Fusion and breakup in the reactions of 6,7Li and 9Be
线粒体融合和裂变失衡 英文
线粒体融合和裂变失衡英文Mitochondrial Fusion and Fission Imbalance.Mitochondria are dynamic organelles that undergo continuous fusion and fission events. These processes are essential for maintaining mitochondrial morphology, function, and quality control. Fusion allows mitochondria to exchange genetic material and proteins, thereby promoting complementation and repair. Fission, on the other hand, enables the segregation of damaged mitochondria for subsequent removal by mitophagy.An imbalance between mitochondrial fusion and fission can lead to various cellular abnormalities and diseases. Excessive fusion can result in the formation of hyperfused mitochondrial networks, which may impede mitochondrial motility and hinder the efficient distribution of mitochondria to subcellular compartments. Conversely, excessive fission can lead to mitochondrial fragmentation, which may compromise mitochondrial function and increasethe susceptibility to mitophagy.Causes of Mitochondrial Fusion and Fission Imbalance.Several factors can disrupt the balance between mitochondrial fusion and fission, including:Mutations in mitochondrial fusion and fission genes: Mutations in genes encoding mitochondrial fusion proteins (e.g., Mfn1, Mfn2, OPA1) or fission proteins (e.g., Drp1, Fis1) can impair their function and lead to an imbalance in fusion and fission events.Oxidative stress: Excessive reactive oxygen species (ROS) production can induce mitochondrial fission by activating Drp1 and inhibiting Mfn2.Calcium overload: Elevated intracellular calciumlevels can trigger mitochondrial fission by activating calcineurin, which dephosphorylates Drp1 and promotes its translocation to the mitochondria.Metabolic stress: Nutrient deprivation or hypoxia can induce mitochondrial fission to promote mitophagy and conserve energy.Viral infections: Certain viruses can interfere with mitochondrial fusion and fission processes, leading to mitochondrial dysfunction and cell death.Neurodegenerative diseases: Mitochondrial fusion and fission imbalances have been implicated in the pathogenesis of several neurodegenerative diseases, includingAlzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS).Consequences of Mitochondrial Fusion and Fission Imbalance.Mitochondrial fusion and fission imbalance can have a range of consequences, including:Impaired mitochondrial function: Excessive fusion or fission can disrupt mitochondrial oxidative phosphorylation,ATP production, and calcium homeostasis.Increased susceptibility to apoptosis: Mitochondrial fragmentation can trigger the release of pro-apoptotic factors and promote cell death.Neurological dysfunction: Mitochondrial fusion and fission imbalances have been linked to cognitive decline, synaptic dysfunction, and neuroinflammation.Cardiovascular disease: Impaired mitochondrial fusion and fission can contribute to cardiac dysfunction and heart failure.Metabolic disorders: Mitochondrial fusion and fission imbalances have been implicated in obesity, insulin resistance, and type 2 diabetes.Therapeutic Strategies.Modulating mitochondrial fusion and fission processes holds therapeutic potential for treating a variety ofdiseases. Strategies aimed at restoring the balance between fusion and fission include:Pharmacological interventions: Small molecules that target mitochondrial fusion or fission proteins are being developed as potential therapeutic agents.Gene therapy: Gene therapy approaches aim to correct mutations in mitochondrial fusion and fission genes.Antioxidant therapies: Antioxidants can combat oxidative stress and protect mitochondria from excessive fission.Dietary interventions: Dietary modifications that promote mitochondrial biogenesis and reduce oxidative stress may improve mitochondrial fusion and fission dynamics.Conclusion.Mitochondrial fusion and fission are essentialprocesses for maintaining mitochondrial homeostasis and function. Imbalances between these processes can lead to cellular dysfunction and the development of various diseases. Understanding the mechanisms underlying mitochondrial fusion and fission imbalance and developing therapeutic strategies to restore balance hold promise for treating a range of pathological conditions.。
专业英语电子版教材
Chapter 3 Inorganic Chemistry (28)3.1 The Atomic Nature of Matter (28)3.2 Electronic Structure of Atoms (30)3.3 Periodicity of Atomic Properties (32)3.5 Molecular Geometry and Bonding Theories......................................................... 错误!未定义书签。
3.6 Chemical Reactions................................................................................................. 错误!未定义书签。
3.7 The Behavior of Gases ............................................................................................ 错误!未定义书签。
3.8 Aqueous Reactions and Solution Stoichiometry................................................... 错误!未定义书签。
3.9 Chemical Equilibrium ............................................................................................ 错误!未定义书签。
3.10 Thermochemistry.................................................................................................. 错误!未定义书签。
融合创新 毁誉参半作文
融合创新毁誉参半作文英文回答:Fusion Innovation: A Double-Edged Sword.Fusion innovation has emerged as a promising solution to address the world's growing energy demands while mitigating environmental concerns. By combining elements from different disciplines and technologies, fusion innovation offers the potential to unlock novel and groundbreaking advancements. However, it is essential to acknowledge the inherent complexities and potentialpitfalls associated with this approach.One of the primary benefits of fusion innovation lies in its potential to harness vast and sustainable energy sources. By mimicking the nuclear fusion processes that occur within stars, fusion reactors could generate enormous amounts of energy without producing significant greenhouse gas emissions. This clean and virtually limitless energysource holds the promise of powering our societies for generations to come.Moreover, fusion innovation fosters interdisciplinary collaboration and the cross-pollination of ideas. By bringing together scientists, engineers, and other experts from diverse backgrounds, fusion research encourages a holistic approach to problem-solving. This collaborative environment can lead to breakthroughs that may not have been possible through isolated efforts.However, fusion innovation is not without its challenges. The development of fusion reactors requires a substantial investment of resources and time, as the technology is still in its nascent stages. Furthermore, the construction and operation of fusion reactors pose significant technical and safety concerns. The handling of radioactive materials and the potential for accidents or incidents necessitate rigorous safety protocols and robust regulatory frameworks.Another consideration is the potential social andethical implications of fusion innovation. The deployment of fusion reactors on a large scale may raise questions about resource allocation, equitable access to energy, and the potential for misuse or proliferation of nuclear technology. It is crucial to engage in open and informed public discourse to address these concerns and ensure that fusion innovation aligns with societal values and ethical principles.In summary, fusion innovation presents a tantalizing yet complex path towards sustainable energy solutions. While it holds immense potential to revolutionize our energy landscape, it is essential to proceed with caution and address the technical, safety, and ethical challenges associated with this transformative technology. Careful consideration, transparent decision-making, and robust governance mechanisms are paramount to harness the benefits of fusion innovation while mitigating its potential risks.中文回答:融合创新,一把双刃剑。
用fusion造句
用fusion造句
1. The success of the project hinges on the fusion of traditional and modern design elements.
这个项目的成功取决于传统和现代设计元素的融合。
2. Fusion power is a promising technology that could provide clean and unlimited energy in the future.
核聚变能是一种有前景的技术,未来可能提供清洁且无限的能源。
3. The fusion of different cultures in the city creates a vibrant and diverse atmosphere.
城市中不同文化的融合创造了一个充满活力和多样性的氛围。
4. The artist's work is a fusion of painting and sculpture, creating a unique and captivating visual experience.
这位艺术家的作品是绘画和雕塑的融合,创造了一种独特且引人入胜的视觉体验。
5. The new restaurant combines the fusion of Eastern and Western cuisine, offering a unique dining experience.
这家新开的餐厅结合了东西方美食的融合,提供了一次独特的用餐体验。
吸附时和过渡态能量
吸附时和过渡态能量英文回答:Adsorption and Transition State Energies.In the context of surface science and catalysis, adsorption is the process by which a molecule or atom adheres to a surface. This interaction can be characterized by the adsorption energy, which is the difference in energy between the adsorbed state and the gas phase. Thetransition state energy, on the other hand, is the energy barrier that must be overcome for the molecule or atom to adsorb on the surface.The adsorption and transition state energies are important factors in determining the kinetics and thermodynamics of surface reactions. For example, a higher adsorption energy will lead to a stronger binding of the molecule or atom to the surface, which can inhibit the reaction rate. Conversely, a lower transition state energywill facilitate the adsorption process and increase the reaction rate.The adsorption and transition state energies can be calculated using a variety of theoretical methods, including density functional theory (DFT) and molecular dynamics simulations. These methods can provide insights into the nature of the surface-adsorbate interaction and the reaction mechanisms involved.中文回答:吸附和过渡态能量。
胺基保护——邻苯二甲酰亚胺脱保护
New1H-Pyrazole-Containing Polyamine Receptors Able ToComplex L-Glutamate in Water at Physiological pH ValuesCarlos Miranda,†Francisco Escartı´,‡Laurent Lamarque,†Marı´a J.R.Yunta,§Pilar Navarro,*,†Enrique Garcı´a-Espan˜a,*,‡and M.Luisa Jimeno†Contribution from the Instituto de Quı´mica Me´dica,Centro de Quı´mica Orga´nica Manuel Lora Tamayo,CSIC,C/Juan de la Cier V a3,28006Madrid,Spain,Departamento de Quı´mica Inorga´nica,Facultad de Quı´mica,Uni V ersidad de Valencia,c/Doctor Moliner50, 46100Burjassot(Valencia),Spain,and Departamento de Quı´mica Orga´nica,Facultad deQuı´mica,Uni V ersidad Complutense de Madrid,A V plutense s/n,28040Madrid,SpainReceived April16,2003;E-mail:enrique.garcia-es@uv.esAbstract:The interaction of the pyrazole-containing macrocyclic receptors3,6,9,12,13,16,19,22,25,26-decaazatricyclo-[22.2.1.111,14]-octacosa-1(27),11,14(28),24-tetraene1[L1],13,26-dibenzyl-3,6,9,12,13,16,-19,22,25,26-decaazatricyclo-[22.2.1.111,14]-octacosa-1(27),11,14(28),24-tetraene2[L2],3,9,12,13,16,22,-25,26-octaazatricyclo-[22.2.1.111,14]-octacosa-1(27),11,14(28),24-tetraene3[L3],6,19-dibenzyl-3,6,9,12,13,-16,19,22,25,26-decaazatricyclo-[22.2.1.111,14]-octacosa-1(27),11,14(28),24-tetraene4[L4],6,19-diphenethyl-3,6,9,12,13,16,19,22,25,26-decaazatricyclo-[22.2.1.111,14]-octacosa-1(27),11,14(28),24-tetraene5[L5],and 6,19-dioctyl-3,6,9,12,13,16,19,22,25,26-decaazatricyclo-[22.2.1.111,14]-octacosa-1(27),11,14(28),24-tetra-ene6[L6]with L-glutamate in aqueous solution has been studied by potentiometric techniques.The synthesis of receptors3-6[L3-L6]is described for the first time.The potentiometric results show that4[L4]containing benzyl groups in the central nitrogens of the polyamine side chains is the receptor displaying the larger interaction at pH7.4(K eff)2.04×104).The presence of phenethyl5[L5]or octyl groups6[L6]instead of benzyl groups4[L4]in the central nitrogens of the chains produces a drastic decrease in the stability[K eff )3.51×102(5),K eff)3.64×102(6)].The studies show the relevance of the central polyaminic nitrogen in the interaction with glutamate.1[L1]and2[L2]with secondary nitrogens in this position present significantly larger interactions than3[L3],which lacks an amino group in the center of the chains.The NMR and modeling studies suggest the important contribution of hydrogen bonding andπ-cation interaction to adduct formation.IntroductionThe search for the L-glutamate receptor field has been andcontinues to be in a state of almost explosive development.1 L-Glutamate(Glu)is thought to be the predominant excitatory transmitter in the central nervous system(CNS)acting at a rangeof excitatory amino acid receptors.It is well-known that it playsa vital role mediating a great part of the synaptic transmission.2However,there is an increasing amount of experimentalevidence that metabolic defects and glutamatergic abnormalitiescan exacerbate or induce glutamate-mediated excitotoxic damageand consequently neurological disorders.3,4Overactivation ofionotropic(NMDA,AMPA,and Kainate)receptors(iGluRs)by Glu yields an excessive Ca2+influx that produces irreversible loss of neurons of specific areas of the brain.5There is much evidence that these processes induce,at least in part,neuro-degenerative illnesses such as Parkinson,Alzheimer,Huntington, AIDS,dementia,and amyotrophic lateral sclerosis(ALS).6In particular,ALS is one of the neurodegenerative disorders for which there is more evidence that excitotoxicity due to an increase in Glu concentration may contribute to the pathology of the disease.7Memantine,a drug able to antagonize the pathological effects of sustained,but relatively small,increases in extracellular glutamate concentration,has been recently received for the treatment of Alzheimer disease.8However,there is not an effective treatment for ALS.Therefore,the preparation of adequately functionalized synthetic receptors for L-glutamate seems to be an important target in finding new routes for controlling abnormal excitatory processes.However,effective recognition in water of aminocarboxylic acids is not an easy task due to its zwitterionic character at physiological pH values and to the strong competition that it finds in its own solvent.9†Centro de Quı´mica Orga´nica Manuel Lora Tamayo.‡Universidad de Valencia.§Universidad Complutense de Madrid.(1)Jane,D.E.In Medicinal Chemistry into the Millenium;Campbell,M.M.,Blagbrough,I.S.,Eds.;Royal Society of Chemistry:Cambridge,2001;pp67-84.(2)(a)Standaert,D.G.;Young,A.B.In The Pharmacological Basis ofTherapeutics;Hardman,J.G.,Goodman Gilman,A.,Limbird,L.E.,Eds.;McGraw-Hill:New York,1996;Chapter22,p503.(b)Fletcher,E.J.;Loge,D.In An Introduction to Neurotransmission in Health and Disease;Riederer,P.,Kopp,N.,Pearson,J.,Eds.;Oxford University Press:New York,1990;Chapter7,p79.(3)Michaelis,E.K.Prog.Neurobiol.1998,54,369-415.(4)Olney,J.W.Science1969,164,719-721.(5)Green,J.G.;Greenamyre,J.T.Prog.Neurobiol.1996,48,613-63.(6)Bra¨un-Osborne,H.;Egebjerg,J.;Nielsen,E.O.;Madsen,U.;Krogsgaard-Larsen,P.J.Med.Chem.2000,43,2609-2645and references therein.(7)(a)Shaw,P.J.;Ince,P.G.J.Neurol.1997,244(Suppl2),S3-S14.(b)Plaitakis,A.;Fesdjian,C.O.;Shashidharan,S Drugs1996,5,437-456.(8)Frantz,A.;Smith,A.Nat.Re V.Drug Dico V ery2003,2,9.Published on Web12/30/200310.1021/ja035671m CCC:$27.50©2004American Chemical Society J.AM.CHEM.SOC.2004,126,823-8339823There are many types of receptors able to interact with carboxylic acids and amino acids in organic solvents,10-13yielding selective complexation in some instances.However,the number of reported receptors of glutamate in aqueous solution is very scarce.In this sense,one of the few reports concerns an optical sensor based on a Zn(II)complex of a 2,2′:6′,2′′-terpyridine derivative in which L -aspartate and L -glutamate were efficiently bound as axial ligands (K s )104-105M -1)in 50/50water/methanol mixtures.14Among the receptors employed for carboxylic acid recogni-tion,the polyamine macrocycles I -IV in Chart 1are of particular relevance to this work.In a seminal paper,Lehn et al.15showed that saturated polyamines I and II could exert chain-length discrimination between different R ,ω-dicarboxylic acids as a function of the number of methylene groups between the two triamine units of the receptor.Such compounds were also able to interact with a glutamic acid derivative which has the ammonium group protected with an acyl moiety.15,16Compounds III and IV reported by Gotor and Lehn interact in their protonated forms in aqueous solution with protected N -acetyl-L -glutamate and N -acetyl-D -glutamate,showing a higher stability for the interaction with the D -isomer.17In both reports,the interaction with protected N -acetyl-L -glutamate at physiological pH yields constants of ca.3logarithmic units.Recently,we have shown that 1H -pyrazole-containing mac-rocycles present desirable properties for the binding of dopam-ine.18These polyaza macrocycles,apart from having a highpositive charge at neutral pH values,can form hydrogen bonds not only through the ammonium or amine groups but also through the pyrazole nitrogens that can behave as hydrogen bond donors or acceptors.In fact,Elguero et al.19have recently shown the ability of the pyrazole rings to form hydrogen bonds with carboxylic and carboxylate functions.These features can be used to recognize the functionalities of glutamic acid,the carboxylic and/or carboxylate functions and the ammonium group.Apart from this,the introduction of aromatic donor groups appropriately arranged within the macrocyclic framework or appended to it through arms of adequate length may contribute to the recognition event through π-cation interactions with the ammonium group of L -glutamate.