a unified framework many old and more recent algorithms proposed independently in a number of applied science areas. Both (Liu et al., 1998) and (Doucet, 1997) (Doucet, 1998) underline the central rˆ ole of sequential importance sampling in Bayesian filtering. However, contrary to (Liu et al., 1998) which emphasizes the use of hybrid schemes combining elements of importance sampling with Markov Chain Monte Carlo (MCMC), we focus here on computationally cheaper alternatives. We describe also how it is possible to improve current existing methods via Rao-Blackwellisation for a useful class of dynamic models. Finally, we show how to extend these methods to compute the prediction and fixed-interval smoothing distributions as well as the likelihood. The paper is organised as follows. In section 2, we briefly review the Bayesian filtering problem and classical Bayesian importance sampling is proposed for its solution. We then present a sequential version of this method which allows us to obtain a general recursive MC filter: the sequential importance sampling (SIS) filter. Under a criterion of minimum conditional variance of the importance weights, we obtain the optimal importance function for this method. Unfortunately, for numerous models of applied interest the optimal importance function leads to non-analytic importance weights, and hence we propose several suboptimal distributions and show how to obtain as special cases many of the algorithms presented in the literature. Firstly we consider local linearisation methods of either the state space model 3
Oracle基础(习题卷8)
Oracle基础(习题卷8)第1部分:单项选择题,共63题,每题只有一个正确答案,多选或少选均不得分。
1.[单选题]下列()不是一个角色A)CONNECTB)DBAC)RESOURCED)CREATE SESSION答案:D解析:2.[单选题]在以下命令中,一个使用哪一个来激活(开启)一个角色?( )A)SET ROLLB)ALTER USERC)CREATE ROLED)ALTER SYSTEM答案:A解析:3.[单选题]当一个段需要额外的磁盘空间时,应该增加哪一种数据库的逻辑组件?( )A)区段( extents)B)表空间C)数据库块D)操作系统块答案:A解析:4.[单选题]存储数据的逻辑单位,按大小依次为()。
A)表空间、数据块、区和段B)区、表空间、数据块和段C)段、区、表空间和数据块D)表空间、段、区和数据块答案:D解析:5.[单选题]A non-correlated subquery can be defined as . (Choose the best answer.)A)A set of one or more sequential queries in which generally the result of the inner query is used as the search value in the outer query.B)A set of sequential queries, all of which must return values from the same table.C)A set of sequential queries, all of which must always return a single value.D)A SELECT statement that can be embedded in a clause of another SELECT statement only.答案:A解析:C)alter system remove user brent cascade;D)drop user brent cascade;答案:D解析:7.[单选题]系统事件触发器共支持5种系统事件,下列()事件不会激发触发器。
Sequential-correlational method of evaluation of p
专利名称:Sequential-correlational method ofevaluation of probabilistic characteristics ofa hierarchical functional structure发明人:Alexander Bushel,Arkadi Relin申请号:US10424643申请日:20030428公开号:US20040215427A1公开日:20041028专利内容由知识产权出版社提供专利附图:摘要:Sequential-correlational method of evaluation of probabilistic characteristics of a hierarchical functional structure comprising structural elements described by respectivemathematical models of structural elements, that include input and output parameters, and dependencies between structural elements described by respective mathematical models of dependencies between structural elements, that include input and output parameters. In the method in order to implement the process of executing simulation steps the following is performed: generating random values of variable input parameters of mathematical models of the structural elements, in each simulation step, according to the specified rules of their variability, and determining the values of output parameters of the mathematical models of the structural elements taking into account the output parameters of linked to said structural elements mathematical models of dependencies between structural elements, in each simulation step; accumulating the simulation information about the values of output parameters of the said mathematical models of structural elements, and evaluating the probabilistic characteristics of said structural elements upon completion of all simulation steps utilizing the said accumulated simulation information.申请人:BUSHEL ALEXANDER,RELIN ARKADI更多信息请下载全文后查看。
sequential backward feature selection
sequential backward feature selection Sequential backward feature selection (SBFS) is a popular method used in machine learning and data analysis for feature selection. It involves iteratively removing features from a given dataset in a sequential manner, based on the performance of a selected model or classifier. Instead of starting with an empty set and adding features one by one like forward feature selection, SBFS starts with all the features and removes them step by step.The main objective of SBFS is to select a subset of features that can maximize the performance of the chosen model or classifier. This process helps to reduce the complexity of the model and increase its interpretability by removing irrelevant or redundant features.SBFS typically follows these steps:1. Initialization: All features are initially included in the subset.初始化:所有特征最开始都包含在子集中。
SOFA评分对特重度烧伤患者并发脓毒症的评估意义
SOFA评分对特重度烧伤患者并发脓毒症的评估意义研究生:邓燎原导师:李利平 主任医师、教授周昌宁 副主任医师南华大学附属第一医院 烧伤整形外科专业摘要:目的:回顾性研究SOFA评分在特重度烧伤患者并发脓毒症过程中的变化关系,明确特重度烧伤患者并发脓毒症的SOFA平均临界值。
寻找患者并发脓毒症的影响因素,为临床对特重度烧伤患者的个体化治疗,脓毒症及时有效的防治提供参考依据。
方法:回顾性分析2004年01月-2018年12月在南华大学附属第一医院烧伤整形外科住院的117例特重度烧伤患者的临床数据。
