Dryer Section(12)Optimisation of the Air Conditions in the Dryer Section low

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SPX FLOW Spray Dryer升级与优化指南说明书

SPX FLOW Spray Dryer升级与优化指南说明书

MAXIMISING LIFETIME VALUEUpgrade Today to Meet the Demands of TomorrowAchieving Maximum Value from Your Spray Dryer • M• E xpanded capacity • I ncreased availability • A • T • I mproved safety • V alidated processes• R • R educed emissionsWhy Modernise?Upgrading your spray dryers can yield great rewards. Y our plant will be more efficient, your people and plant will be safer, and you will be well positioned to take advantage of new market opportunities. Plus, you can get it all done with minimal CAPEX. Identifying Your NeedsEquipped with proven techniques refined over decades of experience, SPX FLOW Rebuild & Upgrade specialists visit your site to assess your operations and identify areas where the greatest impact can be achieved. We then provide full installation, commissioning, and startup services, or can supervise your teams to ensure they are doing things right.TAPPING THE HIDDEN VALUE IN YOUR SPRAY DRYER PLANTEfficient spray drying reduces energy use and otheroperating costs while improving process stability, yield, and hygiene.A carefully planned rebuild or upgrade scenario improves performance and extends the life of your equipment.Our spray dry process experts apply a unique methodology to rejuvenate under-performing air heaters, dehumidification, and heat recovery systems. They also make your process smarter with software that self-corrects process anomalies and dramatically compresses product delivery schedules via dual feed lines.With SPX FLOW, you can rest assured you are getting maximum return on your assets.PLANTEFFICIENCY321ABCDRebuilding and upgrading is not simply about fixing what is broken. Our customers often want to raise their operations to a new level - perhaps to modify a product or meet an emerging market trend. Whatever optimisation is required, SPX FLOW has the experts and equipment necessary to make it happen.Product Preparation and Air ParametersF eed (water % + solids %)A ir inlet (temperature and moisture content)A ir outlet (temperature and moisture content)E nd product (solids % + moisture content %)OPTIMISE PROCESSES AND ENVIRONMENTAL PROTECTION65246Safety is a critical factor for most rebuild and upgrade projects. An inefficient operation can put your people and plant at risk, and negatively affect profitability. SPX FLOW helps identify and eliminate potential hazards while offering solutions that make your operation safer than ever.IMPROVE SPRAY DRYER PLANTSAFETYWhere most spray dryer solution providers provide expertise in just a few areas and rely on third-party solutions to address your needs, SPX FLOW delivers a single solution from beginning to end. The result is a system composed of high-quality components that work seamlessly together to deliver maximum value. Additionally, we offer a single point of contact so that you always know an expert is on the job. Our goal is to deliver lower operating costs with increased performance and higher production value. That is the SPX FLOW difference.A SINGLE SOLUTION FROM INQUIRY TO ACCEPTANCES ol u De l iv P ro po So l u• W • I • E • D • L• M • M • MY criteria:• C • P • M • S • ISPX FLOW, Inc. reserves the right to incorporate our latest design and material changes without notice or obligation. Design features, materials of construction and dimensional data, as described in this bulletin, are provided for your information only and should not be relied upon unless confirmed in writing. Please contact your local sales representative for product availability in your region. The green “ ” is a trademark of SPX FLOW, Inc.For more information, visit .©2022 SPX FLOW, Inc.ANH_Spray-Dryer-Plant-Rebuild-and-Upgrade_BRO_0822_GB Version: 08/2022。

美标超声波无损探伤UTII级考试习题翻译

美标超声波无损探伤UTII级考试习题翻译

4.1 The size of a penetrant indication depends on:渗透剂的显示大小取决于:A.the size of the discontinuity. 不连续的大小B.the discontinuity entrapment efficiency.C.the technique of penetrant testing. 渗透检测技术D.all of the above. 上面全部E.only a and c above. 只有上面的a和b4.2 The most sensitive application technique for dry developer is:对干燥显像剂最为敏感的应用技术是:A.Immersion. 浸入B.a dust cloud. 粉尘云C.A fluidized bed. 流化床D.A dust cloud —electrostatic gun. 粉尘云—静电抢4.3 one advantage of having a little background fluorescence is that it:小背景荧光的一个优点是它:A.reduces the contrast of the indication. 减少现象的对比度B.Indicates that the part was not overwashed. 显示不被清洗的部分C.Reveals an excessive emulsification time. 显示过度乳化时间D.Is hard to remove when a highly sensitive penetrant is applied to rough or porous surfaces.很难去除用在粗糙或多孔表面的高灵敏度渗透剂4.4 the water wash test is used to evaluate the washing properties of penetrant and emulsifiers. The spray nozzle is held 30 cm(12 in.) from the wash surface. The water pressure must not exceed:水洗涤实验用于评估渗透剂和乳化剂的洗涤性能。

