Topiramate_97240-79-4_DataSheet_MedChemExpress
艾美捷OLFM4酶联免疫吸附试剂盒使用说明书
（本试剂盒仅供体外研究使用，不用于临床诊断！）产品货号：E-EL-H6102产品规格：96T/48T/24T人嗅素4(OLFM4)酶联免疫吸附测定试剂盒使用说明书Human OLFM4(Olfactomedin 4) ELISA Kit使用前请仔细阅读说明书。
如果有任何问题，请通过以下方式联系我们：销售部电话************，************技术部电话************QQ客服800110755具体保质期请见试剂盒外包装标签。
请在保质期内使用试剂盒。
联系时请提供产品批号(见试剂盒标签)，以便我们更高效地为您服务。
用途该试剂盒用于体外定量检测人血清、血浆或其它相关生物液体中OLFM4浓度。
灵敏度、检测范围、特异性和重复性●灵敏度：1.88ng/mL。
●检测范围：3.13-200ng/mL。
●特异性：可检测样本中的人OLFM4,且与其它类似物无明显交叉反应。
●重复性：板内，板间变异系数均<10%。
检测原理本试剂盒采用双抗体夹心ELISA法。
用抗人OLFM4抗体包被于酶标板上，实验时样品（或标准品）中的人OLFM4会与包被抗体结合，游离的成分被洗去。
后依次加入生物素化的抗人OLFM4抗体和辣根过氧化物酶标记的亲和素，抗人OLFM4抗体与结合在包被抗体上的人OLFM4结合，生物素与亲和素特异性结合而形成免疫复合物，游离的成分被洗去。
加入显色底物(TMB)，TMB在辣根过氧化物酶的催化下呈现蓝色，加终止液后变成黄色。
用酶标仪在450nm波长处测OD值，OLFM4浓度与OD450值之间呈正比，通过绘制标准曲线计算出样品中OLFM4的浓度。
试剂盒组成及保存未拆封的试剂盒可在2-8℃保存一周；如果一周以后才使用试剂盒，请拆开试剂盒并按照下表中的条件分别保存各组分。
试剂体积以实际发货版说明书为准。
相关试剂在分装时会比标签上标明的体积稍多一些，请在使用时量取而非直接倒出。
试验所需自备物品1.酶标仪(450nm波长滤光片)2.高精度移液器，EP管及一次性吸头：0.5-10μL, 2-20μL, 20-200μL, 200-1000μL3.37℃恒温箱，双蒸水或去离子水4.吸水纸5.加样槽注意事项1.试验中请穿着实验服并戴乳胶手套做好防护工作。
TOPACTIVE DES-脱普DES
第四部分 急救措施
眼睛接触 皮肤接触
吸入 食入
销售的产品
: 用水细心冲洗数分钟。 如戴隐形眼镜并可方便地取出，取出隐形眼镜。 继续冲洗。 立即就医。
: 立即脱掉所有被污染的衣服。 用水冲洗皮肤或淋浴。 立即就医。 衣物重新使用前应清洗。 鞋子在重新使用前应彻底清洗。
: 将患者转移到空气新鲜处，休息， 保持利于呼吸的体位。 立即就医。
: 放在儿童伸手不及之处。 保持容器密闭。 将容器置于阴凉，通风处。 与还原剂和可燃物分离。
稀释后使用的产品 操作后，彻底冲洗。
放在儿童伸手不及之处。
禁止在如下温度以上保存： 35℃
第八部分 接触控制/人身保护
控制参数 组分名称
接触限值
过氧化氢；双氧水 乙酸；冰醋酸
GBZ-2 (中国, 4/2007)。 PC-TWA: 1.5 mg/m³ 8 小时。
: 国家安全生产监督管理局化学品登记中心 应急电话: +86 532 8388 9090 (24小时)
第二部分 危险标识
GHS危险性类别 GHS标签要素
销售的产品
: 氧化性液体 - 3 急性毒性: 口服 - 5 皮肤腐蚀/刺激 - 1B 严重眼睛损伤/眼睛刺激性 - 1 危害水生环境—急性危险 - 2
稀释后使用的产品 无规定。
警示词 符号
: 危险 :
无信号词。
危险性说明 防范说明 预防措施 事故响应
安全储存 903713-01
: 可加剧燃烧；氧化剂。 吞咽可能有害。 引起严重的皮肤灼伤和眼睛损伤。 对水生生物有毒。
没有明显的已知作用或严重危险。
: 戴防护手套。 戴防护眼镜、防护面罩。 穿防护服。 远离热源。-- 禁止吸烟。 远离衣物、禁配物和可燃物保存。 避免排入环境。 操作后彻底清洗手部。
Perkadox 14-40B-PD-S 产品数据表说明书
Product Data SheetPerkadox 14-40B-PD-S Di(tert-butylperoxyisopropyl) benzenePerkadox® 14-40B-PD-S is a 40% formulation on an inert carrier system in powder form.CAS number2212-81-9, 25155-25-3EINECS/ELINCS No.218-664-7TSCA statuslisted on inventoryMolecular weight338.5Active oxygen contentperoxide9.45%Concentration3.7-3.9%SpecificationsAppearance Off-white powderAssay39.0-41.0 %ApplicationsPerkadox® 14-40B-PD-S is a bifunctional peroxide which is used for the crosslinking of natural rubber and synthetic rubbers, as well as polyolefins. Rubber compounds containing Perkadox® 14-40B-PD-S have excellent scorch safety, and under certain conditions one step mixing is possible. Safe processing temperature: 135°C (rheometer ts2 > 20 min.). Typical crosslinking temperature: 175°C (rheometer t90 about 12 min.).Thermal stabilityOrganic peroxides are thermally unstable substances, which may undergo self-accelerating decomposition. The lowest temperature at which self-accelerating decomposition of a substance in the original packaging may occur is the Self-Accelerating Decomposition Temperature (SADT). The SADT is determined on the basis of the Heat Accumulation Storage Test.SADT80°CMethod The Heat Accumulation Storage Test is a recognized test method for thedetermination of the SADT of organic peroxides (see Recommendations on theTransport of Dangerous Goods, Manual of Tests and Criteria - United Nations, NewYork and Geneva).StorageDue to the relatively unstable nature of organic peroxides a loss of quality can be detected over a period of time. To minimize the loss of quality, Nouryon recommends a maximum storage temperature (Ts max.) for each organic peroxide product.Ts max.30°CNote When stored under strictly recommended storage conditions, Perkadox® 14-40B-PD-S will remain within the Nouryon specifications for a period of at least 12months after delivery.Packaging and transportThe standard packaging is a cardboard box for 25 kg peroxide formulation. Both packaging and transport meet the international regulations. For the availability of other packed quantities consult your Nouryon representative. Perkadox®14-40B-PD-S is classified as Flammable solid, class 4. 1, UN 1325.Safety and handlingKeep containers tightly closed. Store and handle Perkadox® 14-40B-PD-S in a dry well-ventilated place away from sources of heat or ignition and direct sunlight. Never weigh out in the storage room. Avoid contact with reducing agents (e. g. amines), acids, alkalines and heavy metal compounds (e. g. accelerators, driers and metal soaps). Please refer to the Safety Data Sheet (SDS) for further information on the safe storage, use and handling of Perkadox® 14-40B-PD-S. This information should be thoroughly reviewed prior to acceptance of this product. The SDS is available at /sds-search.Major decomposition productsMethane, Acetone, tert-Butanol, Di(2-hydroxyisopropyl)benzene, Diacetylbenzene, Acetyl 2-hydroxyisopropyl benzeneAll information concerning this product and/or suggestions for handling and use contained herein are offered in good faith and are believed to be reliable.Nouryon, however, makes no warranty as to accuracy and/or sufficiency of such information and/or suggestions, as to the product's merchantability or fitness for any particular purpose, or that any suggested use will not infringe any patent. Nouryon does not accept any liability whatsoever arising out of the use of or reliance on this information, or out of the use or the performance of the product. Nothing contained herein shall be construed as granting or extending any license under any patent. Customer must determine for himself, by preliminary tests or otherwise, the suitability of this product for his purposes.The information contained herein supersedes all previously issued information on the subject matter covered. The customer may forward, distribute, and/or photocopy this document only if unaltered and complete, including all of its headers and footers, and should refrain from any unauthorized use. Don’t copythis document to a website.Perkadox® is a registered trademark of Nouryon Functional Chemicals B. V. or affiliates in one or more territories.Contact UsPolymer Specialties Americas************************Polymer Specialties Europe, Middle East, India and Africa*************************Polymer Specialties Asia Pacific************************2022-12-5© 2022Polymer crosslinking Perkadox 14-40B-PD-S。
PCR仪种类与生产公司情况
PCR仪种类与生产公司情况我所整理的PCR仪种类和生产公司情况（有点乱，给您添麻烦了。
）美国Applied Biosystems公司（原PE公司）ABI Prism(r) 7000型荧光定量PCR仪7700型定量PCR及点突变检测系统（AIB RPISM 7700 Sequence Detection System）ABI Prism(r) 7900型高通量荧光定量PCR仪7900HT 型荧光定量PCR仪是继7700、5700型荧光定量PCR仪之后，ABI公司最新推出的高通量实时荧光定量PCR系统。
它是唯一兼容96孔板和384孔板的荧光定量PCR仪，也是唯一可选手工进样和自动进样的荧光定量PCR仪。
7900HT型荧光定量PCR仪可满足从中通量到高通量实验的需求。
ABI PRISM? 6100核酸提取仪6700型全自动核酸提取工作站6700型全自动核酸提取工作站利用全自动的机械手臂和特制的提取试剂盒，实现了从复杂的生物样本中自动提取和纯化核酸，包括总RNA、DNA，并可将mRNA自动转录成cDNA。
制备好的核酸样品可用于基因表达的定量分析、等位基因点突变检测、序列分析等。
TaqMan荧光定量PCR试剂盒1999 年底,PE公司推出检测大肠杆菌E. Coli O157:H7菌种及其Shiga毒素基因的TaqMan荧光定量PCR试剂盒. 闻名的大肠杆菌O157:H7有了快速准确的检测试剂盒. 仅在美国, 每年有20000人因食用 E. Coli O157:H7污染的食品而得病,其中250-500人死亡。
ABI PRISE 310型全自动DNA测序仪（遗传分析仪）3700型遗传分析仪ABI Prism(r) 3100遗传分析仪测序试剂盒片段分析试剂盒应用试剂盒:1. 农业2. 疾病研究3. 个体识别4. 分子诊断5. 微生物研究分析软件:序列分析和片段分析软件基因型分析软件日本大和PCR仪英国HYBAID定量PCR仪杭州大和热磁电子有限公司-荧光定量PCR分析系统美国应用生物系统公司-全自动核酸提取工作站BIOTECH-97基因扩增仪国产PCR仪TOUCHgene GENIUS Progene-2 Progene-1PCR仪生产厂家型号PCR 系列优惠价: 见 VWRCN公司中国办事处基因扩增仪珠海黑马医学仪器有限公司Hema240基因扩增仪珠海黑马医学仪器有限公司Hema 8000基因扩增仪珠海黑马医学仪器有限公司Hema4800基因扩增仪（进口组件）珠海黑马医学仪器有限公司Hema480大容量DNA扩增仪MJ RESEARCH PTC-225型PCR仪销售及维修英国techne公司progen和geniuspcr仪英国techgene384孔透明PCR板美国AXYGEN PCR-384-C96孔透明PCR板美国AXYGEN PCR-96-CPCR仪Biometra基因扩增仪北京新未来世纪科技发展有限公司NEW FUTUREE半导体式全自动PCR仪杭州朗基科学仪器有限公司Mygene25全自动半导本式PCR仪杭州朗基科学仪器有限公司Mygene16型全自动半导体式PCR仪杭州朗基科学仪器有限公司Mygene25 plus（精品型）梯度PCR 德国Whatman/Biometra TgrientPCR 德国Whatman/Biometra T1PCR 德国Whatman/Biometra T3个人PCR 德国Whatman/Biometra Tpersonal高效水冷全自动基因扩增仪上海理工大学高机实业总公司SRX-481、SRX-48/35 水浴式PCR扩增仪上海博通经贸有限公司博士舰PCR 英国TECHNEPCR-MHC基因检测仪杭州大和热磁电子有限公司PCR仪日本FERROTEC Super-PCR TC-48/88/96基因扩增仪北京市君意机电技术公司JY01型（原WD9402增强型）PCR样品处理器北京市君意机电技术公司JY05型PCR仪美国Ericomp TCX-20APCR仪美国Ericomp TCX-60PCR仪(冷冻型) 北京仪诚科技公司JK-236PCR仪美国Ericomp TCX-20PCR仪德国BIOMETRA T3PCR仪德国BIOMETRA T-personal CyclePCR仪日本三洋MIR-D40PCR仪日本三洋MIR-D30梯度PCR仪德国BIOMETRA T-GradientPCR仪日本FERROTEC Life Express TC-48/88/96PCR仪日本FERROTEC Little Genius TC-16/25基因扩增仪澳大利亚Corbett FTS-320APCR仪美国伯乐170-6701PCR仪美国MJ PTC-200PCR仪美国MJ PTC-150PCR仪美国MJ PTC-100PCR仪英国JOYOR TC-480微电脑基因扩增仪北京科普仪器厂KP-32PCR仪英国JOYOR TC-410APCR仪英国JOYOR TC-410基因扩增仪澳大利亚Corbett FTS-960基因扩增仪北京市新技术应用研究所1109 (2A)基因扩增仪北京六一仪器厂WD-9402基因扩增仪英国Techne Progene分子杂交点样器(斑点式抽滤) 北京科普仪器厂KP-30PCR仪美国MJ RESEARCH基因扩增仪北京市新技术应用研究所1109PCR仪英国JOYOR TC-410PCR仪(定量) 美国AcuGen System AG-96PCR仪(定性) 美国AcuGen System AG-96基因扩增仪(气冷型) 北京四环科学仪器厂JK-232B基因扩增仪北京市新技术应用研究所1449PCR仪英国JOYORPCR仪(全自动四孔水浴式) 上海复申高科技(集团)实业公司FS-919PCR仪美国MJ RESEARCH PTC-100全自动基因扩增仪上海高机应用技术研究所SRX-481全自动基因扩增仪比利时ThermojeT Termoje全自动基因扩增仪美国BIO-RAD BIO-RAD全自动基因扩增仪美国安普A TC1605 英国EQUIBIO 25 PCR仪英国EQUIBIO 36PCR放污染罩上海复星实业股份有限公司FX-441基因扩增仪英国Gene E- 1智能基因扩增仪上海跃进医疗器械厂PCR-1109基因扩增仪温州孚华分析仪器厂DTC-3A基因扩增仪美国GL Applied Inc. GTC-2PCR仪德国EPPENDORF 5332PCR仪美国COY 110PPCR仪美国COY 110SPCR仪美国MJ RESEARCH PTC-100AGVPCR仪（原位）美国MJ RESEARCH PTC16MS大容量PCR仪美国MJ RESEARCH PTC-225梯度PCR仪德国eppendorf MastercyclerDNA扩增仪美国STRATAGENE RoboCycler 40DNA扩增仪(梯度型) 美国STRATAGENE GRADIENT 40 全自动基因扩增仪上海复日生物实验技术研制所FR-900 自动基因扩增仪上海市离心机械研究所JK-1PCR仪德国EPPENDORF 5330基因扩增仪上海FR-800英国TECHNE公司Cyclogene基因扩增仪英国TECHNE公司GeneE基因扩增仪英国TECHNE公司PROGENE基因扩增仪英国TECHNE PROGENEDNA扩增仪美国TE CHNE。