π-Cation interactions are a key feature in many enzymatic centers,a classical example being acetylcholine esterase.20The role of such an interaction in abiotic systems was very well illustrated several years ago in a seminal work carried out by Dougherty and Stauffer.21Since then,many other examples have been reported both in biotic and in abiotic systems.22Taking into account all of these considerations,here we report on the ability of receptors 1[L 1]-6[L 6](Chart 2)to interact with L -glutamic acid.These receptors display structures which differ from one another in only one feature,which helps to obtain clear-cut relations between structure and interaction(9)Rebek,J.,Jr.;Askew,B.;Nemeth,D.;Parris,K.J.Am.Chem.Soc.1987,109,2432-2434.(10)Seel,C.;de Mendoza,J.In Comprehensi V e Supramolecular Chemistry ;Vogtle,F.,Ed.;Elsevier Science:New York,1996;Vol.2,p 519.(11)(a)Sessler,J.L.;Sanson,P.I.;Andrievesky,A.;Kral,V.In SupramolecularChemistry of Anions ;Bianchi,A.,Bowman-James,K.,Garcı´a-Espan ˜a,E.,Eds.;John Wiley &Sons:New York,1997;Chapter 10,pp 369-375.(b)Sessler,J.L.;Andrievsky,A.;Kra ´l,V.;Lynch,V.J.Am.Chem.Soc.1997,119,9385-9392.(12)Fitzmaurice,R.J.;Kyne,G.M.;Douheret,D.;Kilburn,J.D.J.Chem.Soc.,Perkin Trans.12002,7,841-864and references therein.(13)Rossi,S.;Kyne,G.M.;Turner,D.L.;Wells,N.J.;Kilburn,J.D.Angew.Chem.,Int.Ed.2002,41,4233-4236.(14)Aı¨t-Haddou,H.;Wiskur,S.L.;Lynch,V.M.;Anslyn,E.V.J.Am.Chem.Soc.2001,123,11296-11297.(15)Hosseini,M.W.;Lehn,J.-M.J.Am.Chem.Soc.1982,104,3525-3527.(16)(a)Hosseini,M.W.;Lehn,J.-M.Hel V .Chim.Acta 1986,69,587-603.(b)Heyer,D.;Lehn,J.-M.Tetrahedron Lett.1986,27,5869-5872.(17)(a)Alfonso,I.;Dietrich,B.;Rebolledo,F.;Gotor,V.;Lehn,J.-M.Hel V .Chim.Acta 2001,84,280-295.(b)Alfonso,I.;Rebolledo,F.;Gotor,V.Chem.-Eur.J.2000,6,3331-3338.(18)Lamarque,L.;Navarro,P.;Miranda,C.;Ara ´n,V.J.;Ochoa,C.;Escartı´,F.;Garcı´a-Espan ˜a,E.;Latorre,J.;Luis,S.V.;Miravet,J.F.J.Am.Chem.Soc .2001,123,10560-10570.(19)Foces-Foces,C.;Echevarria,A.;Jagerovic,N.;Alkorta,I.;Elguero,J.;Langer,U.;Klein,O.;Minguet-Bonvehı´,H.-H.J.Am.Chem.Soc.2001,123,7898-7906.(20)Sussman,J.L.;Harel,M.;Frolow,F.;Oefner,C.;Goldman,A.;Toker,L.;Silman,I.Science 1991,253,872-879.(21)Dougherty,D.A.;Stauffer,D.A.Science 1990,250,1558-1560.(22)(a)Sutcliffe,M.J.;Smeeton,A.H.;Wo,Z.G.;Oswald,R.E.FaradayDiscuss.1998,111,259-272.(b)Kearney,P.C.;Mizoue,L.S.;Kumpf,R.A.;Forman,J.E.;McCurdy,A.;Dougherty,D.A.J.Am.Chem.Soc.1993,115,9907-9919.(c)Bra ¨uner-Osborne,H.;Egebjerg,J.;Nielsen,E.;Madsen,U.;Krogsgaard-Larsen,P.J.Med.Chem.2000,43,2609-2645.(d)Zacharias,N.;Dougherty,D.A.Trends Pharmacol.Sci.2002,23,281-287.(e)Hu,J.;Barbour,L.J.;Gokel,G.W.J.Am.Chem.Soc.2002,124,10940-10941.Chart 1.Some Receptors Employed for Dicarboxylic Acid and N -AcetylglutamateRecognitionChart 2.New 1H -Pyrazole-Containing Polyamine Receptors Able To Complex L -Glutamate inWaterA R T I C L E SMiranda et al.824J.AM.CHEM.SOC.9VOL.126,NO.3,2004strengths.1[L1]and2[L2]differ in the N-benzylation of the pyrazole moiety,and1[L1]and3[L3]differ in the presence in the center of the polyamine side chains of an amino group or of a methylene group.The receptors4[L4]and5[L5]present the central nitrogens of the chain N-functionalized with benzyl or phenethyl groups,and6[L6]has large hydrophobic octyl groups.Results and DiscussionSynthesis of3-6.Macrocycles3-6have been obtained following the procedure previously reported for the preparation of1and2.23The method includes a first dipodal(2+2) condensation of the1H-pyrazol-3,5-dicarbaldehyde7with the corresponding R,ω-diamine,followed by hydrogenation of the resulting Schiff base imine bonds.In the case of receptor3,the Schiff base formed by condensation with1,5-pentanediamine is a stable solid(8,mp208-210°C)which precipitated in68% yield from the reaction mixture.Further reduction with NaBH4 in absolute ethanol gave the expected tetraazamacrocycle3, which after crystallization from toluene was isolated as a pure compound(mp184-186°C).In the cases of receptors4-6, the precursor R,ω-diamines(11a-11c)(Scheme1B)were obtained,by using a procedure previously described for11a.24 This procedure is based on the previous protection of the primary amino groups of1,5-diamino-3-azapentane by treatment with phthalic anhydride,followed by alkylation of the secondary amino group of1,5-diphthalimido-3-azapentane9with benzyl, phenethyl,or octyl bromide.Finally,the phthalimido groups of the N-alkyl substituted intermediates10a-10c were removed by treatment with hydrazine to afford the desired amines11a-11c,which were obtained in moderate yield(54-63%).In contrast with the behavior previously observed in the synthesis of3,in the(2+2)dipodal condensations of7with 3-benzyl-,3-phenethyl-,and3-octyl-substituted3-aza-1,5-pentanediamine11a,11b,and11c,respectively,there was not precipitation of the expected Schiff bases(Scheme1A). Consequently,the reaction mixtures were directly reduced in situ with NaBH4to obtain the desired hexaamines4-6,which after being carefully purified by chromatography afforded purecolorless oils in51%,63%,and31%yield,respectively.The structures of all of these new cyclic polyamines have been established from the analytical and spectroscopic data(MS(ES+), 1H and13C NMR)of both the free ligands3-6and their corresponding hydrochloride salts[3‚4HCl,4‚6HCl,5‚6HCl, and6‚6HCl],which were obtained as stable solids following the same procedure previously reported18for1‚6HCl and2‚6HCl.As usually occurs for3,5-disubstituted1H-pyrazole deriva-tives,either the free ligands3-6or their hydrochlorides show very simple1H and13C NMR spectra,in which signals indicate that,because of the prototropic equilibrium of the pyrazole ring, all of these compounds present average4-fold symmetry on the NMR scale.The quaternary C3and C5carbons appear together,and the pairs of methylene carbons C6,C7,and C8are magnetically equivalent(see Experimental Section).In the13C NMR spectra registered in CDCl3solution, significant differences can be observed between ligand3,without an amino group in the center of the side chain,and the N-substituted ligands4-6.In3,the C3,5signal appears as a broad singlet.However,in4-6,it almost disappears within the baseline of the spectra,and the methylene carbon atoms C6and C8experience a significant broadening.Additionally,a remark-able line-broadening is also observed in the C1′carbon signals belonging to the phenethyl and octyl groups of L5and L6, respectively.All of these data suggest that as the N-substituents located in the middle of the side chains of4-6are larger,the dynamic exchange rate of the pyrazole prototropic equilibrium is gradually lower,probably due to a relation between proto-tropic and conformational equilibria.Acid-Base Behavior.To follow the complexation of L-glutamate(hereafter abbreviated as Glu2-)and its protonated forms(HGlu-,H2Glu,and H3Glu+)by the receptors L1-L6, the acid-base behavior of L-glutamate has to be revisited under the experimental conditions of this work,298K and0.15mol dm-3.The protonation constants obtained,included in the first column of Table1,agree with the literature25and show that the zwitterionic HGlu-species is the only species present in aqueous solution at physiological pH values(Scheme2and Figure S1of Supporting Information).Therefore,receptors for(23)Ara´n,V.J.;Kumar,M.;Molina,J.;Lamarque,L.;Navarro,P.;Garcı´a-Espan˜a,E.;Ramı´rez,J.A.;Luis,S.V.;Escuder,.Chem.1999, 64,6137-6146.(24)(a)Yuen Ng,C.;Motekaitis,R.J.;Martell,A.E.Inorg.Chem.1979,18,2982-2986.(b)Anelli,P.L.;Lunazzi,L.;Montanari,F.;Quici,.Chem.1984,49,4197-4203.Scheme1.Synthesis of the Pyrazole-Containing MacrocyclicReceptorsNew1H-Pyrazole-Containing Polyamine Receptors A R T I C L E SJ.AM.CHEM.SOC.9VOL.126,NO.3,2004825glutamate recognition able to address both the negative charges of the carboxylate groups and the positive charge of ammonium are highly relevant.The protonation constants of L 3-L 6are included in Table 1,together with those we have previously reported for receptors L 1and L 2.23A comparison of the constants of L 4-L 6with those of the nonfunctionalized receptor L 1shows a reduced basicity of the receptors L 4-L 6with tertiary nitrogens at the middle of the polyamine bridges.Such a reduction in basicity prevented the potentiometric detection of the last protonation for these ligands in aqueous solution.A similar reduction in basicity was previously reported for the macrocycle with the N -benzylated pyrazole spacers (L 2).23These diminished basicities are related to the lower probability of the tertiary nitrogens for stabilizing the positive charges through hydrogen bond formation either with adjacent nonprotonated amino groups of the molecule or with water molecules.Also,the increase in the hydrophobicity of these molecules will contribute to their lower basicity.The stepwise basicity constants are relatively high for the first four protonation steps,which is attributable to the fact that these protons can bind to the nitrogen atoms adjacent to the pyrazole groups leaving the central nitrogen free,the electrostatic repulsions between them being therefore of little significance.The remaining protonation steps will occur in the central nitrogen atom,which will produce an important increase in the electrostatic repulsion in the molecule and therefore a reduction in basicity.As stated above,the tertiary nitrogen atoms present in L 4-L 6will also contribute to this diminished basicity.To analyze the interaction with glutamic acid,it is important to know the protonation degree of the ligands at physiological pH values.In Table 2,we have calculated the percentages ofthe different protonated species existing in solution at pH 7.4for receptors L 1-L 6.As can be seen,except for the receptor with the pentamethylenic chains L 3in which the tetraprotonated species prevails,all of the other systems show that the di-and triprotonated species prevail,although to different extents.Interaction with Glutamate.The stepwise constants for the interaction of the receptors L 1-L 6with glutamate are shown in Table 3,and selected distribution diagrams are plotted in Figure 1A -C.All of the studied receptors interact with glutamate forming adduct species with protonation degrees (j )which vary between 8and 0depending on the system (see Table 3).The stepwise constants have been derived from the overall association constants (L +Glu 2-+j H +)H j LGlu (j -2)+,log j )provided by the fitting of the pH-metric titration curves.This takes into account the basicities of the receptors and glutamate (vide supra)and the pH range in which a given species prevails in solution.In this respect,except below pH ca.4and above pH 9,HGlu -can be chosen as the protonated form of glutamate involved in the formation of the different adducts.Below pH 4,the participation of H 2Glu in the equilibria has also to be considered (entries 9and 10in Table 3).For instance,the formation of the H 6LGlu 4+species can proceed through the equilibria HGlu -+H 5L 5+)H 6LGlu 4+(entry 8,Table 3),and H 2Glu +H 4L 4+)H 6LGlu 4(entry 9Table 3),with percentages of participation that depend on pH.One of the effects of the interaction is to render somewhat more basic the receptor,and somewhat more acidic glutamic acid,facilitating the attraction between op-positely charged partners.A first inspection of Table 3and of the diagrams A,B,and C in Figure 1shows that the interaction strengths differ markedly from one system to another depending on the structural features of the receptors involved.L 4is the receptor that presents the highest capacity for interacting with glutamate throughout all of the pH range explored.It must also be remarked that there are not clear-cut trends in the values of the stepwise constants as a function of the protonation degree of the receptors.This suggests that charge -charge attractions do not play the most(25)(a)Martell,E.;Smith,R.M.Critical Stability Constants ;Plenum:NewYork,1975.(b)Motekaitis,R.J.NIST Critically Selected Stability Constants of Metal Complexes Database ;NIST Standard Reference Database,version 4,1997.Table 1.Protonation Constants of Glutamic Acid and Receptors L 1-L 6Determined in NaCl 0.15mol dm -3at 298.1KreactionGluL 1aL 2aL 3bL 4L 5L 6L +H )L H c 9.574(2)d 9.74(2)8.90(3)9.56(1)9.25(3)9.49(4)9.34(5)L H +H )L H 2 4.165(3)8.86(2)8.27(2)8.939(7)8.38(3)8.11(5)8.13(5)L H 2+H )L H 3 2.18(2)7.96(2) 6.62(3)8.02(1) 6.89(5)7.17(6)7.46(7)L H 3+H )L H 4 6.83(2) 5.85(4)7.63(1) 6.32(5) 6.35(6) 5.97(8)L H 4+H )L H 5 4.57(3) 3.37(4) 2.72(8) 2.84(9) 3.23(9)L H 5+H )L H 6 3.18(3) 2.27(6)∑log K H n L41.135.334.233.634.034.1aTaken from ref 23.b These data were previously cited in a short communication (ref 26).c Charges omitted for clarity.d Values in parentheses are the standard deviations in the last significant figure.Scheme 2.L -Glutamate Acid -BaseBehaviorTable 2.Percentages of the Different Protonated Species at pH 7.4H 1L aH 2LH 3LH 4LL 11186417L 21077130L 3083458L 4083458L 51154323L 6842482aCharges omitted for clarity.A R T I C L E SMiranda et al.826J.AM.CHEM.SOC.9VOL.126,NO.3,2004outstanding role and that other forces contribute very importantly to these processes.26However,in systems such as these,which present overlapping equilibria,it is convenient to use conditional constants because they provide a clearer picture of the selectivity trends.27These constants are defined as the quotient between the overall amounts of complexed species and those of free receptor and substrate at a given pH[eq1].In Figure2are presented the logarithms of the effective constants versus pH for all of the studied systems.Receptors L1and L2with a nonfunctionalized secondary amino group in the side chains display opposite trend from all other receptors. While the stability of the L1and L2adducts tends to increase with pH,the other ligands show a decreasing interaction. Additionally,L1and L2present a close interaction over the entire pH range under study.The tetraaminic macrocycle L3is a better(26)Escartı´,F.;Miranda,C.;Lamarque,L.;Latorre,J.;Garcı´a-Espan˜a,E.;Kumar,M.;Ara´n,V.J.;Navarro,mun.2002,9,936-937.(27)(a)Bianchi,A.;Garcı´a-Espan˜a,c.1999,12,1725-1732.(b)Aguilar,J.A.;Celda,B.;Garcı´a-Espan˜a,E.;Luis,S.V.;Martı´nez,M.;Ramı´rez,J.A.;Soriano,C.;Tejero,B.J.Chem.Soc.,Perkin Trans.22000, 7,1323-1328.Table3.Stability Constants for the Interaction of L1-L6with the Different Protonated Forms of Glutamate(Glu) entry reaction a L1L2L3L4L5L6 1Glu+L)Glu L 3.30(2)b 4.11(1)2HGlu+L)HGlu L 3.65(2) 4.11(1) 3.68(2) 3.38(4) 3Glu+H L)HGlu L 3.89(2) 4.48(1) 3.96(2) 3.57(4) 4HGlu+H L)H2Glu L 3.49(2) 3.89(1) 2.37(4) 3.71(2)5HGlu+H2L)H3Glu L 3.44(2) 3.73(1) 2.34(3) 4.14(2) 2.46(4) 2.61(7) 6HGlu+H3L)H4Glu L 3.33(2) 3.56(2) 2.66(3) 4.65(2) 2.74(3) 2.55(7) 7HGlu+H4L)H5Glu L 3.02(2) 3.26(2) 2.58(3) 4.77(2) 2.87(3) 2.91(5) 8HGlu+H5L)H6Glu L 3.11(3) 3.54(2) 6.76(3) 4.96(3) 4.47(3) 9H2Glu+H4L)H6Glu L 2.54(3) 3.05(2) 3.88(2) 5.35(3) 3.66(4) 3.56(3) 10H2Glu+H5L)H7Glu L 2.61(6) 2.73(4) 5.51(3) 3.57(4) 3.22(8) 11H3Glu+H4L)H7Glu L 4.82(2) 4.12(9)a Charges omitted for clarity.b Values in parentheses are standard deviations in the last significantfigure.Figure1.Distribution diagrams for the systems(A)L1-glutamic acid, (B)L4-glutamic acid,and(C)L5-glutamicacid.Figure2.Representation of the variation of K cond(M-1)for the interaction of glutamic acid with(A)L1and L3,(B)L2,L4,L5,and L6.Initial concentrations of glutamate and receptors are10-3mol dm-3.Kcond)∑[(H i L)‚(H j Glu)]/{∑[H i L]∑[H j Glu]}(1)New1H-Pyrazole-Containing Polyamine Receptors A R T I C L E SJ.AM.CHEM.SOC.9VOL.126,NO.3,2004827receptor at acidic pH,but its interaction markedly decreases on raising the pH.These results strongly suggest the implication of the central nitrogens of the lateral polyamine chains in the stabilization of the adducts.Among the N-functionalized receptors,L4presents the largest interaction with glutamate.Interestingly enough,L5,which differs from L4only in having a phenethyl group instead of a benzyl one,presents much lower stability of its adducts.Since the basicity and thereby the protonation states that L4and L5 present with pH are very close,the reason for the larger stability of the L4adducts could reside on a better spatial disposition for formingπ-cation interactions with the ammonium group of the amino acid.In addition,as already pointed out,L4presents the highest affinity for glutamic acid in a wide pH range,being overcome only by L1and L2at pH values over9.This observation again supports the contribution ofπ-cation inter-actions in the system L4-glutamic because at these pH values the ammonium functionality will start to deprotonate(see Scheme2and Figure1B).Table4gathers the percentages of the species existing in equilibria at