福莫特罗治疗支气管哮喘的效果观察

福莫特罗治疗支气管哮喘的效果观察
杨劲松
【期刊名称】《中国医药导刊》
【年(卷),期】2012(14)5
【摘要】目的:观察福莫特罗高剂量与低剂量对支气管哮喘患者的治疗效果.方法:共有218 例支气管哮喘患者参加研究.患者随机分为高剂量组(110 例)和低剂量组(108 例),分别给予福莫特罗24μg及12μg16 周,以严重哮喘恶化作为主要研究终点,次要终点为因症状加重需要使用皮质激素、症状恶化及FEV1 改变.结果:3 例患者出现呼吸系统相关的严重不良反应事件(SAEs) 住院:24μg 组2例,12μg组1例.所有事件均与哮喘有关.明显哮喘恶化(需要全身激素治疗)两组相似,24μg组为7例(6.3%),12μg组为6例(5.5%).两组患者治疗前后比较FEV1 均有显著改善(P < 0.005).结论:福莫特罗治疗重症支气管哮喘有显著效果,12～24μg均不增加哮喘的恶化率,且二者不良反应基本相似.%Objective:To observe the effect of the high-dose and lower dose formoterol in patients with bronchial asthma. Methods:A total of 218 patients with asthma to participate in the study. Patients were randomly divided into high-dose group ( n = 110) or lower dose group (108 cases) and were given formoterol 24 ug or 12 ug for 16 weeks, respectively. Serious asthma exacerbations (life threatening or requir-ing hospitalization) were the primary end point. Secondary end points included significantexacerbations requiring systemic corticosteroids,all exacerbations, and changes in FEV; .Results: 2 patients had respiratory related serious adverse events ( SAEs ) in high-dose group
andl in lower dose group,The serious adverse events were associated with asthma. The significant asthma exacerbations (the need for systemic hormone therapy) was similar in the two groups,high-dose group was 7 (6.3%) and lower dose group 6 patients (5.5%),respectively. All formoterol treatment regimens had a significant effect on FEV1 measured after dose during the study (P < 0.005). Conclusion:Treatment with formoterol for patients with severe bronchial asthma has a significant effect,12 or 24 ug was not increased asthma exacerbation rate and adverse events similar.【总页数】2页(P817-818)
【作者】杨劲松
【作者单位】河南省鹤壁市鹤壁煤业集团总医院药剂科,鹤壁458000
【正文语种】中文
【中图分类】R652.25;R977.1
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