Reconsidering the moral hazard-risk avoidance tradeoff
高三现代科技前沿探索英语阅读理解20题
高三现代科技前沿探索英语阅读理解20题1<背景文章>Artificial intelligence (AI) is rapidly transforming the field of healthcare. In recent years, AI has made significant progress in various aspects of medical care, bringing new opportunities and challenges.One of the major applications of AI in healthcare is in disease diagnosis. AI-powered systems can analyze large amounts of medical data, such as medical images and patient records, to detect diseases at an early stage. For example, deep learning algorithms can accurately identify tumors in medical images, helping doctors make more accurate diagnoses.Another area where AI is making a big impact is in drug discovery. By analyzing vast amounts of biological data, AI can help researchers identify potential drug targets and design new drugs more efficiently. This can significantly shorten the time and cost of drug development.AI also has the potential to improve patient care by providing personalized treatment plans. Based on a patient's genetic information, medical history, and other factors, AI can recommend the most appropriate treatment options.However, the application of AI in healthcare also faces some challenges. One of the main concerns is data privacy and security. Medicaldata is highly sensitive, and ensuring its protection is crucial. Another challenge is the lack of transparency in AI algorithms. Doctors and patients need to understand how AI makes decisions in order to trust its recommendations.In conclusion, while AI holds great promise for improving healthcare, it also poses significant challenges that need to be addressed.1. What is one of the major applications of AI in healthcare?A. Disease prevention.B. Disease diagnosis.C. Health maintenance.D. Medical education.答案:B。
雷斯应有谨慎辩护国家一致标准-LaceyDueCareStandard
为了更繁荣的明天,现在就开始行动一致通过2012年5月21日雷斯应有谨慎辩护国家一致标准©意图声明本标准的意图旨在确定企业为了证明他们能够满足《雷斯法案》2008年修正案(《美国法典》第16卷第3371-3378节)的要求,可以采取的“应有谨慎”措施。
本标准活动的相关个人和组织都极力支持《雷斯法案》修正案的意图,即打击全世界非法采伐和非法采伐林产品贸易。
我们还意识到,目前尚无哪份文件或行动明确符合雷斯法案的应有谨慎要求。
但是从商业、国际贸易,甚至森林保护角度来说,明确了解企业的哪些行动始终符合雷斯的要求,这点非常重要。
因此,本标准的一个重要目的是阐明期望和行动,让全球企业和政府更加了解雷斯法案中应有谨慎的含义。
本雷斯应有谨慎一致标准符合国家的一致标准要求,其意图:• 使企业能向政府及其他方提供行动证明,证明其履行了雷斯应有谨慎和辩护责任 • 提高对法律的遵守• 保护和加强森林环境欲知更多信息,请联系Capital Markets Partnership (CMP)或登录 。
此次措施以CMP 为首,并获得其他众多机构的协助。
CMP 是Market Transformation to Sustainability (MTS)的子公司。
MTS 为获得美国国家标准学会(ANSI )认可的开发商。
1511 Wisconsin Avenue, NWWashington, DC 20007电话 202-338-3131电子邮箱 **********************************网址 _____________________________________________目录1. 标准目的、范围、背景和定义31.1 目的 31.2 范围 31.3 背景和成功先例 31.4 《技术转让法》项下政府采用一致标准的义务 31.5 《行政程序法》规则制定申请方案与司法审查 41.6 标准构成法律意见的意图 41.7 本标准纳入领导标准 41.8 标准要求森林认证以及风险、法律和合规性审核 41.9 定义42. 《雷斯法案》目的与追溯适用52.1 法案目的 52.2 《雷斯法案》的独特价值 62.3 《雷斯法案》的追溯适用 63. 法律项下应有谨慎的定义是什么? 63.1 法律解释 63.2 立法历史 63.3 司法部和美国农业部指南 63.4 第九巡回法院指示73.5 判例法增强实体的知识水平和责任73.6 知情非法行为的要求 83.7 不知情的非法行为要求 83.8 供应链需要应有谨慎 83.9 识别潜在违法行为 83.10 扣押和没收应有谨慎规定 84. 鼓励遵守雷斯法案以及利益84.1 标准意图:森林认证能够如雷斯规定保护森林环境 84.2 标准的意图为满足对规定诚信辩护责任的巨大市场需求 94.3 标准能降低诉讼,因此资源能用于遵守标准法案 94.4 标准的意图为适当转移通过第11条认证的实体的责任 94.5 标准的意图为通过阻止非法采伐帮助制止无法逆转的危险气候变化 94.6 标准包括《雷斯法案》中的普通法责任 95. 应有谨慎要求的理由及启示96. 应有谨慎、行动计划和应有谨慎图的管辖原则106.1 法律解释 106.2 判例法 106.3 立法历史 106.4 机构指导106.5 完成法定目标、意图和目的,以便禁止非法并保护森林环境 106.6 行业共识标准的作用 106.7 森林认证 106.8 应有谨慎法律框架 116.9 应有谨慎行动计划137. 应有谨慎要求137.1 风险审核137.2 法律和惯例审核 137.3 合规性审核147.4 森林认证方案:FSC第3步 / PEFC / Seneca Creek / AHEC 147.5 遵守全球非法采伐规则 177.6 应有谨慎流程图 178. FSC第2步方案198.1 先决条件198.2 FSC认证要求 198.3 木制品类型的分类 198.4 木材原产地、来源及分类识别 199. FSC第1步方案199.1 先决条件199.2 识别木材原产地和来源 209.3 产品必须是经FSC验证的产品 2010. 等效申请和举证责任2011. 具有法律约束力的标准认证-方案和产品标识 2012. 修订及管辖权 2213. 非强制性附录2214. 强制性附件—《雷斯法案》追溯适用讨论 26雷斯应有谨慎辩护国家一致标准1. 标准目的、范围、背景和定义1.1 本标准的目的旨在界定《雷斯法案》2008年修正案中规定的应有谨慎措施,并规定销售非法采伐木材为违法行为。
成都普瑞法科技开发有限公司 千里光碱 说明书
成都普瑞法科技开发有限公司Chengdu Biopurify Phytochemicals Ltd.Material Safety Data Sheet Version 2.7Revision Date 11/01/20171. Chemical Product and company IdentificationProduct Name:千里光碱English Name: SenecionineCatalogue No:130-01-8Supplier: Chengdu Biopurify Phytochemicals Ltd.Address: No.11 Building,No.388 Rongtaidadao CNSTP,Wenjiang Zone,Chengdu Sichuan 611130 ChinaTel:+86-28-82633987 Fax:+86-28-82633165Website: Email: **********************2、Composition, Information on IngredientsAlias: AureineCAS Number:130-01-8Mol. Formula: C18H25NO5Mol. Weight :335.4Identified uses: Laboratory chemicals, for R&DStorage: Room temperature for transportation, 2~8℃ for long term storage, protected from strong light, keep package airproofed when not in use.3、Hazards identificationClassification of the substance or mixtureClassification according to Regulation (EC) No 1272/2008Acute toxicity, Oral (Category 3), H301For the full text of the HStatements mentioned in this Section, see Section 16.Classification according to EU Directives 67/548/EEC or 1999/45/ECT Toxic R25For the full text of the Rphrases mentioned in this Section, see Section 16.Label elementsLabelling according Regulation (EC) No 1272/2008PictogramSignal word DangerHazard statement(s)H301 Toxic if swallowed.Precautionary statement(s)P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.Supplemental Hazard noneStatementsOther hazards none4、First-aid measuresIf inhaledIf breathed in, move person into fresh air. If not breathing, give artificial respiration.Consult a doctor.In case of skin contactWash off with soap and plenty of water. Consult a doctor.In case of eye contactFlush eyes with water as a precaution. Consult a doctor.If swallowedNever give anything by mouth to an unconscious person. Rinse mouth with water. Consult a doctor.Indication of any immediate medical attention and special treatment neededNo data availableShow this safety data sheet to the doctor in attendance.Immediate medical attention is required.5、Fire-fighting measuresConditions of flammabilityNot flammable or combustible.Suitable extinguishing mediaUse water spray, alcohol-resistant foam, dry chemical or carbon dioxide.Special protective equipment for firefightersWear self contained breathing apparatus for fire fighting if necessary.Hazardous combustion productsHazardous decomposition products formed under fire conditions. - Carbon oxides6、Accidental release measuresPersonal precautionsUse personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust.Environmental precautionsDo not let product enter drains.Methods and materials for containment and cleaning upPick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal.7、Handing and storageHandling:Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation. Keep away from sources of ignition. Avoid prolonged or repeated exposure.Storage:Store in a well closed container. Protected from air and light, put into refrigerate or freeze forlong term storage.Specific end usesUse in a laboratory fume hood where possible. Refer to employer is COSHH risk assessment.8、Exposure controls, personal protectionContains no substances with occupational exposure limit values.Personal protective equipmentRespiratory protectionWhere risk assessment shows air-purifying respirators are appropriate use a full-face particle respirator type N100 (US) or type P3 (EN 143) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).Hand protectionHandle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. Eye protectionFace shield and safety glasses Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).Skin and body protectionComplete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Hygiene measuresHandle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.9、Physical and chemical propertiesPhysical Description : Off-white powderProperty ValuespHNo information availableMelting point/freezing point236ºC(lit.)Boiling point563.744ºC at 760 mmHgFlash point294.742ºCDensity 1.255g/cm3Evaporation rate No information availableUpper flammability limits No information availableLower flammability limit No information availableVapor pressure0mmHg at 25°CVapor density No information availableSpecific gravity No information availableWater solubility No information availableSolubility in other solvents No information availablePartition coefficient No information availableAutoignition temperature No information availableKinematic viscosity No information availableDecomposition temperature No information availableExplosive properties No information availableOxidizing properties No information available10、Stability and reactivityChemical stabilityStable under recommended storage conditions.Possibility of hazardous reactionsno data availableConditions to avoidno data availableMaterials to avoidStrong oxidizing agentsHazardous decomposition productsHazardous decomposition products formed under fire conditions. - Carbon oxidesOther decomposition products - no data available11、Toxicological informationAcute toxicityOral LD50: LD50 Oral rat 85 mg/kgInhalation LC50: no data availableDermal LD50: no data availableOther information on acute toxicity: no data availableno data availableSerious eye damage/eye irritationno data availableRespiratory or skin sensitisationno data availableGerm cell mutagenicityno data availableCarcinogenicityIARC: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.ACGIH: No component of this product present at levels greater than or equal to 0.1% is identified as a carcinogen or potential carcinogen by ACGIH.NTP: No component of this product present at levels greater than or equal to 0.1% is identified as a known or anticipated carcinogen by NTP.OSHA: No component of this product present at levels greater than or equal to 0.1% is identified as a carcinogen or potential carcinogen by OSHA.Reproductive toxicityno data availableTeratogenicityno data availableSpecific target organ toxicity - single exposure (Globally Harmonized System)no data availableSpecific target organ toxicity - repeated exposure (Globally Harmonized System)no data availableAspiration hazardno data availablePotential health effectsInhalation May be harmful if inhaled. Causes respiratory tract irritation.Ingestion May be harmful if swallowed.Skin May be harmful if absorbed through skin. Causes skin irritation.Eyes May be caused eye irritation.Synergistic effectsno data availableAdditional InformationRTECS: Not available12、Ecological informationToxicityno data availablePersistence and degradabilityno data availableBioaccumulative potentialno data availableMobility in soilno data availablePBT and vPvB assessmentno data availableOther adverse effectsno data available13、Disposal considerationsProductOffer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material.Contaminated packagingDispose of as unused product.14、Transport informationUN numberADR/RID: 2811 IMDG: 2811 IATA: 2811UN proper shipping nameADR/RID: TOXIC SOLID, ORGANIC, N.O.S. (12Hydroxysenecionan11,16dione)IMDG: TOXIC SOLID, ORGANIC, N.O.S. (12Hydroxysenecionan11,16dione)IATA: Toxic solid, organic, n.o.s. (12Hydroxysenecionan11,16dione)Transport hazard class(es)ADR/RID: 6.1 IMDG: 6.1 IATA: 6.1Packaging groupADR/RID: III IMDG: III IATA: IIIEnvironmental hazardsADR/RID: no IMDG Marine pollutant: no IATA: noSpecial precautions for userno data available15、Regulatory informationThis safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.Safety, health and environmental regulations/legislation specific for the substance or mixtureno data availableChemical Safety AssessmentFor this product a chemical safety assessment was not carried out16、Other informationDISCLAIMERFor R&D use only. Not for drug, household or other uses.WARRANTYThe above information is believed to be correct but does not purport to be all inclusive and shall beused only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Biopurify and its Affiliates shall not be held liable for any damage resulting from handling or from contact with the above product. See and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.。
安全工程专业英语
Advanced Monitoring and Surveillance Systems
Utilizes cutting-edge technologies such as AI, IoT, and remote sensing to provide real-time monitoring and early warning of potential safety hazards.
English • English communication and exchange in
safety engineering
01
Overview of Safety Engineering
Definition of Safety Engineering
Safety Engineering is a branch of engineering that focuses on the design and management of safe systems and processes within various industries. It involves the identification, assessment, and control of risks associated with the operation of machines, equipment, and processes.