pH7.4together with the values of the conditional constant at this pH.In correspondence with Figure1A,1C and Figure S2(Supporting Information),it can be seen that for L1, L2,L5,and L6the prevailing species are[H2L‚HGlu]+and[H3L‚HGlu]2+(protonation degrees3and4,respectively),while for L3the main species are[H3L‚HGlu]+and[H4L‚HGlu]2+ (protonation degrees4and5,respectively).The most effective receptor at this pH would be L4which joins hydrogen bonding, charge-charge,andπ-cation contributions for the stabilization of the adducts.To check the selectivity of this receptor,we have also studied its interaction with L-aspartate,which is a competitor of L-glutamate in the biologic receptors.The conditional constant at pH7.4has a value of3.1logarithmic units for the system Asp-L4.Therefore,the selectivity of L4 for glutamate over aspartate(K cond(L4-glu)/K cond(L4-asp))will be of ca.15.It is interesting to remark that the affinity of L4 for zwiterionic L-glutamate at pH7.4is even larger than that displayed by receptors III and IV(Chart1)with the protected dianion N-acetyl-L-glutamate lacking the zwitterionic charac-teristics.Applying eq1and the stability constants reported in ref17,conditional constants at pH7.4of 3.24and 2.96 logarithmic units can be derived for the systems III-L-Glu and IV-L-Glu,respectively.Molecular Modeling Studies.Molecular mechanics-based methods involving docking studies have been used to study the binding orientations and affinities for the complexation of glutamate by L1-L6receptors.The quality of a computer simulation depends on two factors:accuracy of the force field that describes intra-and intermolecular interactions,and an adequate sampling of the conformational and configuration space of the system.28The additive AMBER force field is appropriate for describing the complexation processes of our compounds,as it is one of the best methods29in reproducing H-bonding and stacking stabiliza-tion energies.The experimental data show that at pH7.4,L1-L6exist in different protonation states.So,a theoretical study of the protonation of these ligands was done,including all of the species shown in5%or more abundance in the potentiometric measurements(Table4).In each case,the more favored positions of protons were calculated for mono-,di-,tri-,and tetraprotonated species.Molecular dynamics studies were performed to find the minimum energy conformations with simulated solvent effects.Molecular modeling studies were carried out using the AMBER30method implemented in the Hyperchem6.0pack-age,31modified by the inclusion of appropriate parameters. Where available,the parameters came from analogous ones used in the literature.32All others were developed following Koll-man33and Hopfinger34procedures.The equilibrium bond length and angle values came from experimental values of reasonable reference compounds.All of the compounds were constructed using standard geometry and standard bond lengths.To develop suitable parameters for NH‚‚‚N hydrogen bonding,ab initio calculations at the STO-3G level35were used to calculate atomic charges compatible with the AMBER force field charges,as they gave excellent results,and,at the same time,this method allows the study of aryl-amine interactions.In all cases,full geometry optimizations with the Polak-Ribiere algorithm were carried out,with no restraints.Ions are separated far away and well solvated in water due to the fact that water has a high dielectric constant and hydrogen bond network.Consequently,there is no need to use counteri-ons36in the modelization studies.In the absence of explicit solvent molecules,a distance-dependent dielectric factor quali-tatively simulates the presence of water,as it takes into account the fact that the intermolecular electrostatic interactions should vanish more rapidly with distance than in the gas phase.The same results can be obtained using a constant dielectric factor greater than1.We have chosen to use a distance-dependent dielectric constant( )4R ij)as this was the method used by Weiner et al.37to develop the AMBER force field.Table8 shows the theoretical differences in protonation energy(∆E p) of mono-,bi-,and triprotonated hexaamine ligands,for the (28)Urban,J.J.;Cronin,C.W.;Roberts,R.R.;Famini,G.R.J.Am.Chem.Soc.1997,119,12292-12299.(29)Hobza,P.;Kabelac,M.;Sponer,J.;Mejzlik,P.;Vondrasek,put.Chem.1997,18,1136-1150.(30)Cornell,W.D.;Cieplak,P.;Bayly,C.I.;Gould,I.R.;Merz,K.M.,Jr.;Ferguson,D.M.;Spelmeyer,D.C.;Fox,T.;Caldwell,J.W.;Kollman,P.A.J.Am.Chem.Soc.1995,117,5179-5197.(31)Hyperchem6.0(Hypercube Inc.).(32)(a)Fox,T.;Scanlan,T.S.;Kollman,P.A.J.Am.Chem.Soc.1997,119,11571-11577.(b)Grootenhuis,P.D.;Kollman,P.A.J.Am.Chem.Soc.1989,111,2152-2158.(c)Moyna,G.;Hernandez,G.;Williams,H.J.;Nachman,R.J.;Scott,put.Sci.1997,37,951-956.(d)Boden,C.D.J.;Patenden,put.-Aided Mol.Des.1999, 13,153-166.(33)/amber.(34)Hopfinger,A.J.;Pearlstein,put.Chem.1984,5,486-499.(35)Glennon,T.M.;Zheng,Y.-J.;Le Grand,S.M.;Shutzberg,B.A.;Merz,K.M.,put.Chem.1994,15,1019-1040.(36)Wang,J.;Kollman,P.A.J.Am.Chem.Soc.1998,120,11106-11114.Table4.Percentages of the Different Protonated Adducts[HGlu‚H j L](j-1)+,Overall Percentages of Complexation,andConditional Constants(K Cond)at pH7.4for the Interaction ofGlutamate(HGlu-)with Receptors L1-L6at Physiological pH[H n L‚HGlu]an)1n)2n)3n)4∑{[H n L‚HGlu]}K cond(M-1)L13272353 2.44×103L2947763 4.12×103L31101324 3.99×102L423737581 2.04×104L51010222 3.51×102L6121224 3.64×102a Charges omitted for clarity.A R T I C L E S Miranda et al. 828J.AM.CHEM.SOC.9VOL.126,NO.3,2004。
为打翻的牛奶哭泣是没有用的英语作文
为打翻的牛奶哭泣是没有用的英语作文全文共3篇示例,供读者参考篇1Crying Over Spilled Milk Is UselessWe've all been there – you're carrying a big glass of milk to the table, being as careful as can be, and then bam! You trip over your little brother's toy car on the floor and the whole glass goes flying. Milk splatters everywhere, making a soggy mess of the kitchen floor. In that moment of horror and dismay, some kids might burst into tears. But I've learned that crying over spilled milk accomplishes nothing except wasting more time and energy. It's better to take a deep breath, clean up the mess, and move on.I remember one afternoon when I was about 8 years old, my mom asked me to take a glass of milk upstairs for my baby sister who was napping. I was so proud that she trusted me with this важно task. I carefully gripped the glass with both hands and slowly made my way up the creaky wooden stairs. Just a few steps from the top, I missed a step and started to fall forward. The milk glass slipped from my hands and seemed to defygravity for a split second before crashing onto the stairs, drenching the carpet with a huge white splatter. I felt my eyes instantly well up with tears as I took in the mess I had made.My mom came running when she heard the commotion. I braced myself for her to yell at me, but instead she just sighed and said reassuringly, "It's okay, sweetie, accidents happen. Why don't you go grab some towels from the bathroom while I get the carpet cleaner?" I nodded, doing my best to blink back the tears. As I watched her blotting up the spill, humming a little tune to herself like it was no big deal, it struck me how useless it would be to just sit there crying. Spilled milk can't be re-spilled. No amount of tears could pour that milk back into the glass. The only thing to do was to clean it up and move forward.From that day on, whenever I spilled or broke something by accident, I would take a deep breath to shake off the initial shock and remorse, and then I'd spring into action to deal with the situation. If I broke a toy, I realized crying wouldn't put it back together, so I would try to fix it with tape or glue as best I could. If I tipped over my bowl at the dinner table, causing food to go everywhere, I wouldn't dissolve into a puddle of tears and go hungry. Instead, I'd grab some paper towels and help mom wipe it up so I could still eat my meal. Essentially, I learned it wasbetter to put my energy into finding solutions rather than venting emotions that didn't change anything.This pragmatic approach to dealing with accidents and mistakes has served me well over the years. In 5th grade, I spilled a bottle of red acrylic paint all over my art project right before it was due. I felt that familiar pang of self-remorse, but I refused to cry about it. Instead, I quickly cleaned up the mess and started over on a new art project, working feverishly until I had an even better one completed with time to spare. More recently, I was pouring myself a glass of orange juice before school and managed to drop and shatter the entire glass pitcher on the tile floor. Orange juice sprayed everywhere like a small explosion. As I stood there surrounded by shards of glass and puddles of sticky juice, my first thought was, "Well, this is a great way to start my day." But after uttering a few choice words under my breath, I got the broom and started sweeping.I've found that this level-headed response extends beyond just cleaning up physical messes and mistakes too. If I accidently dismiss an important notification on my phone, crying won'tun-dismiss it so I have to find a solution. If I get a ba d grade on a test I studied hard for, crying won't change that grade so I have to focus my efforts on doing better next time. Essentially, cryingover spilled milk, whether literal or metaphorical, is a useless pouring out of emotions. It's like a car spinning its wheels –making a lot of noise and expendiding energy but going nowhere. As a pragmatist, I prefer to save my emotional energy for things I have more control over, likechoosing my attitude and mindset.Does this mean I never allow myself to feel or express emotions like sadness, frustration, disappointment or remorse? Of course not – that would be unhealthy. We all need ways to process difficult feelings in a productive way, whether it篇2Crying Over Spilled Milk is UselessWe've all been there - you're carrying a glass of milk to the table, and suddenly, it slips from your hand and shatters on the floor. The white liquid spreads out in a puddle as your heart sinks. Your first instinct might be to burst into tears over the spilled milk. But as the saying goes, crying over spilled milk is useless. It's a waste of time and energy that could be better spent cleaning up the mess and moving forward.As a student, I've learned this lesson the hard way more times than I can count. Whether it's a failed test, a rejectedapplication, or a broken relationship, life is full of little "spills" that can leave us feeling defeated and tempted to wallow in self-pity. But giving in to that urge rarely does any good. It's far more productive to take a deep breath, accept what happened, and focus on what you can control going forward.Take my experience with the dreaded chemistry midterm exam last semester. I had studied relentlessly for weeks, sacrificing sleep and a social life to master the complex material.I walked into that exam feeling confident and well-prepared. Imagine my devastation when I received my graded test back and saw a failing score glaring up at me in harsh red ink. In that moment, I wanted nothing more than to crawl into bed, pull the covers over my head, and cry for days over my shattered dreams of getting an A.But what good would that have done? Crying wouldn't have changed my grade or erased the fact that I had underperformed on the exam. The only thing I could do was pick myself up, analyze where I had gone wrong in my studying approach, and create a better plan for next time. I sought out extra tutoring, refined my note-taking methods, and approached practice problems with a renewed vigor. And in the end, I managed topull my grade up and pass the class – all because I refused to waste time and energy mourning over my spilled milk.The same principle applies to all areas of life. When you experience a setback or disappointment, whether big or small, the worst thing you can do is dwell on it unproductively. Crying, complaining, or lashing out at others solves nothing and can even create new problems. I've seen friends get so mired in self-pity over a breakup that they neglect their studies and damage other relationships. I've witnessed classmates throwing tantrums after a poor grade, alienating the very professors who could have helped them improve. These reactions are not only useless, but actively harmful.Instead, the healthiest and most effective response is to acknowledge the disappointment, feel whatever emotions come up, and then redirect your focus to what you can do to move forward in a positive direction. Spilled milk can't be un-spilled, but you can always wipe it up and pour yourself a fresh glass. Failed a test? Reflect on what went wrong and make an appointment with the professor to get back on track. Didn't get into your dream school? Explore other exciting options and make the most of wherever you end up. Lost a relationship?Grieve the loss, but don't let it consume you – focus on nurturing other treasured connections in your life.Of course, this is all easier said than done. When you're in the heat of the moment, awash in disappointment and sadness, it can be extremely difficult to pull yourself out of the negative spiral. That's when it's crucial to lean on your support system –friends, family, mentors, or counselors who can offer a compassionate ear and some tough love. Sometimes we all need that outside perspective to remind us that one spilled thing, no matter how devastating it may feel, is hardly the end of the world.I've found that maintaining a long-term, big-picture mindset also helps temper my reactions to short-term setbacks. As a student, it's easy to get hyper-focused on individual assignments, tests, and activities. But when I zoom out and consider the grand scale of my education and future goals, any one "failure" pales in significance. That chemistry midterm, for instance, will barely be a blip on the radar a few years from now when I'm pursuing my dream career. The relationships that truly matter will long outlast any high school romance. My life's journey is a long and winding road, and there are bound to be plenty of spills along the way.What matters is that I keep pushing forward, savoring the good times and learning from the rough patches.So yes, spilled milk can be disappointing and frustrating in the moment. It's okay to feel that disappointment and even shed a few tears if you need to. But then, pick yourself up, grab a towel, and get cleaning. The sooner you stop crying over the spilled milk, the sooner you can pour a fresh glass and move forward with your life. Don't waste your time and energy stuck in the past – the future is wide open and full of possibilities if you're willing to embrace them. As for me, I'll keep my head held high, learn from my mistakes, and march onward, making a point to set down my milk glasses very carefully from now on.