记录患者性别、年龄、烧伤面积(total body surfacearea ,TBSA)、有无吸入性损伤,记录住院第1、3、7、10、14、21天的氧合指数(PaO2/FiO2)、血小板计数(Platelet,PLT)、胆红素值、平均动脉压(Mean Arterial Pressure,MAP)、格拉斯哥评分(Glasgow Coma Scale,GCS)、血肌酐值、24小时尿量,根据序贯器官衰竭评分(Sequential Organ Failure Assessment,SOFA)标准统计SOFA值。
按第21天预后分为脓毒症组(试验组)和非脓毒症组(对照组);根据患者年龄分为青壮年组(18-40周岁)和中老年组(41-60周岁)。
采用配对t检验分析SOFA值在试验组与对照组间的差异。
LSD-t检验分析 组内SOFAI值的变化差异。
绘制SOFA值ROC曲线,根据AUC、P值、临界值、敏感度、特异度及95%CI等结果分析SOFA平均值与患者并发脓毒症的关系。
对SOFA值与患者并发脓毒症进行Pearson相关性分析。
对患者性别、年龄、烧伤面积及吸入性损伤4个变量进行多因素分析,找出其中对患者并发脓毒症的影响因素。
对多因素分析得出的影响因素采用Logistic分析,根据Β回归系数、OR值及P值预测影响因素存在时,患者并发脓毒症的风险性,得出独立危险因素。
gru 高光谱分类
gru 高光谱分类英文回答:GRU (Gated Recurrent Unit) is a type of recurrent neural network (RNN) that has been widely used in various applications, including hyperspectral image classification. In hyperspectral image classification, the goal is to assign each pixel in an image to a specific class or category based on its spectral information. GRU has shown promising results in this task due to its ability to capture long-term dependencies and handle variable-length sequences.One advantage of using GRU for hyperspectral image classification is its ability to effectively model the temporal dependencies present in the spectral data. Each pixel in a hyperspectral image represents the reflectance values at different wavelengths, and these values are highly correlated. GRU can capture the sequential patterns in the spectral data and learn to make accurate predictionsbased on the previous observations.Another advantage of GRU is its ability to handle variable-length sequences. In hyperspectral image classification, the number of spectral bands can vary across different images. Traditional methods often require fixed-length inputs, which can lead to information loss or inefficient processing. GRU can handle variable-length sequences by adaptively updating its hidden state and selectively attending to relevant information at each time step.Furthermore, GRU has a gating mechanism that allows it to control the flow of information within the network. The gating mechanism consists of an update gate and a reset gate, which regulate the flow of information from the previous time step and the current input. This gating mechanism helps GRU to selectively update its hidden state and filter out irrelevant information, leading to improved performance in hyperspectral image classification.In summary, GRU is a powerful tool for hyperspectralimage classification due to its ability to capture long-term dependencies, handle variable-length sequences, and selectively update its hidden state. By effectively modeling the temporal dependencies in the spectral data, GRU can improve the accuracy of classification results.中文回答:GRU(门控循环单元)是一种递归神经网络(RNN),在各种应用中被广泛用于高光谱图像分类。
omq-SOFA评分、降钙素原与脓毒症病情严重程度及预后的关系分析
- 110 -(4):1147-1153.[18] ZENG Q,HUANG Z,WEI L,et al. Correlations of serumcystatin C level and gene polymorphism with vascular cognitive impairment after acute cerebral infarction[J]. Neurol Sci,2019,40(5):1049-1054.[19] LAURIOLA M,D'ONOFRIO G,CICCONE F,et al.Relationship of homocysteine plasma levels with mild cognitive impairment, Alzheimer's disease, vascular dementia, psychobehavioral, and functional complications[J]. J AlzheimersDis,2021,82(1):235-248.[20] SERDAREVIC N,STANCIU A E,BEGIC L,et al. Serumuric acid concentration in patients with cerebrovascular disease (ischemic stroke and vascular dementia)[J]. Med Arch,2020,74(2):95-99.[21]陈新星,肖珊.丁苯酞联合多巴丝肼片治疗血管性帕金森综合征的临床疗效分析[J].山西医药杂志,2021,50(4):591-593.(收稿日期:2023-07-06)①潜江市中心医院 湖北 潜江 433100②荆州市第一人民医院omq-SOFA评分、降钙素原与脓毒症病情严重程度及预后的关系分析樊金山① 毛旭龙② 李世松①【摘要】 目的:分析产科改良快速序贯器官衰竭评估(obstetrics meliorate quick-sequential organ failure assessment,omq-SOFA)评分、降钙素原(procalcitonin,PCT)与脓毒症病情严重程度及预后的关系。
SUMMARY
and ^ k
( )
N ( ; Vk ), where
2
Vk = (X k T
and con dence intervals on termination. In a clinical trial comparing two treatments, the univariate parameter representing the treatment di erence is of prime importance and repeated z or t-tests can be used to monitor normally distributed data. If more than one endpoint is observed, a group sequential test can be based on a univariate measure formed from a linear combination of endpoints (see, for example, O`Brien, 1984), or the full multivariate mean may be investigated with major interest in whether the mean vector lies in the positive orthant (see Tang, Gnecco and Geller, 1989 and Jennison and Turnbull, 1993). In other applications it may be appropriate to test the null hypothesis that a multivariate mean is equal to zero against a general alternative. As an example, an engineer might wish to test for any change in the means of several outcome variables after carrying out modi cations to an industrial process. In this case, a group sequential or F -test is needed. To date, most exact results concerning group sequential analysis of normal linear models have been obtained for the case of known variances and covariances; see Jennison and Turnbull (1997) for a review of existing results. In this paper we develop the exact distribution theory needed to implement group sequential t, and F -tests, generalizing the results of Jennison and Turnbull (1991), which were obtained for i.i.d. normal observations. We suppose univariate observations Y ; Y ; : : : are normally distributed with means depending on a parameter vector = ( ; : : : ; p)T . In a group sequential study with a maximum of K groups of observations, we denote the total number of observations in the rst k groups by nk , k = 1; : : : ; K , thus n < : : : < nK , and we denote by Y k = (Y ; : : :; Ynk )T the vector of observations available at the kth analysis. We assume Y K , has a multivariate normal distribution with design matrix X K and variance matrix K , where X K and K are known. At analyses k = 1; : : : ; K we observe Y k N (X k ; k ), where X k and k can be deduced from X K and K by extracting the elements relating to the rst nk components of Y K . If is estimable from Y k , the maximum likelihood estimate based on Y k is the generalized least squares estimate ^ k = (X k T k ? X k )? X k T k ? Y k ; k = 1; : : : ; K; (1)