健康经济学(巴塔查里亚 曹乾)课后判断题 答案 (10)[3页]
11Moral HazardComprehension Questions1.When the price elasticity of demand for health care is zero,health insurancecoverage induces no moral hazard.TRUE.Moral hazard only occurs if a price distortion induces a change in behavior.If the price elasticity is zero,behavior does not change as a result of being insured.2.An uninsured patient who incessantly visits his doctor because he alwaysthinks he is getting sick is an example of moral hazard.FALSE.Assuming the patient is truly uninsured and must pay the full cost of his treatment,then he faces no price distortion and his actions do not con-stitute moral hazard.3.A woman who uses herfireplace only after she buys homeowner’s insuranceis an example of moral hazard.TRUE.If the woman faces a price distortion due to the insurance and would not have used herfireplace otherwise,then this decision is an example of moral hazard.4.A previously-uninsured man who enrolls in his workplace health insuranceplan after being diagnosed with multiple sclerosis is an example of moral hazard.12|Health Economics Answer KeyFALSE.The man was uninsured before he was diagnosed,so his disease is in no way attributable to a price distortion induced by insurance.Meanwhile, we have no indication that the man’s behavior changes once he obtains in-surance.This is much better described as an example of adverse selection. 5.Pauly(1974)shows that the socially optimal level of insurance in a marketis either full or none,depending on whether moral hazard or risk aversion predominates.FALSE.The socially optimal level of insurance balances the positive effects of insurance(risk reduction)with the negative effects of insurance(moral haz-ard).It is possible that this balance could be achieved with a partial insurance contract.6.Besides the common practice of charging copayments,health insurers haveno successful strategies for combating moral hazard.FALSE.Insurance customers can also use coinsurance,deductibles,and mon-itoring techniques to reduce moral hazard.Coinsurance and deductibles combat moral hazard by reducing price distortions;monitoring reduces moral hazard by mitigating information asymmetries.7.If a health insurance company could somehow monitor everything a cus-tomer does and thinks,it could create a full-insurance contract with no moral hazard.TRUE.Moral hazard depends entirely on information asymmetry between insurer and customer.8.It would be easy for private health insurers to eliminate moral hazard by re-designing insurance contracts,but they are prevented from doing so by strict government regulations(at least in most developed countries).FALSE.Insurmountable information asymmetry is the cause of moral haz-ard,not regulations on insurance contract design.Even in an unregulated market,insurers would have no easy way of telling whether their customers are always washing their hands or avoiding friends with theflu.9.Moral hazard is mostly a problem in countries with universal insurance pro-grams like the United Kingdom.FALSE.Moral hazard can arise in any insurance contract,even outside the context of a universal or public insurance program.c Bhattacharya,Hyde&Tu20132Chapter11|Moral Hazard|3 10.The fact that more free-plan participants logged ER visits for broken bonesthan cost-sharing plan participants in the RAND Health Insurance Experi-ment is evidence of moral hazard.TRUE.Moral hazard occurs when health insurance induces customers to be less careful with their health or induces them to seek more treatment when they do get hurt.11.An all-you-can-eat buffet is a classic example of moral hazard,because a pricedistortion induces overconsumption.FALSE.Moral hazard only occurs in the presence of asymmetric information.The restaurant could easily charge customers marginal costs for the food they eat,so the fact that they choose not to do so indicates there is something eco-nomically valuable about the all-you-can-eat system.Put another way,ban-ning all-you-can-eat buffets would not increase social welfare.3c Bhattacharya,Hyde&Tu2013。
Rapid health transition in China, 1990–2010
Articles Vol 381 June 8, 20131987Rapid health transition in China, 1990–2010: fi ndings from the Global Burden of Disease Study 2010Gonghuan Yang*, Yu Wang*, Yixin Zeng, George F Gao, Xiaofeng Liang, Maigeng Zhou, Xia Wan, Shicheng Yu, Yuhong Jiang, Mohsen Naghavi, Theo Vos, Haidong Wang, Alan D Lopez, Christopher J L MurraySummaryBackground China has undergone rapid demographic and epidemiological changes in the past few decades, including striking declines in fertility and child mortality and increases in life expectancy at birth. Popular discontent with the health system has led to major reforms. To help inform these reforms, we did a comprehensive assessment of disease burden in China, how it changed between 1990 and 2010, and how China’s health burden compares with other nations.Methods We used results of the Global Burden of Diseases, Injuries, and Risk Factors Study 2010 (GBD 2010) for 1990 and 2010 for China and 18 other countries in the G20 to assess rates and trends in mortality, causes of death, years of life lost (YLLs), years lived with disability (YLDs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE). We present results for 231 diseases and injuries and for 67 risk factors or clusters of risk factors relevant to China. We assessed relative performance of China against G20 countries (signifi cantly better, worse, or indistinguishable from the G20 mean) with age-standardised rates and 95% uncertainty intervals.Findings The leading causes of death in China in 2010 were stroke (1·7 million deaths, 95% UI 1·5–1·8 million), ischaemic heart disease (948 700 deaths, 774 500–1024 600), and chronic obstructive pulmonary disease (934 000 deaths, 846 600–1 032 300). Age-standardised YLLs in China were lower in 2010 than all emerging economies in the G20, and only slightly higher than noted in the USA. China had the lowest age-standardised YLD rate in the G20 in 2010. China also ranked tenth (95% UI eighth to tenth) for HALE and 12th (11th to 13th) for life expectancy. YLLs from neonatal causes, infectious diseases, and injuries in children declined substantially between 1990 and 2010. Mental and behavioural disorders, substance use disorders, and musculoskeletal disorders were responsible for almost half of all YLDs. The fraction of DALYs from YLDs rose from 28·1% (95% UI 24·2–32·5) in 1990 to 39·4% (34·9–43·8) in 2010. Leading causes of DALYs in 2010 were cardiovascular diseases (stroke and ischaemic heart disease), cancers (lung and liver cancer), low back pain, and depression. Dietary risk factors, high blood pressure, and tobacco exposure are the risk factors that constituted the largest number of attributable DALYs in China. Ambient air pollution ranked fourth (third to fi fth; the second highest in the G20) and household air pollution ranked fi fth (fourth to sixth; the third highest in the G20) in terms of the age-standardised DALY rate in 2010.Interpretation The rapid rise of non-communicable diseases driven by urbanisation, rising incomes, and ageing poses major challenges for China’s health system, as does a shift to chronic disability. Reduction of population exposures from poor diet, high blood pressure, tobacco use, cholesterol, and fasting blood glucose are public policy priorities for China, as are the control of ambient and household air pollution. These changes will require an integrated government response to improve primary care and undertake required multisectoral action to tackle key risks. Analyses of disease burden provide a useful framework to guide policy responses to the changing disease spectrum in China.Funding Bill & Melinda Gates Foundation.IntroductionChina has made enormous strides in improving health in the past few decades. Between 1970 and 2010, male life expectancy increased from 60·4 years to 72·9 years and female life expectancy increased from 63·5 years to 79·0 years;1 the under-5 mortality rate reduced from 100·6 per 1000 to 12·9 per 1000;1 and the total fertility rate declined from 4·77 to 1·64 children per woman.2 Rapidly increasing income per head, an ageing population, and longer lifespans have led to a rapid change in the health profi le of the nation. Some counties within the country, however, remain relatively poor and continue to have aset of health challenges dominated by communicable, maternal, and neonatal causes.3,4 China needs to under-stand and formulate a long-range strategy to tackle several challenges in public health and medical care at the same time.Before health-care reform was announced in 2009,5 the Chinese Government was faced with widespread public discontent stemming from unaff ordable access to health care and growing inequalities in access to health care and health status across regions and populations.6–9 Health improvement fell short of what China’s rapid economic growth should have aff orded.10 Some previously eliminatedLancet 2013; 381: 1987–2015See Comment pages 1961 and 1964*Joint fi rst authorsInstitute of Basic Medical Sciences, Chinese Academy of Medical Sciences & School ofBasic Medicine, Peking Union Medical College, Beijing, China (Prof G Yang MD, X Wan PhD); Chinese Center for DiseasePrevention and Control,Beijing, China (Y Wang MD, Y Zeng MD, G F Gao PhD,X Liang PhD, M Zhou PhD,S Yu PhD); Peking UnionMedical College, Beijing, China(Y Jiang MBA); Institute for Health Metrics and Evaluation, University of Washington, Seattle, WA, USA(M Naghavi PhD,Prof T Vos PhD, H Wang PhD, Prof C J L Murray MD); and Melbourne School ofPopulation and Global Health,The University of Melbourne,Melbourne, Australia (Prof A D Lopez PhD)Correspondence to:Prof Christopher J L Murray, Institute for Health Metrics and Evaluation, University ofWashington, 2301 Fifth Avenue, Suite 600, Seattle, WA 98121, USAcjlm@Articles1988 Vol 381 June 8, 2013infectious diseases re-emerged 11 and incidence of some non-communicable diseases increased.12,13 The 2002–03 severe acute respiratory syndrome (SARS) outbreak was a wake-up call exposing the inadequacies of the public health protection and surveillance system, and emphasis-ing the important role for government in guidance of the evolution of health in China. Health system reforms focused on delivering improved access to quality clinical care 14 are now underway but can be better informed by a broad assessment of China’s progress in health.Several data systems provide substantial detail about levels and trends in health in China, including various national surveys of health, civil registration, medical certifi cation of causes of death in some cities and counties,15 the Disease Surveillance Points system,16 a sophisticated infectious disease surveillance network,17 population-based cancer registries,18 a maternal and child surveillance system,17 and demographic surveys 19,20 and censuses.21,22 Despite these data systems, a comprehensive and comparable assessment of health challenges and how they change over time is not available. Opportunities to compare China’s health performance with other countries to learn where China has done well and where scope for improvement exists have thus been limited.In this report, we use the results of the Global Burden of Diseases, Injuries, and Risk Factors Study 2010 (GBD 2010) to examine in detail the transformation of health in China from 1990 to 2010 and to benchmark health challenges in China to 18 major high-income and rapidly developing countries that are members of the G20.MethodsOverviewDetail on the data, approaches to enhancing data qualityand comparability, and statistical modelling and metrics for the G BD 2010 have been reported elsewhere.1,23–29 In brief, G BD 2010 lists 291 diseases and injuries, organised in a hierarchy. For each of these causes, up to 24 sequelae exist that are clinical outcomes related to specifi c diseases and injuries, such as neuropathy due to diabetes. The study included 1160 sequelae.The 2010 GBD study used numerous metrics to report results on health loss related to specifi c causes of disease and injury: deaths and death rates, years of life lost due to premature mortality (YLLs), years lived with disability (YLDs), and disability-adjusted life-years (DALYs). YLLs are computed by multiplying the number of deaths in each age group by a reference life expectancy at that age. The life expectancy at birth in the reference life table is 86·0 years based on the lowest reported death rates for each age group across countries in 2010, and is intended to represent an achievable pattern of mortality.26 Years lived with disability are calculated from the prevalence of a sequela multiplied by the disability weight for that sequela. Disability weights are based on surveys of the general population.27 DALYs are the sum of YLLs and YLDs. The G BD uses another indicator, healthy lifeexpectancy (HALE), to summarise overall population health in one number, accounting for both length of life and levels of ill health at diff erent ages.28MortalityWang and colleagues 1 provide a detailed description on how rates of age-specifi c mortality have been estimated for each sex, country, and year. Appendix p 1 provides details on each of the sources available for measurement of the under-5 mortality rate, and appendix pp 2–3 provides similar information on measuring the prob-ability of death between ages 15 years and 60 years. Available national data sources on the age pattern of mortality provide similar distributions of deaths for individuals aged 15–79 years (appendix pp 4–5).Causes of deathWe calculated numbers of deaths and YLLs based on underlying cause of death estimates for 235 of 291 causes of mortality, and for 20 age groups, both sexes, and 187 countries.24 The appendix p 11 provides a listing of the major sources of information used to assess causes of death in China since 1980, including population-based cancer registry data. We assessed the quality of each data source, and mapped the codes for various Chinese variants of the International Classifi cation of Diseases and Injuries (ICD) tabulation lists to the GBD 2010 cause list. We reassigned deaths assigned to ill-defi ned diagnoses or to disorders that are not likely to be underlying causes of death with standard algorithms.30,31 G BD 2010 provides the most comprehensive eff ort to date to enhance the comparability of cause of death data across countries because it adjusts for revisions of the ICD and the redistribution of garbage codes. G arbage codes are causes of death that should not be identifi ed as underlying causes of death but have been entered as the underlying cause of death on death certifi cates. Classic examples of garbage codes include senility or cardiopulmonary arrest. Uncertainty in cause of death estimates has been captured with standard simulation methods by taking 1000 draws 32 for each age, sex, country, year, and cause.24 Final uncertainty for death numbers and YLLs also refl ects uncertainty in the levels of all-cause mortality in each age-sex-country-year.YLDS and HALEWe undertook prevalence estimation for each sequela with a systematic analysis of published and available unpublished data sources for prevalence, incidence, remission, and excess mortality. For most sequelae, we made estimates on the basis of a database for all age-sex-country-year groups, with a Bayesian meta-regression technique developed for the G BD 2010 (DisMod-MR). Several data sources have been used for the estimates of YLDs in China, including published studies,33–38 multiple national surveys,39,40 a set of 46 cancer registries,41–46 and the Centers for Disease Control andSee Online for appendixArticles Vol 381 June 8, 2013 1989Articles1990 Vol 381 June 8, 2013Prevention (CDC) surveillance system.47–53 The eff ects of treatment depending on the cause are captured through changes in prevalence, changes in the severity distribution across sequelae (eg, for chronic obstructive pulmonary disease), and for some injuries diff erent disability weights for treated and untreated outcomes. Access to treatment for injuries is estimated on the basis of an indicator of access to health systems.29For G BD 2010, disability weights were measured for 220 unique health states that cover the 1160 disease and injury sequelae.27 Disability weights were generated from more than 30 000 respondents collected through population-based surveys in fi ve countries—USA, Peru, Tanzania, Bangladesh, and Indonesia—and an open internet survey. 