高血压之脉压差≥70mmhg的中西医治疗浅析
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(1)多奈哌齐:一种新型的胆碱酯酶抑制剂,可能通过抑制突触 末端胆碱酶活性,增加乙酰胆碱的活性,对心脏及血管产生保护作用。
ABSTRACT: Hypertension is one of the main diseases that endanger human health. Pulse pressure difference is 70 MMHG hypertension or long development external clinical manifestation, pathological changes of the body to severely damaged its pathological mechanism is by the biological changes of genes within the body, the change of blood rheology and blood dynamics, the change of blood clotting mechanism, vascular endothelial damage, vascular remodeling decreased elasticity, molecular genetics, metabonomics and the participation of environmental factors, such as the result. Traditional Chinese medicine is believed to be caused by the invasion of external pathogens and liver, spleen, kidney and other viscera meridian function decline, uncoordinated, unobstructed. The treatment should start from the comprehensive factors of hypertension early active intervention treatment, as far as possible to avoid the occurrence of single or multiple organs of serious pathological changes in the deep-water areas after the exploration of treatment. Do “on the treatment of disease”, so that hypertension patients to get a real recovery! KEY WORDS: Hypertension; Treatment of traditional Chinese and Western Medicine
1 西医治疗
1.1 从干预(心脏)自主神经活性 [1] 治疗高血压降脉压 1.1.1 交感神经(SNA)的干预。SNA 可通过 α 和 β 肾上腺素 能引起高血压病,心肌和血管的纤维化和肥厚。中枢性的 α 受 体阻断药,如利血平、甲基多巴等能够抑制 SNA 的活性。长期 服用选择性 α1 受体阻断药能改善高血压心肌重构和血管重构, 使血管趋向原状,有利降控血压,降低脉压,防止心脑血管事件。 β 受体阻断剂(β-B),如倍他洛克可抑制 SNA 系统过度激活, 主要机制减慢心率,降低心排血量,改善压力感受器的血压调节 功能,降低血压、脉压,以改善心脏及血管重构,提高心功能, 但药物有依赖性。另研究发现:阿伐他汀通过改善氧化应激状态 和下调 NGF 表达,来改善交感神经重构。 1.1.2 干预迷走神经,保护血管内皮,实现降血压、脉压,降低 血管事件。
世界最新医学信息文摘 2019 年第 19 卷第 99 期g 的中西医治疗浅析
陶德俊 1,陶业伟 2
(1. 河北省邯郸市馆陶县妇幼保健院,河北 邯郸;2. 山东省聊城市中医院,山东 聊城)
摘要:高血压病是危害人类健康的主要疾病之一。脉压差 ≥70mmHg 是高血压病漫长发展机体受损至严重病变的外在临床表现,其病理机制 是由机体内基因生物学改变、血液流变学、血液动力学的改变、血液凝血机制的改变,血管内皮受损、血管重构弹性下降、分子遗传学、代谢 组学等与环境因素共同参与的结果。中医认为是由外邪入侵和肝脾肾等脏腑经络功能衰退、不协调、不通畅造成的。治疗上应从致高血压病的 因素综合入手及早积极干预治疗,尽量避免病变出现单一或多脏器有严重的病变深水重灾区后再作探索治疗。做到“上工治未病”,使高血压 病人获得真正康复 ! 关键词:高血压;中西医治疗 中图分类号:R544.1 文献标识码:A DOI: 10.19613/ki.1671-3141.2019.99.029 本文引用格式:陶德俊 , 陶业伟 . 高血压之脉压差≥ 70mmHg 的中西医治疗浅析 [J]. 世界最新医学信息文摘 ,2019,19(99):65-67.