进口器械耗材试剂目录表1
1.乳酸脱氢酶试剂盒 (Siemens Medical Solutions Diagnostics 国食药监械(进)字2002.肌酸激酶试剂盒 (Siemens Medical Solutions Diagnostics 国食药监械(进)字2004第3400291号(更3.碱性磷酸酶试剂盒 (Siemens Medical Solutions Diagnostics 国食药监械(进)字2004第3400293号(4.丙氨酸氨基转移酶试剂盒 (Siemens Medical Solutions Diagnostics 国食药监械(进)字2004第34005.淀粉酶试剂盒 (Siemens Medical Solutions Diagnostics 国食药监械(进)字2004第3400294号(更))6.CD45RO-PE荧光单克隆抗体试剂 (法国 IMMUNOTECH S.A.S （美国贝克曼库尔特有限公司分公司） 国7.CD3-FITC/CD(16+56)-PE荧光单克隆抗体试剂 (法国 IMMUNOTECH S.A.S （美国贝克曼库尔特有限公司8.CD45RA-FITC荧光单克隆抗体试剂 (法国 IMMUNOTECH S.A.S （美国贝克曼库尔特有限公司分公司）9.ISE－缓冲液 (Siemens Medical Solutions Diagnostics 国食药监械(进)字2004第3400162号(更))10.稀释液 ( 国食药监械（进）字2007第3400992号)11.质控品 (美国SYSMEX CORPORATION希森美康株式会社 国食药监械（进）字2007第3400993号)12.质控品 (美国 SYSMEX CORPORATION希森美康株式会社 国食药监械（进）字2007第3400994号)13.皮质醇试剂包 ( 国食药监械（进）字2007第3401009号)14.三碘甲状腺原氨酸摄取试剂包 (Ortho-Clinical Diagnostics Inc., 国食药监械（进）字2007第3415.肌酸激酶MB亚单位质量试剂包 ( 国食药监械（进）字2007第3401011号)16.采血针 (德国 罗氏诊断有限公司 国食药监械（进）字2007第3410922号)17.苯妥英试剂盒 ( 国食药监械(进)字2005第3401316号(更))18.凝血酶原时间测试试剂 (德国 Dade Behring Marburg公司 国食药监械（进）字2007第3400990号)19.GPA-PE荧光单克隆抗体试剂 (法国 IMMUNOTECH S.A.S （美国贝克曼库尔特有限公司分公司） 国食20.腔镜手助器(商品名：兰碟斯) (Hakko Co., Ltd. 国食药监械(进)字2007第3660631号)21.高压注射连接管 (美国 Argon Medical Devices, Inc 国食药监械(进)字2007第3660652号)22.球囊扩张导管(商品名：Extensor) ( 国食药监械(进)字2007第3770536号)23.弹簧圈(商品名：GDC) (Boston Scientific Corporation 国食药监械(进)字2007第3770569号)24.穿刺导引套装 英文名称：Exacta Percutaneous Sheath Introducer Kits (Becton Dickinson Cri25.7.382缓冲液 ( 国食药监械(进)字2004第3401401号(更))26.尿液总蛋白试剂盒 ( 国食药监械(进)字2005第3401707号(更))27.网织红细胞稀释液·染色液 (日本 SYSMEX CORPORATION希森美康株式会社 国食药监械（进）字20028.肺通气功能测定仪(商品名：肺功能仪) (日本福田产业株式会社 国食药监械(进)字2007第2400718号29.高密度脂质胆固醇诊断试剂盒 (日本 协和医药株式会社 国食药监械(进)字2007第2400722号)30.白蛋白检测试剂盒 (西班牙博士泰公司 国食药监械(进)字2007第2400723号)31.镁检测试剂盒 (西班牙博士泰公司 国食药监械(进)字2007第2400724号)32.葡萄糖检测试剂盒 (西班牙博士泰公司 国食药监械(进)字2007第2400725号)33.HL-9000/IONEA型高电位治疗器 (株式会社日本医疗科学 国药管械(进)2002第2210693号(更))34.BIO 2001 生殖泌尿系统生物反馈电刺激治疗仪 (METRASOL公司 国食药监械(进)字2004第3260453号35.CD3-FITC荧光单克隆抗体试剂 (法国 IMMUNOTECH S.A.S （美国贝克曼库尔特有限公司分公司） 国36.CD38-FITC荧光单克隆抗体试剂 (法国 IMMUNOTECH S.A.S （美国贝克曼库尔特有限公司分公司） 国37.胰淀粉酶测定试剂盒 (关东化学株式会社 国食药监械(进)字2007第2400711号)38.类风湿因子诊断试剂盒 ( 国食药监械(进)字2005第3401715号(更))39.前白蛋白诊断试剂盒 (Siemens Medical Solutions Diagnostics 国食药监械(进)字2005第240145140.组织脱水机(商品名：珊顿组织脱水机) (美国 Thermo Electron Corporation 国食药监械(进)字2041.切片机(商品名：珊顿冷冻切片机) (美国 Thermo Electron Corporation 国食药监械(进)字2007第42.组织脱水机(商品名：珊顿全密封组织脱水机) (美国 Thermo Electron Corporation 国食药监械(进43.呼吸球及附件 (VBM Medizintechnik GmbH 国食药监械(进)字2007第1540638号)44.麻醉面罩 (Mallinckrodt Dar S.r.l. 国食药监械(进)字2007第1540643号)45.牙科种植体手术工具 (MegaGen Co.,Ltd. 国食药监械(进)字2007第1550546号)46.酒精诊断试剂盒 (德国 罗氏诊断有限公司 国食药监械(进)字2007第3400693号)47.转铁蛋白诊断试剂盒 ( 国食药监械(进)字2005第3401771号(更))48.全段甲状旁腺激素试剂盒 ( 国食药监械(进)字2006第3401974号(更))49.全自动荧光磁微粒酶免分析仪 (日本东曹株式会社日本东曹株式会社 国食药监械(进)字2007第240050.化学发光分析仪 (德国 DiaSorin Deutschland GmbH 国食药监械(进)字2007第2400559号)51.丙氨酸氨基转移酶试剂盒 (Dade Behring Inc. 国食药监械(进)字2007第2400705号)52.低密度脂质胆固醇诊断试剂盒 (协和医药株式会社 国食药监械(进)字2007第2400708号)53.甘油三酯诊断试剂盒 (协和医药株式会社 国食药监械(进)字2007第2400709号)54.手术膜 (美国 3M Company3M Company 国食药监械(进)字2007第2640542号)55.高密度/低密度胆固醇校准液 ( 国食药监械(进)字2005第3402329号(更))56.通用稀释液8 ( 国食药监械(进)字2005第3401703号(更))57.植入式心脏起搏器 (美国 Guidant Corporation Cardiac Pacemakers Inc. 国食药监械(进)字200658.通用稀释液1 ( 国食药监械(进)字2005第3401697号(更))59.中空螺钉(商品名：Magana-Fx内固定中空螺钉) (美国 Zimmer Inc. 捷迈公司 国食药60.带锁髓内钉(商品名：M/DN) (美国 Zimmer Inc. 捷迈公司 国食药监械（进）字2007第3461044号)61.全髋关节系统(商品名：Elite Plus) (英国 DePuy International Ltd 国食药监械（进）字2007第62.内固定线缆系统(商品名：ATLAS) (美国 Medtronic Sofamor Danek USA Inc. 国食药监械（进）字63.髋关节假体(商品名：VerSys推荐型髋关节假体) (美国 Zimmer Inc. 捷迈公司 国食药监械（进）字64.鼻塞(商品名：Raucocel 鼻塞) (（Deutschland）Lohmann & Rauscher 国际股份有限公司 国食药监65.腹腔镜及附件(商品名：腹腔镜及附件) (奥林巴斯苇音特和意北公司 国食药监械(进)字2007第322066.Acculan电池动力系统 (Aesculap AG & Co. KG 国食药监械(进)字2004第2211422号(更))67.透析用碳酸氢钠干粉 (B. Braun Medizintechnologie GmbH 国食药监械(进)字2004第3451444号(更68.二氧化碳校准液/稀释液 (Siemens Medical Solutions Diagnostics 国食药监械(进)字2005第340269.乙烯基聚硅氧烷咬合检测印模材料(商品名:而至精确咬合记录II型) (日本株式会社而至 国食药监械70.用于口腔粘膜的亲水乙烯基聚硅氧烷印模材料(商品名:而至精确义齿记录) (日本株式会社而至 国食71.而至快速自凝基托树脂 (株式会社而至 国食药监械(进)字2005第3632051号(更))72.而至义齿贴合点指示剂 (而至株式会社 国食药监械(进)字2005第2633109号(更))73.胰岛素校准液 ( 国食药监械(进)字2005第3402318号(更))74.通用稀释液10 ( 国食药监械(进)字2005第3401704号(更))75.铜蓝蛋白试剂盒 (英国 THE BINDING SITE公司 国食药监械(进)字2007第3400649号)76.补体C4试剂盒 (The Binding Site Limited 国食药监械(进)字2007第3400650号)77.气动动力系统 (Aesculap AG & CO.KG 国食药监械(进)字2005第2541844号(更))78.避孕套 (马来西亚康乐工业有限公司 国食药监械(进)字2006第3661816号(更))79.导引导管 (Boston Scientific Corporation 国食药监械(进)字2005第3773129号(更))80.Cardio MD（单光子发射计算机断层）伽玛相机系统 (ADAC Laboratories A Philips Medical Syst81.全自动组织脱水机 (德国徕卡仪器公司Leica Microsystems Nussloch GmbH 国食药监械(进)字200382.耐甲氧西林金黄色葡萄球菌鉴定培养基 (bioMerieux,sa 国食药监械(进)字2006第3400205号(更))83.洗脱缓冲液 (日本 TOSOH CORPORATION 国食药监械（进）字2007第3400983号)84.C反应蛋白校准品 ( 国食药监械（进）字2007第3400985号)85.胆红素定标品 ( 国食药监械（进）字2007第3400986号)86.脂类定标品 (SYSMEX CORPORATION 国食药监械（进）字2007第3400987号)87.质控品 ( 国食药监械（进）字2007第3400988号)88.糖化血清蛋白测定试剂盒（生化酶法） (英国 Genzyme Diagnostic 国食药监械（进）字2007第34089.高频电烧装置 (日本 奥林巴斯医疗株式会社 OLYMPUS MEDICAL SYSTEMS CORP. 国食药监械(进)字290.正电子发射及计算机断层扫描系统 (美国 Siemens Medical Solutions USA,Inc 国食药监械(进)字91.荧光探针脱氧核糖核酸检测系统 (美国 Becton,Dickinsonand Company公司 国食药监械(进)字200792.促肾上腺皮质激素定标液 (Roche Diagnostics GmbH 国食药监械(进)字2007第3400501号)93.水杨酸盐试剂盒 (Dade Behring, Inc. 国食药监械(进)字2007第3400646号)94.叶酸诊断试剂盒 (德国 罗氏诊断有限公司Roche Diagnostics GmbH 国食药监械(进)字2007第3400695.免疫球蛋白M试剂盒 (The Binding Site Limited 国食药监械(进)字2007第3400648号)96.一次性胰岛素注射器带针头 ( 国食药监械(进)字2004第3152002号(更))97.带恒速调节器的输液管路 (Baxter S.A. 国食药监械(进)字2004第3661717号(更))98.百耐凝胶（Bionect gel） (意大利 Fidia制药厂 国食药监械(进)字2005第2640099号(更))99.自粘性硅胶片(商品名：仙卡) (Smith & Nephew Medical Ltd. 国食药监械(进)字2007第2660635号100.一次性使用真空采血管 (Greiner Bio-One Gmbh 国食药监械(进)字2007第2660642号)101.喉罩导气管 (塞舌尔 The Laryngeal Mask Company Limited 国食药监械(进)字2007第2660719号) 102.甲状腺过氧化酶自身抗体试剂盒 (Siemens Medical Solutions Diagnostics 国食药监械(进)字20 103.通用稀释液7 ( 国食药监械(进)字2005第3401702号(更))104.X射线摄影暗匣(商品名：柯达 X-OMAT 暗盒) (美国 EASTMAN KODAK COMPANYEASTMAN KODAK COMPA 105.电解质参比液 (德国 罗氏诊断有限公司 国食药监械(进)字2007第1400716号)106.诱导剂 (芬兰 PerkinElmer Life and Analytical Sciences，Wallac Oy 国食药监械(进)字2007第107.甲状腺球蛋白试剂盒 (Siemens Medical Solutions Diagnostics 国食药监械(进)字2004第340054108.甲状腺过氧化物酶抗体试剂盒 (Siemens Medical Solutions Diagnostics 国食药监械(进)字2004 109.四碘甲状腺原氨酸试剂盒 (Siemens Medical Solutions Diagnostics 国食药监械(进)字2004第34 110.植入式心脏起搏器 (美国 Guidant Corporation Cardiac Pacemakers Inc. 国食药监械(进)字200 111.超声诊断系统和探头 (Philips Ultrasound, INC. 国食药监械(进)字2004第3230502号(更))112.血糖监测仪 (Infopia CO.,Ltd. 国食药监械(进)字2005第2402628号(更))113.血糖试条 (Infopia Co.,Ltd 国食药监械(进)字2005第2402611号(更))114.低温等离子体灭菌器 ( 国食药监械(进)字2005第2571415号(更))115.地高辛试剂盒 ( 国食药监械(进)字2005第3401304号(更))116.万古霉素试剂盒 ( 国食药监械(进)字2005第3401383号(更))117.卡马西平试剂盒 ( 国食药监械(进)字2005第3401379号(更))118.高频电外手科术和电凝设备(商品名：VIO系列高频电外科系统) (德国 爱尔博电子医疗仪器公司 国119.肺炎链球菌抗生素敏感实验用抗生素 (美国 biomerieux,Inc. 国食药监械(进)字2007第3400685号120.维生素B12试剂盒 ( 国食药监械(进)字2005第3401380号(更)121.白蛋白试剂盒Albumin (Siemens Medical Solutions Diagnostics 国食药监械(进)字2004第34001 122.甘油三酯试剂盒 (Siemens Medical Solutions Diagnostics 国食药监械(进)字2004第3400140号( 123.齿科烤瓷合金(商品名：Ceradelta 2) (Metalor Technologies SA 国食药监械(进)字2007第26306124.排龈膏 (法国 Produits Dentaires Pierre Rolland SAS,Acteon Pharma Division 国食药监械(进125.烤瓷瓷粉(商品名：烤瓷瓷粉) (德国 Hager & Werken GmbH & Co.，KG 国食药监械(进)字2007第2 126.医疗压力带(商品名：医疗压力带) (LABORATORI PIAZZA S.r.l. 国食药监械(进)字2007第2640509 127.藻酸钙止血贴 (美国 TZ Medical Inc.TZ Medical Inc. 国食药监械(进)字2007第2640512号) 128.抗核抗体谱(IgG)检测试剂盒(欧蒙印迹法) (德国 EUROIMMUN Medizinische Labordiagnostika AG 129.医用诊断X射线管组件 (美国 Varian Medical Systems 国食药监械(进)字2007第2310622号)130.血糖仪 (韩国 i-SENS.Inc 国食药监械(进)字2007第2400442号)131.尿液分析仪 (盈东电子株式会社 国食药监械(进)字2007第2400447号)132.碳13红外光谱仪 (日本 大塚电子株式会社 国食药监械(进)字2007第2400451号)133.血糖检测系统(商品名：罗康全优越型) (德国 罗氏诊断有限公司 国食药监械(进)字2007第240045 134.半自动血凝分析仪 (德国 MERLIN medical GmbH 国食药监械(进)字2007第2400476号)135.疝环充填补片(商品名：巴德) (美国 Davol Inc.,Subsidiary of C.R. Bard,Inc. 国食药监械(进 136.