271 respondents of the internet survey were from China. Uncertainty in the disability weight for each sequela has been propagated into the estimates of YLDs for each disease and injury. We combined information about age-specifi c mortality rates, and about overall age-specifi c YLDs per person into the overall measure of health expectancy, HALE, using a standard approach to extending the life table to capture adjust-ments for non-fatal health outcomes.28Risk factorsDeaths, YLLs, YLDs, and DALYs attributable to 67 risk factors or clusters of risk factors were assessed with three key inputs.23 First, for each risk–outcome pair, relative risks of mortality or morbidity, or both, were estimated on the basis of meta-analyses of the published literature. Second, each risk factor exposure distribution in each country, age, and sex group was estimated on the basis of published and unpublished data sources with mostly Bayesian estimation methods.23 For China, key sources included the 2002 China National Nutrition and Health Survey, the China G lobal Youth Tobacco Survey, the Second National Health Services Survey, the 1996 G lobal Youth Tobacco Survey, the 1996 National Prevalence Survey, the After-MONICA, the INTERSALT Beijing, the INTERMAP Beijing, and the 2000 and 2005 national censuses. Third, we estimated attributable deaths or DALYs by comparing the present distribution of exposure to a theoretical minimum risk counterfactual distribution of exposure selected for each risk factor. Each risk factor or cluster of risk factors was analysed separately and therefore the sum of attributable fractions for a disease or injury can be greater than 100%. Uncertainty in the relative risks, exposure estimates, and theoretical minimum risk distributions and uncertainty in the background outcome rates have been propagated into the fi nal estimates.BenchmarkingFor outcomes measured for specifi c age groups (deaths, YLLs, YLDs, and DALYs), we directly computed age-standardised rates with the WHO age-standard.54 This standard is very close to the distribution of China’s population in 2010. For each disease, injury, or riskArticles Vol 381 June 8, 20131991factor, we ranked countries in 1990 and 2010 by the age-standardised rates for each outcome measure. We compared China outcomes to the 18 other countries that are members of the G 20 (the 20th member is the European Union). The G 20 is the set of developed and developing countries identifi ed as global agenda setters. Comparisons of China with this group provide insights into China’s standing relative to this set of developed or rapidly developing countries. For each quantity of interest in the G BD, 1000 draws were taken from the posterior distribution. We computed ranks across causes and percentage change from 1990 to 2010 at the draw level. We report 95% uncertainty intervals for ranks. For percentage change from 1990 to 2010 com p uted at the level of each draw, we report the median percentage change, which is less sensitive to extreme values than the mean percentage change. For a specifi c country and cause, we tested whether a country was signifi cantly greater than the G20 mean, in-distin g uish a ble from the mean, or below the mean.Role of the funding sourceThe sponsor of the study had no role in study design, data collection, data analysis, data interpretation, or writing of the report. The corresponding author had full access to all the data in the study and had fi nal respon s ibility to submit for publication.ResultsTable 1 provides an overall comparative view of health across the G 20. Between 1990 and 2010, China had a 6·4 year improvement in life expectancy at birth for both sexes combined (from 69·3 years to 75·7 years), rising one rank past Mexico in a league table of G 20 countries. In terms of the age-standardised death rate, China ranked 13th (95% uncertainty interval [UI] 11th to 14th) in 2010, ahead of Turkey, Brazil, Indonesia, Russia, India, and South Africa, but behind countries such as South Korea, USA, Saudi Arabia, Argentina, and Mexico. Across the G 20, age-standardised YLL rate varied by more than sevenfold. China had the lowest levels of age-standardised YLDs in 2010 across the G20; although Japan, South Korea, and Mexico had rates that were statistically indistin-guishable from China. Across G20 countries the ratio of the highest to lowest age-standardised YLD rate was only 1·6. China ranks at 10th (8th to 10th) for HALE in 2010, only 0·4 years (95% UI –0·4 to 1·2) behind the USA. Japan had a healthy life expectancy in 2010 that was 5·2 years (4·3–6·2) longer than that reported for China.Changes in age-specifi c mortality rates in China from 1990 to 2010 varied widely by age and sex (fi gure 1). Under-5 mortality rates declined by nearly 70% (95% UI 61·3–77·9). We noted declines in female adult mortality with declines in excess of 50% for age groups 0 years to 30–34 years. Progress in reduction of male mortality was substantially worse than that noted for women. Figure 1 shows comparative progress in reduction of age-specifi c mortality with other G 20 countries. For men, China’sFigure 1: Age-specifi c mortality in China, 1990–2010(A) Percentage change in age-specifi c mortality, by sex, in China between 1990 and 2010. (B) Rank of age-specifi c mortality for male individuals in China compared with 18 other members of the G20. (C) Rank of age-specifi c mortality for female individuals in China compared with 18 other members of the G20. Shaded areas show 95% uncertainty intervals (UI). In some cases, the 95% UI has an upper and lower bound equal to the rank of the mean death rate. Countries have been ranked such that the best performer is ranked as one for each indicator.Articles1992 Vol 381 June 8, 2013Articles Vol 381 June 8, 2013 1993Articles1994 Vol 381 June 8, 2013Articles Vol 381 June 8, 2013 1995Articles1996 Vol 381 June 8, 2013relative rank in terms of age-specifi c mortality was lower than the G 20 average at ages older than 50 years and relatively little changed between 1990 and 2010. For women and girls, however, we noted a substantial relative improvement, with ranks improving from 16th to 10th in the age groups 15–19 years through to 50–54 years. Although we noted a relative improvement for women older than 60 years, the improvement was less pronounced.Table 2 shows the number of deaths and the age-standardised death rate for each cause in 1990 and 2010. Communicable, maternal, neonatal, and nu-tritional disorders have declined by 59·5% (95% UI 54·4–63·8). Among these disorders, however, the large increase in HIV deaths is notable. The number of deaths from non-communicable disease rose from 5·9 million (5·7–6·3) to 7·0 million (6·7–7·3), but age-standardised death rates declined 27·8% (24·2–33·1);this difference was caused by population growth and ageing. Rising age-standardised rates have occurred for some causes such as lung cancer, ischaemic heart disease, atrial fibrillation, peripheral vascular disease, diabetes, and road injury.China has made substantial progress in reduction of the number of child deaths from 1·0 million (95% UI 0·9–1·1 million) in 1990 to 213 0000 (179 600–260 700) in 2010 (table 3). During this period, the main causes of child mortality also changed. The top fi ve specifi c causes, accounting for 59·7% (51·7–69·1) of child deaths in 2010 were (in order of frequency) congenital anomalies, preterm birth complications, lower respiratory infections, neonatal encephalopathy, and drowning. Diarrhoeal diseases were ranked sixth (95% UI fi fth to seventh) in 1990 but accounted for 0·9% (95% UI 0·6–1·3) of child deaths in 2010, and measles were ranked seventh (sixth to 13th) in 1990 but accounted for 0·2% (95% UI <0·05–0·4) of child deaths in 2010.Figure 2 shows the striking transition in YLLs that took place in China between 1990 and 2010. The number of YLLs attributable to neonatal causes, diarrhoea, pneu-monia, and other infectious causes and injuries in children declined profoundly in this period. At the same time, a shift occurred towards a large number of cardio-vascular and cancer YLLs at older ages with a notable peak in cancer YLLs in the 55–59 year age group in 2010. The number, age pattern, and composition of injury YLLs also changed: we noted increases and shifts to older ages in transport injuries and large declines in intentional injuries.Figure 3 shows the transition in leading causes of YLLs from 1990 to 2010. We noted striking declines in major communicable and neonatal causes of premature mortality: lower respiratory infections moved from fi rst (95% UI fi rst to third) to ninth (eighth to 11th); neonatal encephalopathy dropped 14 ranks (sixth to 20th); preterm birth complications dropped ten ranks (ninth to 19th);a 77% (95% UI 72–84) decline in YLLs from tuberculosis led it to drop from 15th (13th to 16th) to 29th (26th to 35th); and diarrhoea and meningitis also had substantial improvements. YLLs from stroke, ischaemic heart disease, road injury, lung cancer, liver cancer, colorectal cancer, and diabetes increased. Although population ageing was a key driver of these increases, age-standardised YLL rates (data not shown) for ischaemic heart disease, road injury,lung cancer, and diabetes also increased between 1990 and 2010. Several disorders that did not increase in incidence remained leading causes of YLLs in 2010: chronic obstructive pulmonary disease, stomach cancer, self-harm, oesophageal cancer, drowning, falls, and congenital anoma l ies. The substantial decrease we noted in pre-mature mortality from drowning deserves note. Incidence of HIV/AIDS increased strikingly in the 20-year period to become the 23rd biggest cause (20th to 29th) of YLLs. Figure 4 shows the levels of premature mortality in China relative to other members of the G20 in 2010. For men in China in 2010, age-standardised rates of years of life lost due to ischaemic heart disease, lower respiratory infections, cirrhosis, diabetes, preterm birth compli-cations, chronic kidney diseases, HIV/AIDS, and tuber-culosis were significantly better than the G20 mean. China had signifi cantly worse ranks than the mean for stroke, chronic obstructive pulmonary disease, liver cancer, stomach cancer, oesophageal cancer, leukaemia, drowning, and falls. The YLL rates of road injury and lung cancer for 2010 are indistinguishable from the mean but the absolute increase in YLLs from these causes is concerning. For women in China, we noted better than G20 average performance on ischaemic heart disease, lower respiratory infections, diabetes, breast cancer, preterm birth complications, chronic kidney diseases, cervical cancer, cirrhosis, and cardiovascular and circulatory diseases. We noted worse than G20 average outcomes for stroke, chronic obstructive pulmonary disease, road injury, self-harm, liver cancer, stomach cancer, oesoph a geal cancer, falls, drowning, and rheumatic heart disease. Even for conditions such as ischaemic heart disease, lung cancer, and diabetes (for which China was better than average in the G20 in 2010), rising rates suggest that this status might change in the near future.Appendix p 6 shows YLDs per head by age in China, by sex, in 1990 and 2010. Compared with substantial declines in mortality, we noted relatively little change in the age-specific YLDs per head. The percentage of DALYs attributable to YLDs increased from 28·1% (95% UI 24·2–32·5) to 39·4% (34·9–43·8) in 2010. Figure 5 shows the prominent role played by mental and behavioural disorders (23·6%, 18·9–28·6) andmusculoskeletal disorders (25·8%, 21·7–29·9) as causes of YLDs in adults. At younger ages, however, nutritional deficiencies, and some neglected tropical diseases make an important contribution. Other important causes included diabetes, urogenital, blood, and endocrine causes; other non-communicable diseases, which includes vision loss, hearing loss, and skin diseases; and unintentional injuries, which includes falls. Although age-specifi c YLDs per head rise with age, the eff ect of population age-structure leads to 77·2% (76·5–78·0) of YLDs occurring before age 60 years in China.Figure 6 compares the leading causes of YLDs in 1990 and 2010. The top 11 causes of YLDs all increased in terms of the absolute numbers of YLDs. Of the top ten causes of disability in 2010, four were musculoskeletalFigure 4: Age-standardised YLL rates in China in 2010 relative to 18 other members of G20, ranked by causedisorders (low back pain, neck pain, other musculoskeletal disorders, and osteoarthritis). Major depression was the second lead i ng cause of disability and alcohol use disorders was the ninth most common cause of YLDs. China ranked among the G20 as having the fi fth lowest age-standardised rate of major de p ression. Diabetes, falls, chronic obstruc t ive pulmonary disease, and hearing loss constituted the other top ten causes of YLDs. Progress on tackling com m uni c able diseases was also evident in the analysis of YLDs. We noted substantial declines (>30·0%) for iron-deficiency anaemia, hook-worm, tuberculosis, and ascariasis.Putting premature mortality and disability together in terms of DALYs provides an overall picture of the leading health problems in China. Table 4 shows the number and rate of DALYs in 1990 and 2010 and the percentage change between 1990 and 2010. The top ten causes have prominent roles for cardiovascular disorders (stroke and ischaemic heart disease) and cancers (lung and liver). Two disorders that largely cause disability, low back pain and major depression, are also leading causes of DALYs. Four other disorders make up the top ten: chronic obstructive pulmonary disease, diabetes, road injuries, and falls, which all make up an important component of premature mortality and disability.Appendix pp 7–8 ranks each country by the age-standardised DALY rate across the G20 for men and women in 2010. Men in China had higher than G20 average rates of DALYs caused by stroke, chronic obstructive pulmonary disease, liver cancer, stomach cancer, oesophageal cancer, and drowning. Chinese women had increased rates of DALYs caused by stroke, chronic obstructive pulmonary disease, road injury, self-harm, liver cancer, and stomach cancer. For someof the leading causes of disability, including low back pain and neck pain, China had rates that are indistinguishable from the G20 mean. Comparing 1990 (data not shown) with 2010, eight causes switched from significantly better than average to indistinguishable from average: falls, congenital anomalies, neonatal encephalopathy, poison i ngs, rheumatic heart disease, hookworm, ascariasis, and cysticercosis. For ischaemic heart disease, road injury and lung cancer (for which China was below the G20 average in 2010), rising rates mean that this situation might soon change.。
Moral Hazard Adverse Selection and Unemployment Insurance.ppt
State Unemployment tax
Some states levy additional taxes (over 5.4%), moreover the base salary may be higher than the federal standard, it differs from state to state. In CO wage base is $10,000 for 2007/08 CO rates: 0.3%-5.4% New employers use 3.1% Average replacement ratio (Ben/Preunemployment earnings): 39.3% Unemployment rate (05/06): 4%
Unemployment Duration and
Unemployment Benefit
Meyer, Bruce “Unemployment Insurance and Unemployment Spells” Econometrica, 58 (1990) pp.757-782
Empirical Findings:
two parties interact one the other this information has a direct implication on the payoffs that the parties receive from a potential contract between them
UC reduces the last cost, thus, firms will layoff more the better is the UC.
How to avoid “subsidizing layoffs”?
经合组织风险认识工具OECD Risk Awareness tool
Governance Zones
ORGANISATION FOR ECONOMIC CO-OPERATION AND DEVELOPMENT
ORGANISATION FOR ECONOMIC CO-OPERATION AND DEVELOPMENT
Foreword
The OECD Risk Awareness Tool for Multinational Enterprises in Weak
Governance Zones aims to help companies that invest in countries where governments are unwilling or unable to assume their responsibilities. It addresses risks and ethical dilemmas that companies are likely to face in such weak governance zones, including obeying the law and observing international instruments, heightened care in managing investments, knowing business partners and clients and dealing with public sector officials, and speaking out about wrongdoing.
© OECD 2006
No reproduction, copy, transmission or translation of this publication may be made without written permission. Applications should be sent to OECD Publishing: rights@ or by fax (33 1) 45 24 13 91. Permission to photocopy a portion of this work should be addressed to the Centre français d'exploitation du droit de copie, 20, rue des Grands-Augustins, 75006 Paris, France (contact@).
外文翻译----风险管理幸存者的前车之鉴
原文:Report from Davos: Risk Management Survivors Offer Cautionary TalesWharton management professor Michael Useem joined heads of state, politicians, CEOs, celebrities and others at this year's World Economic Forum in Davos, Switzerland, where, he says, the mood seemed to be one of muted optimism. But, as he points out, there was also a recognition of how much still needs to be done to prevent the kinds of catastrophes -- both natural and created -- that changed the lives of so many individuals over the past two years. Useem, director of Wharton's Center for Leadership and Change Management, offers this report on Davos.Among the 2,500 business executives, political leaders and others who attended the 2011 meeting of the World Economic Forum in Davos, the mood was one of cautious recuperation from aself-induced, life-threatening illness. The financial crisis had been surmounted but not without lingering frailties, especially the under-employment of the West.The ongoing political upheavals in Tunisia and Egypt added another crisis to the focus in Davos. The Forum arranged a special session on the unfolding actions in North Africa and the Middle East, and many participants sought frequent updates on the historic events, wondering whether the street protests, in the words of the special session, were a "tipping point or tsunami," and whether they would result in a "soft landing or a bloody one."Still, cautious optimism prevailed among the national and corporate leaders in Davos that they had taken the right steps for at least the financial recovery. Not all their actions had worked, but on balance they had, and many of these leaders promised now to better prepare their agencies or enterprises to manage future threats in a world that has become ever more subject tolow-probability but high-consequence events.The Haitian earthquake and BP oil spill in the Gulf of Mexico served as recent reminders that enormous catastrophes were not only financial -- and that much remained to be done for managing extreme risks in a world more vulnerable than ever to both natural and unnatural calamities. The agenda going forward: continue to monitor financial institutions and sovereign debt to prevent systemic collapse, build a learning network, redesign the board and rewire the mind.Continuing VigilanceSeveral of the more than 35 national leaders in Davos vowed to use their state powers to avoid any financial relapse. If governments had learned anything from the near death experience of the crisis, it was to more effectively oversee risk takers and their short-term, self-interested decisions."We were standing on the brink of an abyss," said French President Nicolas Sarkozy of the financial crisis, "and we had to act." But new perils are now leading toward new brinks, he warned, including the teetering sovereign debt of several European nations and a questioning of the euro.In the wake of the banking crisis, governments must again act boldly to prevent further upheaval. "The euro is Europe," he declared. "We will never let the euro be destroyed."German Chancellor Angela Merkel added her own defense of the currency, saying it is "the embodiment of Europe today. Should the euro fail, Europe will fail." She also sought tougher oversight of the players that had brought on the financial meltdown to begin with: "I always said there would be a new deck of cards on the table after the crisis," though governments have not yet managed to deal all the right cards. "Do we have the necessary mechanisms in place to ensure sustainable growth globally? We have laid down the groundwork," she stated, "but we are not there yet."Similarly, U.S. Treasury Secretary Timothy Geithner warned that, despite six quarters of GDP growth in the U.S., national leaders still had work to do to "take catastrophic risks out of the market." And U.K. Prime Minister David Cameron, observing that "given the traumas of recent years, the recovery was always going to be choppy," argued that country officials had no choice but to continue to "modernize and adapt" their economies or otherwise "fall behind and fail."Other country leaders cited additional perils that required still more measures. Indonesian President SusiloBambangYudhoyono worried about emerging conflicts over food, fuel and water that threatened to elevate private "greed" over public "need." Russian President Dmitry Medvedev warned of the continued "fragility of our condition," brought home just days before by a devastating explosion in the Moscow airport. But he, too, cautioned that the economic recovery was not yet complete. Many "tend to speak of the end of the world financial crisis," he stated, but "it is quite obvious that it is not all that simple." While "the crisis has sobered up everyone, we have coped with only one part of the symptoms of the crisis, and so far we have not found a model for growth."Symptomatic of the heightened awareness of risk management, the Prime Minister of Japan, Naoto Kan, referenced the English utilitarian philosopher Jeremy Bentham's principle of creating the "greatest happiness" for the "greatest number." In an era in which the downsides of risk have become more severe, he said that the Japanese government under his leadership, by contrast, would stress policies that generate not the "greatest happiness" -- but rather "a society with the least unhappiness" -- for the greatest number.Building a Learning NetworkGiven the global financial crisis and the