篇3Crying Over Spilled Milk is UselessHave you ever felt that sinking feeling in your stomach when you accidentally knock over a glass and watch the milk spill out everywhere? Or maybe you've dropped a carton of eggs on the floor, watching in horror as the shells crack and the yolks ooze out. In those moments, it can be tempting to burst into tears of frustration and despair. However, as the old saying goes, "There's no use crying over spilled milk." This idiom reminds usthat it's pointless to lament over situations that can't be changed or undone. Instead of wallowing in self-pity, it's better to accept what happened, clean up the mess, and move forward.As a student, I've learned this lesson the hard way countless times. Whether it's failing an exam, missing a deadline, or experiencing a romantic rejection, life is full of disappointments and setbacks. It's only natural to feel upset or discouraged when things don't go as planned. However, dwelling on these negative emotions and dwelling on what could have been achieves nothing. All it does is waste valuable time and energy that could be better spent finding solutions or pursuing new opportunities.I vividly remember a time when I completely bombed an important test in my physics class. I had studied diligently for weeks, sacrificing sleep and social activities to cram as much information into my brain as possible. When I received my graded test back with a failing score, I felt devastated. All of my hard work seemed to have been for nothing. My first instinct was to wallow in self-pity, lamenting about how unfair the test was or how I must not be cut out for science.Fortunately, one of my closest friends snapped me out of my downward spiral. She reminded me that crying over my poor grade wouldn't change anything – the test was done, and thescore was final. Instead of dwelling on the past, she encouraged me to focus my energy on doing better next time. We scheduled a meeting with the professor to go over the material I had struggled with, and I sought out extra tutoring to solidify my understanding of the concepts.By shifting my mindset from dwelling on my failure to actively working towards improvement, I was able to turn that setback into a valuable learning experience. Not only did I end up performing much better on subsequent tests, but I also developed stronger study habits and a more resilient attitude towards academic challenges. If I had spent all my time moping over that one bad grade, I would have missed out on the opportunity to grow and improve.The same principle applies to all aspects of life, not just academics. When faced with disappointments or roadblocks, it's crucial to resist the temptation to indulge in self-pity or place blame on external factors. Instead, we should strive to accept what has happened, learn from the experience, and pivot our focus towards finding constructive solutions or pursuing new paths.This doesn't mean that we should bottle up our emotions or deny ourselves the opportunity to feel disappointed orfrustrated. It's perfectly normal and healthy to experience these feelings – they're part of what makes us human. However, we shouldn't allow ourselves to become consumed by negative emotions or dwell on them indefinitely.One strategy that has helped me deal with setbacks in a more productive manner is to allow myself a set amount of time to process and express my feelings. For instance, if I receive a poor grade on an assignment, I might give myself an hour to vent my frustrations, cry if needed, or engage in any other healthy coping mechanisms. Once that time is up, however, I make a conscious effort to shift my mindset towards finding constructive solutions, such as seeking extra help or adjusting my study methods.Another valuable lesson I've learned is the importance of maintaining perspective. While individual setbacks or disappointments can feel earth-shattering in the moment, it's crucial to remember that they are often only temporary stumbling blocks on a much larger journey. In the grand scheme of things, a single failed exam or missed opportunity is unlikely to derail your entire life or define your overall success.Reflecting on my own experiences, I can recall numerous instances where I thought a particular setback was the end of theworld, only to realize later on that it was merely a minor hiccup on my path to greater achievements. That disastrous physics test I mentioned earlier? While it felt devastating at the time, it ultimately had minimal impact on my overall academic performance or my ability to pursue my chosen career path.In fact, looking back, I'm almost grateful for experiences like that, as they taught me valuable lessons about resilience, perseverance, and the importance of maintaining a growth mindset. If everything had gone perfectly smoothly throughout my academic journey, I might not have developed the grit and determination necessary to overcome more significant challenges later in life.Of course, practicing what I preach isn't always easy. Even after all these years of learning and personal growth, I still catch myself occasionally slipping into old habits of self-pity or dwelling on past mistakes. It's an ongoing process, and there will always be situations that test my ability to maintain a positive and solution-oriented mindset.However, each time I consciously choose to accept what has happened, let go of unproductive negative emotions, and focus my energy on moving forward, I reinforce the valuable lesson that "crying over spilled milk is useless." Life is full of spills,messes, and unexpected obstacles – but it's how we respond to them that truly matters.So the next time you find yourself tempted to wallow in self-pity or despair over a setback or disappointment, take a deep breath and remind yourself of this age-old wisdom. Accept what has happened, clean up the metaphorical mess, and shift your focus towards finding constructive solutions or pursuing new opportunities. While it's perfectly normal and healthy to experience negative emotions, dwelling on them indefinitely serves no purpose and only hinders your ability to grow and move forward.Embrace a mindset of resilience, perseverance, and a willingness to learn from your mistakes and setbacks. Remember that individual stumbling blocks are often just temporary hurdles on a much larger journey, and that your overall success and fulfillment in life depend on your ability to pick yourself up, dust yourself off, and keep moving forward with determination and grace.After all, as the saying goes, "There's no use crying over spilled milk" – so why waste your time and energy doing so when you could be using those valuable resources to create a better future for yourself?。
制药工程专业英语考试题目及答案
专业英语考试内容:单词10分句子翻译24分根据课文回答问题24分英译汉药品说明书21分翻译汉译英摘要21分Unit 11 Tablet (The Pharmaceutical Tablets Dosage Form)药片(医药片剂剂型)Role in TherapyA: The oral route of drug admininistration is the most important method of administering drugs ofr systemic effects.Except in cases of Insulin therapy.the parenteral route is not routinely used for self-administration of medication.The topical route of administration has only recently been employed to deliver drugs to the body for systemic effects,with two classes of marketed products:Nitroglycerin for the treatmint of angina and scopolamine for the treatment of motion sickness.Other drugs are certain to follow,but the topical route of administration is limited in its ability to allow effective drug absorption for systemic drug action.A:口服给药是全身效应用药方法中最为重要的。
除了胰岛素治疗,非肠道药途径不常用在自我服药方面。
Fluent流体数值模拟软件中英对照
Aabort 异常中断, 中途失败, 夭折, 流产, 发育不全,中止计划[任务] accidentally 偶然地, 意外地accretion 增长activation energy 活化能active center 活性中心addition 增加adjacent 相邻的aerosol浮质(气体中的悬浮微粒,如烟,雾等), [化]气溶胶, 气雾剂, 烟雾剂Air flow circuits 气流循环ambient 周围的, 周围环境amines 胺amplitude 广阔, 丰富, 振幅, 物理学名词annular 环流的algebraic stress model(ASM) 代数应力模型algorithm 算法align 排列,使结盟, 使成一行alternately 轮流地analogy 模拟,效仿analytical solution 解析解anisotropic 各向异性的anthracite 无烟煤apparent 显然的, 外观上的,近似的approximation 近似arsenic 砷酸盐assembly 装配associate 联合,联系assume 假设assumption 假设atomization 雾化axial 轴向的Axisymmetry 轴对称的BBaffle 挡流板battlement 城垛式biography 经历bituminous coal 烟煤blow-off water 排污水blowing devices 鼓风(吹风)装置body force 体积力boiler plant 锅炉装置(车间)Boiling 沸腾Boltzmann 玻耳兹曼Bounded central differencing:有界中心差分格式Brownian rotation 布朗转动bulk 庞大的bulk density 堆积密度burner assembly 燃烧器组件burnout 燃尽Ccapability 性能,(实际)能力,容量,接受力carbon monoxide COcarbonate 碳酸盐carry-over loss 飞灰损失Cartesian 迪卡尔坐标的casing 箱,壳,套catalisis 催化channeled 有沟的,有缝的char 焦炭、炭circulation circuit 循环回路circumferential velocity 圆周速度clinkering 熔渣clipped 截尾的clipped Gaussian distribution 截尾高斯分布closure (模型的)封闭cloud of particles 颗粒云close proximity 距离很近cluster 颗粒团coal off-gas 煤的挥发气体coarse 粗糙的coarse grid 疏网格,粗网格Coatingcoaxial 同轴的coefficient of restitution 回弹系数;恢复系数coke 碳collision 碰撞competence 能力competing process 同时发生影响的competing-reactions submodel 平行反应子模型component 部分分量composition 成分computational expense 计算成本cone shape 圆锥体形状configuration 布置,构造confined flames 有界燃烧confirmation 证实, 确认, 批准Configuration 构造,外形conservation 守恒不灭conservation equation 守恒方程conserved scalars 守恒标量considerably 相当地consume 消耗contact angle 接触角contamination 污染contingency 偶然, 可能性, 意外事故, 可能发生的附带事件continuum 连续体Convection 对流converged 收敛的conveyer 输运机convolve 卷cooling duct 冷却管cooling wall 水冷壁coordinate transformation 坐标转换correlation 关联(式)correlation function 相关函数corrosion 腐蚀,锈coupling 联结, 接合, 耦合Cp:等压比热crack 裂缝,裂纹creep up (水)渗上来,蠕升critical 临界critically 精密地cross-correlation 互关联cumulative 累积的curtain wall 护墙,幕墙curve 曲线custom 习惯, 风俗, <动词单用>海关, (封建制度下)定期服劳役, 缴纳租税, 自定义, <偶用作>关税v.定制, 承接定做活的Cyan青色cyano 氰(基),深蓝,青色cyclone 旋风子,旋风,旋风筒cyclone separator 旋风分离器[除尘器]cylindrical 柱坐标的cylindrical coordinate 柱坐标Ddead zones 死区decompose 分解decouple 解藕的defy 使成为不可能Deforming:变形demography 统计Density:密度deposition 沉积derivative with respect to 对…的导数derivation 引出, 来历, 出处, (语言)语源, 词源design cycle 设计流程desposit 积灰,结垢deterministic approach 确定轨道模型deterministic 宿命的deviation 偏差devoid 缺乏devolatilization 析出挥发分,液化作用diffusion 扩散diffusivity 扩散系数digonal 二角(的), 对角的,二维的dilute 稀的diminish 减少direct numerical simulation 直接数值模拟discharge 释放discrete 离散的discrete phase 分散相, 不连续相discretization [数]离散化deselect 取消选定dispersion 弥散dissector 扩流锥dissociate thermally 热分解dissociation 分裂dissipation 消散, 分散, 挥霍, 浪费, 消遣, 放荡, 狂饮distribution of air 布风divide 除以dot line 虚线drag coefficient 牵引系数,阻力系数drag and drop 拖放drag force 曳力drift velocity 漂移速度driving force 驱[传, 主]动力droplet 液滴drum 锅筒dry-bottom-furnace 固态排渣炉dry-bottom 冷灰斗,固态排渣duct 管dump 渣坑dust-air mixture 一次风EEBU---Eddy break up 漩涡破碎模型eddy 涡旋effluent 废气,流出物elastic 弹性的electro-staic precipitators 静电除尘器emanate 散发, 发出, 发源,[罕]发散, 放射embrasure 喷口,枪眼emissivity [物]发射率empirical 经验的endothermic reaction 吸热反应enhance 增,涨enlarge 扩大ensemble 组,群,全体enthalpy 焓entity 实体entrain 携带,夹带entrained-bed 携带床Equation 方程equilibrate 保持平衡equilibrium 化学平衡ESCIMO-----Engulfment(卷吞)Stretching(拉伸)Coherence(粘附)Interdiffusion-interaction(相互扩散和化学反应)Moving-observer(运动观察者)exhaust 用尽, 耗尽, 抽完, 使精疲力尽排气排气装置用不完的, 不会枯竭的exit 出口,排气管exothermic reaction 放热反应expenditure 支出,经费expertise 经验explicitly 明白地, 明确地extinction 熄灭的extract 抽出,提取evaluation 评价,估计,赋值evaporation 蒸发(作用)Eulerian approach 欧拉法Ffacilitate 推动,促进factor 把…分解fast chemistry 快速化学反应fate 天数, 命运, 运气,注定, 送命,最终结果feasible 可行的,可能的feed pump 给水泵feedstock 填料Filling 倒水fine grid 密网格,细网格finite difference approximation 有限差分法flamelet 小火焰单元flame stability 火焰稳定性flow pattern 流型fluctuating velocity 脉动速度fluctuation 脉动,波动flue 烟道(气)flue duck 烟道fluoride 氟化物fold 夹层块forced-and-induced draft fan 鼓引风机forestall 防止Formulation:公式,函数fouling 沾污fraction 碎片部分,百分比fragmentation 破碎fuel-lean flamefuel-rich regions 富燃料区,浓燃料区fuse 熔化,熔融Ggas duct 烟道gas-tight 烟气密封gasification 气化(作用)gasifier 气化器Gauge 厚度,直径,测量仪表,估测。
化学专业英语-马永祥-兰州大学
ContentsTHE ELEMENTS AND THE PERIODIC TABLE01. ......................................................- 3 -THE NONMETAL ELEMENTS02. ..................................................................................- 5 -GROUPS IB AND IIB ELEMENTS03. ............................................................................- 7 -GROUPS IIIB—VIIIB ELEMENTS04. ............................................................................- 9 -INTERHALOGEN AND NOBLE GAS COMPOUNDS05. ...........................................- 11 -06. ....................................- 13 -THE CLASSIFICATION OF INORGANIC COMPOUNDSTHE NOMENCLATURE OF INORGANIC COMPOUNDS07. ....................................- 15 -BRONSTED'S AND LEWIS' ACID-BASE CONCEPTS08. ..........................................- 19 -09. ..........................................................................- 22 -THE COORDINATION COMPLEXALKANES10. ..................................................................................................................- 25 -11. .............................................................................- 28 -UNSATURATED COMPOUNDSTHE NOMENCLATURE OF CYCLIC HYDROCARBONS12. ...................................- 30 -SUBSTITUTIVE NOMENCLATURE13. .......................................................................- 33 -14. .......................................................- 37 -THE COMPOUNDS CONTAINING OXYGENPREPARATION OF A CARBOXYLiC ACID BY THE GRIGNARD METHOD15. ..- 39 -THE STRUCTURES OF COVALENT COMPOUNDS16. ............................................- 41 -OXIDATION AND REDUCTION IN ORGANIC CHEMISTRY17. ............................- 44 -SYNTHESIS OF ALCOHOLS AND DESIGN OF ORGANIC SYNTHESIS18. ..........- 47 -ORGANOMETALLICS—METAL π COMPLEXES19. ................................................- 49 -THE ROLE OF PROTECTIVE GROUPS IN ORGANIC SYNTHESIS20. ...................- 52 -ELECTROPHILIC REACTIONS OF AROMATIC COMPOUNDS21. ........................- 54 -POLYMERS22. ................................................................................................................- 57 -ANALYTICAL CHEMISTRY AND PROBLEMS IN SOCIETY23. ............................- 61 -VOLUMETRIC ANALYSIS24. ......................................................................................- 63 -QUALITATIVE ORGANIC ANALYSIS25. ..................................................................- 65 -VAPOR-PHASE CHROMATOGRAPHY26. .................................................................- 67 -INFRARED SPECTROSCOPY27. ..................................................................................- 70 -NUCLEAR MAGNETIC RESONANCE (I)28. ..............................................................- 72 -NUCLEAR MAGNETIC RESONANCE(II)29. ..............................................................- 75 -A MAP OF PHYSICAL CHEMISTRY30. ......................................................................- 77 -THE CHEMICAL THERMODYNAMICS31. ................................................................- 79 -CHEMICAL EQUILIBRIUM AND KINETICS32. ........................................................- 82 -THE RATES OF CHEMICAL REACTIONS33. ............................................................- 85 -NATURE OF THE COLLOIDAL STATE34. .................................................................- 88 -ELECTROCHEMICAL CELLS35. .................................................................................- 90 -BOILING POINTS AND DISTILLATION36. ...............................................................- 93 -EXTRACTIVE AND AZEOTROPIC DISTILLATION37. ............................................- 96 -CRYSTALLIZATION38. ................................................................................................- 98 -39. ...................................................................................- 100 -MATERIAL ACCOUNTINGTHE LITERATURE MATRIX OF CHEMISTRY40. ...................................................- 102 -01. THE ELEMENTS AND THE PERIODIC TABLEThe number of protons in the nucleus of an atom is referred to as the atomic number, or proton number, Z. The number of electrons in an electrically neutral atom is also equal to the atomic number, Z. The total mass of an atom is determined very nearly by the total number of protons and neutrons in its nucleus. This total is called the mass number, A. The number of neutrons in an atom, the neutron number, is given by the quantity A-Z.The term element refers to, a pure substance with atoms all of a single kind. To the chemist the "kind" of atom is specified by its atomic number, since this is the property that determines its chemical behavior. At present all the atoms from Z = 1 to Z = 107 are known; there are 107 chemical elements. Each chemical element has been given a name and a distinctive symbol. For most elements the symbol is simply the abbreviated form of the English name consisting of one or two letters, for example:oxygen==O nitrogen ==N neon==Ne magnesium ==MgSome elements,which have been known for a long time,have symbols based on their Latin names, for example: iron==Fe(ferrum) copper==Cu(cuprum) lead==Pb(plumbum)A complete listing of the elements may be found in Table 1.Beginning in the late seventeenth century with the work of Robert Boyle, who proposed the presently accepted concept of an element, numerous investigations produced a considerable knowledge of the properties of elements and their compounds1. In 1869, D.Mendeleev and L. Meyer, working independently, proposed the periodic law. In modern form, the law states that the properties of the elements are periodic functions of their atomic numbers. In other words, when the elements are listed in order of increasing atomic number, elements having closely similar properties will fall at definite intervals along the list. Thus it is possible to arrange the list of elements in tabular form with elements having similar properties placed in vertical columns2. Such an arrangement is called a periodic Each horizontal row of elements constitutes a period. It should be noted that the lengths of the periods vary. There is a very short period containing only 2 elements, followed by two short periods of 8 elements each, and then two long periods of 18 elements each. The next period includes 32 elements, and the last period is apparently incomplete. With this arrangement, elements in the same vertical column have similar characteristics. These columns constitute the chemical families or groups. The groups headed by the members of the two 8-element periods are designated as main group elements, and the members of the other groups are called transition or inner transition elements.In the periodic table, a heavy stepped line divides the elements into metals and nonmetals. Elements to the left of this line (with the exception of hydrogen) are metals, while those to the right are nonmetals. This division is for convenience only; elements bordering the line—the metalloids-have properties characteristic of - both metals and nonmetals. It may be seen that most of the elements, including all the transition and inner transition elements, are metals.Except for hydrogen, a gas, the elements of group IA make up the alkali metal family. They are very reactive metals, and they are never found in the elemental state in nature. However, their compounds are widespread. All the members of the alkali metal family, form ions having a charge of 1+ only. In contrast, the elements of group IB —copper, silver, and gold—are