疝修补平片和预裁补片(商品名：巴德) (美国 Davol Inc.,Subsidiary of C.R. Bard,Inc. 国食137.切口疝补片(商品名：巴德) (美国 Davol Inc.,Subsidiary of C.R. Bard,Inc. 国食药监械(进)字138.348 Hct Slope 试剂盒 ( 国食药监械(进)字2004第3401406号(更))139.6.838缓冲液 ( 国食药监械(进)字2004第3401410号(更))140.病人固定系统(商品名：UON-DUON) (比利时 ORFIT INDUSTRIES N.V 国食药监械(进)字2007第1100 141.病人固定系统(商品名：EFFICAST) (比利时 ORFIT Industries N.V 国食药监械(进)字2007第1100 142.病人固定系统(商品名：AIO Solution) (比利时 ORFIT INDUSTRIES N.V 国食药监械(进)字2007第143.矫形外科（骨科）手术器械 (奥地利 I.T.S Implantat-Technologie Systeme GmbH 国食药监械(进144.椎间融合器安装工具(商品名：椎间融合器安装工具) (俄罗斯 《KIMPF》股份有限公司 Closedjoi 145.组件式短柄假体工具(商品名：Metha) (AESCULAP AG & CO.KG 国食药监械(进)字2007第1100568号146.矫形外科手术器械 (韩国GS医疗公司GS Medical 国食药监械(进)字2007第1100706号)147.医用干式胶片(商品名：富士) (日本 Fuji Photo Film Co.,Ltd 国食药监械(进)字2007第1240484 148.接骨板和接骨螺钉(商品名：LINK 接骨板和接骨螺钉系统) ( 国食药监械（进）字2007第3461012号149.机械心脏瓣膜(商品名：Regent) (美国 圣犹达医疗用品有限公司 国食药监械（进）字2007第3461 150.血气分析仪 (Siemens Medical Solutions Diagnostics 国食药监械(进)字2004第2401337号(更)) 151.血气分析仪 (英国 Siemens Medical Solutions Diagnostics Manufacturing Limited 国食药监152.危重症检测分析仪系列 ( 国食药监械(进)字2006第2210279号(更))153.348 Buffer Pack 试剂盒 ( 国食药监械(进)字2004第3401443号(更))154.348/248冲洗液试剂盒 ( 国食药监械(进)字2004第3401531号(更))155.玻璃离子水门汀(商品名：FUJI PLUS) (日本 株式会社而至 国食药监械(进)字2006第3631801号(156.乙烯基聚硅氧烷印模材料(膏剂型)(商品名：而至精确硅橡胶 膏剂型) (株式会社而至 国食药监械157.球囊预装支架传送系统(商品名：TriMaxx 冠状动脉预装支架传送系统) (美国 Abbott Vascular D 158.导丝(商品名：HiWire) (美国 库克泌尿外科公司；Cook Urological Incorporated 国食药监械(进159.导引导管(商品名：Launcher) (Medtronic, Inc. 国食药监械(进)字2007第3770627号)160.护套介入系统(商品名：Brite Tip) (Cordis Corporation 国食药监械(进)字2007第3770629号) 161.革兰氏阴性细菌药敏实验用抗生素 (美国 biomerieux,Inc. 国食药监械(进)字2007第3400686号) 162.皮质醇试剂盒 (美国 Bayer HealthCare LLC 国食药监械(进)字2007第3400687号)163.系列冲洗液/废液试剂盒 (美国 Siemens Medical Solutions Diagnostics 国食药监械(进)字2007 164.测量试剂盒 (美国 Siemens Medical Solutions Diagnostics 国食药监械(进)字2007第3400689号165.便潜血测定试剂盒 (日本株式会社常光 国食药监械(进)字2007第3400690号)166.肌钙蛋白－I测定试剂盒 (日本株式会社常光 国食药监械(进)字2007第3400691号)167.肌红蛋白测定试剂盒 (日本株式会社常光 国食药监械(进)字2007第3400692号)168.穆法 MV 呼吸机 (G.LOHMEIER GmbH 国食药监械(进)字2005第3541326号(更))169.全自动蛋白印迹仪 (Genelabs Diagnostics Pte. Ltd. 国食药监械(进)字2005第3402673号(更)) 170.泌尿系统致病菌鉴定培养基 (bioMerieux,sa 国食药监械(进)字2005第3403472号(更))171.庆大霉素试剂盒 ( 国食药监械(进)字2005第3401378号(更))172.髋部螺钉系统(商品名：亚洲型) (美国 Smith & Nephew, Inc. Orthopaedic Division 国食药监械173.肌酸激酶MB同工酶校准液 ( 国食药监械(进)字2005第3401797号(更))174.移动式X射线诊断设备 (Siemens AG 国食药监械(进)字2007第2300704号)175.影像板扫描处理系统(商品名：柯达 Point-of-Care CR 系统) (美国 Eastman Kodak Company 国食176.X射线口内影像系统 (韩国 VATECH Co.Ltd. 国食药监械(进)字2007第2310517号)177.血液透析用管道Lines for hemodialysis (Gambro DASCO S.p.A 国食药监械（进）字2007第34507 178.管路及滤器H.E.L.P. Consumables (德国 B.Braun Medizintechnologie GmbH 国食药监械（进）字179.血浆分离器(商品名：Haemoselect) (德国 B. Braun Medizintechnologie GmbH 国食药监械（进）180.补体C3诊断试剂盒 (Siemens Medical Solutions Diagnostics 国食药监械(进)字2005第3401775号181.可吸收骨替代材料（商品名：固骼生） (美国诺邦生物制品有限公司 国食药监械(进)字2004第346 182.尿分析阳性和阴性质控试纸 ( 国食药监械(进)字2006第3401062号(更))183.尿液分析仪 (Siemens Medical Solutions Diagnostics 国食药监械(进)字2004第2401280号(更)) 184.尿液分析仪 (Siemens Medical Solutions Diagnostics 国食药监械(进)字2004第2402147号(更)) 185.校准液C ( 国食药监械(进)字2005第3401788号(更))186.校准液B ( 国食药监械(进)字2005第3401800号(更))187.校准液A ( 国食药监械(进)字2005第3401787号(更))188.C反应蛋白（Ⅱ）乳胶试剂盒X2 (日本 DENKA SEIKEN CO., LTD. 国食药监械(进)字2006第3400929 189.D-二聚体排除试验试剂盒 (bioMerieux,sa 国食药监械(进)字2005第3401130号(更))190.多功能医疗护理床系列 (捷克共和国Linet spol.sr.o. 国食药监械(进)字2004第2542365号(更)) 191.Multifiltrate Cassette 管路系统 (德国 Fresenius Medical Care AG & Co.KGaA 国食药监械(进192.透析液过滤器 (Fresenius Medical Care AG & Co.KGaA 国食药监械(进)字2005第3453077号(更)) 193.穿刺针 (Fresenius Medical Care AG & Co.KGaA 国食药监械(进)字2004第3150589号(更))194.游离三碘甲状腺原氨酸试剂盒 (Siemens Medical Solutions Diagnostics 国食药监械(进)字2004 195.游离甲状腺素试剂盒 (Siemens Medical Solutions Diagnostics 国食药监械(进)字2004第340060 196.超声诊断系统 (意大利 ESAOTE SpAESAOTE SpA 国食药监械(进)字2007第3230621号)197.MicroPlex 弹簧圈系统 (MicroVention,Inc 国食药监械(进)字2005第3770791号(更))198.运动负荷试验诊断系统 (Philips Medical Systems 国食药监械(进)字2005第2212430号(更)) 199.动态心电图系统 (Philips Medical Systems 国药管械(进)字2003第2210893号(更))200.心电图机 ( 国食药监械(进)字2004第2210828号(更))201.监护除颤器 (Philips Medical System 国食药监械(进)字2004第3211207号(更))202.正电子发射断层成像系统 (Philips Medical Systems (Cleveland),Inc. 国食药监械(进)字2003第203.免疫球蛋白G诊断试剂盒 (Siemens Medical Solutions Diagnostics 国食药监械(进)字2005第340204.Rapidpoint Coag 快速凝血仪PT-NC测试卡 (Siemens Medical Solutions Diagnostics 国食药监械205.髋关节假体(商品名：SDC and PLC) (德国 AESCULAP AG & Co.KGGermany AESCULAP AG & Co.KG 国206.膝关节系统(商品名：AGC DA) (英国 Biomet UK LTD.Biomet UK LTD. 国食药监械(进)字2007第34 207.疝修补网织片(商品名：巴德 Modified Kugel) ( 国食药监械(进)字2007第3460593号)208.角膜接触镜(商品名：强生彩镜) (美国 VISTAKON Johnson&Johnson Vision Care Inc. 国食药监械209.角膜接触镜(商品名：西武) (G&G CONTACT LENS CO. 国食药监械(进)字2007第3220572号)210.超声诊断仪 (GE Medical Systems Kretztechnik GmbH&Co.,OHG 国食药监械(进)字2007第3230494 211.超声诊断系统(商品名：SONOLINE G60 S) (美国 SIEMENS MEDICAL SOLUTIONS USA, INC. 国食药监212.Rapidpoint Coag 快速凝血aPTT测试卡 (Siemens Medical Solutions Diagnostics 国食药监械(进213.银粉玻璃离子水门汀(商品名：而至 Miracle Mix) (日本株式会社而至 国食药监械(进)字2007第3 214.氟化泡沫(商品名：氟化泡沫) (美国 Laclede, A Laclede, Inc. 国食药监械(进)字2007第215.去白细胞滤器 (Fresenius Kabi AG 国食药监械(进)字2006第3660078号(更))216.硬膜下电极 (AD-Tech Medical Instrument Corporation 国食药监械(进)字2005第3210648号(更) 217.一次性使用去白细胞滤器 ( 国食药监械（进）字2007第3451019号)218.股骨头及内称(商品名：股骨头及内称) (法国 GROUPE LEPINE 国食药监械（进）字2007第3460914 219.补体C4诊断试剂盒 (Siemens Medical Solutions Diagnostics 国食药监械(进)字2005第3401774号220.生化校准液 ( 国食药监械(进)字2006第3400191号(更))221.口腔科手术器械 (德国 Alfred Becht GmbHGermany Alfred Becht GmbH 国食药监械(进)字2007第222.泌尿肛肠外科手术器械 (德国 Aesculap AG & Co.KG 国食药监械(进)字2007第1090477号)223.游离四碘甲状腺原氨酸试剂盒 (Siemens Medical Solutions Diagnostics 国食药监械(进)字2004 224.维生素B12稀释液 ( 国食药监械(进)字2005第3401705号(更))225.B型心钠素校准液 ( 国食药监械(进)字2005第3401785号(更))226.体外循环用插管--心室插管 (Maquet Cardioplumonary AG 国食药监械(进)字2004第3450692号(更227.体外循环用插管--静脉插管 (Maquet Cardioplumonary AG 国食药监械(进)字2004第3450694号(更228.脊椎动力平衡治疗系统 (Optima Health Solutions International Corporation 国食药监械(进) 229.手术室包 (Buckley Lamb Limited 国食药监械(进)字2005第2641933号(更))230.超声成像诊断仪 (Esaote Europe B.V. 国食药监械(进)字2006第3210425号(更))231.免疫球蛋白M诊断试剂盒 ( 国食药监械(进)字2005第3401709号(更))232.妥布霉素试剂盒 ( 国食药监械(进)字2005第3401695号(更))233.苯巴比妥试剂盒 ( 国食药监械(进)字2005第3401693号(更))234.氨测定试剂盒 (日本 关东化学株式会社 国食药监械(进)字2007第3400674号)235.肌红蛋白测定试剂盒 (日本 关东化学株式会社 国食药监械(进)字2007第3400675号)236.胃蛋白酶原Ⅰ测定试剂盒 (关东化学株式会社 国食药监械(进)字2007第3400676号)237.全瓷(商品名：维他全瓷系列) (德国 维他公司 VITA Zahnfabrik H.Rauter Gmbh & Co.KG 国食药238.齿科用铸造合金 (商品名：Solaro 3 ) (瑞士 Metalor Technologies SAMetalor Technologies S 239.齿科烤瓷合金(商品名：V-Gnathos plus ) ( 国食药监械(进)字2007第2630623号)240.齿科烤瓷合金(商品名：V-Deltaloy) (Metalor Technologies SA 国食药监械(进)字2007第263062 241.可吸收外科缝线(商品名：万福（Monosyn）) (德国 AESCULAP AG & CO.KG 国食药监械(进)字2007 242.静脉插管 (美国 Edwards Lifesciences LLC 国食药监械(进)字2007第3660520号)243.肾造瘘扩张器及套装(商品名：Amplatz) (Cook Urological Incorporated 国食药监械(进)字2007 244.连通板英文名称： Merit Manifolds(商品名：麦瑞连通板) (美国 麦瑞医疗设备有限公司麦瑞医疗245.铁蛋白试剂盒 (Siemens Medical Solutions Diagnostics 国食药监械(进)字2004第3400273号(更246.高密度脂蛋白测定试剂盒 (日本 关东化学株式会社 国食药监械(进)字2007第3400673号)247.图像处理装置 (日本 オリンパスメディカルシステムズ株式会社 国食药监械(进)字2007第222044 248.内窥镜摄像系统 (Karl Storz GmbH & Co.KG 国食药监械(进)字2007第2220473号)249.接触式压电眼压计(商品名：动态轮廓眼压计) (SMT Swiss Microtechnology AG 国食药监械(进)字250.内窥镜下无源手术器械(商品名：蛇牌) (Aesculap AG&Co.KG 国食药监械(进)字2007第2220528号) 251.内窥镜摄像系统 (德国 Karl Storz GmbH & Co.KG 国食药监械(进)字2007第2220554号)252.医学影像存储和传输系统(商品名：医学影像存储和传输系统) (德国 Siemens AGSiemens AG 国食253.内窥镜冷光源 (德国 Richard Wolf GmbH 国食药监械(进)字2007第2220633号)254.牛心包生物瓣(商品名：SJM Biocor) (圣犹达医疗用品公司 国食药监械(进)字2007第3460701号) 255.呼吸机(商品名：纽邦呼吸机) (美国 Newport Medical Instruments,Inc.U.S.A.Newport Medical 256.ADVIA 70 血液分析仪 (Siemens Medical Solutions Diagnostics 国药管械(进)2003第2400740号257.ADVIA 血液分析仪 (Siemens Medical Solutions Diagnostics 国药管械(进)2003第2400657号(更258.Kodak Min-R EV乳房X线影像胶片 (Carestream Health,Inc 国食药监械(进)字2004第1310201号(更259.Kodak DVM胶片 ( 国食药监械(进)字2005第1311759号(更))260.超声诊断设备(商品名：超声诊断设备Aplio) (日本 TOSHIBA MEDICAL SYSTEMS CORPORATION 国食261.层析柱 (TOSOH CORPORATION 国食药监械(进)字2007第3460551号)262.自动体外除颤仪 (Medtronic Emergency Response Systems,Inc. 国药管械(进)2002第3211124号( 263.电动动力系统 ( 国食药监械(进)字2005第2211873号(更))264.显微外科手术器械 (德国 Aesculap AG & Co.KGAesculap AG & Co.KG 国食药监械(进)字2007第10 265.根管扩大器 (日本 Mani, Inc. 国食药监械(进)字2007第2550455号)266.喷粉洁牙手机(商品名：PROPHY-MATE) (日本株式会社 中西/Nakanishi Inc. 国食药监械(进)字20 267.脉动预真空压力蒸汽灭菌器 (Tuttnauer Co.Ltd. 国食药监械(进)字2007第2570703号)268.牙科复合树脂充填材料(商品名：SwissTec Composite) (Coltene/Whaledent AG 国食药监械(进)字269.ADVIA 70 鞘液 ( 国食药监械(进)字2003第3400427号(更))270.ADVIA 70 稀释液 ( 国食药监械(进)字2003第3400428号(更))271.ADVIA 70 溶血剂 ( 国食药监械(进)字2003第3400429号(更))272.ADVIA 60 TIMEPAC ( 国食药监械(进)字2005第2400926号(更))273.ADVIA 60 血液分析仪 ( 国食药监械(进)字2005第2401875号(更))274.万古霉素校准液 ( 国食药监械(进)字2005第3401795号(更))275.庆大霉素校准液 (Siemens Medical Solutions Diagnostics 国食药监械(进)字2005第3401794号( 276.