Unit 12

Unit 12

2014-10-12
• In this device, long pipes rotate slowly over a bed of stones, disturbuting the polluted water in continuous sprays. As the water trickles over and around the stones, it offers its nutrients in the presence of air to an abundance of rather unappetizing forms of life. • An alternative technique is the activated sludge process . • unappetizing • alternative • activated sludge 引不起食欲的 二者选其一的 活性污泥
• The next stage is a series of settling chambers designed to remove first the heavy grit, such as sand that rainwater brings in from road surfaces, and then, move slowly, any other suspended solidsincluding organic nutrients that can settle out in an hour or so. Up to this point the entire process, which is called primary treatment, has been relatively inexpensive but has not accomplished much. • settling chamber 沉降室 • grit n. 粗砂 • up to 直到

电子晾衣机说明书

电子晾衣机说明书

4.5.6.7.The dryer contains residual water.Make sure that the airinlet remains unobstructedClean and level2Care and cleaningDryer housing, control panelRemove detergent residues immediately.Wipe with a soft, damp cloth.Do not clean with a water jet.During drying, water may accumulate between the window and the seal.Moisture sensorThe dryer is equipped with stainless steel moisture sensors.Moisture sensors measure how damp the laundry is.A thin layer of limescale may build up on the moisture sensors afterprolonged use.This must be removed regularly.1.Open the door and clean the moisture sensors with a dampsponge that has a rough surface.Do not use steel wool or abrasive materials.Cover for steam nozzle in the drum (depending on the model)After prolonged operation, limescale and fluff may accumulate on the cover of the steamnozzle. Clean regularly:1.Open the door and remove the cover with a screwdriver.Clean the cover under running water.2.Push and click the cover back in place.Clean the filter in the refresher tank if it is dirty (depending on the model)Regularly clean the filter under running water a This prevents stubborn deposits/dirt frombuilding up.1.Remove the condensation container.2.Remove the filter and clean it under running water.3.Re-insert the filter and push in the condensation container until itlocks into place.Heat exchangerThe dryer's heat exchanger is automatically cleaned during drying andbeing rinsedFilter in the condensation containerThe filter is cleaned automatically when the condensation container is emptied.However, the filter should still be cleaned regularly under running water1.Product number Production numberTrust the expertise of the manufacturer. Contact us for assistance. In this way, you can restassured that the repair will be carried out by trained service technicians using original spareparts.Optional accessories5Reversing the door1622.1.7384953.1.2.106119406 / 9000695672*695672*6Reversing the door1116121713181.3.2.141915201.2.16211.2.271.2.3.281.2.1. 2.ContentsPageʋEnvironmentally-friendly disposal . . . . . .1ʋInstallation . . . . . . . . . . . . . . . . . . . . . . . .1ʋFrost protection / Transport. . . . . . . . . . .1ʋCare and cleaning . . . . . . . . . . . . . . . 2/3ʋAfter-sales service. . . . . . . . . . . . . . . . . .4ʋOptional accessories. . . . . . . . . . . . . . . .4ʋTechnical data . . . . . . . . . . . . . . . . . . . .4ʋReversing the door . . . . . . . . . . . . . . . 5/7Read these instructions before operating the dryer.You must also observe the separate instruction manual.Keep all the documents in a safe place for future reference, or to pass on to the next owner.4.5.6.7.The dryer contains residual water.Make sure that the airinlet remains unobstructedClean and level2 Care and cleaningDryer housing, control panelRemove detergent residues immediately.Wipe with a soft, damp cloth.Do not clean with a water jet.During drying, water may accumulate between the window and the seal.Moisture sensorThe dryer is equipped with stainless steel moisture sensors.Moisture sensors measure how damp the laundry is.A thin layer of limescale may build up on the moisture sensors afterprolonged use.This must be removed regularly.1.Open the door and clean the moisture sensors with a dampsponge that has a rough surface.Do not use steel wool or abrasive materials.Cover for steam nozzle in the drum (depending on the model)After prolonged operation, limescale and fluff may accumulate on the cover of the steamnozzle. Clean regularly:1.Open the door and remove the cover with a screwdriver.Clean the cover under running water.2.Push and click the cover back in place.Clean the filter in the refresher tank if it is dirty (depending on the model)Regularly clean the filter under running water a This prevents stubborn deposits/dirt frombuilding up.1.Remove the condensation container.2.Remove the filter and clean it under running water.3.Re-insert the filter and push in the condensation container until itlocks into place.Heat exchangerThe dryer's heat exchanger is automatically cleaned during drying andbeing rinsedFilter in the condensation containerThe filter is cleaned automatically when the condensation container is emptied.However, the filter should still be cleaned regularly under running water1.Product number Production numberTrust the expertise of the manufacturer. Contact us for assistance. In this way, you can restassured that the repair will be carried out by trained service technicians using original spareparts.Optional accessories5Reversing the door1622.1.7384953.1.2.106119406 / 9000695672*695672*6Reversing the door1116121713181.3.2.141915201.2.16211.2.271.2.3.281.2.1. 2.ContentsPageʋEnvironmentally-friendly disposal . . . . . .1ʋInstallation . . . . . . . . . . . . . . . . . . . . . . . .1ʋFrost protection / Transport. . . . . . . . . . .1ʋCare and cleaning . . . . . . . . . . . . . . . 2/3ʋAfter-sales service. . . . . . . . . . . . . . . . . .4ʋOptional accessories. . . . . . . . . . . . . . . .4ʋTechnical data . . . . . . . . . . . . . . . . . . . .4ʋReversing the door . . . . . . . . . . . . . . . 5/7Read these instructions before operating the dryer.You must also observe the separate instruction manual.Keep all the documents in a safe place for future reference, or to pass on to the next owner.。