comparatively inert. They are similar to the alkali metals in that they exist as 1+ ions in many of their compounds. However, as is characteristic of most transition elements, they form ions having other charges as well.The elements of group IIA are known as the alkaline earth metals. Their characteristic ionic charge is 2+. These metals, particularly the last two members of the group, are almost as reactive as the alkali metals. The group IIB elements—zinc, cadmium, and mercury are less reactive than are those of group II A5, but are more reactive than the neighboring elements of group IB. The characteristic charge on their ions is also 2+.With the exception of boron, group IIIA elements are also fairly reactive metals. Aluminum appears to be inert toward reaction with air, but this behavior stems from the fact that the metal forms a thin, invisible film of aluminum oxide on the surface, which protects the bulk of the metal from further oxidation. The metals of group IIIA form ions of 3+ charge. Group IIIB consists of the metals scandium, yttrium, lanthanum, and actinium.Group IVA consists of a nonmetal, carbon, two metalloids, silicon and germanium, and two metals, tin and lead. Each of these elements forms some compounds with formulas which indicate that four other atoms are present per group IVA atom, as, for example, carbon tetrachloride, GCl4. The group IVB metals —titanium, zirconium, and hafnium —also forms compounds in which each group IVB atom is combined with four other atoms; these compounds are nonelectrolytes when pure.The elements of group V A include three nonmetals — nitrogen, phosphorus, and arsenic—and two metals — antimony and bismuth. Although compounds with the formulas N2O5, PCl5, and AsCl5 exist, none of them is ionic. These elements do form compounds-nitrides, phosphides, and arsenides — in which ions having charges of minus three occur. The elements of group VB are all metals. These elements form such a variety of different compounds that their characteristics are not easily generalized.With the exception of polonium, the elements of group VIA are typical nonmetals. They are sometimes known, as the, chalcogens, from the Greek word meaning "ash formers". In their binary compounds with metals they exist as ions having a charge of 2-. The elements of group ⅦA are all nonmetals and are known as the halogens. from the Greek term meaning "salt formers.” They are the most reactive nonmetals and are capable of reacting with practically all the metals and with most nonmetals, including each other.The elements of groups ⅥB, ⅦB, and VIIIB are all metals. They form such a wide Variety of compounds that it is not practical at this point to present any examples as being typical of the behavior of the respective groups.The periodicity of chemical behavior is illustrated by the fact that. excluding the first period, each period begins with a very reactive metal. Successive element along the period show decreasing metallic character, eventually becoming nonmetals, and finally, in group ⅦA, a very reactive nonmetal is found. Each period ends with a member of the noble gas family.02. THE NONMETAL ELEMENTSWe noted earlier. that -nonmetals exhibit properties that are greatly different from those of the metals. As a rule, the nonmetals are poor conductors of electricity (graphitic carbon is an exception) and heat; they are brittle, are often intensely colored, and show an unusually wide range of melting and boiling points. Their molecular structures, usually involving ordinary covalent bonds, vary from the simple diatomic molecules of H2, Cl2, I2, and N2 to the giant molecules of diamond, silicon and boron.The nonmetals that are gases at room temperature are the low-molecular weight diatomic molecules and the noble gases that exert very small intermolecular forces. As the molecular weight increases, we encounter a liquid (Br2) and a solid (I2) whose vapor pressures also indicate small intermolecular forces. Certain properties of a few nonmetals are listed in Table 2.Table 2- Molecular Weights and Melting Points of Certain NonmetalsDiatomic Molecules MolecularWeightMelting Point°CColorH22-239.1'NoneN228-210NoneF238-223Pale yellowO232-218Pale blueCl271-102Yellow — greenBr2160-7.3Red — brownI2254113Gray—blackSimple diatomic molecules are not formed by the heavier members of Groups V and VI at ordinary conditions. This is in direct contrast to the first members of these groups, N2 and O2. The difference arises because of the lower stability of πbonds formed from p orbitals of the third and higher main energy levels as opposed to the second main energy level2. The larger atomic radii and more dense electron clouds of elements of the third period and higher do not allow good parallel overlap of p orbitals necessary for a strong πbond. This is a general phenomenon — strong π bonds are formed only between elements of the second period. Thus, elemental nitrogen and oxygen form stable molecules with both σand π bonds, but other members of their groups form more stable structures based on σbonds only at ordinary conditions. Note3 that Group VII elements form diatomic molecules, but πbonds are not required for saturation of valence.Sulfur exhibits allotropic forms. Solid sulfur exists in two crystalline forms and in an amorphous form. Rhombic sulfur is obtained by crystallization from a suitable solution, such as CS2, and it melts at 112°C. Monoclinic sulfur is formed by cooling melted sulfur and it melts at 119°C. Both forms of crystalline sulfur melt into S-gamma, which is composed of S8 molecules. The S8 molecules are puckered rings and survive heating to about 160°C. Above 160°C, the S8 rings break open, and some of these fragments combine with each other to form a highly viscous mixture of irregularly shaped coils. At a range of higher temperatures the liquid sulfur becomes so viscous that it will not pourfrom its container. The color also changes from straw yellow at sulfur's melting point to a deep reddish-brown as it becomes more viscous.As4 the boiling point of 444 °C is approached, the large-coiled molecules of sulfur are partially degraded and the liquid sulfur decreases in viscosity. If the hot liquid sulfur is quenched by pouring it into cold water, the amorphous form of sulfur is produced. The structure of amorphous sulfur consists of large-coiled helices with eight sulfur atoms to each turn of the helix; the overall nature of amorphous sulfur is described as3 rubbery because it stretches much like ordinary rubber. In a few hours the amorphous sulfur reverts to small rhombic crystals and its rubbery property disappears.Sulfur, an important raw material in industrial chemistry, occurs as the free element, as SO2 in volcanic regions, asH2S in mineral waters, and in a variety of sulfide ores such as iron pyrite FeS2, zinc blende ZnS, galena PbS and such, and in common formations of gypsum CaSO4 • 2H2O, anhydrite CaSO4, and barytes BaSO4 • 2H2O. Sulfur, in one form or another, is used in large quantities for making sulfuric acid, fertilizers, insecticides, and paper.Sulfur in the form of SO2 obtained in the roasting of sulfide ores is recovered and converted to sulfuric acid, although in previous years much of this SO2 was discarded through exceptionally tall smokestacks. Fortunately, it is now economically favorable to recover these gases, thus greatly reducing this type of atmospheric pollution. A typical roasting reaction involves the change:2 ZnS +3 O2—2 ZnO + 2 SO2Phosphorus, below 800℃ consists of tetratomic molecules, P4. Its molecular structure provides for a covalence of three, as may be expected from the three unpaired p electrons in its atomic structure, and each atom is attached to three others6. Instead of a strictly orthogonal orientation, with the three bonds 90° to each other, the bond angles are only 60°. This supposedly strained structure is stabilized by the mutual interaction of the four atoms (each atom is bonded to the other three), but it is chemically the most active form of phosphorus. This form of phosphorus, the white modification, is spontaneously combustible in air. When heated to 260°C it changes to red phosphorus, whose structure is obscure. Red phosphorus is stable in air but, like all forms of phosphorus, it should be handled carefully because of its tendency to migrate to the bones when ingested, resulting in serious physiological damage.Elemental carbon exists in one of two crystalline structures — diamond and graphite. The diamond structure, based on tetrahedral bonding of hybridized sp3orbitals, is encountered among Group IV elements. We may expect that as the bond length increases, the hardness of the diamond-type crystal decreases. Although the tetrahedral structure persists among the elements in this group — carbon, silicon, germanium, and gray tin — the interatomic distances increase from 1.54 A for carbon to 2.80 A for gray tin. Consequently .the bond strengths among the four elements range from very strong to quite weak. In fact, gray tin is so soft that it exists in the form of microcrystals or merely as a powder. Typical of the Group IV diamond-type crystalline elements, it is a nonconductor and shows other nonmetallic properties7.03. GROUPS IB AND IIB ELEMENTSPhysical properties of Group IB and IIBThese elements have a greater bulk use as metals than in compounds, and their physical properties vary widely.Gold is the most malleable and ductile of the metals. It can be hammered into sheets of 0.00001 inch in thickness; one gram of the metal can be drawn into a wire 1.8 mi in length1. Copper and silver are also metals that are mechanically easy to work. Zinc is a little brittle at ordinary temperatures, but may be rolled into sheets at between 120° to 150℃; it becomes brittle again about 200℃-The low-melting temperatures of zinc contribute to the preparation of zinc-coated iron .galvanized iron; clean iron sheet may be dipped into vats of liquid zinc in its preparation. A different procedure is to sprinkle or air blast zinc dust onto hot iron sheeting for a zinc melt and then coating.Cadmium has specific uses because of its low-melting temperature in a number of alloys. Cadmium rods are used in nuclear reactors because the metal is a good neutron absorber.Mercury vapor and its salts are poisonous, though the free metal may be taken internally under certain conditions. Because of its relatively low boiling point and hence volatile nature, free mercury should never be allowed to stand in an open container in the laboratory. Evidence shows that inhalation of its vapors is injurious.The metal alloys readily with most of the metals (except iron and platinum) to form amalgams, the name given to any alloy of mercury.Copper sulfate, or blue vitriol (CuSO4 • 5H2O) is the most important and widely used salt of copper. On heating, the salt slowly loses water to form first the trihydrate (CuSO4 • 3H z O), then the monohydrate (CuSO4 • H2O), and finally the white anhydrous salt. The anhydrous salt is often used to test for the presence of water in organic liquids. For example, some of the anhydrous copper salt added to alcohol (which contains water) will turn blue because of the hydration of the salt.Copper sulfate is used in electroplating. Fishermen dip their nets in copper sulfate solution to inhibit the growth of organisms that would rot the fabric. Paints specifically formulated for use on the bottoms of marine craft contain copper compounds to inhibit the growth of barnacles and other organisms.When dilute ammonium hydroxide is added" to a solution of copper (I) ions, a greenish precipitate of Cu(OH)2 or a basic copper(I) salt is formed. This dissolves as more ammonium hydroxide is added. The excess ammonia forms an ammoniated complex with the copper (I) ion of the composition, Cu(NH3)42+. This ion is only slightly dissociated; hence in an ammoniacal solution very few copper (I) ions are present. Insoluble copper compounds, execpt copper sulfide, are dissolved by ammonium hydroxids. The formation of the copper (I) ammonia ion is often used as a test for Cu2+ because of its deep, intense blue color.Copper (I) ferrocyanide [Cu2Fe(CN)6] is obtained as a reddish-brown precipitate on the addition of a soluble ferrocyanide to a solution of copper ( I )ions. The formation of this salt is also used as a test for the presence of copper (I) ions.Compounds of Silver and GoldSilver nitrate, sometimes called lunar caustic, is the most important salt of silver. It melts readily and may be cast into sticks for use in cauterizing wounds. The salt is prepared by dissolving silver in nitric acid and evaporating the solution.3Ag + 4HNO3—3AgNO3 + NO + 2H2OThe salt is the starting material for most of the compounds of silver, including the halides used in photography. It is readily reduced by organic reducing agents, with the formation of a black deposit of finely divided silver; this action is responsible for black spots left on the fingers from the handling of the salt. Indelible marking inks and pencils take advantage of this property of silver nitrate.The halides of silver, except the fluoride, are very insoluble compounds and may be precipitated by the addition of a solution of silver salt to a solution containing chloride, bromide, or iodide ions.The addition of a strong base to a solution of a silver salt precipitates brown silver oxide (Ag2G). One might expect the hydroxide of silver to precipitate, but it seems likely that silver hydroxide is very unstable and breaks down into the oxide and water — if, indeed, it is ever formed at all3. However, since a solution of silver oxide js definitely basic, there must be hydroxide ions present in solution.Ag2O + H2O = 2Ag+ + 2OH-Because of its inactivity, gold forms relatively few compounds. Two series of compounds are known — monovalent and trivalent. Monovalent (aurous) compounds resemble silver compounds (aurous chloride is water insoluble and light sensitive), while the higher valence (auric) compounds tend to form complexes. Gold is resistant to the action of most chemicals —air, oxygen, and water have no effect. The common acids do not attack the metal, but a mixture of hydrochloric and nitric acids (aqua regia) dissolves it to form gold( I ) chloride or chloroauric acid. The action is probably due to free chlorine present in the aqua regia.3HCl + HNO3----→ NOCl+Cl2 + 2H2O2Au + 3Cl2 ----→ 2AuCl3AuCl3+HCl----→ HAuCl4chloroauric acid (HAuCl4-H2O crystallizes from solution).Compounds of ZincZinc is fairly high in the activity series. It reacts readily with acids to produce hydrogen and displaces less active metals from their salts. 