远程心电事件记录器 (德国 TMS Telemedizinische Systeme GmbH 国食药监械(进)字2007第22105 277.生物显微镜 (德国 Carl Zeiss AG，Werk Gottingen 国食药监械(进)字2007第2220441号)278.深部电极 (Ad-Tech Medical Instrument Corporation 国食药监械(进)字2005第3210459号(更)) 279.硬膜外麻醉导管 (美国 ARROW INTERNATIONAL INC 国食药监械(进)字2007第3660588号)280.膜型血浆分离器 (日本 旭化成医疗株式会社 国食药监械(进)字2007第3660590号)281.血栓抽吸导管(商品名：Rebirth ) (日本 株式会社Goodman 国食药监械(进)字2007第3660607号) 282.一次性使用输液器用输液帽、防回流阀 (德国 Fresenius Kabi AGFresenius Kabi AG 国食药监械283.Rapidpoint Coag 快速凝血仪 (Siemens Medical Solutions Diagnostics 国食药监械(进)字2003284.胃蛋白酶原Ⅱ测定试剂盒 (日本 关东化学株式会社 国食药监械(进)字2007第3400677号)285.血脂正常值质控 (德国罗氏诊断有限公司 国食药监械(进)字2007第3400678号)286.血脂病理值质控 (德国罗氏诊断有限公司 国食药监械(进)字2007第3400679号)287.免疫球蛋白G2试剂 (德国 Dade Behring Marburg GmbH 国食药监械(进)字2007第3400680号)288.免疫球蛋白G1试剂 (德国 Dade Behring Marburg GmbH 国食药监械(进)字2007第3400681号)289.铁蛋白检测试剂盒 (西班牙博士泰公司 国食药监械(进)字2007第3400682号)290.脑脊液/尿液总蛋白检测试剂盒 (西班牙博士泰公司 国食药监械(进)字2007第3400683号)291.HydroCoil栓塞系统 (MicroVention,Inc 国食药监械(进)字2005第3770789号(更))292.泵用输液器 英 文 名 称：Original Infusomat Tubing(商品名：Original Infusomat) (B. Brau 293.麻醉系统(商品名：Zeus) ( 国食药监械(进)字2007第3540615号)294.呼吸加湿过滤系统 (马来西亚 Rusch Sdn Bhd. 国食药监械(进)字2007第3540736号)295.光固化玻璃离子水门汀(商品名：而至富士 II LC ) (日本 株式会社而至 国食药监械(进)字2007第296.C-肽试剂盒 (Siemens Medical Solutions Diagnostics 国食药监械(进)字2004第3400619号(更)) 297.胰岛素试剂盒 (Siemens Medical Solutions Diagnostics 国食药监械(进)字2004第3400287号(更298.胰岛素试剂盒 (Siemens Medical Solutions Diagnostics 国食药监械(进)字2004第3400637号(更299.校准液O ( 国食药监械(进)字2005第3401792号(更))300.茶碱试剂盒 ( 国食药监械(进)字2005第3401694号(更))301.动力系统(商品名：Colibri ) (瑞士 Synthes GmbH 国食药监械(进)字2007第2540714号)302.免疫球蛋白A诊断试剂盒 ( 国食药监械(进)字2005第3401710号(更))303.KODAK DirectView CR950 系统 (Carestream Health,Inc 国食药监械(进)字2003第2310504号(更) 304.通用稀释液3 ( 国食药监械(进)字2005第3401699号(更))305.校准液Z ( 国食药监械(进)字2005第3401786号(更))306.校准液E ( 国食药监械(进)字2005第3401799号(更))307.肌酸激酶MB同工酶液体试剂盒 (DiaSys Diagnostic Systems GmbH 国食药监械(进)字2005第24031 308.自体血连续回输机 (Fresenius Kabi AG 国食药监械(进)字2005第3452722号(更))309.S5L/C5L 血小板套件 (Fresenius Kabi AG 国食药监械(进)字2006第3450453号(更))310.PL1血浆置换组件 (Fresenius Kabi AG 国食药监械(进)字2006第3450452号(更))311.血细胞分离机 (Fresenius Kabi AG 国食药监械(进)字2005第3453128号(更))312.CATS自体血回输机耗材 (Fresenius Kabi AG 国食药监械(进)字2006第3450451号(更))313.去白细胞滤器 (Fresenius Kabi AG 国食药监械(进)字2005第3453185号(更))314.通用稀释液4 ( 国食药监械(进)字2005第3401700号(更))315.C反应蛋白诊断试剂盒 (Siemens Medical Solutions Diagnostics 国食药监械(进)字2005第34017316.腹腔镜用缝合材料及辅助器械 (Ethicon Endo-Surgery, Inc. 国食药监械(进)字20317.一次性使用冲洗装置(商品名：CritiFlo) (新加坡 Becton Dickinson Critical Care Systems P 318.一次性使用电刀笔 (TELEFLEX MEDICAL 国食药监械(进)字2005第2252933号(更))319.导电性粘合电极板 (TELEFLEX MEDICAL 国食药监械(进)字2005第2252946号(更))320.R-Stent Evolution 2 冠状动脉支架系统 (美国 Orbus Neich Medical,Inc. 国食药监械(进)字20 321.程控仪(商品名：ZOOMLATITUDE) (美国 Guidant Corporation Cardiac Pacemakers Inc. 国食药322.植入式心脏除颤电极导管 ( 国食药监械(进)字2006第3211955号(更))323.二氧化碳(CO2)液体试剂盒 ( 国食药监械(进)字2004第3400627号(更))324.铁蛋白测定试剂 ( 国食药监械(进)字2004第3400628号(更))325.超声治疗仪(商品名：骨科超声治疗仪) (赛特力公司 国食药监械(进)字2007第2230109号)326.中频电疗仪(商品名：Superkine SK-SERIES) ( 国食药监械(进)字2007第2260157号)327.影像板扫描处理系统(商品名：柯达 CR 7400 牙科计算机放射成像系统) (美国 Eastman Kodak C 328.凝血酶原时间测定试剂盒 ( 国食药监械(进)字2007第2400118号)329.凝血酶原时间测定试剂盒 ( 国食药监械(进)字2007第2400119号)330.谷氨酰转肽酶测定试剂盒 (和光纯药工业株式会社 国食药监械(进)字2007第2400121号)331.PTA 导管（Amphirion DEEP） (意大利 Invatec S.r.l. 国食药监械(进)字2006第2771389号)。
CDER Drug and Biologic Approvals for Calendar Year 2014
New Drug Application (NDA) Approvals:APPLICATION NUMBER PROPRIETARY NAME ESTABLISHED NAME APPLICANTREVIEWCLASSIFICATION505(B)(2)APPROVALAPPROVAL DATENDA 202293FARXIGA DAPAGLIFLOZIN ASTRAZENECA AB S1/8/2014NDA 204623PENNSAID DICLOFENAC SODIUM MALLINCKRODT INC THE PHARMACEUTICALS BUSINESSOF COVIDIEN S Y1/16/2014NDA 205352ALEVE PM NAPROXEN SODIUM,DIPHENHYDRAMINE HCI BAYER HEALTHCARE CONSUMER CARE S Y1/17/2014NDA 205582DECITABINE SUN PHARMA GLOBAL FZE S Y1/23/2014 NDA 205583DESVENLAFAXINE SUN PHARMA GLOBAL FZE S Y1/28/2014 NDA 205677HETLIOZ TASIMELTEON VANDA PHARMACEUTICALS INC P,O1/31/2014 NDA 204914 (2)LAMIVUDINE AND ZIDOVUDINE MYLAN LABORATORIES LTD S Y2/4/2014 NDA 203202NORTHERA DROXIDOPA CHELSEA THERAPEUTICS INC P,O2/18/2014 NDA 204768TIVORBEX INDOMETHACIN IROKO PHARMACEUTICALS LLC S Y2/24/2014 NDA 022219AVEED TESTOSTERONE UNDECANOATE ENDO PHARMACEUTICALS INC S Y3/5/2014NDA 204031XARTEMIS XR OXYCODONE HYDROCHLORIDE ANDACETAMINOPHEN MALLINCKRODT INC P Y3/11/2014NDA 205122QUDEXY XR TOPIRAMATE UPSHER-SMITH LABORATORIES INC S Y3/11/2014 NDA 202356DOCETAXEL PFIZER LABS S Y3/13/2014 NDA 205596NOXAFIL POSACONAZOLE MERCK SHARP AND DOHME CORP P3/13/2014NDA 205355 (2)LAMIVUDINE AND TENOFOVIRDISOPROXIL FUMARATE WITHNEVIRAPINE HETERO LABS LTD UNIT III S Y3/14/2014NDA 205410HEMANGEOL PROPRANOLOL HYDROCHLORIDE PIERRE FABRE DERMATOLOGIE S,O Y3/14/2014NDA 205508 (2)ATAZANAVIR SULFATE AND RITONAVIR EMCURE PHARMACEUTICALS LTD P Y3/17/2014 NDA 204677NEURACEQ FLORBETABEN PIRAMAL IMAGING SA S3/19/2014 NDA 204684IMPAVIDO MILTEFOSINE PALADIN THERAPEUTICS INC P,O3/19/2014 NDA 205437OTEZLA APREMILAST CELGENE CORP S3/21/2014 NDA 205223METRONIDAZOLE VALEANT PHARMACEUTICAL NORTH AMERICA LLC S3/24/2014 NDA 204655NEXIUM ESOMEPRAZOLE MAGNESIUM ASTRAZENECA LP S3/28/2014 NDA 205787EVZIO NALOXONE HYDROCHLORIDE KALEO INC P Y4/3/2014 NDA 205703 (1)ESMOLOL HCL HQ SPECIALTY PHARMA CORP S Y4/14/2014 NDA 204485VASOSTRICT VASOPRESSIN PAR STERILE PRODUCTS LLC S Y4/17/2014 NDA 204977OMTRYG OMEGA-3 ACID ETHYL ESTERS A TRYGG PHARMA INC S Y4/23/2014 NDA 205641ASMANEX HFA MOMETASONE FUROATE MERCK SHARP AND DOHME CORP S4/25/2014 NDA 205919PURIXAN MERCAPTOPURINE NOVA LABORATORIES LTD S,O Y4/28/2014 NDA 205755ZYKADIA CERITINIB NOVARTIS PHARMACEUTICALS CORP P,O4/29/2014 NDA 205382INCRUSE ELLIPTA UMECLIDINIUM BROMIDE GLAXO GROUP LTD ENGLAND DBA GLAXOSMITHKLINE S4/30/2014 NDA 205060EPANOVA OMEGA-3-CARBOXYLIC ACIDS ASTRAZENECA PHARMACEUTICALS LP S5/5/2014 NDA 204886ZONTIVITY VORAPAXAR MERCK SHARP AND DOHME CORP S5/8/2014 NDA 204822IZBA TRAVOPROST OPHTHALMIC SOLUTION ALCON LABORATORIES INC S5/15/2014 NDA 021883DALVANCE DALBAVANCIN DURATA THERAPEUTICS INTERNATIONAL BV P5/23/2014 NDA 205488NATESTO TESTOSTERONE TRIMEL BIOPHARMA SRL S Y5/28/2014NDA 205388OMIDRIA PHENYLEPHRINE HCL AND KETOROLACTROMETHAMINE OMEROS CORP S Y5/30/2014NDA 206352REYATAZ ATAZANAVIR BRISTOL MYERS SQUIBB CO P6/2/2014 NDA 203567JUBLIA EFINACONAZOLE DOW PHARMACEUTICAL SCIENCES S6/6/2014 NDA 205637BUNAVAIL BUPRENORPHINE AND 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PAK TOBRAMYCIN INHALATION SOLUTION AND PARI LC PLUS REUSABLE NEBULIZER PULMOFLOW INCS 12/2/20148/22/2014NDA 205613UCERISBUDESONIDESALIX PHARMACEUTICALS INCS10/7/20149/15/2014Biologic License Application (BLA) Approvals:BLA NUMBER PROPRIETARY NAMEPROPER NAMEAPPLICANTREVIEWCLASSIFICATIONAPPROVAL DATE BLA 125460/0.0VIMIZIM ELOSULFASE ALFA BIOMARIN PHARMACEUTICAL INC.P,O 2/14/2014BLA 125390/0.0MYALEPT METRELEPTIN AMYLIN PHARMACEUTICALS, LLC P,O 2/24/2014BLA 125431/0.0TANZEUM ALBIGLUTIDE GLAXOSMITHKLINE LLC S 4/15/2014BLA 125477/0.0CYRAMZA RAMUCIRUMAB ELI LILLY AND COMPANY P,O 4/21/2014BLA 125496/0.0SYLVANT SILTUXIMAB JANSSEN BIOTECH, INC.P,O 4/23/2014BLA 125476/0.0ENTYVIO VEDOLIZUMABTAKEDA PHARMACEUTICALS U.S.A., INC.P 5/20/2014BLA 125499/0.0PLEGRIDY PEGINTERFERON BETA-1A BIOGEN IDEC INC.S 8/15/2014BLA 125514/0.0KEYTRUDA PEMBROLIZUMAB MERCK SHARP & DOHME CORP.P,O 9/4/2014BLA 125469/0.0TRULICITY DULAGLUTIDE ELI LILLY AND COMPANY S 9/18/2014BLA 125557/0.0BLINCYTO BLINATUMOMAB AMGEN, INC.P,O 12/3/2014BLA 125554/0.0OPDIVONIVOLUMABBRISTOL-MYERS SQUIBB COMPANYP,O12/22/2014(1) Application has been tentatively approved.(2) Application has been tentatively approved or approved under PEPFAR.Review Classification:P - Priority Review - Significant improvement compared to marketed products, in the treatment, diagnosis, or prevention of a disease.S - Standard Review - Products that do not qualify for priority review.O - Orphan Designation - Pursuant to Section 526 of the Orphan Drug Act (Public Law 97-414 as amended).Tentative Approval (TA) is an action given to an application for a drug that meets all the requirements for approval; however, it may not be legally marketed in the U.S. until the market exclusivity and/or patent term of the listed drug upon which the application relies, has expired.。
国家药监局关于批准注册121个医疗器械产品的公告(2021年3月)
国家药监局关于批准注册121个医疗器械产品的公告(2021年3月)文章属性•【制定机关】国家药品监督管理局•【公布日期】2021.04.15•【文号】国家药品监督管理局公告2021年第55号•【施行日期】2021.04.15•【效力等级】部门规范性文件•【时效性】现行有效•【主题分类】药政管理正文国家药品监督管理局公告2021年第55号国家药监局关于批准注册121个医疗器械产品的公告(2021年3月)2021年3月，国家药品监督管理局共批准注册医疗器械产品121个。
其中，境内第三类医疗器械产品77个，进口第三类医疗器械产品18个，进口第二类医疗器械产品24个，港澳台医疗器械产品2个（具体产品见附件）。
特此公告。