Analysis of the uncertainties affecting predictions of clay contents from

Analysis of the uncertainties affecting predictions of clay contents from

Analysis of the uncertainties affecting predictions of clay contents from VNIR/SWIR hyperspectral dataC.Gomez a ,A.P.A.Drost a ,J.-M.Roger ba IRD,UMR LISAH (INRA-IRD-SupAgro),F-34060Montpellier,France bIRSTEA,UMR ITAP,Montpellier,Francea b s t r a c ta r t i c l e i n f o Article history:Received 3April 2014Received in revised form 25September 2014Accepted 29September 2014Available online xxxxKeyword:Airborne hyperspectral imagery VNIR/SWIR spectroscopy UncertaintyMultivariate calibration Clay content mappingVisible,Near-Infrared and Short Wave Infrared (VNIR/SWIR,350–2500nm)hyperspectral imaging spectroscopy can be used to develop maps of estimated soil properties.The performance of the estimations obtained from regression models is usually assessed with figures of merit such as the standard error of calibration,the standard error of prediction or the ratio of performance deviation.All of these parameters are estimated during the model building and validation stages to evaluate the global model performance.Beyond these global indicators,the evaluation of the uncertainty that affects predictions is a major trend in analytical chemistry and chemometrics but not yet in hyperspectral imagery.Several approximate expressions and resampling methods have been proposed to estimate the prediction uncertainty when using multivariate calibrations from laboratory spectra.Based on these propositions,this paper studies a process of mapping and analyzing the uncertainties that affect soil property predictions obtained from VNIR/SWIR airborne data using several methods.An application to real VNIR/SWIR airborne data of clay content was used to compare the methods.The different cases yielded insights into the sources of uncertainty and showed that uncertainty analysis can guide the user to better sampling,better calibration and ultimately better mapping.©2014Elsevier Inc.All rights reserved.1.IntroductionFor two decades,laboratory Visible,Near-Infrared and Short Wave Infrared (VNIR/SWIR,350–2500nm)spectroscopy has been proven to be a good alternative to costly physical and chemical laboratory soil analyses for estimating a large range of soil properties (e.g.,Ben-Dor &Banin,1995;Cécillon et al.,2009;Viscarra Rossel,Walvoort,McBratney,Janik,&Skjemstad,2006).These studies led to the use of VNIR/SWIR hyperspectral imaging spectroscopy to estimate soil properties.VNIR/SWIR hyperspectral imaging spectroscopy can provide a global view of a study area at a high spatial resolution and can characterize several soil properties simultaneously.Ben-Dor,Patkin,Banin,and Karnieli (2002)began this field of research by applying multivariate calibration statistics to remotely-sensed data.Since then,VNIR/SWIR hyperspectral imaging spectroscopy has bene fited from an increas-ing number of methodologies developed in lab soil property predic-tion studies,including partial least square regression (e.g.,Gomez,Lagacherie,&Coulouma,2008a ),support vector machine regression (e.g.,Stevens et al.,2010),multiple linear regression (e.g.,Bayer,Bachmann,Müller,&Kaufmann,2012),stepwise multiple linear regression (e.g.,Lu,Wang,Niu,Li,&Zhang,2013)and regression rules (Minasny &McBratney,2008).Several studies have successfully mapped soil properties such as clay,calcium carbonate,iron,and soilorganic carbon (e.g.,Ben-Dor et al.,2007;Gomez,Viscarra Rossel,&McBratney,2008b;Gomez,Coulouma,&Lagacherie,2012a;Selige,Bohner,&Schmidhalter,2006;Stevens et al.,2010).Regardless of the regression method,the number of samples in the calibration database,the scale of study or the studied soil properties,the quality of mapping results are expressed using figures of merit such as the standard error of calibration (SEC)and standard error of prediction (SEP),which are referred to as the root mean squared error of calibration (RMSEC)and root mean squared error of prediction (RMSEP),respectively.The coef ficient of determination (R 2)or the ratio of performance deviation (RPD)is also used to measure the accuracy of multivariate model predictions.As mentioned in McBratney and Minasny (2013),the R 2and RPD give dependent information and the use of only one of both indicators is enough.The ratio of performance to interquartile (RPIQ),which is the ratio of the inter-quartile (IQ =Q3−Q1)to the RMSEP,was recently proposed as an alternative to the RPD to better take into account the shape of the distribution (Bellon-Maurel,Fernandez-Ahumada,Palagos,Roger,&McBratney,2010).All of these parameters are estimated during the model building and validation stages to evaluate the global model performance.Selige et al.