1 he action of acids on impure zinc is much more rapid than on pure zinc, since bubbles of hydrogen gas collect on the surface of pure zinc and slow down the action. If another metal is present as an impurity, the hydrogen is liberated from the surface of the contaminating metal rather than from the zinc. An electric couple to facilitate the action is probably Set up between the two metals.Zn + 2H+----→ Zn2+ + H2Zinc oxide (ZnO), the most widely used zinc compound, is a white powder at ordinary temperatures, but changes to yellow on heating. When cooled, it again becomes white. Zinc oxide is obtained by burning zinc in air, by heating the basic carbonate, or by roasting the sulfide. The principal use of ZnO is as a filler in rubber manufacture, particularly in automobile tires. As a body for paints it has the advantage over white lead of not darkening on exposure to an atmosphere containing hydrogen sulfide. Its covering power, however, is inferior to that of white lead.04. GROUPS IIIB—VIIIB ELEMENTSGroup I-B includes the elements scandium, yttrium, lanthanum, and actinium1, and the two rare-earth series of fourteen elements each2 —the lanthanide and actinide series. The principal source of these elements is the high gravity river and beach sands built up by a water-sorting process during long periods of geologic time. Monazite sand, which contains a mixture of rare earth phosphates, and an yttrium silicate in a heavy sand are now commercial sources of a number of these scarce elements.Separation of the elements is a difficult chemical operation. The solubilities of their compounds are so nearly alike that a separation by fractional crystallization is laborious and time-consuming. In recent years, ion exchange resins in high columns have proved effective. When certain acids are allowed to flow down slowly through a column containing a resin to which ions of Group III B metals are adsorbed, ions are successively released from the resin3. The resulting solution is removed from the bottom of the column or tower in bands or sections. Successive sections will contain specific ions in the order of release by the resin. For example .lanthanum ion (La3+) is most tightly held to the resin and is the last to be extracted, lutetium ion (Lu3+) is less tightly held and appears in one of the first sections removed. If the solutions are recycled and the acid concentrations carefully controlled, very effective separations can be accomplished. Quantities of all the lanthanide series (except promethium, Pm, which does not exist in nature as a stable isotope) are produced for the chemical market.The predominant group oxidation number of the lanthanide series is +3, but some of the elements exhibit variable oxidation states. Cerium forms cerium( III )and cerium ( IV ) sulfates, Ce2 (SO4 )3 and Ce(SO4 )2, which are employed in certain oxidation-reduction titrations. Many rare earth compounds are colored and are paramagnetic, presumably as a result of unpaired electrons in the 4f orbitals.All actinide elements have unstable nuclei and exhibit radioactivity. Those with higher atomic numbers have been obtained only in trace amounts. Actinium (89 Ac), like lanthanum, is a regular Group IIIB element.Group IVB ElementsIn chemical properties these elements resemble silicon, but they become increasingly more metallic from titanium to hafnium. The predominant oxidation state is +4 and, as with silica (SiO2), the oxides of these elements occur naturally in small amounts. The formulas and mineral names of the oxides are TiO2, rutile; ZrO2, zirconia; HfO2, hafnia. Titanium is more abundant than is usually realized. It comprises about 0.44%of the earth's crust. It is over 5.0%in average composition of first analyzed moon rock. Zirconium and titanium oxides occur in small percentages in beach sands.Titanium and zirconium metals are prepared by heating their chlorides with magnesium metal. Both are particularly resistant to corrosion and have high melting points.Pure TiO2 is a very white substance which is taking the place of white lead in many paints. Three-fourths of the TiO2 is used in white paints, varnishes, and lacquers. It has the highest index of refraction (2.76) and the greatest hiding power of all the common white paint materials. TiO2 also is used in the paper, rubber, linoleum, leather, and textile industries.Group VB Elements: Vanadium, Niobium, and TantalumThese are transition elements of Group VB, with a predominant oxidation number of + 5. Their occurrence iscomparatively rare.These metals combine directly with oxygen, chlorine, and nitrogen to form oxides, chlorides, and nitrides, respectively. A small percentage of vanadium alloyed with steel gives a high tensile strength product which is very tough and resistant to shock and vibration. For this reason vanadium alloy steels are used in the manufacture ofhigh-speed tools and heavy machinery. Vanadium oxide is employed as a catalyst in the contact process of manufacturing sulfuric acid. Niobium is a very rare element, with limited use as an alloying element in stainless steel. Tantalum has a very high melting point (2850 C) and is resistant to corrosion by most acids and alkalies.Groups VIB and VIIB ElementsChromium, molybdenum, and tungsten are Group VIB elements. Manganese is the only chemically important element of Group VIIB. All these elements exhibit several oxidation states, acting as metallic elements in lower oxidation states and as nonmetallic elements in higher oxidation states. Both chromium and manganese are widely used in alloys, particularly in alloy steels.Group VIIIB MetalsGroup VIIIB contains the three triads of elements. These triads appear at the middle of long periods of elements in the periodic table, and are members of the transition series. The elements of any given horizontal triad have many similar properties, but there are marked differences between the properties of the triads, particularly between the first triad and the other two. Iron, cobalt, and nickel are much more active than members of the other two triads, and are also much more abundant in the earth's crust. Metals of the second and third triads, with many common properties, are usually grouped together and called the platinum metals.These elements all exhibit variable oxidation states and form numerous coordination compounds.CorrosionIron exposed to the action of moist air rusts rapidly, with the formation of a loose, crumbly deposit of the oxide. The oxide does not adhere to the surface of the metal, as does aluminum oxide and certain other metal oxides, but peelsoff .exposing a fresh surface of iron to the action of the air. As a result, a piece of iron will rust away completely in a relatively short time unless steps are taken to prevent the corrosion. The chemical steps in rusting are rather obscure, but it has been established that the rust is a hydrated oxide of iron, formed by the action of both oxygen and moisture, and is markedly speeded up by the presence of minute amounts of carbon dioxide5.Corrosion of iron is inhibited by coating it with numerous substances, such as paint, an aluminum powder gilt, tin, or organic tarry substances or by galvanizing iron with zinc. Alloying iron with metals such as nickel or chromium yields a less corrosive steel. "Cathodic protection" of iron for lessened corrosion is also practiced. For some pipelines and standpipes zinc or magnesium rods in the ground with a wire connecting them to an iron object have the following effect: with soil moisture acting as an electrolyte for a Fe — Zn couple the Fe is lessened in its tendency to become Fe2+. It acts as a cathode rather than an anode.。
情感情绪的英语
情感情绪的英语Emotions and feelings are an integral part of human experience, and they play a significant role in our daily lives. Understanding and expressing these emotions in English can be both simple and complex, depending on the context and the depth of emotional expression required. Here's a breakdown of some key terms and phrases related to emotions in English:1. Basic Emotions: These are the most fundamental emotions that are universally recognized.- Happy: "I'm feeling happy today."- Sad: "She looked sad when she heard the news."- Angry: "He was angry about the situation."- Scared: "The child was scared of the dark."- Surprised: "I was surprised by the sudden noise."2. Intense Emotions: These are more powerful feelings that can overwhelm or deeply affect a person.- Ecstatic: "Winning the lottery made him ecstatic."- Furious: "She was furious at the unfair treatment."- Terrified: "The thought of public speaking terrifies me."- Heartbroken: "He was heartbroken after the breakup."3. Mixed Emotions: Sometimes people experience a blend of emotions, which can be confusing.- Bittersweet: "Saying goodbye to my friends was abittersweet moment."- Confused: "I felt confused about my feelings towards him."- Overwhelmed: "The sudden change left me feeling overwhelmed."4. Emotional Expressions: These are phrases used to describe how someone is showing their emotions.- Burst into tears: "She burst into tears when she saw the surprise."- Break down: "He broke down after the long period of stress."- Smile: "She smiled warmly when she saw her old friends." - Frown: "He frowned at the bad news."5. Emotional States: These terms describe the general condition or mood of a person.- Depressed: "The patient has been in a state of depression."- Content: "She seemed content with her life."- Anxious: "He was anxious about the upcoming exam."6. Emotional Intelligence: This refers to the ability to understand and manage one's own emotions and the emotions of others.- Empathetic: "Being empathetic is an important aspect of emotional intelligence."- Compassionate: "A compassionate person can comfort others in their time of need."7. Emotional Support: This is the act of providing comfortand understanding to someone who is experiencing emotional distress.- Console: "She consoled her friend after the loss."- Support: "He offered emotional support to his partner during the difficult time."8. Emotional Vocabulary: Expanding your emotional vocabulary can help you express yourself more accurately.- Elated: "She was elated with her performance."- Dismayed: "He was dismayed by the outcome."9. Emotional Triggers: Certain situations or stimuli can provoke strong emotional reactions.- Trigger: "The loud noise was a trigger for her anxiety."10. Managing Emotions: Learning to manage one's emotions is a critical life skill.- Calm down: "Take a deep breath and try to calm down." - Express: "It's important to express your emotions in a healthy way."Understanding these terms and how to use them can help you communicate your emotions more effectively in English. It's also important to recognize that emotions are a normal part of life and that expressing them appropriately is key to maintaining good mental health and relationships.。
《学科英语》 华为单元答案
U n i t1预习练习参考答案Passage 11. 科学知识2. 实践知识3. 应用科学4. 科学原理5. 操作条件6. 预期功能7. 机械原理8. 民用建筑9. 技术学科10. 分支学科11. 基础设施12. 制造工程1. scientific knowledge2. practical knowledge3. applied science4. scientific principle5. operating condition6. intended function7. mechanical principle8. civilian structure9. technical discipline10. sub-discipline11. infrastructure12. manufacturing engineeringTask 11. Tissue engineering has been a newly developed _________ which represents the new direction of biological medicine engineering.disciplinea branch of knowledge组织工程学是一门新兴的学科,它代表了生物医学工程领域发展的新方向。
2. What sort of preferential policies can foreign investors in software and integrated _________ industry enjoy?circuitan electrical device that provides a path for electrical current to flow外商投资软件产业和集成电路产业能享受何种优惠政策?3. NC machine tools are difficult to _________ and often result in heavy economic losses when they go wrong due to the high prices.maintainkeep in a certain state数控机床由于价格昂贵,一旦出现故障,维修困难,常带来较大的经济损失。
pangea 用法 -回复
pangea 用法-回复Pangea is a supercontinent that existed approximately 335 million years ago. It was formed by the collision and fusion of several smaller land masses, including what we now know as North America, South America, Africa, Europe, and Asia. Pangea's existence had a significant impact on the Earth's geology, climate, and the evolution of life forms. In this article, we will explore the usage and significance of the term "Pangea" in various scientific disciplines.The term "Pangea" was first proposed by the German meteorologist Alfred Wegener in the early 20th century. Wegener noticed that the coastlines of Africa and South America seemed to fit together like puzzle pieces, suggesting that they were once part of a larger landmass. He also observed similar geological formations and fossil records on these continents, further supporting his theory of continental drift.Continental drift is the movement of Earth's continents over time due to the motion of tectonic plates. In the case of Pangea, Wegener hypothesized that all the continents were once connected in a supercontinent and had since drifted apart. This theoryrevolutionized our understanding of Earth's geological history and laid the foundation for the modern theory of plate tectonics.Plate tectonics is the scientific theory that explains the movement of Earth's lithosphere, which is broken into several rigid plates. These plates float on top of the underlying semi-fluid asthenosphere and interact with each other at their boundaries. The boundaries can be classified as convergent, divergent, or transform, based on the direction of plate motion.Convergent boundaries occur when two plates collide. This collision can result in one plate being forced beneath the other, a process known as subduction. During the formation of Pangea, several such collisions occurred, leading to the fusion of the landmasses.Divergent boundaries, on the other hand, are formed when two plates move away from each other. This process leads to the creation of new crust and the formation of mid-ocean ridges. These boundaries played a crucial role in the breakup of Pangea, as the newly formed crust pushed the continents apart.Transform boundaries occur when two plates slide past each other horizontally. These boundaries are responsible for the formation of faults and can result in the occurrence of earthquakes. They also had a role to play in the breakup of Pangea, as the lateral movement of the plates further contributed to the separation of landmasses.The breakup of Pangea had a profound impact on Earth's climate and the evolution of life forms. As the supercontinent split apart, new oceans formed, reshaping global oceanic and atmospheric circulation patterns. This change in climate led to the extinction of certain species and the emergence of new ecological niches.The separation of the continents also resulted in the isolation of various plant and animal populations. This isolation allowed for the independent evolution of species in different parts of the world, leading to the development of unique ecosystems. For example, the marsupials in Australia and the lemurs in Madagascar are believed to have evolved from common ancestors that were once part of Pangea.Furthermore, the breakup of Pangea created new mountain rangesand geological features. The Appalachian Mountains in North America and the Atlas Mountains in Africa are believed to have formed during this period. These geological formations provide important insights into the Earth's dynamic history.In conclusion, Pangea is a term used to describe the supercontinent that existed 335 million years ago. The concept of Pangea and its breakup are instrumental in our understanding of plate tectonics, continental drift, and Earth's geological history. This knowledge has significant implications for climate dynamics, species evolution, and the formation of geological features. Pangea continues to be studied by scientists from various disciplines, shedding light on the Earth's past and helping us comprehend its future.。
分手了想复合该小英语作文
分手了想复合该小英语作文The Agony of Lost Love and the Redemption of Reconciliation.In the realm of human emotion, where love blossoms and hearts intertwine, the prospect of separation casts an ominous shadow. When two souls decide to part ways, a profound void is left in their wake. The pain of a broken heart is an undeniable torment, a soul-wrenching ache that permeates every fiber of one's being.For those who have experienced the trauma of a breakup, the yearning for reconciliation often becomes an all-consuming obsession. The memories of shared laughter and stolen glances, the comfort and sense of belonging that once defined their relationship become a constant source of longing. The thought of seeing their former flame again can stir up a whirlwind of conflicting emotions: hope, fear, anticipation, and trepidation.Navigating the path to reconciliation after a breakup is fraught with uncertainty and potential pitfalls. The complexities of human nature and the unique dynamics of each relationship present a myriad of challenges that must be carefully considered.Navigating the Emotional Landscape.The initial stages of a breakup are often characterized by intense emotional turmoil. The pain of separation can trigger a range of reactions, from anger and resentment to overwhelming sadness and despair. It is important to acknowledge and honor these feelings without judgment. Allow yourself time to grieve the loss of the relationship and the dreams you once shared.As the dust settles, it is crucial to gain some emotional distance and perspective. Reflect on the factors that led to the breakup, both your own and your ex-partner's. Identify the areas where you could have grown or acted differently. This introspective process can provide valuable insights and empower you to avoid repeating pastmistakes.Initiating Contact and Setting Boundaries.If you believe that reconciliation is possible and mutually desired, reaching out to your ex-partner may be a necessary step. However, it is essential to approach this delicate situation with caution and respect.Start by sending a simple message expressing your desire to reconnect. Be brief, non-confrontational, and avoid placing pressure on them. Let them know that you understand if they need more time or space.If your ex-partner is receptive to your request, be mindful of their boundaries. Respect their need for separation and do not overwhelm them with attention. Allow them to set the pace and dictate the terms of further communication.Rebuilding Trust and Establishing a New Foundation.Reconciliation requires a fundamental shift in the relationship dynamics. Trust, which may have been shattered during the breakup, must be rebuilt gradually. Be honest and open with your ex-partner, sharing your thoughts and feelings without reservation. Actively listen to their perspective and show empathy for their experiences.It is important to recognize that reconciliation is not a simple return to the past. Instead, it is an opportunity to create a new foundation, free from the mistakes of the previous relationship. Discuss your expectations, boundaries, and goals for the future. Be willing to compromise and find mutually acceptable solutions.Learning from the Past and Embracing Growth.The pain and lessons of a breakup can be invaluable for personal growth and development. Embrace the opportunity to reflect on your experiences and identify areas where you can improve as a partner.Consider seeking therapy or professional counseling togain insights into your relationship patterns and unresolved issues. Work on developing self-awareness, emotional intelligence, and communication skills. By doing so, you will become a more mature and resilient individual, better equipped to navigate the complexities of future relationships.The Intrinsic Value of Forgiveness.Holding onto anger and resentment can be a corrosive force that poisons the heart. Forgiveness is not about condoning hurtful behavior or absolving yourself of responsibility. It is about releasing the burden of the past and freeing yourself from the chains of bitterness.Forgiveness allows you to heal the wounds of the breakup and make room for new possibilities. It does not mean that you forget or minimize the pain you have experienced, but rather that you choose to move forward with compassion and grace.The Power of Vulnerability.Reconciliation requires vulnerability and a willingness to expose your true self. Be open with your ex-partner about your fears, insecurities, and hopes. Share your dreams and ambitions, and allow them to see the depths of your soul.Vulnerability can be a daunting prospect, but it is essential for building a genuine and lasting connection. By showing your true colors, you invite your ex-partner to do the same. This reciprocal sharing of vulnerabilitiesfosters intimacy and a deeper level of understanding.The Fragility of Love and the Importance of Cherishing.Reconciliation is a precious gift, born from the ashes of a fallen relationship. It is a testament to the enduring power of love and the resilience of the human spirit.Cherish the opportunity to start anew with your ex-partner. Treat each other with kindness, respect, and love. Remember that relationships require constant nurturing andeffort. Be willing to invest in your partner and the future of your relationship.The path to reconciliation may not always be smooth, but it is a journey worth taking. By navigating the emotional complexities, setting healthy boundaries, rebuilding trust, learning from the past, practicing forgiveness, embracing vulnerability, and cherishing the fragility of love, you can transform the pain of a breakup into the triumph of reconciliation.。