PVR软件包说明书
Package‘PVR’October12,2022Type PackageTitle Phylogenetic Eigenvectors Regression and PhylogenticSignal-Representation CurveVersion0.3Date2018-05-29Author Thiago SantosMaintainer Thiago Santos<***********************.br>DescriptionEstimates(and controls for)phylogenetic signal through phylogenetic eigenvectors regres-sion(PVR)and phylogenetic signal-representation(PSR)curve,along with some plot utilities. License GPL(>=2)Imports splancs,ape,methods,graphics,stats,utils,MASSNeedsCompilation noRepository CRANDate/Publication2018-05-3022:29:01UTCR topics documented:PVR-package (2)PSR (3)PSR-class (4)PSRplot (6)PVR (7)PVR-class (9)PVRdecomp (10)VarPartplot (11)Index1312PVR-package PVR-package Computes P hylogenetic eigen V ectors R egression and P hylogenticS ignal-R epresentation curve(with null and neutral expectations).DescriptionComputes PVR and PSR curve along with some plot utilitties.DetailsPackage:PVRType:PackageVersion: 1.0Date:2018-05-29License:GPL>=2Author(s)Santos,T;Diniz-Filho,J.A.F.;Rangel,T.F.;Bini,L.M.Maintainer:Thiago Santos<***********************.br>ReferencesDiniz-Filho,J.A.F.,Sant’Ana,C.E.R.and Bini,L.M.(1998).An eigenvector method for estimating phylogenetic inertia.Evolution52:1247-1262.Diniz-filho,J.A.F.,Rangel,T.F.,Santos,T.and Bini,L.M.(2012).Exploring patterns of interespe-cific variation in quantitative traits using sequential phylogenetic eigenvector regressions.Evolu-tion,66(4):1079-1090.Diniz-filho,J.A.F.,Bini,L.M.,Rangel,T.F.,Morales-Castilla,I.,Olalla-Tarraga,M.A.,Rodriguez, M.A.and Hawkins,B.A.(2012).On the selection of phylogenetic eigenvectors for ecological analyses.Ecography,35:239-249.See AlsoPVR-class,PSR-class,PVR,PSR,PVRdecomp,PSRplot,VarPartplotExampleslibrary(splancs)#Creating a10tips ultrametric random phylogenylibrary(ape)tree<-rcoal(10)#Decomposing phylogenetic distance matrix derived from tree into a set of orthogonal vectorsPSR3x<-PVRdecomp(tree)trait<-runif(10)y<-PSR(x,trait)yPSR Creates a phylogenetic signal-representation(PSR)curve for a givenphylogeny and trait set and computes its area.DescriptionPhylogenetic signal-representation(PSR)curve,built upon phylogenetic eigenvector regression (PVR).Sequential PVR models arefitted after successively increasing the number of eigenvec-tors and plotting their R2against the accumulated eigenvalues.The PSR area,expressing devia-tions from Brownian motion,is strongly correlated with Blomberg’s K-statistics,so nonlinear PSR curves reveal if traits are evolving at a slower or higher rate than expected.The PSR area is also cor-related with phylogenetic half-life under an OU process,so both methods describe the relationship between interspecific variation and time since divergence among species shape.UsagePSR(x,trait=NULL,null.model=FALSE,Brownian.model=FALSE,times=1000)Argumentsx A object of class PVR(created using PVRdecomp function).trait A vector,data frame or matrix that contains contiuous or binary traits sets(for data frames and matrices,each column must represent a trait set).For now,onlythefirst colunm will be used.null.model Logical.Should the function estimates the null expectation for the PSR area.Default is FALSE.Brownian.model Logical.Should the function estimates the Brownian(neutral)expectation for the PSR area.Default is FALSE.times Number of iterations used in null.model and Brownian.model.ValuePSR function returns a object of(S4)class PSR that extends the(S4)class PVR,by adding:a PSR slot that contains the area(and p if null.model=TRUE)for each trait set,the cumulative eigenvalues and R2that determine the curve;a slot with the null and neutral expectations(if any).Author(s)Santos,T;Diniz-Filho,J.A.F.;Rangel,T.F.;Bini,L.M.ReferencesDiniz-Filho,J.A.F.,Sant’Ana,C.E.R.and Bini,L.M.(1998).An eigenvector method for estimating phylogenetic inertia.Evolution52:1247-1262.Diniz-filho,J.A.F.,Rangel,T.F.,Santos,T.and Bini,L.M.(2012).Exploring patterns of interespe-cific variation in quantitative traits using sequential phylogenetic eigenvector regressions.Evolu-tion,66(4):1079-1090.Diniz-filho,J.A.F.,Bini,L.M.,Rangel,T.F.,Morales-Castilla,I.,Olalla-Tarraga,M.A.,Rodriguez, M.A.and Hawkins,B.A.