附件：2021年3月批准注册医疗器械产品目录国家药监局2021年4月15日附件2021年3月批准注册医疗器械产品目录序号产品名称注册人名称注册证编号境内第三类医疗器械1导引系统先健科技（深圳）有限公司国械注准202130301522一次性使用防针刺精密过滤输液器带针上海宝舜医疗器械有限公司国械注准202131401533导引导管南京沃福曼医疗科技有限公司国械注准20213030154 4血液透析滤过器威海威高血液净化制品有限公司国械注准20213100155 5一次性使用压力延长管深圳市保安医疗用品有限公司国械注准20213030156 6硬脑膜修补片北京博辉瑞进生物科技有限公司国械注准20213130157 7一次性使用单向阀多通连接江苏省华星医疗器械实业有限公国械注准器司202131401588椎间融合器深圳市沃尔德外科医疗器械技术有限公司国械注准202131301599一次性使用精密过滤输液器带针淄博侨森医疗用品股份有限公司国械注准2021314016010椎间融合器武汉德骼拜尔外科植入物有限公司国械注准2021313016111不可吸收带线锚钉北京市富乐科技开发有限公司国械注准20213130162 12一次性使用静脉留置针苏州鑫康道医疗科技有限公司国械注准20213140163 13冠脉球囊扩张导管苏州莱诺医疗器械有限公司国械注准20213030164 14一次性使用输液器带针天津市远东医材有限公司国械注准20213140165 15外周球囊扩张导管北京永益润成科技有限公司国械注准20213030166 16一次性使用体外循环管道常州市康心医疗器械有限公司国械注准20213100167 17钛合金手足锁定接骨板系统创美得医疗器械（天津）有限公司国械注准20213130168 18一次性使用血管内成像导管苏州阿格斯医疗技术有限公司国械注准20213060169 19一次性内镜用注射针诸暨市鹏天医疗器械有限公司国械注准20213140170 20分段控弯导引系统先健科技（深圳）有限公司国械注准20213030171 21一次性使用血液透析管路健帆生物科技集团股份有限公司国械注准2021310017222可折叠人工晶状体天津世纪康泰生物医学工程有限公司国械注准2021316017323乙型肝炎病毒核酸测定试剂上海仁度生物科技有限公司国械注准盒（RNA捕获探针法）2021340017424一次性使用电子输尿管肾盂内窥镜导管北京北方腾达科技发展有限公司国械注准2021306017525新型冠状病毒2019-nCoV核酸检测试剂盒（荧光PCR法）杭州迪安生物技术有限公司国械注准2021340017626儿童手部X射线影像骨龄辅助评估软件杭州依图医疗技术有限公司国械注准2021321017727病人监护仪通用电气医疗系统（中国）有限公司国械注准2021307017828三维腹腔内窥镜山东威高手术机器人有限公司国械注准2021306017929单光子发射计算机断层成像系统滨松光子医疗科技（廊坊）有限公司国械注准2021306018030一次性使用热活检钳诸暨市鹏天医疗器械有限公司国械注准2021301018131一次性使用高频十二指肠乳头切开刀杭州莱恩瑟特医疗技术有限公司国械注准2021301018232生物安全柜苏州安泰空气技术有限公司国械注准2021322018333一次性使用Y型连接阀套装厦门鑫康顺医疗科技有限公司国械注准2021303018434预充式导管冲洗器山东赛克赛斯生物科技有限公司国械注准20213140185 35锚钉系统大博医疗科技股份有限公司国械注准20213130186 36泡沫敷料广州润虹医药科技股份有限公司国械注准2021314018737一次性使用精密过滤避光输液器山东新华安得医疗用品有限公司国械注准2021314018838软性亲水接触镜江苏天眼医药科技股份有限公司国械注准2021316018939一次性使用无菌注射器带针江苏采纳医疗科技有限公司国械注准2021314019040注射用交联透明质酸钠凝胶杭州科腾生物制品有限公司国械注准20213130191 41血液透析浓缩液四川威力生医疗科技有限公司国械注准2021310019242一次性使用防针刺静脉输液针山东威高集团医用高分子制品股份有限公司国械注准2021314019343一次性使用避光输液器河南曙光汇知康生物科技股份有限公司国械注准2021314019444一次性使用精密过滤输液器带针南阳市久康医疗器械有限公司国械注准2021314019545一次性使用无菌自毁式注射器聚民生物科技有限公司国械注准2021314019646夹子装置诸暨市鹏天医疗器械有限公司国械注准2021302019747一次性使用无菌注射针江苏采纳医疗科技有限公司国械注准20213140198 48颅内支撑导管北京久事神康医疗科技有限公司国械注准20213030199 49软性亲水接触镜江苏天眼医药科技股份有限公司国械注准2021316020050一次性使用无菌注射器带针成都市新津事丰医疗器械有限公司国械注准2021314020151一次性使用静脉留置针佳康医用器材（青岛）有限公司国械注准20213140202 52颅内球囊扩张导管依奈德医疗技术（上海）有限公司国械注准2021303020353一次性使用压力延长管山东威高集团医用高分子制品股份有限公司国械注准2021314020454颅内球囊扩张导管浙江归创医疗器械有限公司国械注准2021303020555远端通路导引导管珠海通桥医疗科技有限公司国械注准20213030206 56导管鞘沛嘉医疗科技（苏州）有限公司国械注准20213030207 57一次性使用注射笔用针头甘甘医疗科技江苏有限公司国械注准2021314020858麻醉系统通用电气医疗系统（中国）有限公司国械注准2021308020959肺炎CT影像辅助分诊与评估软件北京推想科技有限公司国械注准2021321021060肺炎CT影像辅助分诊与评估软件杭州深睿博联科技有限公司国械注准2021321021161医用血管造影X射线机东软医疗系统股份有限公司国械注准20213060212 62复合陡脉冲治疗设备上海睿刀医疗科技有限公司国械注准2021309021363放射治疗轮廓勾画软件海创时代（深圳）医疗科技有限公司国械注准2021321021464口腔种植手术导航定位设备北京柏惠维康科技有限公司国械注准20213010215 65超导型磁共振成像系统康达洲际医疗器械有限公司国械注准2021306021666人附睾蛋白4测定试剂盒（化学发光法）深圳市亚辉龙生物科技股份有限公司国械注准2021340021767胃泌素释放肽前体测定试剂盒（化学发光法）深圳市亚辉龙生物科技股份有限公司国械注准2021340021868前列腺酸性磷酸酶测定试剂盒（化学发光免疫分析法）苏州长光华医生物医学工程有限公司国械注准2021340021969神经元特异性烯醇化酶测定试剂盒（化学发光免疫分析法）苏州长光华医生物医学工程有限公司国械注准2021340022070乙型肝炎病毒前S1抗原检迈克生物股份有限公司国械注准测试剂盒（直接化学发光法）2021340022171人JAK2-V617F基因突变检测试剂盒（荧光PCR法）迈杰转化医学研究（苏州）有限公司国械注准2021340022272一次性使用血液透析器广州市恩德氏医疗制品实业有限公司国械注准2021310022373流出道单瓣补片北京佰仁医疗科技股份有限公司国械注准20213130224 74一次性使用静脉留置针威海洁瑞医用制品有限公司国械注准20213140225 75软聚硅酮泡沫敷料江苏诺瓦立医疗用品有限公司国械注准2021314022676幽门螺杆菌23S rRNA基因突变检测试剂盒（PCR-荧光探针法）上海芯超生物科技有限公司国械注准2021340022777新型冠状病毒2019-nCoV核酸检测试剂盒（荧光PCR法）重庆中元汇吉生物技术有限公司国械注准20213400228进口第三类医疗器械78血液透析用中心静脉导管及附件Covidien llc国械注进2021310005779钛夹AESCULAP AG国械注进20213020058 80注射用交联透明质酸钠凝胶Q-Med AB国械注进2021313005981颅内取栓支架Micro Therapeutics,Inc.dba ev3Neurovascular国械注进2021303006082游离前列腺特异性抗原校准品Siemens Healthcare DiagnosticsProducts Limited国械注进2021340007383丙型肝炎病毒（HCV）核酸（RNA）检测试剂盒（实时荧光PCR法）Cepheid AB国械注进2021340007484抗CD20（L26）鼠单克隆抗体试剂（免疫组织化学Ventana Medical Systems, Inc.国械注进20213400075法）85牙科种植体Zimmer Dental, Inc.国械注进20213170076 86空心纤维血液透析器Vital Healthcare Sdn. Bhd.国械注进20213100077 87一次性负压装置及护创敷料Smith & Nephew Medical Ltd国械注进20213140090 88双极器械ERBE Elektromedizin GmbH国械注进2021301009189一次性使用高频圈套器オリンパスメディカルシステムズ株式会社国械注进2021301009290麻醉系统Dr?gerwerk AG & Co. KGaA国械注进20213080093 91X射线计算机体层摄影设备Siemens Healthcare GmbH国械注进20213060094 92关节内窥镜（?）国械注进20213060095 93电子下消化道内窥镜富士フイルム株式会社国械注进20213060096 94植入式给药装置专用针Fresenius Kabi AG国械注进20213140097 95微导管Vascular Solutions LLC国械注进20213030098进口第二类医疗器械96胰岛素样生长因子-1检测试剂盒（电化学发光法）Roche Diagnostics GmbH国械注进2021240006197免疫球蛋白E校准品DiaSys Diagnostic Systems GmbH国械注进2021240006298纤维蛋白原质控品（低值）Instrumentation LaboratoryCompany国械注进2021240006399一次性使用直线型切割吻合器及渐进式钉匣Covidien llc国械注进20212020064100血糖仪OSANG Healthcare Co.,Ltd.国械注进20212220065 101血糖仪OSANG Healthcare Co.,Ltd.国械注进20212220066102内窥镜图像处理及照明装置オリンパスメディカルシステムズ株式会社国械注进20212060067103内镜清洗消毒器STEELCO SPA国械注进20212110068 104电动产床タカラメディカル株式会社国械注进20212180069 105角膜内皮显微镜株式会社コーナン?メディカル国械注进20212160070106肺功能测试系统GANSHORN Medizin ElectronicGmbH国械注进20212070071107牙科低压电动马达株式会社ナカニシ国械注进20212170072108抗β2糖蛋白1结构域1IgG抗体检测试剂盒（化学发光免疫分析法）INOVA Diagnostics, Inc.国械注进20212400078109胱抑素C校准液Siemens Healthcare DiagnosticsInc.国械注进20212400079110降钙素原校准品Ortho-Clinical Diagnostics国械注进20212400080111胰岛素样生长因子-I测定试剂盒（化学发光法）Siemens Healthcare DiagnosticsProducts Limited国械注进20212400081112降钙素原质控品Ortho-Clinical Diagnostics国械注进20212400082113喷砂洁牙机SATELEC A Company ofACTEON Group国械注进20212170083114种植体稳固度检测仪Osstell AB国械注进20212170084 115多导睡眠记录系统SOMNOmedics GmbH国械注进20212070085 116一次性使用超声内窥镜水囊HOYA株式会社豪雅株式会社国械注进20212060086 117多导睡眠记录系统SOMNOmedics GmbH国械注进20212070087 118全自动微生物质谱检测系统ASTA Corporation国械注进20212220088119齿科铸造合金Eisenbacher Dentalwaren EDGmbH国械注进20212170089港澳台医疗器械120软性亲水接触镜望隼科技股份有限公司国械注许20213160003 121软性亲水接触镜星歐光學股份有限公司国械注许20213160004。
免疫组化实验--全套试剂耗材
免疫组化实验试剂耗材大全华越洋---------------------------- 0.1%胰蛋白酶消化液waryong 10ml 110多聚甲醛merk 25g 504%多聚甲醛waryong 500ml 22010X多聚赖氨酸waryong 10ml 260抗荧光衰减封片剂waryong 25ml 230防脱载玻片waryong 50片310mayer'苏木素染液（免疫组化）waryong 100ml 410封闭用正常绵羊/山羊/兔/人血清waryong 10ml 75弗氏不完全佐剂sigma 10ml 180弗氏完全佐剂sigma 10ml 200柠檬酸钠缓冲液0.01mol/L PH6.0 waryong 1L 10DAB amresco 1g 13520XDAB显色液 A，B液各1.5ml waryong 3ml 95NBT amresco 100mg 95BCIP amresco 100mg 310BCIP/NBT底物显色试剂盒waryong 25ml 210PBST(PH7.4)抗体稀释液waryong 1ml 25一抗稀释液waryong 100ml 390HRP标记抗体稀释液waryong 100ml 390AP标记抗体稀释液waryong 100ml 390荧光抗体稀释液waryong 50ml 110免疫组化名称规格价格Super Polymer-二步法IHC试剂盒3ml35818ml1598兔Streptavidin-HRP试剂盒3ml19818ml998鼠Streptavidin-HRP试剂盒3ml19818ml998兔∕鼠通用型Streptavidin-HRP试剂盒3ml25818ml1198山羊抗兔IgG,Biotin(IHC工作液)3ml6818ml298山羊抗鼠IgG,Biotin(IHC工作液)3ml6818ml298山羊抗兔∕鼠IgG,Biotin(IHC工作液)3ml9818ml498 Streptavidin-HRP(IHC工作液)3ml9818ml49860ml258 AEC底物显色试剂盒20ml98 BCIP∕NBT碱性磷酸酶显色试剂盒(40x)40ml198 BCIP/NBT碱性磷酸酶显色试剂40ml229改良型苏木素(IHC常用复染试剂)10ml68柠檬酸缓冲液(IHC抗原修复液,100x)100ml68EDTA缓冲液(IHC抗原修复液，50x)100ml68封闭用正常山羊血清工作液(免疫组化封闭液)10ml68内源性过氧化物酶封闭液10ml68内源性碱性磷酸酶封闭液10ml68Biotin标记抗体稀释液20ml中性树胶100g98水性封片剂10ml98 Super Polymer-二步法IHC试剂盒（带DAB显色液）3ml39818ml1698兔Streptavidin-HRP试剂盒（带DAB显色液）3ml25818ml1098鼠Streptavidin-HRP试剂盒（带DAB显色液）3ml25818ml1098兔∕鼠通用型Streptavidin-HRP试剂盒（带DAB显色液）3ml29818ml1298。
美洲大蠊提取物PAS840_的乙酰胆碱酯酶活性抑制作用及抗氧化能力观察
美洲大蠊提取物PAS840的乙酰胆碱酯酶活性抑制作用及抗氧化能力观察管堂飞，杨鑫，洪灿辉，肖培云，张成桂，何正春大理大学药学院 云南省昆虫生物医药研发重点实验室，云南大理671000摘要：目的 探讨美洲大蠊提取物PAS840的乙酰胆碱酯酶（AChE ）抑制活性和抗氧化活性。
方法 根据预实验确定最佳酶促反应条件得到的数据，AChE 浓度为0.425 U /mL 、底物碘化硫代乙酰胆碱（ATCI ）浓度为15 mmol /L 、反应时间为20 min ，采用改良的Ellman 法进行酶促反应，检测不同浓度（7.8125、15.625、31.25、62.5、125、250 μg /mL ）PAS840对AChE 催化ATCI 分解的抑制率，计算其半数抑制浓度（IC 50），采用米氏方程相关的酶动力学实验测定PAS840对AChE 的抑制类型。
取不同浓度的PAS840溶液或维生素C （V C ），采用1，1-二苯基-2-三硝基苯肼（DPPH ）法检测其对DPPH 自由基的清除率，采用总还原能力测定法检测其对铁氰化钾的还原率，采用水杨酸法检测其对羟自由基的清除率，并计算相关的IC 50。
结果 PAS840对AChE 催化反应进程具有抑制作用，且随着PAS840作用浓度增加和时间延长，其抑制作用更为明显；随着PAS840作用浓度增加，AChE 抑制率先逐渐升高再趋于平缓。
PAS840抑制AChE 催化ATCI 分解的IC 50为22.30 μg /mL ，其抑制类型是混合性抑制。
随着浓度的增加，PAS840、Vc 对DPPH 自由基的清除率均呈先升高后平稳的趋势；500 μg /mL PAS840对DPPH 自由基的清除率为93.95%，同等浓度Vc 的清除率为97.31%；PAS840清除DPPH 自由基的IC 50为43.21 μg /mL 。
随着浓度的增加，PAS840对铁氰化钾的还原率呈先升高后平稳的趋势，Vc 对铁氰化钾的还原率呈比较高的平稳趋势；3.0 mg /mL PAS840对铁氰化钾的还原率为93.95%，同等浓度Vc 的还原率为82.2%；PAS840还原铁氰化钾的IC 50为0.498 mg /mL 。
欧洲药典7.5版
INDEX
To aid users the index includes a reference to the supplement in which the latest version of a text can be found. For example : Amikacin sulfate...............................................7.5-4579 means the monograph Amikacin sulfate can be found on page 4579 of Supplement 7.5. Note that where no reference to a supplement is made, the text can be found in the principal volume.
English index ........................................................................ 4707
Latin index ................................................................................. 4739
EUROPEAN PHARMACOPபைடு நூலகம்EIA 7.5
Index
Numerics 1. General notices ................................................................... 7.5-4453 2.1.1. Droppers...................