(2006)used the partial least square re-gression (PLSR)method with a calibration database of 72soil samples to map sand content over a 7km 2area from HYMAP VNIR/SWIR hyperspectral data.Gomez,Lagacherie,and Bacha (2012b)used the PLSR method with a calibration database of 95soil samples to mapRemote Sensing of Environment 156(2015)58–70E-mail address:cecile.gomez@ird.fr (C.Gomez)./10.1016/j.rse.2014.09.0320034-4257/©2014Elsevier Inc.All rightsreserved.Contents lists available at ScienceDirectRemote Sensing of Environmentj o u r n a l h om e p a g e :w w w.e l s e v i e r.c o m /l o c a t e /r s eclay content over a300km2area from AISA-Dual VNIR/SWIR hyperspectral data.Both studies expressed the quality of the mapping results using the performance of their PLSR models(calculation of the figures of merit)and a visual pedological evaluation of the soil maps.Fi-nally,several studies have used geostatistical analysis to study the spa-tial structure of the predicted soil property(e.g.,Gomez et al.,2012a; Schwanghart&Jarmer,2011).In addition to the global performance indicators,visual pedological evaluations and geostatistical analysis,the uncertainty of a prediction must be assessed to better characterize the quality of prediction maps. The“uncertainty”of a prediction is defined as“a parameter associated with the result of a measurement that characterizes the dispersion of the values that could reasonably be attributed to the measurand”(AFNOR NFX07-001:1994)and is related to the variance of the predic-tion.The uncertainty can be calculated for all new predictions,while the RMSEP and other classicalfigures of merit can be calculated only from points for which the reference values are known.In the PLS regression context,the uncertainty of predictions wasfirst studied by Höskuldsson(1988),Phatak,Reilly,and Penlidis(1993) and Denham(1997),who used the hypothesis of negligible errors in pre-dictors.Those studies were expanded by Faber and Kowalski(1997),who included errors in the predictors under the general errors-in-variables model.A drawback to their approach is that the original expression is de-rived assuming that the errors in the predictors have a constant variance (the homoscedastic case).Faber and Bro(2002)proposed a new expres-sion that accommodated heteroscedastic and correlated errors;however, the expression was derived assuming that the errors in the predictors are identically and independently distributed(i.i.d.),which the authors conjectured applied to most types of heteroscedasticity.Fernandez-Ahumada,Roger,and Palagos(2012)proposed a new expression for the variance of the prediction that could be adapted to any linear calibration model,such as PLSR.This formulation respects the specificities of spec-trometry and particularly the spectral error structure that is induced by the high colinearity of the variables.Based on these studies,this paper proposes an analysis process of the uncertainty that affects predictions obtained from VNIR/SWIR airborne data.A bootstrap procedure is used to calculate the variance of the predic-tions of each VNIR/SWIR airborne spectrum that represents the sum of all of the sources of uncertainty and can be considered as the“true”variance. In addition,the distance between the spectral predictors and the spectral calibration samples is calculated as two uncertainty expressions:i)in a Principal Component Analysis(PCA)space(Mahalanobis distance)and ii)in the multivariate model space(leverage).Finally,the expression for the variance of prediction proposed by Fernandez-Ahumada et al. (2012)is adapted to the VNIR/SWIR airborne data.The adaptation of this formula allows the spatial dimension of these remote sensing data to be taken into account and allows the spatialization of the total variance of predictions and each term of the formula,including i)the variance of the predictions due to the multivariate model,ii)the variance of the pre-dictions due to the spectra and iii)the interaction between these two ef-fects.The proposed analysis process uses the spatial dimension of the VNIR/SWIR airborne data to express the uncertainties in the form of maps.This process of uncertainty analysis is applied to VNIR/SWIR AISA-Dual airborne data acquired over an area of Tunisia,for which an esti-mated clay content map was obtained by Gomez et al.