(2012).On the selection of phylogenetic eigenvectors for ecological analyses.Ecography,35:239-249.See AlsoPVR,PVRdecomp,PSRplot,VarPartplotExampleslibrary(splancs)#Creating a10tips ultrametric random phylogenylibrary(ape)tree<-rcoal(10)#Decomposing phylogenetic distance matrix derived from tree into a set of orthogonal vectors x<-PVRdecomp(tree)trait<-runif(10)y<-PSR(x,trait)summary(y)PSR-class Class"PSR"DescriptionA S4class that extends S4PVR class in order to accommodate PSR analysis results.Objects from the ClassObjects can be created by calls of the form new("PSR",...).SlotsPSRarea:Object of class"data.frame"that contains PSR curve area.PSR:Object of class"data.frame"that contais accumulated r squared and eigenvalues.Expect.area.values:Object of class"list"that contains the expected null and neutral area values.nullPSR:Object of class"matrix"nested in the Expect.area.values slot that contains the expected null area values.BrownianPSR:Object of class"matrix"nested in the Expect.area.values slot that contains the expected Brownian(neutral)area values.Eigen:Object of class"list"that contains the eigenvalues and eigenvectors generated by phylo-genetic distance matrix eigendecomposition.Inherited from PVR class.phyDist:Object of class"matrix"that contains a phylogenetic distance matrix.Inherited from PVR class.phylo:Object of class"phylo"that contains a phylogeny.Inherited from PVR class.Selection:Object of class"list"that contains the selection method(along with its statistics) used to select the vectors,the selected vectors IDs and a matrix that contains the selected vectors.Inherited from PVR class.PVR:Object of class"list"that contains the P hilogenetic Eigen V ectors R egression r squared and residuals.Inherited from PVR class.VarPart:Object of class"list"that contains the variation partition components.Inherited from PVR class.ExtendsClass"PVR",directly.Methodsplot signature(x="PSR"):...show signature(object="PSR"):...Author(s)Santos,T;Diniz-Filho,J.A.F.;Rangel,T.F.;Bini,L.M.ReferencesDiniz-Filho,J.A.F.,Sant’Ana,C.E.R.and Bini,L.M.(1998).An eigenvector method for estimating phylogenetic inertia.Evolution52:1247-1262.Legendre,P.and Legendre,L.(1998).Numerical ecology,2nd Englished.Elsevier.Diniz-filho,J.A.F.,Rangel,T.F.,Santos,T.and Bini,L.M.(2012).Exploring patterns of interespe-cific variation in quantitative traits using sequential phylogenetic eigenvector regressions.Evolu-tion,66(4):1079-1090.Diniz-filho,J.A.F.,Bini,L.M.,Rangel,T.F.,Morales-Castilla,I.,Olalla-Tarraga,M.A.,Rodriguez, M.A.and Hawkins,B.A.(2012).On the selection of phylogenetic eigenvectors for ecological analyses.Ecography,35:239-249.See AlsoPVR-class,PVR,PSR,PVRdecomp,PSRplot,VarPartplotExamplesshowClass("PSR")6PSRplot PSRplot Plot function for objects of class PSRDescriptionPlot PSR curve along with null and neutral expectations curves.UsagePSRplot(x,info=c("area","null","Brownian","both"),...)Argumentsx An object of class PSRinfo Type of information to be ploted.It can be"area"(to plot only the PSR curve), "null"(to plot PSR curve and null PSR curve),"neutral"(to plot PSR curve andneutral PSR curve)and"both"(to plot PSR curve and both null and neutral PSRcurve)....Parameters passed to the plot function.Author(s)Santos,T;Diniz-Filho,J.A.F.;Rangel,T.F.;Bini,L.M.ReferencesDiniz-Filho,J.A.F.,Sant’Ana,C.E.R.and Bini,L.M.(1998).An eigenvector method for estimating phylogenetic inertia.Evolution52:1247-1262.Diniz-filho,J.A.F.,Rangel,T.F.,Santos,T.and Bini,L.M.(2012).Exploring patterns of interespe-cific variation in quantitative traits using sequential phylogenetic eigenvector regressions.Evolu-tion,66(4):1079-1090.Diniz-filho,J.A.F.,Bini,L.M.,Rangel,T.F.,Morales-Castilla,I.,Olalla-Tarraga,M.A.,Rodriguez, M.A.and Hawkins,B.A.(2012).On the selection of phylogenetic eigenvectors for ecological analyses.Ecography,35:239-249.See AlsoPSR,PVRdecomp,PVR,VarPartplotExampleslibrary(splancs)#Creating a10tips ultrametric random phylogenylibrary(ape)tree<-rcoal(10)#Decomposing phylogenetic distance matrix derived from tree into a set of orthogonal vectors x<-PVRdecomp(tree)PVR7 trait<-runif(10)res<-PSR(x,trait=trait,null.model=TRUE,Brownian.model=TRUE,times=10)PSRplot(res,info="both")PVR Phylogenetic eigenvectors regression.DescriptionThe phylogenetic eigenvector regression(PVR)starts by performing an eigendecomposition of a pairwise double-centered phylogenetic distance matrix between species.The eigenvectors(repre-senting the traits under analysis)estimated values express phylogenetic trends in data and residuals express independent evolution of each species.UsagePVR(x,phy,trait,envVar,method="moran",weights,scaled=FALSE,sig=TRUE,sig.t=0.05,MI.t=0.05,psr.t=0.01,accvalue.t=0.9,...)Argumentsx An object of class PVR(created by the PVRdecomp function)or class PSR (requiered by the"PSR"method).phy An object of class phylo that contains an ultrametric phylogeny.trait A vector,data frame or matrix that contains traits sets(for data frames and ma-trices,each column must represent a trait set).envVar A vector,data frame or matrix that contains environmental ed to estimates the variation of a trait set that is explained by phylogeny and by envi-ronment.method Character string.A name for the eigenvectors selection method.It can be "moran","stepwise","psr"or"sequential".weights Weighting matrix based on Phylogenetic distances used in the"moran"method.If no weights matrix is provided,weights will be set to max(D)-Dij,where Dis the phylogenetic distance matrix.scaled Logical.Should the phylogenetic distances be scaled into the range of0to1.Default is FALSE.sig Logical.Should the eigenvectors selected by the"moran"method be selected by the significance of residuals autocorrelation.If FALSE the eigenvectors willbe selected by Moran’s I values.MI.t Minimum residuals Moran’s I value used to select eigenvectors when signifi-cance is FALSE.sig.t The significance treshold used to select eigenvectors by the"moran"method.psr.t The minimum acumulate R2gain treshold used to select eigenvectors by the "PSR"method.8PVR accvalue.t Relative accumulated eigenvalue treshold use to select the eigenvectors by the "sequential"method....Parameters passed to the stepwise regression used in the"AIC"methodValueA PVR class object.Author(s)Santos,T;Diniz-Filho,J.A.F.;Rangel,T.F.;Bini,L.M.ReferencesDiniz-Filho,J.A.F.,Sant’Ana,C.E.R.and Bini,L.M.