脑胶质瘤术后调强放疗联合替莫唑胺化疗的效果观察

18 CHINA MEDICINE AND PHARMACY Vol.7 No.14 July

2017

2017年7月第7卷第14期

·论 著·

脑胶质瘤术后调强放疗联合替莫唑胺化疗的效果观察

罗唯师 罗国轩 朱明华 张 勇▲广东省第二人民医院神经外科，广东广州 510317

[摘要] 目的 对脑胶质瘤术后调强放疗联合替莫唑胺化疗的临床效果观察。 方法 选取2015年6月～2016年6月期间收治的患有脑胶质瘤并预约进行手术治疗的患者30例，随机分为观察组和对照组，两组患者各15例。对患者进行详细术前基础的体质检查，在此基础上，给予对照组患者采用术后单纯放疗，而给予观察组患者在采用放疗的基础上，联用替莫唑胺进行化疗治疗。观察两组患者在治疗后的恢复状况。 结果 观察组（14，93.3％）相对比对照组（11，73.3％）临床总有效率高了20％，两组比较差异有统计学意义（P ＜0.05）；将两组患者在治疗过程中出现的不良反应进行比较，可发现观察组的不良反应发生率较低，两组比较差异有统计学意义（P ＜0.05）。 结论 放疗联合替莫唑胺化疗的手段，有利于患有脑胶质瘤的患者的术后恢复治疗，且患者在治疗期间出现的不良反应较少，应在临床治疗过程中多加推广。

[关键词] 脑胶质瘤；术后化疗；放疗；替莫唑胺；临床疗效

[中图分类号] R739.4 [文献标识码] A [文章编号] 2095-0616（2017）14-18-03

Effect of intensity-modulated radiotherapy combined with

temozolomide chemotherapy on postoperative brain glioma

LUO Weishi LUO Guoxuan ZHU Minghua ZHANG Yong

Department of Neurosurgery,Guangdong Second Provincial General Hospital,Guangzhou 510317,China

[Abstract] Objective To observe the curative effect of intensity-modulated radiotherapy combined with temozolomide chemotherapy on postoperative brain glioma. Methods 30 patients with gliomas and appointment for surgery cured in outpatient and inpatient treatment of our hospital from June 2015 to June 2016 were selected and randomly divided into observation group and control group with 15 cases in each.All the patient underwent a detailed preoperative physical examination,based on this,patients in control group were treated with postoperative radiotherapy alone,and patients in observation group were treated with chemotherapy with temozolomide on the basis of radiotherapy.The state of recovery after treatment of the two groups were observed. Results Compared with the control group(11,73.3%),the clinical total effective rate of the observation group(14,93.3%) was 20% higher than that of the control group, the difference was statistically significant(P ＜0.05).Comparing the adverse reactions of the two groups in the course of treatment, it could be found that the incidence of adverse reactions in the observation group was relatively low, the difference between the two groups was statistically significant(P ＜0.05). Conclusion Radiotherapy combined with temozolomide chemotherapy is beneficial for postoperative recovery therapy in patients with glioma.And the patients have less adverse reactions during treatment,and it should be promoted in the clinical treatment process.

[Key words] Brain glioma;Postoperative chemotherapy;Radiotherapy;Temozolomide;Clinical efficacy

[基金项目] 广东省医学科学技术研究基金（A2014256）。

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通讯作者

脑胶质瘤[1]是一种以神经胶质瘤为主的的颅内肿瘤，该病的发病率占颅内肿瘤病发率的1.4％。临床治疗主要采用手术治疗，但由于该病在手术治疗后易复发，因此有效的放疗以及化疗等治疗对患者术后修复十分关键[2]，可有效控制肿瘤的增长、转移、扩散，控制病情的严重化。因此本实验采用放疗联合替莫唑胺化疗的治疗手段，对脑胶质瘤患者进行治疗，选用我院在2015年6月～2016年6月

期间收治的30例患有脑胶质瘤的患者作为实验研究对象，为今后的临床治疗提供有利参考和证据，现报道如下。1 资料与方法1.1 一般资料

选取2015年6月～2016年6月期间本院收治的患有脑胶质瘤，并预约进行手术治疗的患者30例，根据患者脑部的CT 检测结果，可以判断本实验选取的30例患者均经过医院医学伦理委员会批准。本实验的研究对象排除标准：（1）患者接受放疗的