(2012b).First, all of the uncertainty expressions are calculated and analyzed in a vali-dation database.Then,all of the uncertainty expressions are calculated, mapped and analyzed in a test area.Specific cases highlight several interesting characteristics of these uncertainty expressions.2.Materials2.1.NotationsIn this paper,capital bold characters are used for matrices;e.g.,A.Small bold characters are used for column vectors;e.g.,a i will denote the i th column of A.Row vectors are denoted by the transpose notation;e.g.,a′.Lowercase non-bold italic characters are used for scalar variables;e.g.,indices i.Uppercase non-bold italic characters are used for scalar constants;e.g.,the number of samples N.When needed,the matrix dimensions are indicated;e.g.,A(N×P). The trace of a square matrix A is noted as tr(A).2.2.Site descriptionThe study area is located in the Cap Bon region in northern Tunisia (36°24′N to36°53′N;10°20′E to10°58′E),60km east of Tunis (Fig.1a).This300km2area includes the Lebna catchment,which is mainly rural(N90%)and is devoted to the cultivation of cereals in addition to legumes,olive trees,vineyards and natural vegetation for animals.The region is characterized by rolling hills with elevations between0and226m.The climate varies from humid to semi-arid with inter-annual precipitation of600mm and inter-annual potential evapotranspiration of1500mm.The soil pattern of the Lebna catch-ment is mainly the result of variations in lithology.The variations in the bedrock between Miocene sandstone and marl cause large varia-tions in the physical and chemical soil properties(Zante,Collinet,& Pepin,2005).Furthermore,the distance between successive sandstone outcrops decreases significantly from the ocean to the mountains,this also causes variations in the soil property patterns(Gomez et al., 2012b).The soil materials were redistributed laterally along the slopes during the Holocene,which adds to the complexity of the soil patterns. The main soil types are regosols and eutric regosols(9.6%),which are preferentially associated with sandstone outcrops,and calcic cambisols and vertisols,which preferentially formed on marl outcrops and low-lands.The southeastern region of the study area has aflatter landscape with sandy Pliocene deposits that yield calcosols and rendzinas.2.3.VNIR/SWIR hyperspectral dataOn November2,2010,an AISA-Dual airborne hyperspectral image was acquired for the study area with a spatial resolution of5m (Fig.1b).The area of the image is approximately12km×24km.The AISA-Dual spectrometer measured the reflected radiance in359non-contiguous bands covering the400-to2450-nm spectral domain with 4.6nm bandwidths between400and970nm and6.5nm bandwidths between970and2450nm.The instantaneousfield of view(IFOV) was24°.The radiance units were converted to reflectance units using ASD spectrometer measurements of uniform surfaces(parking lots, asphalt,concrete)that were collected at the same time as the overflight. An empirical line correction method was used to calibrate eachflight line to the reflectance.Topographic corrections were performed using a digital elevation model constructed from the ASTER data and ground control points.In this study,we removed the spectral bands in the blue part of the spectral domain(between400and484nm)due to noise in these bands as well as the spectral bands between1339and 1464nm and between1772and2004nm due to vibrational–rotational H2O absorption bands.Consequently,280AISA-Dual spectral bands were retained.When the image was acquired(November2010)the bare soils represented46.3%of the study area.The rest of the area was covered by urbanization,water and vegetation consisting mainly of olive trees, native forests,green plants and vineyards.To isolate the bare soil areas,the pixels with normalized difference vegetation index(NDVI) values