(1998).An eigenvector method for estimating phylogenetic inertia.Evolution,52:1247-1262.Legendre,P.and Legendre,L.(1998).Numerical ecology,2nd Englished.Elsevier.Desdevises,Y.,Legendre,P.,Azouzi,L.and Morand,S.(2003).Quantifying phylogenetic struc-tured environmental variation,Evolution,57(11):2647-2652Diniz-filho,J.A.F.,Rangel,T.F.,Santos,T.and Bini,L.M.(2012).Exploring patterns of interespe-cific variation in quantitative traits using sequential phylogenetic eigenvector regressions.Evolu-tion,66(4):1079-1090.Diniz-filho,J.A.F.,Bini,L.M.,Rangel,T.F.,Morales-Castilla,I.,Olalla-Tarraga,M.A.,Rodriguez, M.A.and Hawkins,B.A.(2012).On the selection of phylogenetic eigenvectors for ecological analyses.Ecography,35:239-249.See AlsoPSR,PVRdecomp,PSRplot,VarPartplotExampleslibrary(ape)tree<-rcoal(10)#Decomposing phylogenetic distance matrix derived from tree into a set of orthogonal vectors x<-PVRdecomp(tree)trait<-runif(10)y<-PVR(x,trait=trait,method="moran")str(y)PVR-class9 PVR-class Class"PVR"DescriptionA S4class that contains eigenvalues and eigenvectors from decomposition of a phylogenetic dis-tance matrix and PVR r squared and residuals.Objects from the ClassObjects can be created by calls of the form new("PVR",...).SlotsEigen:Object of class"list"that contains the eigenvalues and eigenvectors generated by phylo-genetic distance matrix eigendecomposition.phyDist:Object of class"matrix"that contains a phylogenetic distance matrix.phylo:Object of class"phylo"that contains a phylogeny.Selection:Object of class"list"that contains the selection method(along with its statistics) used to select the vectors,the selected vectors IDs and a matrix that contains the selected vectors.PVR:Object of class"list"that contains the P hilogenetic Eigen V ectors R egression r squared and residuals.VarPart:Object of class"list"that contains the variation partition components.Methodsshow signature(object="PVR"):Always print the Eigen slot.Author(s)Santos,T;Diniz-Filho,J.A.F.;Rangel,T.F.;Bini,L.M.ReferencesDiniz-Filho,J.A.F.,Sant’Ana,C.E.R.and Bini,L.M.(1998).An eigenvector method for estimating phylogenetic inertia.Evolution52:1247-1262.Legendre,P.and Legendre,L.(1998).Numerical ecology,2nd Englished.Elsevier.Diniz-filho,J.A.F.,Rangel,T.F.,Santos,T.and Bini,L.M.(2012).Exploring patterns of interespe-cific variation in quantitative traits using sequential phylogenetic eigenvector regressions.Evolu-tion,66(4):1079-1090.Diniz-filho,J.A.F.,Bini,L.M.,Rangel,T.F.,Morales-Castilla,I.,Olalla-Tarraga,M.A.,Rodriguez, M.A.and Hawkins,B.A.(2012).On the selection of phylogenetic eigenvectors for ecological analyses.Ecography,35:239-249.10PVRdecomp See AlsoPSR-class,PVR,PSR,PVRdecomp,PSRplot,VarPartplotExamplesshowClass("PVR")PVRdecomp Phylogenetic distances matrix(eigen)decomposition.DescriptionThe PVRdecomp function decompose phylogenetic distance matrices(computed based on phylo-genies)into a set of orthongonal eigenvectorsUsagePVRdecomp(phy,type="newick",dist=NULL,scale=FALSE,...)Argumentsphy An object of class phylo that contains a ultrametric phylogeny with branch lengths or a character string that represents a phylogenyfile(must have fullpath)of type given by type.type A character string with the phylogenyfile format.It can be"newick"or"nexus".Used only if phy is a character string,ignored otherwise.dist A phylogenetic distance matrix.Not used.scale Logical.Should the phylogenetic distances be scaled into the range of0to1.Default is FALSE....Not used.ValueThe PVRdecomp funtion returns a object of(S4)class PVR with an Eigen slot that contains eigen-values and eigenvectors computed after the matrix decomposition.Author(s)Santos,T;Diniz-Filho,J.A.F.;Rangel,T.F.;Bini,L.M.ReferencesDiniz-Filho,J.A.F.,Sant’Ana,C.E.R.and Bini,L.M.(1998).An eigenvector method for estimating phylogenetic inertia.Evolution52:1247-1262.Diniz-filho,J.A.F.,Rangel,T.F.,Santos,T.and Bini,L.M.(2012).Exploring patterns of interespe-cific variation in quantitative traits using sequential phylogenetic eigenvector regressions.Evolu-tion,66(4):1079-1090.Diniz-filho,J.A.F.,Bini,L.M.,Rangel,T.F.,Morales-Castilla,I.,Olalla-Tarraga,M.A.,Rodriguez, M.A.and Hawkins,B.A.(2012).On the selection of phylogenetic eigenvectors for ecological analyses.Ecography,35:239-249.See AlsoPVR,PSRExampleslibrary(ape)tree<-rcoal(10)#Decomposing phylogenetic distance matrix derived from tree into a set of orthogonal vectors x<-PVRdecomp(tree,scale=TRUE)str(x)VarPartplot Plot function for objects of class PVR to show variation partition com-ponents.DescriptionPlot a,b,c and d components of traits variation partition between phylogeny and environment(as defined by Desdevises et al.,2003).UsageVarPartplot(x,...)Argumentsx An object of class PVR with a non NULL slot VarPart....Parameters passed to the plot function.Author(s)Santos,T;Diniz-Filho,J.A.F.;Rangel,T.F.;Bini,L.M.ReferencesDiniz-Filho,J.A.F.,Sant’Ana,C.E.R.and Bini,L.M.