音乐对人类的情绪很重要英语作文
音乐对人类的情绪很重要英语作文全文共3篇示例,供读者参考篇1The Profound Impact of Music on the Human Emotional ExperienceMusic is an integral part of the human experience that has shaped cultures, narratives, and emotional connections for centuries. As a student, I have come to appreciate the profound impact that music has on our emotional landscape, serving as a universal language that transcends boundaries and touches the depths of our souls.From the earliest stages of our lives, we are exposed to the soothing melodies of lullabies, which create a sense of comfort and security. These gentle tunes have the power to calm our restless spirits and foster a deep emotional bond between parent and child. As we grow older, music becomes an ever-present companion, weaving its way into the fabric of our daily lives.One of the most remarkable aspects of music is its ability to evoke a wide range of emotions within us. A soaring orchestral piece can ignite a sense of triumph and upliftment, while amournful ballad can tap into our deepest sorrows and heartaches. The power of music lies in its capacity to resonate with our innermost feelings, allowing us to process and express emotions that may otherwise remain buried beneath the surface.During times of joy and celebration, music serves as a powerful catalyst for shared experiences. The infectious rhythms and catchy melodies of upbeat tunes have the remarkable ability to unite people from diverse backgrounds, fostering an atmosphere of camaraderie and togetherness. Whether it's a lively concert, a wedding reception, or a spontaneous dance party among friends, music has the power to elevate our spirits and create cherished memories that will forever be etched in our hearts.Conversely, music can also provide solace and comfort during periods of grief, loss, and hardship. The poignant lyrics and emotive melodies of certain songs can resonate deeply with our pain, offering a sense of validation and understanding. In these moments, music acts as a gentle companion, reminding us that we are not alone in our struggles and that others have traversed similar paths of sorrow and healing.Beyond its emotional impact, music has also proven to be a powerful therapeutic tool. Numerous studies have demonstratedthe benefits of music therapy in alleviating anxiety, reducing stress levels, and even assisting in the recovery process for individuals with various physical and mental health conditions. The rhythmic patterns and melodies can have a calming effect on the mind and body, promoting relaxation and reducing symptoms of depression and anxiety.Moreover, music plays a crucial role in shaping our personal identities and fostering a sense of belonging. Through the shared experience of music, we forge connections with others who resonate with the same genres, artists, or cultural traditions. Music festivals, concerts, and even casual listening sessions with friends create a sense of community and belonging, allowing us to find kindred spirits who understand and appreciate the emotional resonance of the music we love.As a student, I have witnessed firsthand the transformative power of music in academic settings. From the uplifting melodies that energize us during study sessions to the soulful tunes that provide comfort and inspiration during times of stress, music has become an indispensable companion on our educational journeys. It has the ability to motivate, inspire, and even enhance our cognitive abilities, making it an invaluable tool for personal growth and academic success.In conclusion, music is a profound and multifaceted force that profoundly shapes our emotional experiences. From the earliest stages of our lives until our final moments, music accompanies us on our journeys, providing solace, joy, connection, and a means of self-expression. It is a universal language that transcends cultural barriers, uniting us in our shared humanity and reminding us of the depth and richness of the emotional tapestry that weaves through our existence. As a student, I am grateful for the profound impact that music has had on my life, and I look forward to exploring the countless ways in which it will continue to enrich my emotional journey in the years to come.篇2The Power of Music to Shape Our Emotional LandscapeAs students, we often find ourselves navigating through a whirlwind of emotions – joy, sadness, stress, excitement, and everything in between. In these tumultuous times, music emerges as a constant companion, offering solace, inspiration, and a means to express the ineffable. Its ability to profoundly influence our emotional states is undeniable, and it is a testament to the profound connection between sound and the human psyche.From the earliest days of our existence, music has been an integral part of human culture, woven into the fabric of our societies and rituals. Ancient civilizations recognized its power and employed it for various purposes, from religious ceremonies to warfare. Even before we could articulate our feelings, the soothing melodies of lullabies calmed our restless souls, while the rhythmic beats of tribal drums stirred our primal instincts.As we grew older, music became an ever-present force in our lives, shaping our emotional experiences and serving as a soundtrack to our most cherished memories. Who among us hasn't felt the exhilaration of singing along to an upbeat pop song with friends, or the melancholy of a heartfelt ballad during a breakup? Music has the uncanny ability to amplify our emotions, intensifying the joys and sorrows we encounter on our journey through life.But music is more than just a reflection of our feelings; it is a potent tool that can actively shape and influence our emotional states. The right melody, rhythm, and lyrics can transport us to a realm of serenity, boosting our mood and alleviating stress and anxiety. Conversely, a powerful, energetic track can ignite our spirits, filling us with determination and motivation to conquer any obstacle that stands in our way.This emotional resonance is deeply rooted in the intricate relationships between music and the human brain. Scientific studies have revealed that certain musical elements, such as tempo, pitch, and harmony, can trigger specific neurochemical responses and activate regions of the brain associated with emotion processing and reward systems. This physiological connection explains why music can elicit visceral reactions, from the chills that run down our spines during a poignant chorus to the tears that well up in our eyes when a song strikes a profound emotional chord.Moreover, music serves as a universal language, transcending cultural and linguistic barriers. Its ability to evoke shared emotional experiences among diverse populations is truly remarkable. Whether it's the collective euphoria of a live concert or the solitary contemplation of a melancholic melody, music has the power to unite us in our shared humanity, reminding us of the common threads that bind our emotional tapestries.As students, we often turn to music as a means ofself-expression and emotional catharsis. During times of stress and uncertainty, the lyrics of a song can resonate deeply, providing comfort and validation for the turbulent emotions we may be grappling with. It is a safe haven where we can freelyexplore the depths of our feelings, without fear of judgment or misunderstanding.Furthermore, music plays a vital role in shaping our identities and fostering a sense of belonging. The genres and artists we gravitate towards often become intrinsically linked to our personal narratives, serving as auditory markers of our growth and evolution. The music we listened to during our formative years may evoke nostalgia and fond memories, while the songs that accompany us through periods of transformation can become anthems of resilience and self-discovery.In the academic realm, music can also serve as a powerful tool for enhancing learning and cognitive performance. Studies have shown that certain types of music can improve focus, concentration, and information retention, making it a valuable asset in our educational endeavors. Additionally, the creative and analytical aspects of music education can foster critical thinking skills, problem-solving abilities, and emotional intelligence –valuable assets for any student navigating the complexities of higher education.However, it is important to acknowledge that our emotional responses to music are highly subjective and influenced by personal experiences, cultural backgrounds, and individualpreferences. What resonates profoundly with one person may leave another unaffected. This diversity in emotional interpretation is a testament to the rich tapestry of human experience and underscores the importance of respecting and embracing individual expressions of emotion through music.As we continue our academic journeys and venture into the wider world, the role of music in shaping our emotional lives will only become more profound. It will be a constant companion, offering solace in times of adversity, amplifying our joys during celebratory moments, and serving as a conduit forself-expression and personal growth.In conclusion, the impact of music on our emotional landscape is undeniable. From the earliest lullabies that soothed our infant souls to the anthems that inspire us to chase our dreams, music is woven into the fabric of our emotional experiences. It has the power to uplift, console, motivate, and unite us in our shared humanity. As students navigating the complexities of life, embracing the emotional resonance of music can provide us with a vital source of strength, self-expression, and personal growth, enabling us to navigate the rich tapestry of human emotions with grace and resilience.篇3Music and Its Profound Impact on Human EmotionsAs a student passionate about exploring the wonders of the world, I have come to realize that music holds an extraordinary power over our emotional state. From the earliest days of human civilization, music has been an integral part of our existence, deeply woven into the fabric of our cultural tapestries. Its influence transcends mere entertainment; it is a language that speaks directly to our souls, evoking a myriad of emotions that words often fail to capture.In my personal experience, music has been a constant companion, a source of solace, and a catalyst for self-expression. Whether I'm feeling elated or melancholic, there is always a melody or a lyric that resonates with my innermost thoughts and feelings. It is as if composers and songwriters have the uncanny ability to tap into the universal emotions that bind us all together, regardless of our backgrounds or circumstances.One of the most remarkable aspects of music is its ability to evoke nostalgia. A simple tune can transport us back in time, rekindling memories long forgotten. I vividly remember the lullabies my mother used to sing to me as a child, their gentle melodies lulling me into a peaceful slumber. Even now, when I hear those familiar notes, I am instantly transported back tothose cherished moments, my heart swelling with warmth and affection.Music also has the power to uplift our spirits and instill a sense of joy. Whether it's a lively dance track that compels us to move our bodies or an upbeat pop song that gets stuck in our heads, there is something inherently uplifting about certain musical compositions. During times of stress or anxiety, I often turn to my favorite upbeat tunes as a source of comfort and motivation, allowing the rhythms and melodies to wash over me, momentarily lifting the weight of my worries.Conversely, music can also serve as a cathartic outlet for our sorrows and grievances. Through the haunting melodies of a melancholic ballad or the raw intensity of a rock anthem, we find solace in the knowledge that our emotions are shared and validated. The lyrics resonate with our innermost struggles, and the music provides a safe haven for us to process and release our pain. It is a reminder that we are not alone in our suffering, and that the human experience is a tapestry woven with both joy and sorrow.Furthermore, music has the remarkable ability to transcend cultural and linguistic barriers. The universal language of melody and rhythm has the power to unite people from diversebackgrounds, fostering a sense of unity and shared understanding. I have witnessed this firsthand at concerts and festivals, where people from all walks of life come together, united by their love for the music, swaying in sync and losing themselves in the moment.In the realm of education, music has proven to be a valuable tool for enhancing cognitive abilities and fostering creativity. Studies have shown that exposure to music can improve memory, concentration, and problem-solving skills. As a student, I have experienced the benefits of listening to certain genres of music while studying, finding that the rhythms and melodies aid in my focus and retention.Moreover, music plays a crucial role in shaping our cultural identities and preserving our histories. Traditional folk songs, national anthems, and indigenous melodies are intrinsically linked to the stories and struggles of their respective communities. Through these musical expressions, we gain insight into the values, beliefs, and experiences of different cultures, fostering a deeper appreciation for the richness and diversity of our global community.In conclusion, music is an integral part of the human experience, a universal language that speaks directly to ouremotions. Its impact on our lives is profound, transcending mere entertainment and serving as a catalyst for self-expression, emotional healing, and cultural preservation. As a student and a lover of music, I am constantly in awe of its power to touch our souls, unite us across borders, and enrich our lives in ways that words often fail to capture.。
分手了不想复合但是想解释某些事情的小作文
分手了不想复合但是想解释某些事情的小作文Breaking Up: Explaining Matters without ReconciliationThe end of a romantic relationship is often an emotionally challenging experience for both parties involved. Sometimes, even after the decision to break up has been made, one person may feel a deep desire to explain certain aspects or events that led to the separation. While this urge mayarise from a genuine need for closure or clarity, it is essential to approach the situation with tact and consideration for the other person's feelings.分手:解释事情而不复合感情关系的结束往往对于双方来说都是一次充满情感挑战的经历。
有时,即使已经决定结束关系,仍可能有一方强烈渴望解释导致分手的某些方面或事件。
虽然这种欲望可能源自寻求闭合或明确性的真实需求,但在处理这种情况时必须考虑到他人的感受,采取巧妙和体贴的方式。
Instead of dwelling on past mistakes or placing blame onone another, it is crucial to focus on the future andensure open communication. Take time to reflect on what you would like to convey and why it is important for you to do so. It could be about clarifying misunderstandings, expressing unspoken feelings or thoughts, or simplyproviding closure for yourself. Whatever the reason may be, remember that your intention should be to promote understanding rather than seeking reconciliation.与其纠缠于过去的错误或彼此相互责备,更重要的是专注于未来并确保开放的沟通。