greater than an expert-calibrated threshold were masked;a value of0.20was determined after considering twenty parcels that had been visually inspected in thefield.Water areas were also masked using an expert-calibrated threshold;pixels with a reflectance of less than8%at1665nm were removed.Finally,urban areas were masked using a map of urban areas.An initial predicted clay content map over the Lebna catchment was obtained from a multivariate model using these AISA-Dual airborne data(Gomez et al.,2012b).59C.Gomez et al./Remote Sensing of Environment156(2015)58–70Fig.1.a)Location of the hyperspectral image (black rectangle)in Tunisia,b)location of the Kamech catchment (black rectangle)over the hyperspectral AISA-Dual image (in white the masked areas:vegetated-,urban-,and waterareas).Fig.2.Map of bare soils (black areas)over the Kamech catchment.Three studied pixels are located on the center fields (Pix_Soil 1,Pix_Soil 2,Pix_Soil 3),and three other studied pixels are located on the border fields (Pix_BoundaryField 1,Pix_BoundaryField 2,Pix_Urban ).60 C.Gomez et al./Remote Sensing of Environment 156(2015)58–70This paper focuses on a test area for the analysis of maps of the uncertainty expressions.This test area is a6.67km2area that is centered on the Kamech catchment,which contained a high percentage of bare soils during image acquisition and exhibited contrasting soil patterns(Figs.1b,2).The Kamech experimental catchment belongs to a long-term environmental research observatory called OMERE (Mediterranean observatory of water and rural environment)which aims to study the anthropogenic impacts on water and sediment budgets at catchment scale(e.g.,Mekki,Albergel,Ben Mechlia,& Voltz,2006;Raclot&Albergel,2006).The bare soils represent49.2%of the test area and10,705AISA-Dual pixels.In this area,six pixels were selected to study the expressions of uncertainty that affect the predic-tions proposed in this paper.Three of these test pixels are located in the centers of bare soilfields,and the other three are located at the boundaries offields(Fig.2).2.4.Soil sample databaseA dataset of262soil samples was collected from the Lebna catch-ment between2008and2010.All of the samples were composed of five sub-samples collected to a depth of5cm within a10×10m square centered on the geographical position of the sampling plot as recorded by a Garmin GPS instrument.The sampling strategy to collect the data followed a stratified scheme.The study area was divided in72grids of 2×2km.From two to six soil samples were collected per grid,over 60grids of the72designed grids.The remaining12grids corresponded to the Lebna lake,a Sebkha area and some grids inaccessible by cars at the bottom of the Djebel(West border of the study area).Among these262soil samples,129samples were collected infields that were bare during the hyperspectral data acquisition in November2010;58 were collected in June2008,30were collected in October2009,and 41were collected in November2010.These129samples were located over55of the72designed grids,with one to three soil samples per grid.These129soil samples constituted the soil database used in this study.After homogenizing the sample,approximately20g was devoted to the soil property analysis.The initial samples were air-dried and sieved with a2mm sieve prior to being transported to the laboratory for analysis.The clay content(granulometric fraction b2μm)was deter-mined using a pipette method(method NF X31–107,particle size dis-tribution by sedimentation,Baize&Jabiol,1995).The clay contents of the129soil samples vary between46and777g/kg and follow a normal distribution.3.Prediction model:PLSRThe partial least square regression(PLSR)method(Wold,Sjöström, &Eriksson;,2001)was used to establish relationships between the soil clay content and the VNIR/SWIR hyperspectral imaging data.The spectroscopic and chemometric analyses were implemented in R (Version1.17).Prior to the quantitative statistical analysis,the reflectance was converted into“pseudo absorbance”(log[1/reflectance]).Noise reduction was achieved through standard pre-treatments,including a Savitzky–Golayfilter with second-order polynomial smoothing and window widths of30nm(Savitzky&Golay,1964)for noise removal and a standard normal variate correction(Barnes,Dhanoa,& Lister,1993)for additive