devastating events in Haiti and the Gulf, it came as no surprise that the World Economic Forum, under the continuing leadership of founder Klaus Schwab, turned the spotlight at this year's 41st annual meeting on both the principles and strategies of risk management. The Forum launched a new Risk Response Network (RRN), an initiative to identify leading global risks and to better equip public, private and non-profit leaders with shared means for preventing, anticipating or responding to the risks.As part of the RRN initiative, an annual Global Risks report, already in its sixth year, will continue to rank global perils as one pillar of the new network (the Wharton Risk Managementand Decision Processes Center collaborates in the annual report's preparation). At the top of the report's ranking this year were the two inter-related risks of economic disparities and failing governance. The report warned that the benefits of globalization have not been evenly shared, and when combined with unresponsive or ineffective regimes, "resurgent nationalism and populism" are a likely product. Evidently, it was just those factors in toxic combination that played a major role in stimulating the popular revolt against the long-serving but poorly governed regimes in Tunisia and Egypt.Two other RRN initiatives announced in Davos were intended to furnish country, company and NGO leaders with better tools for appraising risks and responding to disasters. A new Leading Practices Exchange will provide them with guidance on how to manage and mitigate risks. And a Community of Risk Officers will establish a network for mutual learning and peer counseling among those at the forefront of risk management. The first risks to be tackled by the new network include currency volatility, cyber security and resource scarcity, with others to be added.With this initiative, the World Economic Forum has created an on-going platform to give those engaged in risk management better access to detailed data, proven practices and experienced players.By way of one example: A physician at the Davos meeting who had been active in recovery from the Haitian earthquake reported that in some areas, relief agencies provided fresh water to survivors free of charge, while in others a modest charge was imposed. The latter practice would help ration and allocate a still scarce resource, vital for recovery. But the physician found that cholera spread far more often through camps that charged for water than through camps that didn't charge, evidently because even a small cost led survivors to use less water in personal hygiene and food preparation. While charging a nominal amount for potable water made good economic sense, the experience here called into question whether it made public health sense.Redesigning the BoardThe governing board is potentially one of the most pivotal places for the introduction of risk management practices in the view of those attending an annual-meeting session on "Redesigning the Board." Chaired by Berkeley professor Laura D'Andrea Tyson, who serves on the boards of several publicly traded companies, the dialogue drew on the experience of Donald J. Gogel, CEO of Clayton, Dubilier& Rice; Richard Haythornthwaite, chair of MasterCard Worldwide; Kevin Kelly, CEO, Heidrick& Struggles; Davide Serra, managing partner of Algebris Investments, and Daniel Vasella, chair of Novartis.Leaving aside the question of whether company boards contributed to the recent financial crisis, the boardroom could serve as a barricade against the next crisis -- if properly redesigned. The board's traditional focus has been on "compliance, control and compensation," fulfilling the oversight function mandated by both government regulators and listing requirements. But that is no longer sufficient, suggested several panel members. Directors should also be engaged in "company strategy, talent development and risk management." It is a matter of not only "feedingthe beast" -- providing investors with expected quarterly returns -- but also "building the business" -- advising executives on strategic direction and appropriate risk.To that end, directors should bring not just oversight capabilities to the boardroom. They should also be ready to challenge management practices, exercise independent judgment and resist when executive actions pose excessive risk. It goes the other way, too, suggested one veteran board member: "The worst thing is when a management team does not speak out." Directors, another participant pointed out, "want management to speak up with its concerns." For both sides to speak up, however, smaller boards make better forums. "Seven to eight people can debate strategy," noted one governance veteran, "the way a board of 15 cannot."If boards were once more ceremonial than substantive, more honorary than productive, that is a dying tradition in an era when directors are increasingly called -- or demand -- to serve as strategic advisors. Several directors reported that their boards regularly conduct 360-degree feedback surveys of one another, inviting company executives to appraise their individual performance as well. One board chair even interviews every board member, asking for their appraisals of the other directors, and he then circles back with feedback, commending each director for his or her contribution to the boardroom but also citing one area for the director's "improvement." Another director with extensive boardroom experience found that the one best question to ask of each director about the others is, "If you were the only shareholder of the company, would you want this person on the board?"If well redesigned, company boards can thus help their companies in "a race to the top" -- building long-term value and avoiding excessive short-term risks -- rather than permitting a "race to the bottom" that had driven some companies into the cauldron of the crisis. In another session, JPMorgan Chase CEO James Dimon reported that his own board had played just such a role when the more recent European sovereign crises materialized. With billions of dollars of European exposure and short-term losses likely, his board had advised against pulling back. "Let's be rational and careful," he said the directors told him. "We're in Europe for the long term, we serve a lot of European companies," and staying invested despite the crisis was the right thing to do.Rewiring the MindFor individuals, there are few better opportunities for re-thinking risk management than those offered by studying one's own setbacks as well as the experiences of others. The annual meeting was fortunate to have included panels on "The Merits of Failure" and "Exploring the Extremes;" a session with ChesleySullenberger, the USAir pilot who safely landed his aircraft in the Hudson River after both engines failed; and an event with adventurer Alison Levine, who has reached the South Pole, North Pole, and Mt. Everest summit.Working in extremely high stakes environments requires taking calculated risks, the antithesis of recklessness that had driven the sub-prime mortgage lending that sparked the financial crisis. And when critical decision points are reached -- going for a dangerous summit, landing a stricken aircraft -- a total focus on the task at hand and the ability to draw on a lifetime of experience are vital for surmounting the perils of the moment.Cautionary Lessons for Managing RiskAmong the more unforgettable personal lessons from the World Economic Forum's focus this year on managing risk in a more risky world: Will-power is essential, calculate the risks, and focus on the goal at hand however stressful the moment -- whether restoring an economy, avoiding default, landing an aircraft or climbing a summit. And among the more enduring company and country lessons: Complacency will kill you, good governance is essential, and learn from others' mistakes to avoid your own.The annual meeting in Davos served to reinforce a host of such messages. Between meetings, its Risk Response Network, Leading Practices Exchange and Community of Risk Officers will continue the Forum's efforts to provide better ways to anticipate, mitigate, and even prevent catastrophic risks from becoming the kinds of disasters that we have witnessed in the financial crisis, Haiti, the Gulf and beyond.译文:达沃斯报告:风险管理幸存者的前车之鉴今年,各国政府首脑、政界精英、企业总裁及各界名人齐聚瑞士达沃斯世界经济论坛,沃顿商学院管理学教授、沃顿领导力与变革管理中心主任迈克尔·尤西姆(Michael Useem)在论坛上表示,论坛期间涌动着谨慎乐观的情绪。
社区获得型肺炎英国指南
347Downloaded from at Library of Medical Center of Fudan University on April 21, 2014/348Bartlett et al.CID2000;31(August)is not available initially but is subsequently reported,changing to the antimicrobial agent that is most cost-effective,least toxic, and most narrow in spectrum is encouraged.Recommendations for treating patients who require empirical antibiotic selection are based on severity of illness,pathogen probabilities,resis-tance patterns of S.pneumoniae(the most commonly implicated etiologic agent),and comorbid conditions.The recommendation for outpatients is administration of a macrolide,doxycycline,orfluoroquinolone with enhanced ac-tivity against S.pneumoniae.For patients who are hospitalized, the recommendation is administration of afluoroquinolone alone or an extended-spectrum cephalosporin(cefotaxime or ceftriaxone)plus a macrolide.Patients hospitalized in the in-tensive care unit(ICU)should receive ceftriaxone,cefotaxime, ampicillin-sulbactam,or piperacillin-tazobactam in combina-tion with afluoroquinolone or macrolide.b-lactams,other than those noted,are not recommended.Intravenous antibiotics may be switched to oral agents when the patient is improving clin-ically,is hemodynamically stable,and is able to ingest drugs. Most patients show a clinical response within3–5days. Changes evident on chest radiographs usually lag behind the clinical response,and repeated chest radiography is generally not indicated for patients who respond.The failure to respond usually indicates an incorrect diagnosis;host failure;inappro-priate antibiotic;inappropriate dose or route of administration; unusual or unanticipated pathogen;adverse drug reaction;or complication,such as pulmonary superinfection or empyema. Prognosis.The most frequent causes of lethal community-acquired pneumonia are S.pneumoniae and Legionella.The most frequent reason for failure to respond is progression of pathophysiological changes,despite appropriate antibiotic treatment.Pneumococcal pneumonia.S.pneumoniae,the most com-mon identifiable etiologic agent of pneumonia in virtually all studies,accounts for about two-thirds of bacteremic pneumonia cases,and pneumococci are the most frequent cause of lethal community-acquired pneumonia.Management has been com-plicated in recent years by the evolution of multidrug resistance. b-lactams(amoxicillin,cefotaxime,and ceftriaxone)are gen-erally regarded as the drugs of choice,although pneumonia caused by resistant strains(MIC,у2m g/mL)may not respond as readily as pneumonia caused by more susceptible strains. The activity of macrolides and doxycycline or other b-lactams, including cefuroxime,is good against penicillin-susceptible strains but less predictable with strains that show reduced pen-icillin-susceptibility.Vancomycin,linezolid,and quinupristin/ dalfopristin are the only drugs with predictable in vitro activity. Fluoroquinolones are generally active against strains that are susceptible or resistant to penicillin,but recent reports indicate increasing resistance in selective locations that correlate with excessivefluoroquinolone use.Prevention.The major preventive measures are use of in-fluenza vaccine and use of pneumococcal vaccine,according to guidelines of the Advisory Council on Immunization Practicesof the Centers for Disease Control and Prevention(CDC). Performance indicators.Recommendations for perform-ance indicators include the collection of blood culture speci-mens before antibiotic treatment and the institution of anti-biotic treatment within8h of hospitalization,since both aresupported on the basis of evidence-based trials.Additional per-formance indicators recommended are laboratory tests for Le-gionella in patients hospitalized in the ICU,demonstration ofan infiltrate on chest radiographs of patients with an ICD-9 (International Classification of Diseases,9th edition)code for pneumonia,and measurement of blood gases or pulse oximetrywithin24h of admission.IntroductionLower respiratory tract infections are the major cause ofdeath in the world and the major cause of death due to infec-tious diseases in the United States.Recent advances in thefieldinclude the identification of new pathogens(Chlamydia pneu-moniae and hantavirus),new methods of microbial detection (PCR),and new antimicrobial agents(macrolides,b-lactamagents,fluoroquinolones,oxazolidinones,and streptogramins).Despite extensive studies,there are few conditions in medicinethat are so controversial in terms of management.Guidelinesfor management were published in1993by the American Tho-racic Society[1],the British Thoracic Society[2],and the Ca-nadian Infectious Disease Society[3],as well as the InfectiousDiseases Society of America(IDSA)in1998[4].The presentguidelines represent revised recommendations of the IDSA. Compared with previous guidelines,these guidelines are in-tended to reflect updated information,provide more extensive recommendations in selected areas,and indicate an evolutionof opinion.These therapeutic guidelines are restricted to com-munity-acquired pneumonia(CAP)in immunocompetentadults.Recommendations are given alphabetical ranking to reflecttheir strength and a Roman numeral ranking to reflect thequality of supporting evidence(table1).This is customary forquality standards from the IDSA[5].It should be acknowledgedthat no set of standards can be constructed to deal with themultitude of variables that influence decisions regarding site ofcare,diagnostic evaluation,and selection of antibiotics.Thus,these standards should not supplant good clinical judgement.EpidemiologyMagnitudeCAP is commonly defined as an acute infection of the pul-monary parenchyma that is associated with at least some symp-toms of acute infection,accompanied by the presence of anacute infiltrate on a chest radiograph or auscultatoryfindingsconsistent with pneumonia(such as altered breath sounds and/at Library of Medical Center of Fudan University on April 21, 2014/Downloaded fromCID2000;31(August)IDSA Guidelines for CAP in Adults349Table1.Categories for ranking recommendations in the therapeutic guidelines.Category DescriptionStrength of recommendationA Good evidence to support a recommendation for useB Moderate evidence to support a recommendation for useC Poor evidence to support a recommendationD Moderate evidence to support a recommendation against useE Good evidence to support a recommendation against useQuality of evidenceI Evidence from at least1randomized,controlled trialII Evidence from at least1well-designed clinical trial without randomizationIII Evidence from opinions of respected authorities,based on clinical experi-ence,descriptive studies,or reports of expert committeesor localized rales),in a patient not hospitalized or residing in a long-term-care facility forу14days before onset of symp-toms.Symptoms of acute lower respiratory infection may in-clude several(in most studies,at least2)of the following:fever or hypothermia,rigors,sweats,new cough with or without sputum production or change in color of respiratory secretions in a patient with chronic cough,chest discomfort,or the onset of dyspnea.Most patients also have nonspecific symptoms, such as fatigue,myalgias,abdominal pain,anorexia,and headache.Pneumonia is the sixth most common cause of death in the United States.From1979through1994,the overall rates of death due to pneumonia and influenza increased by59%(on the basis of ICD-9codes on death certificates)in the United States[6].Much of this increase is due to a greater proportion of persons agedу65years;however,age-adjusted rates also increased by22%,which suggests that other factors may have contributed to a changing epidemiology of pneumonia,includ-ing a greater proportion of the population with underlying med-ical conditions at increased risk of respiratory infection. Annually,2–3million cases of CAP result in∼10million physician visits,500,000hospitalizations,and45,000deaths in the United States[7,8].The incidence of CAP that requires hospitalization is estimated to be258persons per100,000pop-ulation and962per100,000persons agedу65years[8].Al-though mortality has ranged from2%to30%among hospi-talized patients in a variety of studies,the average is∼14%[9]. Mortality is estimated to be!1%for patients not hospitalized [9,10].The incidence of CAP is heavily weighted toward the winter months.Prognosis,Risk Stratification,and the Initial Site-of-Treatment DecisionKnowledge about the prognosis of a disease allows physi-cians to inform their patients about the expected natural history of an illness,the likelihood of potential complications,and the probability of successful treatment.Understanding the prog-nosis of CAP is of particular clinical relevance,since it ranges from rapid recovery from symptoms without functional im-pairment to serious morbid complications and death.The abil-ity to accurately predict medical outcomes in cases of CAP hasa major impact on management.The decision to hospitalize apatient or to treat him or her as an outpatient(figure1)isperhaps the single most important clinical decision made by physicians during the entire course of illness,which has directbearing on the location and intensity of laboratory evaluation,antibiotic therapy,and costs.The estimated total treatment costfor an episode of CAP managed in the hospital is$7500(USdollars)[11],120-fold higher than the cost of outpatient treatment.Numerous studies have identified risk factors for death incases of CAP[9,10,12].These factors were well-defined in thepre–penicillin era;studies of adults showed an increased riskwith alcohol consumption,increasing age,the presence of leu-kopenia,the presence of bacteremia,and radiographic changes[12].More recent studies have confirmed thesefindings[2,13–18].Independent associations with increased mortality havealso been demonstrated for a variety of comorbid illnesses,suchas active malignancies[10,16,19],immunosuppression[20,21], neurological disease[19,22,23],congestive heart failure[10,17,19],coronary artery disease[19],and diabetes mellitus[10,19,24].Signs and symptoms independently associated with in-creased mortality consist of dyspnea[10],chills[25],alteredmental status[10,19,23,26],hypothermia or hyperthermia[10,16,17,20],tachypnea[10,19,23,27],and hypotension(diastolic and systolic)[10,19,26–28].Laboratory and radiographicfindings independently asso-ciated with increased mortality are hyponatremia[10,19],hy-perglycemia[10,19],azotemia[10,19,27,28],hypoalbumi-nemia[16,19,22,25],hypoxemia[10,19],liver function test abnormalities[19],and pleural effusion[29].Infections due togram-negative bacilli or S.aureus,postobstructive pneumonia,and aspiration pneumonia are also independently associatedwith higher mortality[30].Despite our knowledge regarding the associations of clinical, laboratory,and radiographic factors and patient mortality,there is wide geographic variation in hospital admission ratesfor CAP[31,32].This variation suggests that physicians donot use a uniform strategy to relate the decision to hospitalizeto the prognosis.In fact,physicians often overestimate the riskof death for patients with CAP,and the degree of overesti-at Library of Medical Center of Fudan University on April 21, 2014/Downloaded from350Bartlett et al.CID2000;31(August)Figure1.Evaluation for diagnosis and management of community-acquired pneumonia,including site,duration,and type of treatment. b-Lactam:cefotaxime,ceftriaxone,or a b-lactam/b-lactamase inhibitor.Fluoroquinolone:levofloxacin,moxifloxacin,or gatifloxacin or another fluoroquinolone with enhanced antipneumococcal activity.Macrolide:erythromycin,clarithromycin,or azithromycin.CBC,complete blood cell count;ICU,intensive care unit.