(1998).An eigenvector method for estimating phylogenetic inertia.Evolution52:1247-1262.Legendre,P.and Legendre,L.(1998).Numerical ecology,2nd Englished.Elsevier.Desdevises,Y.,Legendre,P.,Azouzi,L.and Morand,S.(2003).Quantifying phylogenetic struc-tured environmental variation,Evolution,57(11):2647-2652.Diniz-filho,J.A.F.,Rangel,T.F.,Santos,T.and Bini,L.M.(2012).Exploring patterns of interespe-cific variation in quantitative traits using sequential phylogenetic eigenvector regressions.Evolu-tion,66(4):1079-1090.Diniz-filho,J.A.F.,Bini,L.M.,Rangel,T.F.,Morales-Castilla,I.,Olalla-Tarraga,M.A.,Rodriguez, M.A.and Hawkins,B.A.(2012).On the selection of phylogenetic eigenvectors for ecological analyses.Ecography,35:239-249.See AlsoPSR,PVRdecomp,PVR,PSRplotExampleslibrary(ape)tree<-rcoal(10)#Decomposing phylogenetic distance matrix derived from tree into a set of orthogonal vectors x<-PVRdecomp(tree)trait<-runif(10)envvar<-runif(10)y<-PVR(x,trait=trait,envVar=envvar,method="moran")VarPartplot(y)Index∗PSR areaPSRplot,6∗PSRVarPartplot,11∗PVRPSRplot,6∗Phylogenetic modelsPVR,7∗Phylogenetic signalPVR,7VarPartplot,11∗classesPSR-class,4PVR-class,9∗packagePVR-package,2∗phylogenetic signalPSR,3PVRdecomp,10∗phylogenyPSR,3PVRdecomp,10plot,PSR-method(PSR-class),4PSR,2,3,5,6,8,10–12PSR-class,4PSRplot,2,4,5,6,8,10,12PVR,2,4–6,7,10–12PVR-class,9PVR-package,2PVRdecomp,2,4–6,8,10,10,12show,PSR-method(PSR-class),4show,PVR-method(PVR-class),9VarPartplot,2,4–6,8,10,1113。
完形填空+词汇+翻译
完形填空About a year from now. 1.triangular 2.dubbed 3.taking baby steps estone5.momentum6.worthy of7.genomes8.feasible9.unfold 10.starry-eyedWind and hydroelectric power. 1. 2. 3. 4.turbines 5.essentially 6.windmills7.renewable 8.harnessed 9.dams 10.convertWomen generally out live men. 1.exploring 2.Evolution 3.in women’s favor4.snapshot5.expectancy6.outlive7.engage in8.ultimately9.homicides10.genderCopyright was invented after the advent of the printing press. 1.enacted 2.archaic 3.era 4.concern 5.disclosed 6aaamit 7.discriminate 8.cooperate 9.integrity 10.oversee Air-powered car is made by French auto engineer Guy Negre 1aaapressed 2.marginally 3.impractical 4.reliant 5aaapared to 6.fraction 7.crucially 8.radically 9.make a dent 10.licensed词汇1.clues to the identity room2.a city vibrant with life3.have reverence for their teacher4.Grow restless with the long wait5.be shocked by the fragility of his opponent6.a blot on the landscape7.an important milestone in the relations between our two countries8.Stretch back to the distant past9.the first one to navigate the Atlantic Ocean10.Traverse hundreds of miles of desert11.The addiction propel him towards a life of crime12.in the course of millennia12.encode the message for security reasons14.A plane hover on our house15.The ship is about to weigh anchor in15.Take baby steps toward active lifestyle16.dry up all their herbs17.Bear the lessons of his time as an astronautunch a great crusade against homelessness2.Pollutants are constantly being released into the atmosphere3.A by-product of wheat flour processing4.Purify the water by distilling5.There’s too great a consumption of alcohol in China6.a structure positioned on a disk7.the installation of specific software on system8.Had no alternative but to confess9.the vibration of the tuning fork10.defence mechanism against many diseases11.consciousness of sustainable development12.he practical application of a theory1.a few tears of frustration2.the downfall of his rivals3.a period of sequential technological development and innovation4.confuse audiences by sill y subtleties5.metals have certain qualities in common6.reconstruct the history of civilization7.Individual has a physiological requirement for each nutrient8.an intimate knowledge of African religions10.A good novelist needs great powers of conception11.We were completely outnumbered by the enemy12.SARS is a type of atypical pneumonia13.I am primarily interested in history14.Don’t smoke during pregnancy15.Pneumonia can result in fatality if left untreated1.a literal interpretation of the Biblemit an offense against decency3.a gradual approach to the ideal state of things4.Natural and agricultural ecosystems form continuum5.She notified us of the meeting6the motive for the crime7vow revenge on their enemies8.Jealousy is foreign to her nature9.be punished for one’s disobedience10.She developed a few harmless eccentricities11.More often than not,you’d end up with something far better than what you are prepared for.12.excessively large memory space requirement13.a legislator appointed by the party14.This child is obstinate and rebellious15.The law presume innocence until guilt is proved16.a man of complete integrity17.ethics deals with moral conduct18.a genetic predisposition to allergies19.His speech disrupted the meeting20.Italy declared fo r neutrality in this war1.The film compresses several years into half an hour2.by a fraction of an inch3.This year’s profits were marginally higher than last year’s4.be heavily reliant on bank loans5.the prototype for future school buildings6.the replacement of conventional weapons by nuclear weapons7.an