巨大的情感上的波动英语
巨大的情感上的波动英语In the realm of human experience, emotional fluctuations are a natural part of life. However, when we speak of "huge emotional swings," we are referring to the intense and often rapid changes in mood that can significantly impact aperson's well-being and daily functioning.### Causes of Emotional Swings1. Hormonal Changes: Hormones play a critical role in mood regulation. Fluctuations in hormone levels, such as during puberty, pregnancy, or menopause, can lead to significant emotional swings.2. Stress: Chronic stress can lead to heightened emotional responses and mood swings. It can exacerbate existing mental health conditions or lead to the development of new ones.3. Sleep Deprivation: Lack of sleep can have a profoundeffect on mood, making individuals more susceptible to emotional volatility.4. Mental Health Disorders: Conditions such as bipolar disorder, depression, and anxiety can cause dramatic shifts in mood and emotional stability.5. Life Events: Major life events like the loss of a loved one, a breakup, or job loss can trigger intense emotional reactions.### Symptoms of Emotional Swings- Rapid Mood Changes: Moving quickly from one emotional state to another, such as from happiness to sadness or anger.- Irritability: Becoming easily annoyed or frustrated.- Lability: Emotional instability, where one's mood can change in response to minor events.- Intense Emotional Reactions: Experiencing strong emotional responses that may seem disproportionate to the situation.### Coping Strategies1. Self-Awareness: Recognizing the triggers for emotional swings can help in managing them more effectively.2. Stress Management: Techniques such as meditation, yoga, and deep breathing can help reduce stress levels.3. Healthy Lifestyle: Regular exercise, a balanced diet, and adequate sleep are essential for emotional stability.4. Professional Help: Seeking therapy or counseling can provide tools and strategies to cope with emotional swings.5. Support Networks: Having a strong support system of friends and family can provide emotional stability and comfort.### ConclusionHuge emotional swings can be challenging to navigate, but with the right support and strategies, they can be managed. It's important to remember that everyone experiences emotional fluctuations, and seeking help when needed is a sign of strength, not weakness. Understanding the causes and symptoms can empower individuals to take control of their emotional health and lead a more balanced life.。
与人相处时要站在对方的立场作文
与人相处时要站在对方的立场作文英文回答:When it comes to interacting with others, I believe it is crucial to put myself in their shoes and consider their perspective. This allows me to have a better understanding of their thoughts, feelings, and needs, which ultimately leads to more effective communication and stronger relationships.By taking the time to see things from the otherperson's point of view, I am able to empathize with their experiences and emotions. This helps me to be more compassionate and supportive, as I can relate to their struggles and challenges. For example, if a friend is going through a difficult breakup, I can imagine how heartbroken and vulnerable they must be feeling. Instead of offering unsolicited advice or dismissing their emotions, I can provide a listening ear and offer comforting words.Furthermore, considering the other person's perspective allows me to anticipate their reactions and adjust my own behavior accordingly. For instance, if I know that someone is particularly sensitive about a certain topic, I will be careful with my choice of words and avoid saying anything that may inadvertently hurt or offend them. By being mindful of their feelings, I can foster a more positive and harmonious interaction.In addition, standing in the other person's shoes helps me to see beyond my own biases and prejudices. It encourages me to challenge my own assumptions and broaden my horizons. For example, if I have a disagreement with a colleague from a different cultural background, I can try to understand their cultural values and norms. This allows me to appreciate their perspective and find common ground, rather than letting our differences create a barrier between us.中文回答:在与他人相处时,我认为站在对方的立场是至关重要的。
聚变 碰撞 反应
聚变碰撞反应(中英文实用版)Title: Fusion, Collision, ReactionTitle: 聚变、碰撞、反应In the pursuit of knowledge, the concepts of fusion, collision, and reaction have always fascinated scholars across various fields.Fusion, the process of combining two or more entities to form a new whole, holds great significance in both the physical and metaphorical sense.It is the coming together of different elements, resulting in a unique synergy that surpasses the sum of its parts.在追求知识的旅程中,聚变、碰撞和反应这些概念始终吸引着来自各个领域的学者。
聚变,这个将两个或更多实体结合成一个新的整体的进程,在物理和比喻层面上都具有重要意义。
这是不同元素的汇聚,产生出独特的协同效应,超越了其部分之和。
Collision, on the other hand, refers to the interaction between two or more objects or ideas.This interaction can lead to a variety of outcomes, depending on the nature of the objects or ideas involved.Like a chemical reaction, a collision can result in the formation of new substances or the alteration of existing ones.另一方面,碰撞是指两个或更多对象或观念之间的相互作用。
Nuclear Fusion Powering the Future
Nuclear Fusion Powering the FutureNuclear fusion has long been hailed as the holy grail of clean and limitless energy. The idea of harnessing the power of the sun to provide an abundant and sustainable source of electricity has captured the imagination of scientists and policymakers for decades. However, despite significant progress in the field, practical nuclear fusion power generation remains elusive. In this response, we will explore the potential of nuclear fusion as a future energy source, the challenges that must be overcome to make it a reality, and the implications of successful fusion power for the world.First and foremost, it is important to understand the basic principles of nuclear fusion. Unlike nuclear fission, which powers traditional nuclear reactors by splitting heavy atoms, nuclear fusion generates energy by fusing light atoms, such as isotopes of hydrogen, together. This process releases an enormous amount of energy, far greater than what is possible with fission, and produces no long-lived radioactive waste. In addition, the fuel for fusion, such as deuterium and tritium, is abundant and can be extracted from seawater, making it a virtually limitless resource. These unique characteristics make nuclear fusion an extremely attractive prospect for meeting the world's growing energy needs while mitigating the impact of climate change.One of the most promising approaches to achieving practical nuclear fusion is through magnetic confinement fusion, which involves using powerful magnetic fields to contain and control the hot plasma where the fusion reactions take place. Projects such as the International Thermonuclear Experimental Reactor (ITER) in France and the National Ignition Facility (NIF) in the United States are at the forefront of this research, aiming to demonstrate the feasibility of sustained fusion reactions and eventually pave the way for commercial fusion power plants.Despite the immense potential of nuclear fusion, significant technical and engineering challenges remain. The extreme conditions required for fusion, including temperatures of over 100 million degrees Celsius and the confinement of the plasma for prolonged periods, present formidable obstacles. Developing materials that can withstand such harsh environments, designing efficient plasma confinement systems, and achieving a net energygain from fusion reactions are just a few of the complex problems that must be solved. Furthermore, the high cost of building and operating fusion facilities, as well as the long timelines for research and development, pose additional barriers to the widespread adoption of fusion power.In addition to the technical challenges, there are also social, political, and ethical considerations surrounding the development of nuclear fusion. The potential for nuclear proliferation, the management of nuclear waste from fusion reactors, and the displacement of existing energy industries are all issues that must be carefully addressed. Moreover, the equitable distribution of fusion energy resources and the impact on global energy geopolitics are important factors to consider in the transition to fusion power.If practical nuclear fusion power can be achieved, the implications for the world would be profound. With virtually unlimited and clean energy at our disposal, we could significantly reduce our reliance on fossil fuels, mitigate the effects of climate change, and provide access to electricity for billions of people around the globe. The development of fusion power could also spur technological innovation, create new industries and jobs, and fundamentally transform the way we produce and consume energy. However, realizing these benefits will require sustained investment, collaboration, and commitment from the international community.In conclusion, nuclear fusion holds immense promise as a future energy source, offering the potential for abundant, clean, and sustainable electricity. While significant challenges and uncertainties remain, the pursuit of practical fusion power is a worthy endeavor that could have far-reaching implications for the world. By addressing the technical, social, and geopolitical aspects of fusion energy, we can work towards a future where nuclear fusion powers the world and helps to build a more prosperous and sustainable society.。
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a r X i v :n u c l -t h /0401026v 1 13 J a n 20041Fusion and breakup in the reactions of6,7Li and 9BeK.Hagino a ,M.Dasgupta b and D.J.Hinde baYukawa Institute for Theoretical Physics,Kyoto University,Kyoto 606-8502,JapanbDepartment of Nuclear Physics,Research School of Physical Sciences and Engineering,Australian National University,Canberra ACT 0200,AustraliaWe develop a three body classical trajectory Monte Carlo (CTMC)method to dicsuss the effect of the breakup process on heavy-ion fusion reactions induced by weakly bound nuclei.This method follows the classical trajectories of breakup fragments after the breakup takes place,and thus provides an unambiguous separation between complete and incomplete fusion cross sections.Applying this method to the fusion reaction 6Li +209Bi,we find that there is a significant contribution to the total complete fusion cross sections from the process where all the breakup fragments are captured by the target nucleus (i.e.,the breakup followed by complete fusion).1.IntroductionThe fusion reactions of neutron-rich nuclei around the Coulomb barrier provide a good opportunity to study the interplay between quantum tunneling and the breakup process.An important question here is:does the breakup process influence fusion reactions in a similar way as the inelastic process,which leads to subbarrier enhancement [1]of fusion cross sections over predictions for a single barrier?In addressing this question,measure-ments with weakly bound stable nuclei,such as 9Be,6Li,and 7Li,have been proved to be useful[2,3,4].These beams are currently much more intense than radioactive beams,allowing more precise and extensive experimental studies.Also,these nuclei predomi-nantly break up into charge fragments (9Be →2α+n or α+5He,7Li →α+t ,and 6Li →α+d ),which are more easily detected.This allows a clean separation of the products of complete fusion from those of incomplete fusion,where only a part of the projectile is captured.To describe the effect of breakup on fusion reactions theoretically,a model has to take into account the following three different processes:(i)the projectile as a whole is captured by the target,(ii)only one of the breakup fragments is captured,(iii)all the breakup fragments are absorbed after the breakup takes place near the target nucleus.Process (ii)is referred to as an incomplete fusion reaction,while both of processes (i)and (iii)lead to complete fusion.Calculations based on the continuum-discretized coupled-channels method may account for the total fusion cross section (the sum of all the processes)and/or the separate contribution of process (i)[5,6],but it is not easy to compute cross sections for process (iii),that is,the breakup followed by complete fusion.In order to model2this process,we need to follow the trajectories of the breakup fragments to determine whether one or both fragments are captured by the target nucleus.In this contribution, we present such a model[3],where many classical trajectories are sampled by the Monte Carlo method to compute the total complete fusion cross section.We note that a very similar model,called the three-body classical trajectory Monte Carlo(CTMC)method, has been developed in thefield of atomic and molecular physics,and has been successfully applied to ion-atom ionization and charge transfer collisions[7,8,9].2.Three-body classical trajectory Monte Carlo(CTMC)modelLet us assume the following Hamiltonian for a reaction of a projectile nucleus which consists of two cluster fragments P1and P2,H=p212m2+p2Tm1+m2r0cosθ,y1(0)=b+m2m1+m2r0cosθ,y2(0)=b−m12m1p rel cosθ,v y1(0)=12m2p rel cosθ,v y2(0)=−122µ[Q bu−V12(r12(0))] withµ=m1m2/(m1+m2).The value of r0is restricted to0≤r0≤r t,where r t satisfiesV12(r t)=Q bu.With these initial conditions,we solve the Newtonian equations to follow the time evolution of the trajectories for each particle,x i(t),y i(t),v xi(t),and v yi(t),(i=1,2,T). At each time,we monitor the relative distance between the particles.We assume that the projectile fragment P i(i=1,2)is absorbed by the target nucleus when the relative3 distance between the fragment and the target is smaller than r iT<1.1(A1/3i+A1/3T)fm, and that the breakup occurs when the relative distance between P1and P2is larger than the barrier radius for the potential V12.By sampling many trajectories for random values of r0andθwith the Monte Carlo method,we calculate partial cross sections for a given impact parameter b.Total cross sections are then obtained by integrating them over the value of b.solid lines correspond to the trajectories for theαparticle and deuteron,respec-tively,while the dotted line is for the cen-ter of mass of the projectile fragments.Figure3.The complete fusion(CF)and the incomplete fusion(ICF)cross sections for the6Li+209Bi reaction.The experi-mental data are taken from Ref.[3].43.Application to6Li+209Bi reactionWe now apply the three-body classical trajectory Monte Carlo method to the6Li+ 209Bi system and discuss the effect of breakup of6Li into d+αon the fusion reaction near the Coulomb barrier.We assume the Woods-Saxon form in calculating V12,V1T,and V2T,using the same values for the parameters as in Refs.[10,11].We take R max=200 fm.Fig.1(a)–1(c)shows sample trajectories at E cm=40MeV.These are for b=2.5, 4.65,and5.5fm,respectively.For relatively small values of the impact parameter(Fig. 1(a)),the projectile nucleus6Li is captured by the target before breaking up intoαand d,leading to complete fusion.For b=5.5fm(Fig.1(c)),only the deuteron is captured while the alpha particle escapes from the target.This is an example of incomplete fusion. For intermediate values of b,breakup takes place near the target,but both of the breakup fragments get absorbed(Fig.1(b)).This is breakup followed by complete fusion.Figure 2shows the partial fusion cross sections for these processes as a function of the impact parameter,for E cm=40MeV.Figure3shows fusion cross sections as a function of energy in the center of mass frame. The dotted line denotes the sum of complete and incomplete fusion cross sections.The dashed line indicates the absorption of the whole projectile from the bound states,while the solid line shows the total complete fusion cross sections.The difference between the solid and the dashed line thus represents the contribution from breakup followed by fusion of both fragments.This makes a significant contribution to complete fusion at energies above the barrier.4.SummaryWe present a three body classical trajectory Monte Carlo method for fusion of weakly bound nuclei.Applying this method to the6Li+209Bi reaction,we have demonstrated that there is a significant contribution of breakup followed by complete fusion to the total complete fusion cross sections.This process has not been considered in any coupled-channels calculations so far,and the present result suggests that a consistent definition of complete fusion is necessary when one compares experimental data with theoretical calculations.REFERENCES1.M.Dasgupta,et al.,Annu.Rev.Nucl.Part.Sci.48(1998)401.2.M.Dasgupta et al.,Phys.Rev.Lett.82(1999)1395.3.M.Dasgupta et al.,Phys.Rev.C66(2002)041602(R).4.I.Padron et al.,Phys.Rev.C66(2002)044608.5.K.Hagino,A.Vitturi,C.H.Dasso,and S.M.Lenzi,Phys.Rev.C61(2000)037602.6. 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