*Other tests for selected patients:see text,Diagnostic Evaluation:Etiology.**See table15for special considerations.mation is independently associated with the decision to hos-pitalize[30].Over the past10years,at least13studies have used multi-variate analysis to identify predictors of prognosis for patients with CAP[10,16–20,25–27,33–35].The Pneumonia PORT developed a methodologically sound clinical prediction rule that quantifies short-term mortality for patients with this illness [10].Used as a guideline,this rule may help physicians make decisions about the initial location and intensity of treatment for patients with this illness(table2).The Pneumonia PORT prediction rule was derived with 14,199inpatients with CAP;it was independently validated with 38,039inpatients with CAP and2287inpatients and outpatients prospectively enrolled in the Pneumonia PORT cohort study. With this rule,patients are stratified into5severity classes by means of a2-step process.In step1,patients are classified as risk class I(the lowest severity level)if they are agedр50years,have none of5important comorbid conditions(neoplastic dis-ease,liver disease,congestive heart failure,cerebrovascular dis-ease,or renal disease),and have normal or only mildly derangedvital signs and normal mental status.In step2,all patients whoare not assigned to risk class I on the basis of the initial historyand physical examinationfindings alone are stratified into clas-ses II–V,on the basis of points assigned for3demographicvariables(age,sex,and nursing home residence),5comorbidconditions(listed above),5physical examinationfindings(al-tered mental status,tachypnea,tachycardia,systolic hypoten-sion,hypothermia,or hyperthermia),and7laboratory or ra-diographicfindings(acidemia,elevated blood urea nitrogen, hyponatremia,hyperglycemia,anemia,hypoxemia,or pleuraleffusion;table3).Point assignments correspond with the fol-lowing classes:р70,class II;71–90,class III;91–130,class IV;and1130,class V.In the derivation and validation of this rule,mortality wasat Library of Medical Center of Fudan University on April 21, 2014/Downloaded fromCID2000;31(August)IDSA Guidelines for CAP in Adults351 parison of risk class–specific mortality rates in the derivation and validation cohorts.Risk class a (total points)MedisGroups MedisGroupsPneumonia PORT validation cohortderivation cohort validation cohort Inpatients Outpatients All patientsn Mortality,%n Mortality,%n Mortality,%n Mortality,%n Mortality,%I13720.430340.11850.55870.07720.1II(р70)24120.757780.62330.92440.44770.6III(71–90)2632 2.86790 2.8254 1.2720.03260.9IV(91–130)46978.513,1048.24469.04012.54869.3V(1130)308631.1933329.222527.110.022627.0 Total14,19910.238,03910.613438.09440.62287 5.2 NOTE.No statistically significant differences in overall mortality or mortality within risk class existed among patients in the MedisGroups derivation,MedisGroups validation,and overall Pneumonia Patient Outcome Research Team(PORT)validation cohorts(n denotes the no.of patients within each risk class in the derivation and validation cohorts).P values for the comparisons of mortality across risk classes are as follows:class I,;class II,;class III,;class IV,;and class V,.P p.22P p.67P p.12P p.69P p.09a Risk class I was determined by the absence of all predictors identified in step1of the prediction rule.Risk classes II–V were determined by a patient’s total risk score,which is computed by use of the point scoring system shown in table3.low for risk classes I–III(0.1%–2.8%),intermediate for class IV(8.2%–9.3%),and high for class V(27.0%–31.1%).Increases in risk class were also associated with subsequent hospitaliza-tion and delayed return to usual activities for outpatients and with rates of admission to the ICU and length of stay for inpatients in the Pneumonia PORT validation cohort.On the basis of these observations,Pneumonia PORT investigators suggest that patients in risk classes I or II generally are can-didates for outpatient treatment,risk class III patients are po-tential candidates for outpatient treatment or brief inpatient observation,and patients in classes IV and V should be hos-pitalized(table4).Estimates from the Pneumonia PORT cohort study suggest that these recommendations would reduce the proportion of patients receiving traditional inpatient care by 31%and that there would be a brief observational inpatient stay for an additional19%.The effectiveness and safety of applying the Pneumonia PORT prediction rule to the initial site of care for an indepen-dent population of patients with CAP have been examined with use of a modified version of the Pneumonia PORT prediction rule[36].Emergency room physicians were educated about the rule and were encouraged to treat those in risk classes I–III as outpatients,with close,structured follow-up and provision of oral clarithromycin at no cost to the patient,if desired.The outcomes for those treated at home during this intervention phase were compared with the outcomes for historical control subjects from the time period immediately preceding the intervention.During the intervention period,there were166eligible pa-tients classified as“low risk”for short-term mortality(risk classes I–III)for comparison with147control subjects.The percentage treated initially as outpatients was higher during the intervention period than during the control period(57%vs. 42%;relative increase of36%;).When initial plus sub-P p.01sequent hospitalization was used as the outcome measure,there was a trend toward more outpatient care during the interven-tion period,but the difference was no longer statistically sig-nificant(52%vs.42%;).None of those initially treatedP p.07in the outpatient setting during the intervention period diedwithin4weeks of presentation.A second multicenter controlled trial subsequently assessedthe effectiveness and safety of using the Pneumonia PORT pre-diction rule for the initial site-of-treatment decision[37].In thistrial,19emergency departments were randomly assigned eitherto continue conventional management of CAP or to implementa critical pathway that included the Pneumonia PORT predic-tion rule to guide the admission decision.Emergency room physicians were educated about the rule and were encouragedto treat those in risk classes I–III as outpatients with oral levo-floxacin.Overall,1743patients with CAP were enrolled in this6-month e of the prediction rule resulted in an18%reduction in the admission of low-risk patients(31%vs.49%;).Use of the rule did not result in an increase in mor-P p.013tality or morbidity and did not compromise patients’30-dayfunctional status.These studies support use of the PneumoniaPORT prediction rule to help physicians identify low-risk pa-tients who can be safely treated in the outpatient setting.The IDSA panel endorses thefindings of the PneumoniaPORT prediction rule,which identifies valid predictors for mor-tality and provides a rational foundation for the decision re-garding hospitalization.However,it should be emphasized thatthe PORT prediction rule is validated as a mortality predictionmodel and not as a method to triage patients with CAP.Newstudies are required to test the basic premise underlying the useof this rule in the initial site-of-treatment decision,so that pa-tients classified as“low risk”and treated in the outpatient set-ting will have outcomes equivalent to or better than those ofsimilar“low-risk”patients who are hospitalized.It is important to note that prediction rules are meant tocontribute to rather than to supersede physicians’judgment.Another limitation is that factors other than severity of illnessmust also be considered in determining whether an individualpatient is a candidate for outpatient care.Patients designatedas“low risk”may have important medical and psychosocial contraindications to outpatient care,including expected com-pliance problems with medical treatment or poor social supportat Library of Medical Center of Fudan University on April 21, 2014/Downloaded from352Bartlett et al.CID 2000;31(August)Table 3.Scoring system for step 2of the prediction rule:assignment to risk classes II–V .Patient characteristicPoints assignedaDemographic factor Age Male No.of years of age FemaleNo.of years of age Ϫ10Nursing home resident ϩ10Comorbid illnessesNeoplastic diseasebϩ30Liver diseasecϩ20Congestive heart failuredϩ10Cerebrovascular diseaseeϩ10Renal diseasefϩ10Physical examination findingAltered mental statusgϩ20Respiratory rate 130breaths/min ϩ20Systolic blood pressure !90mm Hg ϩ20Temperature !35ЊC or 140ЊC ϩ15Pulse 1125beats/minϩ10Laboratory or radiographic finding Arterial pH !7.35ϩ30Blood urea nitrogen 130mg/dL ϩ20Sodium !130mEq/L ϩ20Glucose 1250mg/dL ϩ10Hematocrit !30%ϩ10Arterial partial pressure of oxygen !60mm Hg hϩ10Pleural effusionϩ10aA total point score for a given patient is obtained by adding the patient’s age in years (age Ϫ10,for females)and the points for each applicable patient char-acteristic.Points assigned to each predictor variable were based on coefficients obtained from the logistic regression model used in step 2of the prediction rule.bAny cancer except basal or squamous cell cancer of the skin that was active at the time of presentation or diagnosed within 1year of presentation.cA clinical or histologic diagnosis of cirrhosis or other form of chronic liver disease such as chronic active hepatitis.dSystolic or diastolic ventricular dysfunction documented by history and physical examination,as well as chest radiography,echocardiography,Muga scanning,or left ventriculography.eA clinical diagnosis of stroke,transient ischemic attack,or stroke docu-mented by MRI or computed axial tomography.fA history of chronic renal disease or abnormal blood urea nitrogen and creatinine values documented in the medical record.gDisorientation (to person,place,or time,not known to be chronic),stupor,or coma.hIn the Pneumonia Patient Outcome Research Team cohort study,an oxygen saturation value !90%on pulse oximetry or intubation before admission was also considered abnormal.Table 4.Risk-class mortality rates.Risk class No.of points Validation cohortRecommended site of care No.of patientsMortality,%I —a30340.1Outpatient II р7057780.6Outpatient III 71–906790 2.8Outpatient or brief inpatient IV 91–13013,1048.2Inpatient V1130933329.2InpatientNOTE.Table is adapted from [10].aAbsence of predictors.at home.Ability to maintain oral intake,history of substance abuse,cognitive impairment,and ability to perform activities of daily living must be considered.In addition,patients may have rare conditions,such as severe neuromuscular disease or immunosuppression,which are not included as predictors in these prediction rules but increase the likelihood of a poor prognosis.Prediction rules may also oversimplify the way physicians interpret important predictor variables.For example,extreme alterations in any one variable have the same effect on risk stratification as lesser changes,despite obvious differences in clinical import (e.g.,a systolic blood pressure of 40mm Hg vs.one of 88mm Hg).Furthermore,such rules discount the cu-mulative importance of multiple simultaneous physiological de-rangements,especially if each derangement alone does not reach the threshold that defines an abnormal value (e.g.,systolicblood pressure of 90/40mm Hg,respiratory rate of 28breaths/min,and pulse of 120beats/min).Finally,prediction rules often neglect the importance of patients’preferences in clinical de-cision-making.This point is highlighted by the observation that the vast majority of low-risk patients with CAP do not have their preferences for site of care solicited,despite strong pref-erences for outpatient care [38].Role of Specific Pathogens in CAPProspective studies evaluating the causes of CAP in adults have failed to identify the cause of 40%–60%of cases of CAP and have detected у2etiologies in 2%–5%[2,7,26,39,40].The most common etiologic agent identified in virtually all studies of CAP is S.pneumoniae,which accounts for about two-thirds of all cases of bacteremic pneumonia cases [9].Other pathogens implicated less frequently include H.influenzae (most strains of which are nontypeable),Mycoplasma pneumoniae,C.pneumoniae,S.aureus,Streptococcus pyogenes,N.meningitidis,Moraxella catarrhalis,Klebsiella pneumoniae and other gram-negative rods,Legionella species,influenza virus (depending on the season),respiratory syncytial virus,adenovirus,parainflu-enza virus,and other microbes.The frequency of other etiol-ogies is dependent on specific epidemiological factors,as with Chlamydia psittaci (psittacosis),Coxiella burnetii (Q fever),Francisella tularensis (tularemia),and endemic fungi (histo-plasmosis,blastomycosis,and coccidioidomycosis).Comparisons of relative frequency of each of the etiologies of pneumonia are hampered by the varying levels of sensitivity and specificity of the tests used for each of the pathogens that they detect;for example,in some studies,tests used for legi-onella infections provide a much higher degree of sensitivity and possibly specificity than do tests used for pneumococcal infections.Thus,the relative contribution of many causes to the incidence of CAP is undoubtedly either exaggerated or un-derestimated,depending on the sensitivity and specificity of tests used in each of the studies.Etiology-Specific Diagnoses and the Clinical SettingNo convincing association has been demonstrated between individual symptoms,physical findings,or laboratory test re-sults and specific etiology [39].Even time-honored beliefs,suchat Library of Medical Center of Fudan University on April 21, 2014/Downloaded fromCID2000;31(August)IDSA Guidelines for CAP in Adults353Table5.Diagnostic studies for evaluation of community-acquired pneumonia.Baseline assessmentChest radiography to substantiate diagnosis of pneumonia,to detect associated lung diseases,to gain insightinto causative agent(in some cases),to assess severity,and as baseline to assess responseOutpatientsSputum Gram stain and culture for conventional bacteria are optionalInpatientsDetermination of complete blood cell and differential countsSerum creatinine,urea nitrogen,glucose,electrolyte,bilirubin,and liver enzyme valuesHIV serological status for persons aged15–54yearsO2saturation arterial blood gas values for selected patientsBlood cultures(ϫ2;before treatment)Gram stain and culture of sputum aTest for Mycobacterium tuberculosis,with acid-fast bacilli staining and culture for selected patients,especiallythose with cough for11mo,other common symptoms,or suggestive radiographic changesTest for Legionella in selected patients,including all seriously ill patients without an alternative diagnosis,es-pecially if aged140years,immunocompromised,or nonresponsive to b-lactam antibiotics,if clinicalfeatures are suggestive of this diagnosis,or in outbreak settingsThoracentesis with stain,culture,and determination of pH and leukocyte count differential(pleuralfluid)Alternative specimens to expectorated sputumAspirates of intubated patients,tracheostomy aspirates,and nasotracheal aspirates:manage as with expec-torated sputumInduced sputum:recommended for detection of M.tuberculosis or Pneumocystis cariniiBronchoscopy(see text under Special Considerations:Pnemococcal Pneumonia)Transtracheal aspiration:recommended only in cases of enigmatic pneumonia,to be done by personsskilled in the technique,preferably before antibiotic treatmentOptionalAdditional cytological or microbiological tests,as listed in table8,depending on clinical features,availableresources,underlying conditions,and/or epidemiological associations of the patientSerum:to be frozen and saved for serological analysis,if needed ba Should be deep-cough specimen obtained before antibiotic therapy.Gram stain should be interpreted by trainedpersonnel and culture done only if specimen is adequate by cytological criteria,except for Legionella and myco-bacteria.Consider diagnostic studies for endemic fungi and mycobacteria when clinical features suggest infectionwith these.For hospitalized patients with severe pneumonia or clinical features that suggest legionnaires’disease,perform culture and urinary antigen testing for Legionella.Inability to obtain specimens for diagnostic studiesshould not delay antibiotic treatment of acutely ill patients.b Serological tests would include those for Mycoplasma pneumoniae,Legionella pneumophila,Chlamydia pneu-moniae,or others(i.e.,viruses,Chlamydia psittaci,or Coxiella burnetii),depending on the circumstances.as the absence of productive cough or inflammatory sputum in pneumonia due to Mycoplasma,Legionella,or Chlamydia species,have not withstood close inspection.On the other hand, most comparisons have involved relatively small numbers of patients and have not evaluated the potential for separating causes by use of constellations of symptoms and physical findings.In one study,as yet unconfirmed,that compared patients identified in a prospective standardized fashion,a scoring sys-tem using5symptoms and laboratory abnormalities was able to differentiate most patients with legionnaires’disease from the other patients[41].A similar type of system has been devised for identifying patients with hantavirus pulmonary syndrome (HPS)[42].If validated,such scoring systems may be useful for identifying patients who should undergo specific diagnostic tests(which are too expensive to use routinely for all patients with CAP)and be empirically treated with specific antimicrobial drugs while test results are pending.Certain pathogens cause pneumonia more commonly among persons with specific risk factors.For instance,pneumococcal pneumonia is especially likely to occur in the elderly and in patients with a variety of medical conditions,including alco-holism,chronic cardiovascular disease,chronic obstructed air-way disease,immunoglobulin deficiency,hematologic malig-nancy,and HIV infection.However,outbreaks occur amongyoung adults under conditions of crowding,such as in armycamps or prisons.S.pneumoniae is second only to Pneumocystiscarinii as the most common identifiable cause of acute pneu-monia in patients with AIDS[43–45].Legionella is an oppor-tunistic pathogen;legionella pneumonia is rarely recognized inhealthy young children and young adults.It is an importantcause of pneumonia in organ transplant recipients and in pa-tients with renal failure and occurs with increased frequency inpatients with chronic lung disease,smokers,and possibly thosewith AIDS[46].Although M.pneumoniae historically has beenthought primarily to involve children and young adults,someevidence suggests that it causes pneumonia in healthy adultsof any age[8].There are seasonal differences in incidence of many of thecauses of CAP.Pneumonia due to S.pneumoniae,H.influenzae,and influenza occurs predominantly in winter months,whereasC.pneumoniae appears to cause pneumonia year-round.Al-though there is a summer prevalence of outbreaks of legion-naires’disease,sporadic cases occur with similar frequency dur-ing all seasons[8,46].Some studies suggest that there is noseasonal variation in mycoplasma infection;however,otherdata suggest that its incidence is greatest during the fall andwinter months[47].at Library of Medical Center of Fudan University on April 21, 2014/Downloaded from。