actress of great glamour8.This dictionary is available in electronic version9.make her debut in the new comedy10.The candidates competed for the union’s endorsement11.manufacture a false story to hide the facts12.The arrival of reinforcements seals our victory13.The street was congested with traffic14.picked all the pins up with a magnet15.a small inconspicuous crake in the vase16.thrust his hands into his pocket17.a commuter from the suburban gentry18.The show was an overnight success on Broadway1.It took a complex analysis of NAS A’s two Mars orbiters to eventually reveal the shape of that basin.2.NASA attempts to use a vibrant space exploration program to engage the public,encourage students and help develop the high-tech workforce3.A series of NASA’s observatory images has provided a dramatic view of a violent restless nature4.In the bottom of their heart,what counted most was their motherland’s advancement and prosperity5.When the radio program was signing off ,its audience had gained a deeper perception about the Earth’s fragility.6.The significance of technology is not about what are produced;it is about in what way the products influence the world.7.Astronauts are happier to see human beings’ raised awareness on Earth-protection than to receive their admiration.8.Human beings know more than ever before about what role they are playing in the cosmos after lunar landing.9.The Universe does not challenge human beings as much as it provides them the opportunity to demonstrate their power.10.The solar sail,or lightsail,as it is dubbed by researchers,is another marvelous creation by using solar energy.11.Those hours,from Yang Liwer’s space flight to Zhai Zhigang’s space walk,will mark a milestone for Chinese space exploration.1.These words are appropriate to literature rather than everyday speech or writhing.2.What seems easy to some people seems difficult to others3.It is only when you have your own children that you realize the troubles of parenthood.4.How to create a personal web album is a big challenge for him now.5.It is one thing to own a library;it is another to use it wisely6.Manufacturing ,installing a maintaining solar panels should add 63million job by 2030.7.Fuel cells remain an essential part of the space program, reliably powering the space shuttles.8.The 10000 project,which covers a six-block area, allows anyone to connects to the Internet through wi-fi transmitters powered by solar panels on nearby rooftops.9.Science has n ot only improved people’s quality of living,but also raised their understanding and promoted their spiritual and intellectual growth.10.It was mentioned in his artical that burning such biomass to produce electricity delievered more environmental benefits than transforming it into liquid fuels.1.The nation’s population continues to rise at a rate of 12 million per year2.The more exercise you take,the less likely you are to catch a cold3.If I were you,I would have accepted such an offer given by the manager4.While crossing the mountain area,all the men carried guns est they should be attacked by wild animals5.Since my childhood I have found that nothing is more attractive to me than reading6.Man who tend not to deal with their stress as well as woman man be more prone to internalizing stress,rather than letting out.7.In the society,the background for everyone are different,the social positions are different,the jobs are different,the values are different,but one thing is the same dignity.8.Man under 65 are four times more likely to commit suicide than woman while injury ratesin men under the age of 60 are nearly three times higher than woman.9.As academic organization for passing civilization and developing science,difficult kind of universities have a lot in common,such as their management and functional mechanism. 10.Men in general tend to look upon themselves as being tough and independent,they ignore health problem until it’s too late while woman being more open to asking for help,will seak wedical treatment sooner.1.Google’s App Inventor makes it easy for everyone easily to create mobile applications for smart phones running its Android operating system2.We must try our best hold on to our market share and increase profitability3.Recent surveys have shown that the average salary is positively correlated with length of education4.The poem shoud not be taken in its literal sense.5.A great many legislators have convincingly argued in favor of network censorship that blocks unclassified websites.6.T here is a gradual continuum between works that are completely original and works that are completely derivative.7.Some experts state that the Internet has undermined the interpersonal communication between the youth degree.8.What if you have not saved the current document before shutting down the word proccer.cational systems more often than not reflect the essential nature of the society.10.It is no accident that financial crisis occurred in the Wall Street in America.1.Scientists know how to get better inages from the data than are produced by current devices,the necessary calculations take so long that they are impractical2.Work may be carried out to tes whether an alteration of diet in individuals has any effecton ,he incidence,3.The class consisted of twenty-four students,ranging in age from seven to thirteen4.The