OECD Test No. 460 Fluorescein Leakage Test Method for Identifying Ocular Corrosives and Severe Irrit
OECD/OCDE460Adopted: 2 October 2012© OECD, (2012)You are free to use this material for personal, non-commercial purposes without seeking prior consent from the OECD, provided the source is duly mentioned. Any commercial use of this material is subject to written permission from the OECD.OECD GUIDELINE FOR THE TESTING OF CHEMICALS Fluorescein Leakage Test Method for Identifying Ocular Corrosives and Severe IrritantsINTRODUCTION1. The Fluorescein Leakage (FL) test method is an in vitro test method that can be used under certain circumstances and with specific limitations to classify chemicals (substances and mixtures) as ocular corrosives and severe irritants, as defined by the United Nations (UN) Globally Harmonized System of Classification and Labelling of Chemicals (GHS) (Category 1), the European Union (EU) Regulation on Classification, Labelling and Packaging of Substances and Mixtures (CLP) (Category 1), and the U.S. Environmental Protection Agency (EPA) (Category I) (1) (2) (3). For the purpose of this Test Guideline, severe irritants are defined as chemicals that cause tissue damage in the eye following test substance administration that is not reversible within 21 days or causes serious physical decay of vision, while ocular corrosives are chemicals that cause irreversible tissue damage to the eye. These chemicals are classified as UN GHS Category 1, EU CLP Category 1, or U.S. EPA Category I.2. While the FL test method is not considered valid as a complete replacement for the in vivo rabbit eye test, the FL is recommended for use as part of a tiered testing strategy for regulatory classification and labelling. Thus, the FL is recommended as an initial step within a Top-Down approach to identify ocular corrosives/severe irritants, specifically for limited types of chemicals (i.e. water soluble substances and mixtures) (4)(5).3. It is currently generally accepted that, in the foreseeable future, no single in vitro eye irritation test will be able to replace the in vivo eye test (TG 405 (6)) to predict across the full range of irritation for different chemical classes. However, strategic combinations of several alternative test methods within a (tiered) testing strategy may be able to replace the in vivo eye test (5). The Top-Down approach (5) is designed to be used when, based on existing information, a chemical is expected to have high irritancy potential.Based on the prediction model detailed in paragraph 35, the FL test method can identify Category 1; EU CLP Category 1; U.S. EPA Category I) without any further testing. The same is assumed for mixtures although mixtures were not used in the validation. Therefore, the FL test method may be used to determine the eye irritancy/corrosivity of chemicals, following the460OECD/OCDEsequential testing strategy of TG 405 (6). However, a chemical that is not predicted as ocular corrosive or severe irritant with the FL test method would need to be tested in one or more additional test methods (in vitro and/or in vivo) that are capable of accurately identifying i) chemicals that are in vitro false negative ocular corrosives/severe irritants in the FL (UN GHS Category 1; EU CLP Category 1; U.S. EPA Category I); ii) chemicals that are not classified for eye corrosion/irritation (UN GHS No Category; EU CLP No Category; U.S. EPA Category IV); and/or iii) chemicals that are moderate/mild eye irritants (UN GHS Categories 2A and 2B; EU CLP Category 2; U.S. EPA Categories II and III).5. The purpose of this Test Guideline is to describe the procedures used to evaluate the potential ocular corrosivity or severe irritancy of a test substance as measured by its ability to induce damage to an impermeable confluent epithelial monolayer. The integrity of trans-epithelial permeability is a major function of an epithelium such as that found in the conjunctiva and the cornea. Trans-epithelial permeability is controlled by various tight junctions. Increasing the permeability of the corneal epithelium in vivo has been shown to correlate with the level of inflammation and surface damage observed as eye irritation develops.6. In the FL test method, toxic effects after a short exposure time to the test substance are measured by an increase in permeability of sodium fluorescein through the epithelial monolayer of Madin-Darby Canine Kidney (MDCK) cells cultured on permeable inserts. The amount of fluorescein leakage that occurs is proportional to the chemical-induced damage to the tight junctions, desmosomal junctions and cell membranes, and can be used to estimate the ocular toxicity potential of a test substance. Annex I provides a diagram of MDCK cells grown on an insert membrane for the FL test method.7. Definitions are provided in Annex II.INITIAL CONSIDERATIONS AND LIMITATIONS8. This Test Guideline is based on the INVITTOX protocol No. 71 (7) that has been evaluated in an international validation study by the European Centre for the Validation of Alternative Methods (ECVAM) (8), in collaboration with the US Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) and the Japanese Center for the Validation of Alternative Methods (JaCVAM).9. The FL test method is not recommended for the identification of chemicals which should be classified as mild/moderate irritants or of chemicals which should not be classified for ocular irritation (substances and mixtures) (i.e. GHS Cat. 2A/2B, no category; EU CLP Cat. 2, no category; US EPA Cat. II/III/IV), as demonstrated by the validation study (4) (8).10. The test method is only applicable to water soluble chemicals (substances and mixtures). The ocular severe irritation potential of chemicals that are water soluble and/or where the toxic effect is not affected by dilution is generally predicted accurately using the FL test method (8). To categorise a chemical as water soluble, under experimental conditions, it should be soluble in sterile calcium-containing (at a concentration of 1.0-1.8 mM), phenol red-free, Hanks’ Buffered Salt Solution (HBSS) at a concentration ≥ 250 mg/mL (one dose above the cut-off of 100 mg/mL). However, if the test substance is soluble below the concentration 100 mg/mL,2© OECD, (2012)OECD/OCDE 460 but already induces a FL induction of 20 % at that concentration (meaning FL20 < 100 mg/mL), it can still be classified as GHS Cat. 1 or EPA Cat. 1.11. The identified limitations for this test method exclude strong acids and bases, cell fixatives and highly volatile chemicals from the applicability domain. These chemicals have mechanisms that are not measured by the FL test method, e.g. extensive coagulation, saponification or specific reactive chemistries. Other identified limitations for this method are based upon the results for the predictive capacity for coloured and viscous test substance (8). It is suggested that both types of chemicals are difficult to remove from the monolayer following the short exposure period and that predictivity of the test method could be improved if a higher number of washing steps was used. Solid chemicals suspended in liquid have the propensity to precipitate out and the final concentration to cells can be difficult to determine. When substances within these chemical and physical classes are excluded from the database, the accuracy of FL across the EU, EPA, and GHS classification systems is substantially improved (8).12. Based on the purpose of this test method (i.e. to identify ocular corrosives/severe irritants only), false negative rates (see Paragraph 13) are not critical since such substances would be subsequently tested with other adequately validated in vitro tests or in rabbits, depending on regulatory requirements, using a sequential testing strategy in a weight of evidence approach (6) (see also paragraphs 3 and 4).13. Other identified limitations of the FL test method are based on false negative and false positive rates. When used as an initial step within a Top-Down approach to identify water soluble ocular corrosive/severe irritant substances and mixtures (UN GHS Category 1; EU CLP Category 1; U.S. EPA Category I), the false positive rate for the FL test method ranged from 7% (7/103; UN GHS and EU CLP) to 9% (9/99; U.S. EPA) and the false negative rate ranged from 54% (15/28; U.S. EPA) to 56% (27/48; UN GHS and EU CLP) when compared to in vivo results. Chemical groups showing false positive and/or false negative results in the FL test method are not defined here.14. Certain technical limitations are specific to the MDCK cell culture. The tight junctions that block the passage of the sodium-fluorescein dye through the monolayer are increasingly compromised with increasing cell passage number. Incomplete formation of the tight junctions results in increased FL in the non-treated control. Therefore, a defined permissible maximal leakage in the non-treated controls is important (see paragraph 38: 0% leakage). As with all in vitro assays there is the potential for the cells to become transformed over time, thus it is vital that passage number ranges for the assays are stated.15. The current applicability domain might be increased in some cases, but only after analyzing an expanded data set of studied test substances, preferably acquired through testing (4). This Test Guideline will be updated accordingly as new information and data are considered.16. For any laboratory initially establishing this assay, the proficiency chemicals provided in Annex III should be used. Laboratories can use these chemicals to demonstrate their technical competence in performing the FL test method prior to submitting FL assay data for regulatory hazard classification purposes.PRINCIPLE OF THE TEST3© OECD, (2012)460OECD/OCDE17. The FL test method is a cytotoxicity and cell-function based in vitro assay that is performed on a confluent monolayer of MDCK CB997 tubular epithelial cells that are grown on semi-permeable inserts and model the non-proliferating state of the in vivo corneal epithelium. The MDCK cell line is well established and forms tight junctions and desmosomal junctions similar to those found on the apical side of conjunctival and corneal epithelia. Tight and desmosomal junctions in vivo prevent solutes and foreign materials penetrating the corneal epithelium. Loss of trans-epithelial impermeability, due to damaged tight junctions and desmosomal junctions, is one of the early events in chemical-induced ocular irritation.18. The test substance is applied to the confluent layer of cells grown on the apical side of the insert. A short 1 min exposure is routinely used to reflect the normal clearance rate in human exposures. An advantage of the short exposure period is that water-based substances and mixtures can be tested neat, if they can be easily removed after the exposure period. This allows more direct comparisons of the results with the chemical effects in humans. The test substance is then removed and the non-toxic, highly fluorescent sodium-fluorescein dye is added to the apical side of the monolayer for 30 minutes. The damage caused by the test substance to the tight junctions is determined by the amount of fluorescein which leaks through the cell layer within a defined period of time.19. The amount of sodium-fluorescein dye that passes through the monolayer and the insert membrane into a set volume of solution present in the well (to which the sodium-fluorescein dye leaks in) is determined by measuring spectrofluorometrically the fluorescein concentration in the well. The amount of fluorescein leakage (FL) is calculated with reference to fluoresence intensity (FI) readings from two controls: a blank control, and a maximum leakage control. The percentage of leakage and therefore amount of damage to the tight junctions is expressed, relative to these controls, for each of the set concentrations of the test substance. Then the FL20 (i.e. concentration that causes 20% FL relative to the value recorded for the untreated confluent monolayer and inserts without cells), is calculated. The FL20 (mg/mL) value is used in the prediction model for identification of ocular corrosives and severe irritants (see paragraph 35).20. Recovery is an important part of a test substance’s toxicity profile that is also assessed by the in vivo ocular irritation test. Preliminary analyses indicated that recovery data (up to 72 h following the chemical exposure) could potentially increase the predictive capacity of INVITTOX Protocol 71 but further evaluation is needed and would benefit from additional data, preferably acquired by further testing (7). This Test Guideline will be updated accordingly as new information and data are considered.PROCEDUREPreparation of the cellular monolayer21. The monolayer of MDCK CB997 cells is prepared using sub-confluent cells growing in cell culture flasks in DMEM/Nutrient Mix F12 (1x concentrate with L-glutamine, 15 mM HEPES, calcium (at a concentration of 1.0-1.8 mM) and 10% heat-inactivated FCS/FBS). Importantly, all media/solutions used throughout the FL assay should contain calcium at a concentration between 1.8 mM (200 mg/L) and 1.0 mM (111 mg/L) to ensure tight junction formation and integrity. Cell passage number range should be controlled to ensure even and4© OECD, (2012)OECD/OCDE 460 reproducible tight junctions formation. Preferably, the cells should be within the passage range 3-30 from thawing because cells within this passage range have similar functionality, which aids assay results to be reproducible.22. Prior to performing the FL test method, the cells are detached from the flask by trypsinisation, centrifuged and an appropriate amount of cells is seeded into the inserts placed in 24-well plates (see Annex I). Twelve mm diameter inserts with membrane of mixed cellulose esters, a thickness of 80-150 µm and a pore size of 0.45 µm, should be used to seed the cells. In the validation study, Millicell-HA 12 mm inserts were used. The properties of the insert and membrane type are important as these may affect cell growth and chemical binding. Certain types of chemicals may bind to the Millicell-HA insert membrane, which could affect the interpretation of results. Proficiency chemicals (see Annex III) should be used to demonstrate equivalency if other membranes are used.23. Chemical binding to the insert membrane is more common for cationic chemicals, such as benzalkonium chloride, which are attracted to the positively charged membrane (8). Chemical binding to the insert membrane may increase the chemical exposure period, leading to an over-estimation of the toxic potential of the chemical, but can also physically reduce the leakage of fluorescein through the insert by binding of the dye to the cationic chemical bound to the insert membrane, leading to an under-estimation of the toxic potential of the chemical. This can be readily monitored by exposing the membrane alone to the top concentration of the chemical tested and then adding sodium-fluorescein dye at the normal concentration for the standard time (no cell control). If binding of the sodium-fluorescein dye occurs, the insert membrane appears yellow after the test material has been washed-off. Thus, it is essential to know the binding properties of the test substance in order to be able to interpret the effect of the chemical on the cells.24. Cell seeding on inserts should produce a confluent monolayer at the time of chemical exposure. 