Toward_a_Global_Pandemic_Strategy
14CHINA TODAYinTeraCTion voiCePANDEMICS cause panic, fear, and chaos. We have seen this pattern unfold repeatedly across the world with waves of the COVID-19 pan-demic rippling through our populations. Whenhumans are stressed, we tend to close doors and bor-ders to protect ourselves, make impulsive decisions, be suspicious of others, and even deny the situation.In the past, when travel and human interactions were relatively slow, this instinct served to protect families and communities from new infectious diseases such as the plague. However, in today’s complex and globalized world, with large and mobile populations, these instincts do not serve us well, and we need to find alternative solutions.To be able to do so, we need to recognize the frailty of being human, and our intrinsic and biological links with the health of animals and our planet. We are all interconnected, and the health of all relies on valuing the health of each and every one of us, including the animals that we depend upon and live side by side with. Aside from honest reflection, combined with objective evaluation to understand why the world is in such chaos, we need to also learn from the many successes and sto-ries of compassionate action that every community and country brings to guide us forward.There is a clear need for a global strategy, as the panic caused by the pandemic has permeated political leadership and the ability of multilateral agencies to provide a clear pathway out of this chaos.The COVID-19 pandemic has already had a devastat-ing impact upon the global economy, with an estimated loss of US $10 trillion or 4.3 percent of the GDP for 2020-2021, according to a report by the World Bank. Inequali-ties within communities, and across and between coun-tries are widening around the world. They are visibly evidenced by vaccine nationalism – with low-income countries receiving just 0.2 percent of all COVID-19 shots given, and a significant drop in life expectancy in many parts of the world.This represents a significant threat to our wider global security. Aside from the very real threat of death,By JOANNA NURSEthe pandemic has impacted our basic needs, including income and food security, resulted in civil unrest, and risked the collapse of nation states.Inequalities are also increased by the global response to the pandemic, which has been overly dominated by political and nationalist agendas within high-income countries and coalitions such as the G7. The dominant narrative and pandemic response from many of these countries is driving the pandemic everywhere to an endemic scenario, which risks further pandemic waves with the emergence of new COVID-19 variants that our vaccines are not effective against.With the Delta variant, vaccine coverage – or the lev-el of herd immunity – is estimated to be in the range of 70-85 percent of the total population, and due to wan-ing immunity after five to six months, booster doses are required. High-income countries may be able to ride these further pandemic waves if they keep ahead with new vaccines; however the reality of supply and roll-out of vaccine programs has proved to be challenging even in countries with comprehensive health systems, let alone those with minimal infrastructure.The global focus has so far been on a single-issue solution, dominated by vaccines; when in reality the complex nature of the pandemic requires a strategic framework that allows a flexible multi-solution, multi-country coordinated response. Focusing primarily upon vaccines and achieving an endemic steady state risks the emergence of new variants. This approach will inevitably result in high death rates and overwhelm health services, especially in countries that are unable to protect their populations with vaccines. Aiming for a steady endemic state threatens the health of everyone on our earth. None of us are safe until we are all safe. Moreover, the economic impact of not achieving global vaccination, as low- to middle-income econo-mies continue to not have adequate access to COVID-19 vaccines, has been estimated to cost the global economy up to US $9.2 trillion, and high-income coun-tries up to US $4.5 trillion, according to a study com-missioned by the International Chamber of Commerce (ICC) Research Foundation. Furthermore, the impact upon international trade and travel is substantial, withCopyright ©博看网. All Rights Reserved.15December 2021Copyright ©博看网. All Rights Reserved.。
剔除霉变、腐烂、变质风险的英文保险条款
剔除霉变、腐烂、变质风险的英文保险条款Exclusion of Mold, Decay, and Contamination Risk Insurance Clause1. IntroductionThis insurance policy is designed to provide coverage for a wide range of risks, including fire, theft, and liability claims. However, this policy specifically excludes coverage for losses arising from mold, decay, and contamination risks. This exclusion is intended to protect the insurer from the potentially high costs associated with remediation and repair of properties damaged by these risks.2. DefinitionsFor the purposes of this insurance policy, the following definitions apply:- Mold: Any type of fungus that grows on damp or decaying organic matter, causing discoloration, odor, and structural damage to buildings.- Decay: The natural process of decomposition of organic matter, resulting in deterioration and weakening of structural components.- Contamination: The introduction of harmful substances or contaminants into a property, posing health risks to occupants and requiring extensive remediation efforts.3. Exclusion ClauseThis insurance policy shall not cover losses, damages, or liabilities arising from mold, decay, or contamination risks, including but not limited to:- Any costs associated with the removal, remediation, or repair of mold-infested properties.- Damages caused by decay and deterioration of structural components, such as wood, metal, or concrete.- Health risks and liabilities resulting from exposure to contaminated substances, such as asbestos, lead, or toxic chemicals.4. ExceptionsNotwithstanding the exclusion clause, this insurance policy may provide coverage for losses resulting from mold, decay, or contamination risks in the following circumstances:- If the insured provides proof of regular maintenance, inspection, and remediation efforts to mitigate the risks of mold, decay, or contamination.- If the losses are caused by a covered peril, such as fire, flood, or vandalism, and not solely by mold, decay, or contamination.5. Claims ProcessIn the event of a claim related to mold, decay, or contamination risks, the insured must promptly notify the insurer and provide all relevant documentation, including:- Photos or videos of the affected property showing the extent of damage and contamination.- Reports from certified mold remediation specialists, decay experts, or environmental consultants detailing the causes and extent of the risks.- Estimates of repair and remediation costs from licensed contractors or restoration companies.6. ConclusionThis insurance policy aims to provide comprehensive coverage for a wide range of risks, while excluding losses arisingfrom mold, decay, and contamination risks. It is essential for the insured to take proactive measures to prevent and mitigate these risks, such as conducting regular inspections, maintaining proper ventilation, and promptly addressing water leaks and moisture issues. By understanding and complying with the terms of this exclusion clause, the insured can minimize potential liabilities and ensure effective risk management for their properties.。
风险管理和保险原理精品文档阅读、
– A risk may be transferred to another party through contracts, hedging, or incorporation
1-15
Types of Pure Risks
• Property risks involve the possibility of losses associated with the destruction or theft of property:
–Physical damage to home and personal property from fire, tornado, vandalism, or other causes
risk • High subjective risk often results in conservative behavior
1-9
Chance of Loss
• Chance of loss: The probability that an event will occur
• Objective Probability vs. Subjective Probability
– Objective probability refers to the long-run relative frequency of an event assuming an infinite number of observations and no change in the underlying conditions
1-16
Types of Pure Risks
• Liability risks involve the possibility of being held liable for bodily injury or property damage to someone else
职业病危害因素检测问题追责
职业病危害因素检测问题追责英文回答:Occupational disease is a serious issue that affectsthe health and well-being of workers in various industries. It refers to any illness or health condition that is caused or aggravated by exposure to workplace hazards. These hazards can include physical, chemical, biological, and ergonomic factors. Detecting and assessing the hazards and risks associated with occupational diseases is crucial in order to prevent their occurrence and protect workers' health.In many countries, there are regulations and guidelines in place to ensure that employers take responsibility forthe detection and control of occupational hazards. These regulations often require employers to conduct regular inspections and assessments of the workplace to identify potential hazards and assess the risks they pose to workers. This can involve measuring and monitoring exposure levels,conducting medical examinations, and implementing control measures to eliminate or minimize the hazards.If a workplace is found to have hazardous conditions that could lead to occupational diseases, the employer may be held accountable for failing to provide a safe working environment. In some cases, legal actions can be taken against the employer for negligence or non-compliance with occupational health and safety regulations. The employer may be required to compensate affected workers for medical expenses, loss of income, and other damages resulting from the occupational disease.For example, let's consider a scenario where a worker develops respiratory problems due to prolonged exposure to dust and chemicals in a manufacturing facility. If it is determined that the employer did not adequately monitor and control the exposure levels, and failed to provide proper personal protective equipment, the employer could be held responsible for the worker's illness. The worker may be entitled to compensation for medical treatment, lost wages, and other related expenses.In conclusion, the detection of occupational disease hazards and the responsibility for their prevention lieswith the employers. It is essential for employers toconduct regular inspections and assessments to identify and control workplace hazards. Failure to do so can result in legal consequences and financial liabilities. Workers have the right to a safe and healthy work environment, and employers must take the necessary measures to ensure their well-being.中文回答:职业病是一个严重的问题,影响着各行各业工人的健康和福祉。
Safety-related Topics in English
Know how to shut off utilities such as gas and water in case of an emergency
Call for emergency assistance urgently if someone is injured or if there is a fire or other serious hazard
Poorly designed workspaces or equipment can lead to musculoskeletal disorders or other long term health issues
Responsibilities and Rules in Ensuring Safety
Types of Safety Hazards
Physical hazards
Chemical hazards
These include slips, trips, falls, and objects falling from heights, which can cause body damage
Preventive Measures for Home Hazards
Inspect electrical systems regularly and have them repaired by a professional if
necessary
Store household chemicals and cleaners out of reach of children and pets
Biological hazards
Exposure to hazardous chemicals, gases, or substances can lead to serious health problems or even fatalities
2024年度工伤保险新政策英文版
2024年度工伤保险新政策英文版Title: New Work Injury Insurance Policies for the Year 2024In the year 2024, the work injury insurance policies are expected to undergo significant changes. These changes will impact both employers and employees in various ways. It is important for all stakeholders to be aware of these new policies to ensure compliance and understanding.One of the key changes in the 2024 work injury insurance policies is the introduction of enhanced coverage for work-related injuries. This means that employees who suffer injuries while on the job will be entitled to increased benefits and compensation. Employers will need to ensure that they have proper insurance coverage to meet these new requirements.Additionally, the 2024 policies will place a greater emphasis on workplace safety and prevention measures. Employers will be required to implement stricter safety protocols to reduce the risk of work-relatedinjuries. Failure to comply with these regulations could result in penalties and fines for the employer.Another important aspect of the new policies is the inclusion of rehabilitation services for injured employees. Employers will be responsible for providing necessary rehabilitation services to help injured employees recover and return to work as quickly as possible. This will not only benefit the employee but also help reduce overall costs for the employer.Overall, the 2024 work injury insurance policies aim to create a safer and more supportive work environment for employees. By implementing these new policies, employers can protect their workforce, reduce costs associated with injuries, and improve overall productivity. It is essential for all stakeholders to stay informed and compliant with these new regulations to ensure a smooth transition in the year 2024.。
洁面洗手槽产品说明书
-753Installation Instructions NOTE:Read the entire instruction manual before starting theinstallation.SAFETY CONSIDERATIONSImproper installation,adjustment,alteration,service,maintenance,or use can cause explosion,fire,electrical shock,orother conditions which may cause death,personal injury,orproperty damage.Consult a qualified installer,service agency,oryour distributor or branch for information or assistance.Thequalified installer or agency must use factory--authorized kits oraccessories when modifying this product.Refer to the individualinstructions packaged with the kits or accessories when installing.Follow all safety codes.Wear safety glasses,protective clothing,and work gloves.Have a fire extinguisher available.Read theseinstructions thoroughly and follow all warnings or cautionsinclude in literature and attached to the unit.Consult localbuilding codes,the current editions of the National Fuel GasCode(NFGC)NFPA54/ANSI Z223.1and the NationalElectrical Code(NEC)NFPA70.In Canada,refer to the current editions of the National Standardsof Canada CAN/CSA--B149.1and.2Natural Gas and PropaneInstallation Codes,and Canadian Electrical Code CSA C22.1Recognize safety information.This is the safety--alertsymbol.When you see this symbol on the unit and in instructions or manuals,be alert to the potential for personal injury. Understand the signal words DANGER,WARNING,and CAUTION.These words are used with the safety--alert symbol.DANGER identifies the most serious hazards which will result in severe personal injury or death.WARNING signifies hazards which could result in personal injury or death.CAUTION is used to identify unsafe practices which may result in minor personal injury or product and property damage.NOTE is used to highlight suggestions which will result in enhanced installation,reliability,or operation.Table 1–ModelsMODELSERIES FIGURE340AAV /58MCB All 2350AAV /58MXB All 2352AAV /58MTB All 6352MAV /58MTA All 6353AAV /58MEBAll 2353BAV /58MEC /PG9MXAAll 6355AAV /58MVB All 4355MAV /58MVPAll 4355BAV /58UVB /PG9UAAAll 4355CAV /58MVC All 7490BAV /PG9MABAll 2351DASAll5340MAV 350MAV 490AAVA1B and C,D (prior to 2496A02149and after 1098A02241)and later series2D (between 2496A02149and 1098A02241)358MCA1001100and 120,130(prior to 2496A02149and after 1098A02241)and later series2130(between 2496A02149and 1098A02241)358MXA 1001110and 120,130(prior to 2496A02149and after 1098A02241),and later series2130(between 2496A02149and 1098A02241)3345MAV PG9MAA A (through 1098A02241)3A (after 1098A02241),and later series 258MSA100(through 1098A02241)3100(after 1098A02241),and later series2INTRODUCTIONThis kit covers the installation of all parts necessary to replace the rubber tubing,the inducer cap,and the vent coupling.See Table 1for models and Table 2for kit contents.Table 2–Kit ContentsPART NO.DESCRIPTION QUANTITY314781---701Drain Tube 1314781---702Drain Tube1322057---301Inducer /Trap Elbow 1324157---402Inducer End Cap 1325423---401Vent Coupling 1KA69JM300Hose Clamp 1311162---430Pressure Tubing 1KA69UM031Tubing Clamp18KA70PY191Tee3KA70PS010Tubing Connector1INSTALLATION INSTRUCTIONS1.Turn off gas and electrical supplies to the unit.2.Remove the furnace door.3.Some tubing may need to be cut.The appropriate lengths and locations of the tubing are illustrated in the reference figures listed in Table 1.NOTE :Pressure tubing in units may be routed differently than what is show in the diagrams.Where possible,refer to the tubing label on the unit.4.Replace the rubber parts in the furnace that are listed in Table 2.NOTE :Remove and replace one tube at a time.Ensure that tubing is routed in the same manner as the original pressure tubing.e the existing clamps to tighten down the new inducer end cap and the new vent coupling.Tighten clamp screws to 15in.--lb.of torque.6.Place pressure tubes behind casing clips (if applicable).Make sure the tubes are not kinked or pinched,as this will affect furnace operation.7.Check tubing connections to ensure that they are secure.8.Turn on the gas and electrical supplies.9.Cycle test the unit with the room thermostat,to ensure proper operation.10.Reinstall the furnace door.CONDENSATE TRAPA94267 Maximum Pressure Tube Length*UNIT SIZETUBE LENGTH(IN./MM)A B C D E{0408/203.213/330.22/50.88---3/4/222.318---1/2/469.9 0608/203.213/330.22/50.88---3/4/222.318---1/2/469.9 0808/203.213/330.22/50.88---3/4/222.320---1/2/520.7 1008/203.213/330.22/50.88---3/4/222.320---1/2/520.7 1208/203.213/330.22/50.88---3/4/222.320---1/2/520.7 *Shorter lengths may be required to avoid kinking tubing.This will depend upon the gas valve and pressure switch used.Refer to existing tubing lengths,ifpossible.{Length will vary depending on location of furnace condensate trap.Fig.1--Pressure Tube Connection Diagram for Series A Models340MA V,350MA V,and490AA V and Series100Models of58MCA and58MXA40--in.(1016mm)Tall Multipoise Furnaces(Upflow Orientation Shown)BURNER ENCLOSUREGAS VALVEPRESSURE SWITCH A94268Maximum Pressure Tube Length*UNIT SIZETUBE LENGTH (IN./MM)A B C DE {0405/127.010/254.01---1/2/38.19---1/4/235.024/609.60605/127.010/254.01---1/2/38.19---1/4/235.024/609.60806/152.411---1/2/292.11---1/2/38.19---1/4/235.024/609.61006/152.411---1/2/292.11---1/2/38.19---1/4/235.024/609.61208/203.211---1/2/292.11---1/2/38.19---1/4/235.024/609.6*Shorter lengths may be required to avoid kinking tubing.This will depend upon the gas valve and pressure switch used.Refer to existing tubing lengths,if possible.