ozone layer shields the earth from the sun’s ultraviolet rays5.It is certain that man will continue to improve technoligy and will become more reliant on it.6.After the united States entered Word War 2 in 1941,General Motors signed an agreement with the government to start manufacture tanks,airplanes,weapons.pared to common telescopes,radio telescopes can provide valuable information about the magnetic fields of other planets in our solar system.8.Although Known that there is small change in our routine on Mir,I was living every scientist’s dream’,said one Russian astronaut.9.Given our experience in implementing automated transportation systems,it is not so difficult to develop vehicles that can operate under automatic control10.The laser systems are currently less expensive,while the radar systems are more effective at detecting crazy vehicles.[文档可能无法思考全面,请浏览后下载,另外祝您生活愉快,工作顺利,万事如意!]。
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error
pC ;
W
(2)
where W is the number of random walks used. This means, among other things, that each additional signi cant digit of information requires, on the average, a hundredfold increase in the number of individual random walks simulated. Obviously, this is an unsatisfactory situation when a global solution is sought to great accuracy and when millions of random walks (utilizing hours or even days of the fastest computers) might be needed to achieve errors of perhaps 10%. In 1962, John Halton 4] successfully solved certain matrix problems (which may be thought of as discretized versions of equation (1)) by applying Monte Carlo methods sequentially. Halton's idea was to solve the problem in
0
@ = ? t (x; ) + s R @x ?
1 2
(x; 0 )d 0 ; ?1 1; 0 < x < T; 1; (T; ) = QT ( ); ?1 < 0:
1
(1)
A physical description of this problem and its derivation can be found, for example, in 2] and 3]. In these references one also nds some exploration of the solution, especially in the context of representation through eigenvalues and eigenfunctions. Here we only describe (Fig. 1) the physical phase space that corresponds to problem (1). In Figure 1, we depict a slab of thickness T lled with a homogeneous material. Random walking particles (for example, neutrons or photons), whose source distributions are restricted to x = 0, x = T and are de ned there
successive stages, each of which can be estimated using conventional Monte Carlo methods. With su cient care, the error En after the nth stage can be bounded by the error En? obtained in the previous stage multiplied by a constant (W ) that depends on the number of the random walks used; i.e.,
Sequential Correlated Sampling Methods for Some Transport Problems
Rong Kong & Jerome Spanier
Department of Mathematics Claremont Graduate University 925 N. Dartmouth Ave. Claremont, CA 91711, USA Email: rong.kong@ & jerome.spanier@
1
En
(W )En? :
1
(3)
In fact, often with only a relatively small number of random walks, one can achieve (W ) < 1: Thus, after n stages of such a process, the error can be estimated by En (W )n E ; (4) thus achieving geometric, or exponential, convergence. In this case, additional digits of accuracy can be obtained with only linear, rather than exponential, increases in computer cost, thus o ering enormous potential for improvement over conventional Monte Carlo implementations In this paper, we apply this idea to the continuous transport problem (1), using a generalization of Halton's methods, concentrating here on the algorithms needed and the numerical results obtained. A probabilistic error analysis of this method can be found in 5].
x 0 T
Fig. 1. Phase space corresponding to equation (1)
by Q ( ) and QT ( ); respectively, are injected into the slab from the two boundaries. While moving in the slab, they can be scattered or absorbed, which events are characterized by the total macroscopic cross section, t ; and the scattering cross section, s : For later convenience, we de ne the absorption scattering cross section by a = t ? s The unknown function (x; ) is the particle ux, which is the expected number of particles passing the point x along the direction which makes an angle arccos with the positive x? axis. Our methodology to attack problem (1) will be described in Section 3. Basically, what we do is rst estimate the integral occurring on the right hand side, called the scalar ux, by Monte Carlo methods and then solve the resulting ordinary di erential equation for the full (vector ux) solution. This same idea can also be applied to more general anisotropic transport problems (see 1]). Monte Carlo methods can be useful in solving such problems, but only if the slow convergence associated with conventional applications of the method is overcome. Speci cally, the usual type of probabilistic random walk simulation leads to the estimate of the error, for some constant C;
1 Introduction
In 1], a broad overview is given of Monte Carlo learning algorithms that give rise to geometric convergence for quite general transport problems. In this paper, one of the methods (based on correlated sampling applied sequentially) outlined in 1] is described in much more detail. Similar detail is presented for the method based on importance sampling in 9]. We will consider the following type of transport problem and introduce a new Monte Carlo method to solve it: (0; ) = Q ( ); 0 <