Analysis of traditional Chinese and Western Medicine Treatment of Hypertension With Pulse Pressure Difference ≥70mmHg
TAO De-jun1, TAO Ye-wei2
(1. Maternal and Child Health Hospital of Guantao County, Handan City, Hebei Province, Handan Hebei; 2. Traditional Chinese Medicine Hospital of Liaocheng City, Shandong Province, Liaocheng Shandong)
ABSTRACT: Hypertension is one of the main diseases that endanger human health. Pulse pressure difference is 70 MMHG hypertension or long development external clinical manifestation, pathological changes of the body to severely damaged its pathological mechanism is by the biological changes of genes within the body, the change of blood rheology and blood dynamics, the change of blood clotting mechanism, vascular endothelial damage, vascular remodeling decreased elasticity, molecular genetics, metabonomics and the participation of environmental factors, such as the result. Traditional Chinese medicine is believed to be caused by the invasion of external pathogens and liver, spleen, kidney and other viscera meridian function decline, uncoordinated, unobstructed. The treatment should start from the comprehensive factors of hypertension early active intervention treatment, as far as possible to avoid the occurrence of single or multiple organs of serious pathological changes in the deep-water areas after the exploration of treatment. Do “on the treatment of disease”, so that hypertension patients to get a real recovery! KEY WORDS: Hypertension; Treatment of traditional Chinese and Western Medicine
1 西医治疗
1.1 从干预(心脏)自主神经活性 [1] 治疗高血压降脉压 1.1.1 交感神经(SNA)的干预。SNA 可通过 α 和 β 肾上腺素 能引起高血压病,心肌和血管的纤维化和肥厚。中枢性的 α 受 体阻断药,如利血平、甲基多巴等能够抑制 SNA 的活性。长期 服用选择性 α1 受体阻断药能改善高血压心肌重构和血管重构, 使血管趋向原状,有利降控血压,降低脉压,防止心脑血管事件。 β 受体阻断剂(β-B),如倍他洛克可抑制 SNA 系统过度激活, 主要机制减慢心率,降低心排血量,改善压力感受器的血压调节 功能,降低血压、脉压,以改善心脏及血管重构,提高心功能, 但药物有依赖性。另研究发现:阿伐他汀通过改善氧化应激状态 和下调 NGF 表达,来改善交感神经重构。 1.1.2 干预迷走神经,保护血管内皮,实现降血压、脉压,降低 血管事件。
世界最新医学信息文摘 2019 年第 19 卷第 99 期g 的中西医治疗浅析
陶德俊 1,陶业伟 2
(1. 河北省邯郸市馆陶县妇幼保健院,河北 邯郸;2. 山东省聊城市中医院,山东 聊城)
摘要:高血压病是危害人类健康的主要疾病之一。脉压差 ≥70mmHg 是高血压病漫长发展机体受损至严重病变的外在临床表现,其病理机制 是由机体内基因生物学改变、血液流变学、血液动力学的改变、血液凝血机制的改变,血管内皮受损、血管重构弹性下降、分子遗传学、代谢 组学等与环境因素共同参与的结果。中医认为是由外邪入侵和肝脾肾等脏腑经络功能衰退、不协调、不通畅造成的。治疗上应从致高血压病的 因素综合入手及早积极干预治疗,尽量避免病变出现单一或多脏器有严重的病变深水重灾区后再作探索治疗。做到“上工治未病”,使高血压 病人获得真正康复 ! 关键词:高血压;中西医治疗 中图分类号:R544.1 文献标识码:A DOI: 10.19613/ki.1671-3141.2019.99.029 本文引用格式:陶德俊 , 陶业伟 . 高血压之脉压差≥ 70mmHg 的中西医治疗浅析 [J]. 世界最新医学信息文摘 ,2019,19(99):65-67.
Analysis of traditional Chinese and Western Medicine Treatment of Hypertension With Pulse Pressure Difference ≥70mmHg
TAO De-jun1, TAO Ye-wei2
(1. Maternal and Child Health Hospital of Guantao County, Handan City, Hebei Province, Handan Hebei; 2. Traditional Chinese Medicine Hospital of Liaocheng City, Shandong Province, Liaocheng Shandong)