{Length will vary depending on location of furnace condensate trap.Fig.2--Pressure Tube Connection Diagram in 40--in.(1016mm)Tall Multipoise Furnaces (Upflow Orientation Shown)forModels 340MA V ,350MA V ,and 490AA V Series B,C,D (Prior to 2496A02149and after 1098A02241)and later series;Models 58MCA and 58MXA Series 110,120,130(prior to 2496A02149and after 1098A02241)and later series;Model 345MA V Series A (after 1098A02241)and later series;Model 58MSA Series 100(after 1098A02241)and later series;Models PG9MAA Series A (after 1098A02241)and later series;Model PG9MAB Series A and later series;Models 340AA V and 350AA V Series A and later series;Models 58MCB and 58MXB Series 100and later seriesModels 353AA V Models 58MEBA96252 Maximum Pressure Tube Length*UNIT SIZETUBE LENGTH(IN./MM)A B C D E{0405/127.010/254.01---1/2/38.115---1/4/387.422/558.8 0605/127.010/254.01---1/2/38.115---1/4/387.422/558.8 0806/152.411---1/2/292.11---1/2/38.115---1/4/387.422/558.81006/152.411---1/2/292.11---1/2/38.115---1/4/387.422/558.81208/203.211---1/2/292.11---1/2/38.115---1/4/387.422/558.81408/203.211---1/2/292.11---1/2/38.115---1/4/387.422/558.8*Shorter lengths may be required to avoid kinking tubing.This will depend upon the gas valve and pressure switch used.Refer to existing tubing lengths,if possible.{Length will vary depending on location of furnace condensate trap.Fig.3--Pressure Tube Connection Diagram(Upflow Orientation Shown)for Models340MA V,345MA V,350MA V,58MCA58MSA 58MXA,PG9MAA and490AA V(between2496A02149and1098A02241)A94269Maximum Pressure Tube Length*UNIT SIZETUBE LENGTH (IN./MM)ABC DE {0406---1/2/165.113---1/2/342.93/76.210---1/2/266.724/609.60606---1/2/165.113---1/2/342.93/76.210---1/2/266.724/609.60806---1/2/165.113---1/2/342.93/76.210---1/2/266.724/609.61006---1/2/165.113---1/2/342.93/76.210---1/2/266.724/609.61208/203.213---1/2/342.91---1/2/38.110---1/2/266.724/609.6*Shorter lengths may be required to avoid kinking tubing.This will depend upon the gas valve and pressure switch used.Refer to existing tubing lengths,if possible.{Length will vary depending on location of furnace condensate trap.Fig.4--Pressure Tube Connection Diagram in a 40--in.(1016mm)Tall Multipoise Furnace (Upflow Orientation Shown)forModels 355MA V ,355AA V ,355BA V ,58MVP,58MVB,58UVB,and PG9UAAA99058 Maximum Pressure Tube Length*UNIT SIZETUBE LENGTH(IN./MM)A B C D E0806/152.411---1/2/292.11---1/2/38.126/660.424/609.6*Shorter lengths may be required to avoid kinking tubing.This will depend upon the gas valve and pressure switch used.Refer to existing tubing lengths,if possible.Fig.5--Pressure Tube Connection Diagram for Model351DAS40--in.(1016mm)Tall Downflow FurnacesTUBE CBURNER ENCLOSUREGAS VALVEPRESSURE SWITCHESA01079Maximum Pressure Tube Length*UNIT SIZETUBE LENGTH (IN./MM)A B C DE {0605/127.010/254.01---1/2/38.16/152.424/609.60806/152.411---1/2/292.11---1/2/38.16/152.424/609.61006/152.411---1/2/292.11---1/2/38.16/152.424/609.61208/203.211---1/2/292.11---1/2/38.16/152.424/609.6*Shorter lengths may be required to avoid kinking tubing.This will depend upon the gas valve and pressure switch used.Refer to existing tubing lengths,if possible.Fig.6--Pressure Tube Connection Diagram in a 40--in.(1016mm)Tall Multipoise Furnace (Upflow Orientation Shown)forModels 352MA V ,352AA V ,353BA V ,58MEC,58MTA,58MTB and PG9MXAGAS VALVE ASSEMBLYBURNER ENCLOSURE COLLECTORBOXPRESSURE SWITCHES CONDENSATETRAPTUBE D TUBE E TUBE ATUBE BTUBE CA07660Maximum Pressure Tube Length*UNIT SIZETUBE LENGTH (IN./MM)A BCDE {0606/152.411---1/4/285.86---3/4/171.510---1/2/266.724/609.60806/152.411---1/4/285.86---3/4/171.510---1/2/266.724/609.61006/152.411---1/4/285.86---3/4/171.510---1/2/266.724/609.61206---1/2/165.111---1/4/285.84---1/2/114.310---1/2/266.724/609.6*Shorter lengths may be required to avoid kinking tubing.This will depend upon the gas valve and pressure switch used.Refer to existing tubing lengths,if possible.*Length will vary depending on location of furnace condensate trap.Fig.7--Pressure Tube Connection Diagram for Models 355CA V and 58MVC 40--in.(1016mm)Tall Multipoise Furnaces(Upflow Orientation Shown)Copyright2010CAC/BDP S7310W.Morris St.S Indianapolis,IN46231Manufacturer reserves the right to change,at any time,specifications and designs without notice and without obligations.Catalog No:IIK324806---006Replaces:IIK324806--005Printed in U.S.A.Edition Date:09/10。
下风吸气防护帽安装说明书
NOTE: Read the entire instruction manual before starting the installation.SAFETY CONSIDERATIONSInstalling and servicing of heating equipment can be hazardous due to gas and electrical components. Only trained personnel should install orservice heating equipment.Untrained personnel can perform basic maintenance such as cleaning and replacing filters. All other operations should be performed by trainedservice personnel. When working on heating equipment, observe precautions in the literature, on tags, and on labels attached to the unit.Follow all safety codes. Wear safety glasses and work gloves. Have a fire extinguisher available. Recognize safety information.This is the safety-alert symbol . When you see this symbol on the furnace and in instructions or manuals, be alert to the potential for personalinjury. Understand the signal words DANGER, WARNING, CAUTION, and NOTE. These words are used with the safety-alert symbol. DANGERidentifies the most serious hazards which will result in severe personal injury or death. WARNING signifies a hazard which could result in personalinjury or death. CAUTION is used to identify unsafe practices which would result in minor personal injury or product and property damage. NOTEis used to highlight suggestions which will result in enhanced installation, reliability, or operation.________________________________________________________________________________________________________________________ CAUTION: Sheet metal parts may have sharp edges or burrs. Use care and wear appropriate protectiveclothing and gloves when handling parts. Failure to follow this caution could result in personal injury.INTRODUCTIONTo protect against exposed hot surfaces, the downflow vent guard should always be used when the vent pipe is installed along the outside of thefurnace casing in a downflow application. This kit is designed for single- or double-wall 4” pipe. Type B vent connector after the Vent Guard isREQUIRED for all 2 stage applications.Table 1–Kit ContentsDESCRIPTION PARTNO. QUANTITY Guard Front 327717-401 1.0Guard Back 327718-401 1.0Door Spacer 327719-401 1.0Guard Bottom 327720-401 1.0Screw FBN5806B 13.0 Installation Instructions AG-GAVG-01 1.0INSTALLATION1. Cut templates from installation instructions (see Fig. 8)2. With the furnace in the downflow orientation, align Template #1 with upper and front edges of the furnace3. Align Template #2 with lower and front edges of the furnace casing (See Fig. 1). Mark and drill a 1/8” hole thru the casing where indicatedon templateForm: AG-GAVG-01 Cancels: New Printed in U.S.A. 6/02 Pg. 1 Catalog No. 63GA-VG04. Position the Guard Back on the casing side, aligning the top and bottom holes in theGuard Back flange with the holes in the furnace casing (See Fig. 2). Secure the Guard Back to the casing with screws through these holes. Drill a 1/8” hole through the furnace casing at the center Guard Back flange hole. Insert screw and tighten.5. Reposition furnace vent elbow so outlet is towards left (See furnace Installation Instructions).6. Attach vent pipe and elbow to Furnace vent elbow with at least two field supplied corrosion resistant sheet metal screwslocated 180 degrees apart at each connection joint See Fig. 37. Position Guard Front on Guard Back (See Fig 4). Bend centering tabs equally at top of Guard Back and Guard Front to allowGuard Front to mount flush with Guard Back. Centering tabs on lower right hand opening of Guard Front may also require bending.8. Secure Guard Front to Guard Back with six screws. If necessary, re-bend centering tabs so vent pipe is securely centered invent guard and will not rattle.Fig. 4 – Install Guard FrontFig. 3 – Install Vent PipeFurnace Width‘A’ - Centerline of Pipe to Elbow (Includes Flange)14-3/16" 5-9/32" 17-1/2" 7" 21" 8-3/4" 24-1/2" 10-1/2"2Insert ScrewFig. 2 – Install Guard Back9. Position Guard Bottom at bottom of vent guard and secure with two screws (see Fig. 5).Note: Guard Bottom will have a gap at the back and side when installedScrewAlignFig. 6 – Install Door Spacer10. Remove cut-out for vent pipe on left-hand side of door (See Fig. 6 and furnace Installation Instructions)11. Align Door Spacer with front and lower edges of furnace door (See Fig. 6). Mark and drill 1/8” holes in furnace door atholes.12. Install furnace door on casing and check fit.13. If vent guard needs additional support, field fabricated angle brackets may be installed between the furnace casing and backof vent guard (See Fig. 7).CAUTION: Before drilling additional holes in furnace casing or vent guard, be aware of what is on the other side. Screws tips may damage internal furnace components or vent system resulting in electrical shocks or shorting, flue gas leakage, or other hazardous conditions. Failure to follow this could result in personal injury or property damage.Fig. 7 – Field-Fabricated Optional Support Bracket3Fig. 8 – Screw Location Templates2002 CAC/BDP P.O. Box 70, Indianapolis, IN 46206 aggavg01 Pg. 4 Catalog No. 63GA-VG0。
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Journal of Health Economics25(2006)1005–1014Reconsidering the moral hazard-riskavoidance tradeoffଝJoseph P.NewhouseHarvard University,180Longwood Avenue,Boston,MA02115,United StatesReceived14June2006;accepted14June2006Available online24July2006AbstractThe received model for optimal demand-side cost sharing trades off moral hazard and risk avoidance. This model appears to lie behind recent increases in initial cost sharing,such as those embodied in Health Savings Accounts and Health Reimbursement Accounts.At the same time there is evidence that lower cost sharing for certain drugs can reduce future total health care costs and/or improve future health,and this may be true of other medical services as well.To the degree that individuals remain in the same common insurance pool,lower cost sharing that induces increases in certain services that reduce total costs,including future costs,represents a classic case for a subsidy and will minimize an employer’s labor costs.Even if total costs increase,the value of a change in health could increase more.In that case such a subsidy is consistent with recent work in behavioral economics for those with self-control problems.©2006Elsevier B.V.All rights reserved.Keywords:Moral hazard;Risk avoidance;Cost sharing;Optimal insurance contracts;Hyperbolic discounting Our traditional view of demand prices or cost sharing comes from several classic papers, among them(Arrow,1963,1968;Pauly,1968;Zeckhauser,1970).These papers frame demand prices as a tradeoff between moral hazard and risk avoidance,and that is how health economics textbooks present the problem,for example,(Phelps,2003),chapter10;(Feldstein,1999),chapter 6;(Zweifel and Breyer,1997),chapter6.Because moral hazard and risk avoidance are both estimable,one can use this framework to estimate optimal demand prices or an optimal insurance contract.Indeed,many years ago my colleagues and I did just that as part of the RAND health insurance experiment.Specifically,we estimated that an optimal insurance policy would have an individual deductible of around$200ଝPresidential address to the2006meeting of the American Society of Health Economists.E-mail address:joseph newhouse@.0167-6296/$–see front matter©2006Elsevier B.V.All rights reserved.doi:10.1016/j.jhealeco.2006.06.0031006J.P.Newhouse/Journal of Health Economics25(2006)1005–1014in1983dollars,followed by about25%coinsurance,to a stop loss of$1500(Newhouse and the Health Insurance Experiment Group,1993),Table4.21.Our estimates were marginally higher than values common in then prevalent indemnity policies,but they did not account for the tax subsidy to employer paid premiums,which would have reduced the optimal cost sharing,nor did they account for any cashflow problems that some liquidity constrained individuals may have, which would have also reduced it.Cutting in the other direction,the estimates also assumed actuarily fair insurance.Although the RAND Experiment results were widely disseminated,after their publication the initial cost sharing in health insurance did not keep up with the increase in prices and total spending on medical care.Instead,we moved from the era of indemnity insurance to the era of managed care,typically with copayments at a level well below the foregoing calculation of an optimal insurance policy.The assumption was that supply-side cost sharing altered the tradeoff between moral hazard and risk,which it probably did,but at least two problems remained:(1) supply-side cost sharing was not well placed to affect whether consumers initiated treatment for an episode,whereas the main effect of demand-side cost sharing was on the margin of patients’initiating treatment(Newhouse and the Health Insurance Experiment Group,1993);hence,one source of moral hazard remained;(2)supply-side cost sharing by itself left no mechanism for consumers to reveal their willingness-to-pay for treatment(Pauly and Ramsey,1999;Rosenthal and Newhouse,2002).As a result,if highly valued services were not delivered because of supply-side cost sharing,it is logically possible that consumer surplus net of deadweight loss could have fallen as supply-side cost sharing rose.In any event,the possibility that some highly valued services might not be delivered because of supply-side cost sharing may have been one cause of the managed care backlash of the mid-1990s.Whether because of that backlash or because managed care was mainly about once-and-for-all reductions in spending,or both,since the late1990s real health care spending growth has resumed at approximately its historical rate.As a result,though controversial,the issue of greater cost shar-ing has come back into the discussion,most prominently with Health Savings Accounts(HSAs) and Health Reimbursement Accounts(Cogan et al.,2005;Davis,2004;Lee and Zapert,2005).The2003legislation authorizing HSAs and the regulations implementing them are reasonably prescriptive.For a policy to qualify for favorable tax treatment,the minimum deductible for an individual policy in2006must be$1050and the maximum out-of-pocket expense$5250. Preventive services are allowed to be exempt from the deductible,however,and the Treasury has defined the following services as preventive:periodic health examinations;routine prenatal and well-child care;immunizations;tobacco cessation programs;weight loss programs;and various screening programs.Importantly,however,in its initial guidance the Treasury explicitly said preventive care did not include services that treat existing conditions and so such services must be subject to cost sharing.1But is this cost sharing structure optimal?Nominal per capita health spending in2006is about five times greater than in1983.2If one is willing to ignore the differences in product over the two decades and simply uses afigure offive to adjust the optimal deductible calculated from the RAND experiment data,the$1050figure for health savings accounts is in line.The stop loss figure calculated by inflating the RAND$1500figure byfive is above the HSA maximum,but just inflating the1983dollarfigure ignores the increased risk from the increased share of income 1/offices/public-affairs/hsa/pdf/notice2004-23.pdf.2/NationalHealthExpendData/02NationalHealthAccountsHistorical.asp#TopOfPage.J.P.Newhouse/Journal of Health Economics25(2006)1005–10141007 going to health care today and hence overstates the optimal stop loss feature.It also ignores the increased number of individuals who will be liquidity constrained.Although the minimum deductible for an HSA seems roughly in line with crudely inflating the calculations from the RAND Experiment and the maximum out-of-pocket may not be too far below them,a possible improvement,consistent with the allowable exemption of preventive services,would be reduced cost sharing for chronic maintenance drugs or other medical services that treat existing conditions but could lower future expenditure,at least on expectation,and/or improve future health.I explore this possibility in the remainder of the essay.1.Empirical evidence on cost sharing and complianceCompliance with prescribed regimens is a general problem in medicine,but I am interested in a subset of the general problem,the elasticity of compliance with respect to the demand price and the effects of the resulting improved compliance on overall spending and health.Considerable evidence suggests that compliance with drug regimens by patients with certain chronic diseases increases with lower cost sharing,and it seems reasonable that improved compli-ance might reduce total lifetime spending and improve health outcomes.Hsu et al.,find that caps on drug benefits for those over the age of65reduce compliance with recommended behavior and thereby reduce drug spending,but also worsen physiologic measures of health and raise spend-ing for other medical services,even over a period as short as a year(Hsu et al.,2006).In their study the increase in non-drug medical costs,largely increased emergency department visits and increased non-elective hospitalizations,is roughly the same magnitude as the induced decrease in drug costs,but could well be greater as time passes,assuming compliance does not improve and physiologic health worsens.In earlier work Soumerai et al.showed that limiting the number of prescriptions in a month in a Medicaid program to three saved money on drugs but led to offsetting increases elsewhere;in the case of schizophrenic patients,the increase in other spending was17times the savings on drugs (Soumerai et al.,1994;Soumerai et al.,1991).(Tamblyn et al.,2001)have shown that imposition of cost sharing for drugs in Quebec decreased use of“essential”drugs among the elderly and among welfare recipients by15–22%,which led to an approximate doubling of serious adverse events,defined as hospitalization,nursing home admission,or death,as well as an increase in emergency department visits.Although they do not present cost data,the magnitude of the increase in serious adverse events seems likely to have raised total costs.(Rosen et al.,2005)have simulated that it would save money and increase QALYs for Medicare to make ACE inhibitors available at no charge for elderly diabetics when compared with the default cost sharing in the Medicare drug benefit;the induced increase in the use and cost of ACE inhibitors would be more than offset in averted medical costs.