1.6 x 105 cells should be added per insert (400 µL of a cell suspension with a density of 4 x 105 cells / mL). Under these conditions, a confluent monolayer is usually obtained after 96 hours in culture. Inserts should be examined visually prior to seeding, so as to ensure that any damages recorded at the visual control described at paragraph 30 is due to handling.25. The MDCK cell cultures should be kept in incubators in a humidified atmosphere, at 5% ± 1% CO2and 37 ± 1 ºC. The cells should be free of contamination by bacteria, viruses, mycoplasma and fungi.Application of the Test and Control Chemicals26. A fresh stock solution of test substance should be prepared for each experimental run and used within 30 minutes of preparation. Test substances should be prepared in calcium-containing (at a concentration of 1.0-1.8 mM), phenol red-free, HBSS to avoid serum protein binding. Solubility of the chemical at 250 mg/mL in HBSS should be assessed prior to testing. If at this concentration the chemical forms a stable suspension or emulsion (i.e.maintains uniformity and does not settle or separate into more than one phase) over 30 minutes, HBSS can still be used as solvent. However, if the chemical is found to be insoluble in HBSS at this concentration, the use of other test methods instead of FL should be considered. The use of light mineral oil as a solvent, in cases where the chemical is found to be insoluble in HBSS, should be5© OECD, (2012)460OECD/OCDEconsidered with caution as there is not enough data available to conclude on the performance of the FL assay under such conditions.27. All chemicals to be tested are prepared in sterile calcium-containing (at a concentration of 1.0-1.8 mM), phenol red-free, HBSS from the stock solution, at five fixed concentrations diluted on a weight per volume basis: 1, 25, 100, 250 mg/mL and a neat or a saturated solution. When testing a solid chemical, a very high concentration of 750 mg/mL should be included. This concentration of chemical may have to be applied on the cells using a positive displacement pipette. If the toxicity is found to be between 25 and 100 mg/mL, the following additional concentrations should be tested twice: 1, 25, 50, 75, 100 mg/mL. The FL20value should be derived from these concentrations provided the acceptance criteria were met.28. The test substances are applied to the confluent cell monolayers after removal of the cell culture medium and washing twice with sterile, warm (37ºC), calcium-containing (at a concentration of 1.0-1.8 mM), phenol red-free, HBSS. Previously, the filters have been visually checked for any pre-existing damages that could be falsely attributed to potential incompatibilities with test chemicals. At least three replicates should be used for each concentration of the test substance and for the controls in each run. After 1 min of exposure at room temperature, the test substance should be carefully removed by aspiration, the monolayer should be washed twice with sterile, warm (37ºC), calcium-containing (at a concentration of 1.0-1.8 mM), phenol red-free, HBSS, and the fluorescein leakage should be immediately measured. 29. Concurrent negative (NC) and positive controls (PC) should be used in each run to demonstrate that monolayer integrity (NC) and sensitivity of the cells (PC) are within a defined historical acceptance range. The suggested PC chemical is Brij 35 (CAS No. 9002-92-0) at 100 mg/mL. This concentration should give approximately 30% fluorescein leakage (acceptable range 20-40% fluorescein leakage, i.e. damage to cell layer). The suggested NC chemical is calcium-containing (at a concentration of 1.0-1.8 mM), phenol red-free, HBSS (untreated, blank control).A maximum leakage control should also be included in each run to allow for the calculation of FL20 values. Maximum leakage is determined using a control insert without cells.Determination of fluorescein permeability30. Immediately after removal of the test and control substances, 400μL of 0.1 mg/mL sodium-fluorescein solution (0.01% (w/v) in calcium-containing [at a concentration of 1.0-1.8 mM], phenol red-free, HBSS) is added to the Millicell-HA inserts. The cultures are kept for 30 minutes at room temperature. At the end of the incubation with fluorescein, the inserts are carefully removed from each well. Visual check is performed on each filter and any damage which may have occurred during handling is recorded.31. The amount of fluorescein that leaked through the monolayer and the insert is quantified in the solution which remained in the wells after removal of the inserts. Measurements are done in a spectrofluorometer at excitation and emission wavelengths of 485 nm and 530 nm, respectively. The sensitivity of the spectrofluorometer should be set so that there is the highest numerical difference between the maximum FL (insert with no cells) and the minimum FL (insert with confluent monolayer treated with NC). Because of the differences in the used spectrofluorometer, it is suggested that a sensitivity is used which will give fluorescence intensity > 4000 at the maximum fluorescein leakage control. The maximum FL value should not be6© OECD, (2012)OECD/OCDE 460 greater than 9999. The maximum fluorescence leakage intensity should fall within the linear range of the spectrofluorometer used.Interpretation of results and Prediction model32. The amount of FL is proportional to the chemical-induced damage to the tight junctions. The percentage of FL for each tested concentration of chemical is calculated from the FL values obtained for the test substance with reference to FL values from the NC (reading from the confluent monolayer of cells treated with the NC) and a maximum leakage control (reading for the amount of FL through an insert without cells).The mean maximum leakage fluorescence intensity = xThe mean 0% leakage fluorescence intensity (NC) = yThe mean 100% leakage is obtained by subtracting the mean 0% leakage from the mean maximum leakage,i.e. x - y = z33. The percentage leakage for each fixed dose is obtained by subtracting the 0% leakage to the mean fluorescence intensity of the three replicate readings (m), and dividing this value by the 100% leakage, i.e. %FL = [(m-y) / z] x 100%, where:m = the mean fluorescence intensity of the three replicate measurements for the concentration involved% FL = the percent of the fluorescein which leaks through the cell layer34. The following equation for the calculation of the chemical concentration causing 20% FL should be applied:FL D = [(A-B) / (C-B)] x (M C –M B) + M BWhere:D = % of inhibitionA = % damage (20% fluorescein leakage)B = % fluorescein leakage < AC = % fluorescein leakage > AM C = Concentration (mg/mL) of CM B = Concentration (mg/mL) of B35. The cut-off value of FL20 for predicting chemicals as ocular corrosives/severe irritants is given below:7© OECD, (2012)460OECD/OCDE36. The FL test method is recommended only for the identification of water soluble ocular corrosives and severe irritants (UN GHS Category 1, EU CLP Category 1, U.S. EPA Category I) (see paragraphs 1 and 10).37. In order to identify water soluble chemicals (substances and mixtures) (4) (7) (8) as "inducing serious eye damage" (UN GHS/EU CLP Category 1) or as an "ocular corrosive or severe irritant" (U.S. EPA Category I), the test substance should induce an FL20 value of ≤ 100 mg/mL.Acceptance of results38. The mean maximum fluorescein leakage value (x) should be higher than 4000 (see paragraph 31), the mean 0% leakage (y) should be equal or lower than 300, and the mean 100% leakage (z) should fall between 3700 and 6000.39. A test is considered acceptable if the positive control produced 20% to 40% damage to the cell layer (measure as % fluorescein leakage).DATA AND REPORTINGData40. For each run, data from individual replicate wells (e.g. fluorescence intensity values and calculated percentage FL data for each test substance, including classification) should be reported in tabular form. In addition, means ± SD of individual replicate measurements in each run should be reported.Test Report41. The test report should include the following information:Test and Control Substances-Chemical name(s) such as the structural name used by the Chemical Abstracts Service (CAS), followed by other names, if known;-Chemical CAS number, if known;-Purity and composition of the substance or mixture (in percentage(s) by weight), to the extent this information is available;-Physical-chemical properties relevant to the conduct of the study (e.g. physical state, volatility, pH, stability, water solubility, chemical class);-Treatment of the test/control substance prior to testing, if applicable (e.g. warming, grinding);-Storage conditions;Justification of the Test Method and Protocol Used-Should include considerations regarding applicability domain and limitations of the test method;Test Conditions8© OECD, (2012)OECD/OCDE 460 -Description of cell system used, including certificate of authenticity and the mycoplasma status of the cell line;-Details of test procedure used;-Test substance concentration(s) used;-Duration of exposure to the test substance;-Duration of incubation with fluorescein;-Description of any modifications of the test procedure;-Description of evaluation criteria used;-Reference to historical data of the model (e.g. negative and positive controls, benchmark chemicals, if applicable);-Information on the technical proficiency demonstrated by the laboratory;Results-Tabulation of data from individual test substances and controls for each run and each replicate measurement (including individual results, means and SDs);-The derived classification(s) with reference to the prediction model and/or decision criteria used;-Description of other effects observed;Discussion of the Results-Should include considerations regarding a non-conclusive outcome (paragraph 35: FL20 > 100 mg/mL) and further testing;Conclusions9© OECD, (2012)460OECD/OCDELITERATURE1.UN (2009), United Nations Globally Harmonized System of Classification and Labelling ofChemicals (GHS), Third revised edition, New York & Geneva: United Nations Publications.ISBN: 978-92-1-117006-1. Available at:[/trans/danger/publi/ghs/ghs_rev03/03files_e.html]2.EC (2008), Regulation (EC) No 1272/2008 of the European Parliament and of the Council of16 December 2008 on classification, labelling and packaging of substances and mixtures,amending and repealing Directives 67/548/EEC and 1999/45/EC, and amending Regulation (EC) No 1907/2006, Official Journal of the European Union L353, 1-1355.3.U.S. EPA (1996), Label Review Manual: 2nd Edition, EPA737-B-96-001, Washington DC:U.S. Environmental Protection Agency.4.EC-ECVAM (2009), Statement on the scientific validity of cytotoxicity/cell-function based invitro assays for eye irritation testing. Available under Publications at: [http://ecvam.jrc.it/index.htm]5.Scott, L. et al. (2010), A proposed eye irritation testing strategy to reduce and replace in vivostudies using Bottom-Up and Top-Down approaches, Toxicol. In Vitro 24, 1-9.6.OECD (2002), Test No. 405: Acute Eye Irritation/Corrosion, OECD Guidelines for theTesting of Chemicals, Section 4, OECD Publishing. doi: 10.1787/9789264070646-en7.EC-ECVAM (1999), INVITOX Protocol 71: Fluorescein Leakage Test, Ispra, Italy:European Centre for the Validation of Alternative Methods (ECVAM). Available at: [http://ecvam-dbalm.jrc.ec.europa.eu]8.EC-ECVAM (2008), Fluorescein Leakage Assay Background Review Document as anAlternative Method for Eye Irritation Testing. Available under Validation Study Documents, Section Eye Irritation at: [http://ecvam.jrc.it/index.htm]9.OECD (2005), Guidance Document on the Validation and International Acceptance of Newor Updated Test Methods for Hazard Assessment, OECD Series on Testing and Assessment No. 34. OECD, Paris. Available at: [/env/testguidelines]10© OECD, (2012)。
艾默生谷轮半封闭活塞压缩机产品规格书说明书
Emerson 2SKW-0750 Copeland semi-hermetic reciprocating compressor /file/1893559From collects and classifies the global productinstrunction manuals to help users access anytime andanywhere, helping users make better use of products.Home: / Chinese: /EMERSON. CONSIDER IT SOLVED7.5265.1/5431.2启动电流(LRA)(A)EWL380-420V 3PH 50Hz 85.3最大运行电流(MCC)(A)EWL380-420V 3PH 50Hz16.470排气管Discharge Port 7/8"吸气管Suction Port 11/8"长Length560宽Width 330高(不带风扇）Height395295X279(22)2.4净重Net Weight 92毛重Gross Weight97型号Model2SKW-0750缸径×行程(mm)Bore×Stroke 名义功率(HP)Norminal Input Power 缸数Number Of Cylinders 产品技术参数 Technical Data接管外径尺寸(Inch)Connection Size曲轴箱加热器功率(W)Crankcase Heater外型尺寸(mm)Dimension底脚安装尺寸(孔径)(mm)Mounting Size油充注量(L)Oil Charging重量(kg)Weight排气量(m 3/h)Displacement压缩机铭牌示例 NameplateRD ORBN BK压缩机配置 Compressor Configuration 硬底脚组件电机热保护器(外置模块)弹簧底脚组件OPS 可选配置冷却风扇红色棕色黑色颜色代码标准配置桔色压缩机应用指导 Application Guideline1/4" - 18 NPSL SL-AIR 风冷吸气位置（2SC2-0550 AIR)1. 低压接口丝堵3. 电子式油压差控制器接口5. 注油口丝堵规格请参考《2S系列半封闭制冷压缩机使用说明书》1/8” - 27 NPTF4. 油加热器孔塞1/8” - 27 NPTF 3/8" - 18 NPSLSL 回气冷却吸气管DL 排气管2. 高压接口丝堵规格艾默生环境优化技术上海分公司上海市中山南路28号久事大厦16楼电话 021-********传真 021-********广州分公司广州市黄埔大道西76号富力盈隆广场508-509室电话 020-********传真 020-********北京分公司北京市西城区南礼士路66号建威大厦310室电话 010-********传真 010-********EMERSON. CONSIDER IT SOLVED。
IWPT系列无线温度传感器操作手册说明书
|IWPT SeriesINDUSTRIAL WIRELESS PRESSURE TRANSMITTERWhilst every effort has been taken to ensure the accuracy of this document, we accept no responsibility for damage, injury, loss, or expense resulting from errors or omissions, and reserve the right of amendment without notice.Information for usersThis equipment has been tested and found to comply with the limits for a Class B device, pursuant to part 15 of the FCC Rules. These limits are designed to provide reasonable protection against harmful interference in a residential installation. This equipment generates uses and can radiate radio frequency energy, and if not installed and used in accordance with the instructions, may cause harmful interference to radio communications. However, there is no guarantee that interference will not occur in a particular installation. If this equipment does cause harmful interference to radio or television reception, which can be determined by turning the equipment off and on, the user is encouraged to try to correct the interference by one or more of the following measures:•Reorient or relocate the receiving antenna•Increase the separation between the equipment and receiver•Connect the equipment into an outlet on a circuit different from that which the receiver is connected•Consult the dealer or an experienced radio/TV technician for helpCaution: To satisfy FCC RF Exposure requirements for mobile and base station transmission devices, a separation distance of 20cm or more should be maintained between the antenna of this device and persons during operation. To ensure compliance operation at closer than this distance is not recommended. The antenna used for this transmitter must not be co-located or operating in conjunction with any other antenna or transmitter. No other antenna may be used with this equipment other than the PCB antenna supplied with this equipment.This document may not be reproduced in any way without the prior written permission of the company.Cynergy3 Components Ltd7 Cobham Road, Ferndown Industrial Estate, WimborneDorset BH21 7PE, United KingdomTel:+44(0)1202897969,email:******************CONTENTS1.INTRODUCTION _______________________________________________________ 21.1 SAFETY INFORMATION _____________________________________________________ 21.2HARDWARE FEATURES ____________________________________________________ 22.UNPACKING__________________________________________________________ 33.PRODUCT IDENTIFICATION LABEL _____________________________________ 35.SETTING UP THE IWPT WIRELESS PRESSURE TRANSMITTER ___________ 46.TROUBLE-SHOOTING GUIDE__________________________________________ 67.SYSTEM PART NUMBERS______________________________________________ 78.SPECIFICATIONS & CERTIFICATIONS__________________________________ 9 1. INTRODUCTION1.1 Safety InformationThis manual contains information that must be observed in the interest of your safety and to avoid damage to assets. Please read this manual before installing and commissioning the device and keep the manual in an accessible location for all users.Contains FCC ID: W70MRF24J40MDMECaution: To satisfy FCC RF Exposure requirements for mobile and base station transmission devices, a separation distance of 20cm or more should be maintained between the antenna of this device and persons during operation. To ensure compliance operation at closer than this distance is not recommended. The antenna used for this transmitter must not be co-located or operating in conjunction with any other antenna or transmitter. No other antenna may be used with this equipment other than the PCB antenna supplied with this equipment.Please see the Certifications section for more information on RF Exposure Compliance 1.2 Hardware FeaturesThe IWPT range of Wireless Pressure Transmitters has been designed to measure the pressure of the medium connected and transmit the value to one of the IWR range of receivers where the value can be outputted as either a 4-20 mA or 1-5 V dc signal.The IWR-1 has a single output and the IWR-5 has five outputs, each of which can be linked to an IWPT transmitter. The IWPT pressure transmitter works on the license-free 2.4 GHz band.Ranges of up to 500 m are possible using the standard transmitter and receiver unit with the optional 3dBi antenna giving a range of up to 750 m. The transmitter is powered by a 3.6V lithium cell and care must be taken to insert the battery in the