(Huskamp et al.,2003)and (Goldman et al.,2004)have shown that medications known to be efficacious for certain chronic disease,such as statins,ACE inhibitors,anti-hypertensives,and anti-diabetics,are sensitive to the amount of cost sharing,although they have not quantified the effect on other spending.An extreme version of what I have in mind–in the sense that the demand price is negative–is paying those with tuberculosis to come in so they can be observed swallowing their prescribed medications (Directly Observed Therapy).To sum up,these empiricalfindings are strongly suggestive that some individuals,especially those with certain chronic diseases,can be induced by less cost sharing to take actions today that ex ante will reduce their future use of medical services and/or improve their future health.1008J.P.Newhouse/Journal of Health Economics25(2006)1005–10142.Optimal cost sharing and compliance:elaborating the standard modelWith thesefindings as background,I want to argue that the textbook treatment of moral hazard can usefully be elaborated.In a too little noticed paper Held and Pauly considered an analogous problem,which they termed benign moral hazard(Held and Pauly,1990).Held and Pauly,however, took insurance coverage of certain medical services such as hospital and physician as given and asked about optimal coverage for“preventive”services.In principle,one must consider the optimal cost sharing structure for all services;that is,the nature of the insurance contract.In other words, there are several relevant medical“products”being insured,and one needs to consider the cross-price elasticities among them.For concreteness,however,I will stay with the example of a drug for a chronic disease such as diabetes or hypertension.An easy case is when the marginal social cost of another pill is negligible,as it often is.In that instance,assuming there is no adverse effect on the use of other medical services,a subsidy that induces greater consumption of drugs should not even be considered moral hazard,so there is no tradeoff between moral hazard and risk avoidance.But for the remainder of the paper I want to assume the additional drugs or services have non-trivial marginal social costs.And even in the case of the pill,there will virtually always be a non-trivial marginal private cost to the employer or purchaser.Before proceeding past the easy case of negligible marginal social cost,some remarks about the determinants of cost sharing are in order.Because almost all Americans with insur-ance are insured either through their employer or through a public program,the cost sharing faced by many individuals is exogenous or nearly exogenous,because it is determined by the employer or by a public body.3Furthermore,and importantly for my story,because of a com-mon insurance pool,each individual’s spending represents an external expense for others in the pool.Given the prevalence of employment based insurance,it is natural to ask what determines the employer’s decision with respect to cost sharing.(Goldstein and Pauly,1976)in their sem-inal work on the problem suggested that the employer acts to minimize labor cost and thus look at the outcome for the marginal employee.Goldstein and Pauly also discuss unions as agents for groups of employees and assume that if the union determined fringe benefits,it did so to satisfy the median employee.Although Goldstein and Pauly do not consider public insur-ance,their model of union choice would appear to extend straightforwardly to a median voter model.In a recent paper Nolan Miller has suggested that when offering two or more plans,an employer interested in minimizing total compensation cost would offer a moderate health plan,with a more generous plan available as an“upgrade”(Miller,2005).In Miller’s model the employer tries3Complete exogeneity requires several assumptions that are unlikely to hold completely but may hold approximately. One is that individuals do not choose their employer on the basis of the amount of cost sharing in the health insurance plan(s)the employer offers.A second is that the individual either is single or that the spouse’s employer does not offer insurance with materially different cost sharing or that the spouse does not work.The clearest case of exogeneity or near exogeneity occurs when an employee has no choice of plan at work and the employer subsidizes the plan sufficiently that it is not rational to decline coverage.But even for those who have a choice among plans at the workplace,the employer may have standardized cost sharing among the options.For many Medicare beneficiaries the only choice of cost sharing within traditional Medicare is through the purchase of an individual Medigap policy,which only a minority of beneficiaries choose,perhaps because of high loading charges,though others may have a choice about the purchase of supplementary insurance through the employer.I think one can safely ignore the possibility that an individual chooses a job based on the availability of retiree health insurance.J.P.Newhouse/Journal of Health Economics25(2006)1005–10141009 to manage selection among multiple plans to minimize total compensation cost.4In effect,the employer has some market power in selling insurance to workers and prices the upgraded policy to recover some of the surplus workers receive.Assume a multi-period context,that the incidence of employer-paid premiums is on employees, and that the employer is minimizing cost.Then the employer would structure cost sharing for any given current level of overall employer subsidy to induce individuals in the group to act so as to minimize the group’s lifetime health care costs for the period of time they are in the group and would also account for any effects on productivity at the workplace.5In this case if subsidizing drugs for chronic diseases or routine maintenance visits improves compliance and reduces health care costs for the group,the increased consumption is not a deadweight loss,as the usual textbook model suggests,but rather a subsidy to recognize the positive externality within the group.Ceteris paribus,that externality will be greater,the longer job tenure is with an employer. It follows that a cost-minimizing employer will provide more generous insurance for medical services that decrease future health care insurance costs and/or increase future productivity,the longer the job tenure at that employer.I leave it for others to test this implication.If the employer does not consider benefits after the person leaves employment,for example savings to Medicare, cost sharing for these types of services will be too high from a social perspective.I note in passing that when calculating the moral hazard-risk avoidance tradeoff,the substantial intertemporal correlation in spending among those with chronic disease means the calculation of risk on a lifetime basis,holding constant cost sharing,will be greater than on an annual basis. This caveat applies to the calculations from the RAND Experiment data on the optimal tradeoff between moral hazard and risk avoidance cited above.3.Optimal cost sharing and compliance:a behavioral economics modelThe foregoing is an elaboration of traditional theory,but I think there is more to the story. One might ask why an individual does not comply with a physician’s recommendations to take medication even with no subsidy.A standard answer,which surely applies in a number of cases, points to the insured nature of any medical costs resulting from non-compliance and argues that the private monetary benefits of compliance are not that large.And perhaps the non-monetary benefits are not all that large either if the problem is not very annoying.Or,perhaps more likely, there could be side effects that outweigh the benefits.But this answer does not seem very plausible for many of the chronic diseases considered above.We probably all heard as children the injunction from our mothers to“take your medicine.”Our mother’s“advice”was probably delivered with a tone of“you will take your medicine”rather than“you should take your medicine,”suggesting we might not have taken it if our mothers had not been around to admonish us.This implies some greater inducement than simply information may be needed to induce compliance that will improve our future health–and possibly save us money depending on the structure of cost sharing for other medical services–and that a model from behavioral economics might be applicable.64In the usual case in which wages are not adjusted for individual health costs,the cost minimizing solution will not be an equal subsidy to all plans offered.5If there is an effect on pensions,in principle the employer would account for that as well.6This case is somewhat analogous to those cases considered by della Vigna and Malmendier,who show that if con-sumption of a good today raises future demand,a profit-maximizingfirm will price the good today below marginal cost, and conversely(della Vigna and Malmendier,2004).1010J.P.Newhouse/Journal of Health Economics25(2006)1005–1014 Beginning with(Strotz,1955–1956),economists have worked on models with time-inconsistent preferences,or discount rates that are higher in the short run than the long run.A common example of behavior that these models generate comes from individuals who put off saving or dieting today but plan to begin tomorrow;when tomorrow comes,however,these per-sons decide to put it off another day,and so on.In other words,the assumption of time-inconsistent preferences manifests itself as a self-control problem.There is now a considerable theoretical literature in this domain,including among others (Phelps and Pollak,1968),(Thaler and Shefrin,1981),(Ainslie,1991),(Akerlof,1991)(Laibson, 1997),and(O’Donoghue and Rabin,1999a,b).There is also a large amount of experimental evidence from psychologists that supports time-inconsistent preferences;see(Ainslie,1992),as well as references in several of the papers just cited.7An excellent review of this and much additional literature is(Frederick et al.,2002).To write down a model,I use Laibson’s model of a utility-maximizing consumer with quasi-hyperbolic discounting;i.e.,a discount rate on immediate decisions that exceeds that for decisions in the future,with a constant discount rate on future decisions.In a conventional health economics model with time-constant exponential discounting,utility at a point in time t is a function of the consumption of non-medical goods and services x and a stock of health H t,which in turn depends on the consumption of x as well as medical goods and services m.Thus,U t=U(x t,H t(m,x)),(1) where I have not subscripted either m or x in the health care production function to indicate that health may depend upon prior period consumption.Discounted lifetime utility in the standard model is:T−ti=0δi U t+i(2)Individuals are assumed to act to maximize(2)subject to a lifetime budget constraint.In some formulations of the model x and H are also functions of time spent in the activity,and there is a time budget constraint as well as an income constraint.Importantly for my purposes,in this model the assumption of time-consistent preferences implies that if I prefer to wait one day to undertake an activity today,I will prefer to wait one day before undertaking the activity two weeks from now,and conversely.In the quasi-hyperbolic discounting model discounted lifetime utility is instead:U t+βT−t1δi U t+i(3)δandβare between zero and one,withβstrictly less than one,so that there is a discontinuity in the discount rate between the initial period(δ)and all subsequent periods(βδ).8 Solutions to maximizing(3)subject to a lifetime budget constraint depend upon assumptions about the awareness of the individual of the time-inconsistent preferences.One extreme assump-7Work in neuroeconomics suggests time-inconsistent behavior may have a biological basis,in that different parts of the brain process behavior dealing with immediate gratification or avoidance of harm than behavior consistent with rational calculation of future consequences(Bernheim and Rangel,2004).8In more general forms of the model the discount rate declines smoothly as a function of the distance from the present.J.P.Newhouse/Journal of Health Economics25(2006)1005–10141011 tion is that the individual is myopic and does not realize that he or she has such preferences (na¨ıve behavior),and therefore does not account for future behavior in today’s actions.The other extreme assumption is that the individual knows that he or she has such preferences and therefore accounts for those preferences in current behavior(sophisticated behavior).In general,solutions are easier if na¨ıve behavior is assumed.Furthermore,solutions can differ depending whether the action in question generates immedi-ate costs or immediate rewards.In the compliance application I have in mind there are immediate costs,in which case a small bias for the present–βonly a little less thanδ–can generate a large welfare loss if there is na¨ıve behavior(O’Donoghue and Rabin,1999a).Recently these models have been applied to cigarette smoking by Gruber and Koszegi(Gruber and Koszegi,2001,2004),with the important results that:(a)if individuals have time-inconsistent preferences,welfare would be maximized with much higher cigarette taxes than at present because health benefits would accrue to individuals who would otherwise begin to smoke;in effect,the higher taxes induce individuals to comply with a no smoking regime;(b)because the benefits of not beginning to smoke accrue disproportionately to lower income individuals,cigarette excise taxes are much less regressive than usually assumed and may even be progressive.In addition to applications involving addictive behavior,the model of time-inconsistency sketched above can apply straightforwardly in the context of lowering cost sharing to induce greater compliance.9In effect,there is a subsidy for something with a future good rather than a tax for something with a future bad.In particular,there may well be cases in which subsidizing certain medical goods or services increases total medical cost,but increases health sufficiently such that the benefits outweigh the cost increase.In effect,the individual may overweight imme-diate costs relative to future benefits.From a social perspective,thefirst order condition in this case would decrease cost sharing until the marginal health benefit equaled the marginal increase in induced health care cost.The type of cost sharing structure suggested by the empirical studies above–selected subsidies for specific medical services for specific persons,such as the full coverage of ACE inhibitors for diabetics suggested by(Rosen et al.,2005)–presumably are not observed for reasons of selection. The recent growth of disease management and case management,however,seems to be a non-price method intended to accomplish similar ends by targeting specific individuals for specific medical interventions.A cost-minimizing employer,of course,would not lower cost sharing for medical goods that are not valued by the employee at the present.An employer who has an element of paternalism or a public plan such as Medicare,however,might do so.Inducing greater compliance with such medical goods as chronic maintenance drugs is in the spirit of Save More Tomorrow,a method several employers now use to increase employee saving by having employees commit today to earmark a portion of future raises to401(k)plans(Benartzi and Thaler,2004).It is also in the spirit of the action by some employers to make the default in their401(k)plans enrollment in a prespecified fund or combination of funds rather than no enrollment(Madrian and Shea, 2001).Importantly,however,in these last two examples the employer’s actions are costless to the employer,whereas more complete coverage of certain drugs or services is potentially costly.David Cutler has suggested to me a few additional applications of behavioral economics that an employer might apply to induce healthier behaviors.One is analogous to the Save More Tomorrow9The use of models with time inconsistency is but one use of behavioral economics in health economics;other appli-cations of behavioral economics to health care are discussed in an insightful paper by Richard Frank(Frank,2006).1012J.P.Newhouse/Journal of Health Economics25(2006)1005–1014idea;employers could have employees who smoke pay something today and for the next several months.If they completed a smoking cessation course in the future,say next year;the monies they paid would be refunded with an additional amount.A second is to lower the time cost as well as the money cost of healthy behaviors and raise the time cost for unhealthy behaviors.Discovering opportunities to modify the health insurance contract by subsidizing specific medical goods or services in order to minimize future medical costs and/or improve health and productivity seems like a rich vein for empirical research,including experimental research,even though past research has not been kind to suggestions that coverage of certain services would reduce medical costs.I offer two examples.Despite evidence from observational data that it would do so(Roemer et al.,1975),the RAND Experiment data showed that more complete coverage of office visits did not reduce future costs by detecting disease early but instead increased both inpatient and outpatient costs.10The Channeling demonstration showed that increased coverage of home and community based services only modestly reduced the use of nursing home services and on balance increased costs,though it did produce benefits(Kemper,1988).I believe the problem in these instances were that the subsidies were not sufficiently specific;rather than a subsidy for all office visits,for example,there could be a subsidy,or an additional subsidy,for routine maintenance visits for those with certain chronic diseases.And because some of the cost-saving benefits from subsidies in employment-based insurance may spill over to Medicare, whereas others may spill over to future employers that provide health insurance,strong evidence of cost saving would provide a case for certain mandates.To sum up,from a social perspective there are reasons from both the nature of health insurance markets and individual behavior to suspect that markets will not lead to optimal cost sharing. Employers may not internalize future cost reductions,and consumers may systematically under-value future benefits.Moreover,inducing greater consumption of some drugs may not even represent moral hazard in the conventional sense of the term if the social cost of another pill is negligible.Even from a private perspective,uniform cost sharing across people within a group and across services such as physician visits or drugs is unlikely to be optimal.If it was,the market for disease management services would be limited.Discovering opportunities to refine cost sharing seems like an important part of the health economics research agenda.In any event,optimal cost sharing looks to be much more specific than the current statute law and resulting regulations mandates for HSAs.AcknowledgementsI would like to thank David Cutler,Richard Frank,Jon Gruber,Tom McGuire,and Richard Zeckhauser for comments on a draft of this paper.The usual disclaimer applies.ReferencesAinslie,George,1991.Derivation of‘rational’economic behavior from hyperbolic discount curves.American Economic Review81(2),334–340.Ainslie,George,1992.Picoeconomics:The Strategic Interaction of Successive Motivational States.Cambridge University Press,New York.Akerlof,George,1991.Procrastination and obedience.American Economic Review81(2),1–19.10See(Helms et al.,1978)for the problems with the observational data.。