correct polarity.2. UNPACKINGThe instrument should be carefully inspected for signs of damage that may have occurred in transit. In the unlikely case that damage has been sustained, DO NOT use the instrument, but please retain all packaging for our inspection and contact your supplier immediately.3. PRODUCT IDENTIFICATION LABELThe unit delivered should be carefully inspected to ensure it is suitable for the application required. Detailed information on the product is included in the identification label and the user manual.Please ensure in particular, that the pressure range of the IWPT is suitable for the intended application and that the IWPT unit will not be subjected to pressures and/or temperatures greater than those specified in this manual.4.INSTALLING/CHANGING THE BATTERYA Lithium 3.6V battery is included inside the IWPT transmitter. The battery may be changed at any time but the correct polarity must be observed at all times! After the battery has been changed, the pushbutton SW1 should be pushed for 5s at the same time as the unit is switched on using SW3. This is to ensure the battery life count is set correctly when a new battery is installed.The internal LED will flash 5 times to indicate this procedure has been carried out successfully.The battery life is determined by the rate the transmitter sends the Pressure value to the receiver, this update rate can be selected using Dip Switch 1 and the default value is 10s. Please dispose of all batteries as specified by the legislator according to the Closed Substance Cycle and Waste Management Act or country regulations.! ! WARNING !MAKE SURE THE CORRECT BATTERY POLARITY IS OBSERVED!!! WARNING !INCORRECT BATTERIES MAY DAMAGE THE UNIT USE ONLY 3.6V LITHIUM C CELL BATTERIES5.1 Mounting InstructionsEnsure that:-- The instrument is used on a pressure medium that is compatible with the wetted parts- The correct seal is used and that the maximum torque (see below) is not exceeded- Fluid is not allowed to freeze in the pressure port as the diaphragm may be ruptured- No sharp objects are inserted into the pressure port as the diaphragm may be damagedTighten the unit in place using a wrench on the 18mm A/F hexagon provided on the unit. Ensure that no more than 15Nm is applied, that the system is de-pressurized, and that a suitable pressure seal is used.5.2 SETTING UP THE IWPT WIRELESS PRESSURE TRANSMITTERThe IWPT instrument is shipped in a default configuration which allows the unit to connect with any default IWR receiver unit and transmit the measured pressure every 10s simply by switching the unit on using SW3 on the internal circuit board.If a different update rate is required, or a different network frequency channel is required these parameters can be selected using DIP Switch 1 as detailed below:Switches 1, 2, 3 & 4 select the RF Network the IWPT will transmit on. The default network for both the IWPT transmitter and IWR receiver is network 1. RF NETWORK 1 2 3 4 1 0 0 0 0 2 0 0 0 1 3 0 0 1 0 4 0 0 1 1 5 0 1 0 0 6 0 1 0 1 7 0 1 1 0 8 0 1 1 1DIP SWITCHLED1BATTERYON/OFF Switch SW3SW1USB+9 1 0 0 010 1 0 0 111 1 0 1 012 1 0 1 113 1 1 0 014 1 1 0 115 1 1 1 016 1 1 1 1Switches 5, 6 & 7 select the Transmission rate of the unit. This effectively sets how often the pressure value is sent to the receiver.Transmit time 5 6 710 seconds 0 0 020 seconds 0 0 130 seconds 0 1 060 seconds 0 1 1120 seconds 1 0 0600 seconds 1 0 11 second 1 1 05 seconds 1 1 1Switches 8, 9, and 10 set the Channel Number of the transmitter. This is used with the 5 channel receiver unit (IWR-5) to select which Pressure transmitter is linked to which4-20 mA or 1-5 V dc output channel.Tx Channel Number 8 9 101 0 0 02 0 0 13 0 1 04 0 1 15 1 0 0The IWPT transmitter is now set up and ready to be used. Install the unit into the pipework as required and switch the unit ON using SW3. Pushbutton switch SW1 can be pushed to force the unit to transmit its current pressure and LED 1 will flash twice if the transmission has been received and acknowledged by an IWR receiver unit.If the unit has transmitted successfully the 4-20 mA or 1-5 V dc output of the connected receiver unit will output a value reflecting the pressure level being measured.6.TROUBLE-SHOOTING GUIDEProblem encountered Possible CausesLED1 doesn’t flash when push button SW1 is pressed Unit not switched on, switch on using SW3. The battery is not installed correctly.The battery needs replacing.LED1 only flashes once when SW1 is pressed IWR receiver not switched on. IWR receiver is not set up for the same RFnetwork.IWR receiver not within range of the transmitter.If an IWR-1 receiver is used, ensure that the transmitter is set to Tx Channel 1Output from the IWR receiver isn’t equivalent to the Pressure being monitored IWR receiver set up incorrectly, see IWR user manual for further details.Check that the green external LED on the receiver is flashing when the transmitter push button is pressed as the receiver may be out of range.7. SYSTEM PART NUMBERSPart Number Pressure Range Receiver Output IWPT-G1000-00 0-1 Bar g 4-20 mA or 1-5 V dc IWPT-G6000-00 0-6 Bar g 4-20 mA or 1-5 V dc IWPT-GM1P9-00 -1-+9 Bar g 4-20 mA or 1-5 V dc IWPT-G1002-00 0-10 Bar g 4-20 mA or 1-5 V dc IWPT-G1602-00 0-16 Bar g 4-20 mA or 1-5 V dc IWPT-CO184-00 -1-+24 Bar g 4-20 mA or 1-5 V dc IWPT-G2502-00 0-25 Bar g 4-20 mA or 1-5 V dc IWPT-G4002-00 0-40 Bar g 4-20 mA or 1-5 V dc IWPT-G1003-00 0-100 Bar g 4-20 mA or 1-5 V dc IWPT-G2503-00 0-250 Bar g 4-20 mA or 1-5 V dc IWPT-G4003-00 0-400 Bar g 4-20 mA or 1-5 V dc IWPTU-GP015-00 0-15 psi g 4-20 mA or 1-5 V dc IWPTU-GP030-00 0-30 psi g4-20 mA or 1-5 V dc IWPTU-CO446-00 -14.5 to +150 psi g4-20 mA or 1-5 V dc IWPTU-GP075-00 0-75 psi g4-20 mA or 1-5 V dc IWPTU-GP100-00 0-100 psi g4-20 mA or 1-5 V dc IWPTU-CO447-00 -14.5 to +350 psi g4-20 mA or 1-5 V dc IWPTU-GP150-00 0-150 psi g4-20 mA or 1-5 V dc IWPTU-GP300-00 0-300 psi g4-20 mA or 1-5 V dc IWPTU-GP750-00 0-750 psi g4-20 mA or 1-5 V dc IWPTU-GP1K5-00 0-1500 psi g4-20 mA or 1-5 V dc IWPTU-GP3K6-00 0-3600 psi g4-20 mA or 1-5 V dc IWPTU-GP5K8-00 0-5800 psi g4-20 mA or 1-5 V dc IWPTL-G0050-00 0-50 mbar g 4-20 mA or 1-5 V dc IWPTL-G0100-00 0-100 mbar g 4-20 mA or 1-5 V dc IWPTL-G0250-00 0-250 mbar g 4-20 mA or 1-5 V dc IWPTL-G0500-00 0-500 mbar g 4-20 mA or 1-5 V dc IWPTL-G0750-00 0-750 mbar g 4-20 mA or 1-5 V dc IWPTL-G1000-00 0-1000 mbar g 4-20 mA or 1-5 V dc IWPTL-A0500-00 0-500 mbar abs 4-20 mA or 1-5 V dc IWPTL-A0750-00 0-750 mbar abs 4-20 mA or 1-5 V dc IWPTL-A1000-00 0-1000 mbar abs 4-20 mA or 1-5 V dcPart Number Pressure Range Receiver Output IWPTLU-GP001-00 0-1 psi g 4-20 mA or 1-5 V dc IWPTLU-GP002-00 0-2 psi g 4-20 mA or 1-5 V dc IWPTLU-GP005-00 0-5 psi g 4-20 mA or 1-5 V dc IWPTLU-GP008-00 0-8 psi g 4-20 mA or 1-5 V dc IWPTLU-GP010-00 0-10 psi g 4-20 mA or 1-5 V dc IWPTLU-GP015-00 0-15 psi g 4-20 mA or 1-5 V dc IWPTLU-AP005-00 0-5 psi abs 4-20 mA or 1-5 V dc IWPTLU-AP010-00 0-10 psi g 4-20 mA or 1-5 V dc IWPTLU-AP015-00 0-15 psi g 4-20 mA or 1-5 V dcPart Number Number of Output ChannelsIWR-1 OneIWR-5 FiveIANT-3 3 dBi Antenna IWPT-SA Swivel Adaptor (1/4” BSP)8.SPECIFICATIONS & CERTIFICATIONSUnited States FCCThis equipment has been tested and found to comply with the limits for a Class B device, pursuant to part 15 of the FCC Rules. These limits are designed to provide reasonable protection against harmful interference in a residential installation. This equipment generates, uses, and can radiate radio frequency energy, and if not installed and used in accordance with the instructions, may cause harmful interference to radio communications. However, there is no guarantee that interference will not occur in a particular installation. If this equipment does cause harmful interference to radio or television reception, which can be determined by turning the equipment off and on, the user is encouraged to try to correct the interference by one or more of the following measures:• Reorient or relocate the receiving antenna• Increase the separation between the equipment and receiver• Connect the equipment into an outlet on a circuit different from that which the receiver is connected • Consult the dealer or an experienced radio/TV technician for helpWarning: Changes or modifications not expressly approved by Cynergy3 could void the user’s authority to operate the equipment.RF ExposureContains FCC ID: W70MRF24J40MDMEIn this equipment, the antenna supplied is a PCB antenna and an alternative antenna must not be used.System PerformanceAccuracy (non-linearity & hysteresis <±0.25% / FS (BFSL)Setting ErrorsZero & Full Scale,<±0.5% / FS Thermal Zero Shift <±0.04% / FS / °C Thermal Span Shift <±0.02% / °C typicalMedia Temperature -20 to +135 °C Ambient Temperature -20 to +50 °C Storage Temperature -20 to +80 °CPressure Housing 303 Stainless Steel O Ring Seals Viton DiaphragmCeramic Enclosure Material Acetal Weight310 gRF TransmitterContains FCC W70MRF24J40MDME Power Requirements Lithium Ion C 3.6V CellBattery Life 5 Years (10s transmission rate)Dimensions 132mm x 79mm x 52mm (L x W x D) Mounting Any OrientationSensata Technologies, Inc. (“Sensata”) data sheets are solely intended to assist designers (“Buyers”) who are developing systems that incorporate Sensata products (also referred to herein as “components”). Buyer understands and agrees that Buyer remains responsible for using its independent analysis, evaluation and judgment in designing Buyer’s systems and products. Sensata data sheets have been created using standard laboratory conditions and engineering practices. Sensata has not conducted any testing other than that specifically described in the published documentation for a particular data sheet. Sensata may make corrections, enhancements, improvements and other changes to its data sheets or components without notice.Buyers are authorized to use Sensata data sheets with the Sensata component(s) identified in each particular data sheet. HOWEVER, NO OTHER LICENSE, EXPRESS OR IMPLIED, BY ESTOPPEL OR OTHERWISE TO ANY OTHER SENSATA INTELLECTUAL PROPERTY RIGHT, AND NO LICENSE TO ANY THIRD PARTY TECHNOLOGY OR INTELLECTUAL PROPERTY RIGHT, IS GRANTED HEREIN. SENSATA DATA SHEETS ARE PROVIDED “AS IS”. SENSATA MAKES NO WARRANTIES OR REPRESENTATIONS WITH REGARD TO THE DATA SHEETS OR USE OF THE DATA SHEETS, EXPRESS, IMPLIED OR STATUTORY, INCLUDING ACCURACY OR COMPLETENESS. SENSATA DISCLAIMS ANY WARRANTY OF TITLE AND ANY IMPLIED WARRANTIES OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE, QUIET ENJOYMENT, QUIET POSSESSION, AND NON-INFRINGEMENT OF ANY THIRD PARTY INTELLECTUAL PROPERTY RIGHTS WITH REGARDTO SENSATA DATA SHEETS OR USE THEREOF.All products are sold subject to Sensata’s terms and conditions of sale supplied at SENSATA ASSUMES NO LIABILITY FOR APPLICATIONS ASSISTANCE OR THE DESIGN OF BUYERS’ PRODUCTS. BUYER ACKNOWLEDGES AND AGREES THAT IT IS SOLELY RESPONSIBLE FOR COMPLIANCE WITH ALL LEGAL, REGULATORY AND SAFETY-RELATED REQUIREMENTS CONCERNING ITS PRODUCTS, AND ANY USE OF SENSATA COMPONENTS IN ITS APPLICATIONS, NOTWITHSTANDING ANY APPLICATIONS-RELATED INFORMATION OR CONTACT US EUROPE+44 (0)1202 897969********************* Cynergy3 Components Ltd.7 Cobham Road, Ferndown Industrial Estate, Wimborne, Dorset,BH21 7PE, United Kingdom USACaution: To satisfy FCC RF Exposure requirements for mobile and base station transmission devices, a separation distance of 20cm or more should be maintained between the antenna of this device and persons during operation. To ensure compliance operation at closer than this distance is not recommended. The antenna used for this transmitter must not be co-located or operating in conjunction with any other antenna or transmitter. No other antenna may be used with this equipment other than the PCB antenna supplied with this equipment.Canada (IC)EnglishThis device complies with Industry Canada license-exempt RSS standard(s). Operation is subject to the following two conditions: (1) this device may not cause interference, and (2) this device must accept any interference, including interference that may cause undesired operation of the device.Under Industry Canada regulations, this radio transmitter may only operate using an antenna of the type and maximum (or lesser) gain approved for the transmitter by Industry Canada. To reduce potential radio interference to other users, the antenna type and its gain should be so chosen that the equivalent isotropically radiated power (e.i.r.p.) is not more than that necessary for successful communication. FrenchLe présent appareil est conforme aux CNR d’industrie Canada applicables aux appareils radio exempts de licence. L’explitation est autorisée aux deux conditions suivantes: (1) l’appareil ne doit pas produire de brouillage, et (2) l’utilisateur de l’appareil doit accepter tout brouillage, et (2) l’utilisateur de l’appareil doit accepter tout brouillage radioelectrique subi, même si le brouillage est susceptible d’en compromettre le fonctionnement.Conformément à la réglementation d’Industrie Canada, le présent émetteur radio peut fonctionner avec une antenna d’un type et d’un gain maximal (ou inférieur) approuvé pour l’émetteur par Industrie Canada. Dans le but de réduire les risques de brouillage radioélectrique à I’intention des autres utilisateurs, il fait choisir le type d’antenne et son gain de sorte que la puissance isotrope rayonnée équivalente (p.i.r.e) ne dépasse pas l’intensité nécessaire à l’établissement d’une communication satisfaisante.EuropeThe MRF24J40MD/ME wireless module used in this equipment has been tested to R&TTE Directive 1995/5/EC Essential Requirements for Health and Safety (Article 3.1(a)), Electromagnetic Compatibility (EMC) Article 3.1(b)) and Radio (Article 3.2) and are summarized in the table below. A Notified Body Opinion has also been issued for this module.Certification Standards ArticleSafety EN60950-2006+A11+A1:2010 (3.1(a))Health EN50371:2002-03 (3.1(a))EMC EN301 489-1 V1..8.1 (2008-04_ (3.1(b))EMC EN301-489-17 V2.1.1(2009-05) (3.1(b))Radio EN 300 328 V1.7.1(2006-10) (3.2)。
医疗机构设备名录
SC20/1+1
7 全自动生化分析仪 BK-400
1台
综合科
否
1台
检验科
否
8 血球分析仪
三分类HG-1021
1台
检验科
否
9 离心机
TD-4M
1台
检验科
否
10 尿道分析仪
BW-200
1台
检验科
否
11 B超机
20NCARE-V6
1台
功能科
否
12 脑电图机
JX-2410
颈腰椎治疗多功能
13 牵引床
JYZ-IIIA
幽蓝医院主要仪器设备名录清单
编号 仪器设备名称
型号
数量
所在科室
是否为大型 医用设备
备注
1 电动吸引器
7A-23D
1台
综合科
否
2 心电监护仪
PM-7000M
1台
综合科
否
3 电动洗胃机
DFM-XWA
4 高压灭菌器
CS-50LT
5 数字心电图机 ZQ1203
1台
综合科
否
1台
综合科
否
Hale Waihona Puke 1台综合科否6 组合煎药机
1台
功能科
否
1台
综合科
否
14 医用冷藏箱
BYC-250L
1台
检验科
否
BIOBASE-RO-DI-
15 纯水机
20
1台
检验科
否
16 恒温水域箱
HH-w600
1台
检验科
否
17 显微镜
ZONCARE-S6
1台
检验科
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P d t D t Sh
t Product Name:
Topiramate CAS No.:
97240-79-4Cat. No.:
HY-B0122Product Data Sheet
MWt:
339.36Formula:
C12H21NO8S Purity :>98%
Solubility:
DMSO 68 mg/Ml; Water <1 mg/mL
Mechanisms:
Biological Activity:
Topiramate is an anticonvulsant that antagonizes GluR5 receptors and acts as a positive allosteric Pathways:GPCR/G protein; Target:mGluR
modulator of GABA receptor-mediated currents.
Target: GluR5 receptor; GABA receptor Topiramate (Topamax) is a structurally novel broad-spectrum antiepileptic drug (AED) with
established efficacy as monotherapy or adjunctive therapy in the treatment of adult and paediatric patients with generalised tonic-clonic seizures, partial seizures with or without generalised seizures,and seizures associated with Lennox-Gastaut syndrome [1]. topiramate has been believed to be a type of antiepileptic drug that blocks spread of seizures. Thus far, the mechanisms of its actions have been proven to include use-dependent inhibition of voltage-dependent Na+ channels in
ne rons potentiation of GABA (gamma amino b t ric acid)ind ced Cl infl and inhibitor effects References:
[1]. Lyseng-Williamson KA, et al. Topiramate: a review of its use in the treatment of epilepsy. Drugs.
2007;67(15):2231-56.[2]Nakamura J et al Target pharmacology of topiramate a new antiepileptic drug Nihon neurons, potentiation of GABA (gamma-amino-butyric acid)-induced Cl- influx, and inhibitory effects on inward currents by...
[2]. Nakamura J, et al. Target pharmacology of topiramate, a new antiepileptic drug. Nihon
Yakurigaku Zasshi. 2000 Jan;115(1):53-7.[3]. Ormrod D, et al. Topiramate: a review of its use in childhood epilepsy. Paediatr Drugs.
2001;3(4):293-319.Caution: Not fully tested. For research purposes only
Medchemexpress LLC
18W i l k i n s o n W a y , P r i n c e t o n , N J 08540,U S A
E m a i l : i n f o @m e d c h e m e x p r e s s .c o m W e b : w w w .m e d c h e m e x p r e s s .c o m。