and multiplicative effect removal.The dataset was divided into a calibration set(97samples, or3/4of the total dataset,denoted BD_Calib)and a validation set(32samples,or1/4of the total dataset,denoted BD_Valid). The reference values(soil property)of the dataset were sorted in ascending order.The method starts by selecting the sample with the lowest reference value and putting it in a validation set. The next three samples are then put in the calibration set,and the procedure is continued by alternately placing the next sample in the validation set and the following three samples in the calibration set.Following this process of subdivision of the data, the distributions of the calibration and validation database were similar.Because a limited number of samples were available, a leave-one-out cross-validation procedure was adopted to verify the prediction capability of the PLSR model for the calibration set(Wold,1978).Each time,N−1samples were used to build the regression model from all N samples within the dataset. Based on this model,the value for the soil property of the sample that was not used to develop the model was predicted.This procedure was repeated for all N samples and resulted in predictions for all of the calibration samples.Outliers are commonly defined as observations that are not con-sistent with the majority of the data(Chiang,Pell,&Seasholtz, 2003;Pearson,2002),such as observations that deviate significantly from normal values.An outlier can be defined as a spectral outlier, which is a sample that is spectrally different from the other samples, or a concentration outlier,which is a predicted value with a residual difference that is significantly greater than the mean of the predicted values.One method for identifying spectral outliers uses the princi-ple of the Mahalanobis distance(Mark&Tunnell,1985)applied to PCA-reduced data.In this study,a value of3was selected to identify outliers based on the Mahalanobis distance.The analysis to detect outliers was performed for all of the samples in the calibration set, and the detected spectral and concentration outliers were deleted from the calibration set.In this paper,we only provide a brief description of the PLSR model, which is fully detailed in Wold et al.(2001).The PLSR model is devel-oped from a training set of N observations(number of spectra in the calibration dataset)with K X-variables(number of wavelengths in the spectra)denoted x k(k=1,…,K),and M Y-variables(number of soil properties)denoted y m(m=1,…M).These training data form the two matrices X and Y of dimensions(N×K)and(N×M), respectively.As in all factorial methods,the main principle of PLSR is:i)tofind a subspace of the spectral spaceℝK on which the spectra are projected,yielding a matrix of N scores T(N×k);and ii)to per-form a linear regression between T and Y.Thefirst step is carried out iteratively by searching loadings u and v fromℝK andℝM,respec-tively,such that cov2(Xu,Yv)is maximal.The scores T are thus given by T=XU.The linear regression between T and Y produces an esti-mate^Y¼T T0TÀÁ−1T0Y,so replacing T by XUfinally yields^Y¼XU U0X0XUÀÁ−1U0X0Y.Thefinal regression coefficients are given by b=U(U′X′XU)−1U′X′Y.In the case where Y contains only one re-sponse,b is a K-vector,which is usually called the“b-coefficients”and is generally analyzed as a spectrum.The k columns of U are also K-vectors and are called latent variables.The prediction performances of the PLSR models were evaluated using the coefficient of determination R cal2and R val2of the predicted values against the measured values in the calibration and validation sets,respectively.The root mean square errors of calibration(RMSEC) and the root mean square errors in the validation set(RMSEP)were also analyzed for all of the models.Finally,the proportion of the valida-tion data falling within the prediction interval prediction interval was analyzed.This prediction interval was calculated assuming that the prediction was normally distributed,as±2×SD(^y),where^y is the predicted value.If the uncertainty was correctly specified,then95%of the data should fall within the prescribed limit.4.Measurements of uncertainty affecting predictionsThe estimation^y of the y value for a new sample p can be written as: ^y¼f Xc;Yc;Model;xðÞð1Þwhere(Xc,Yc)contains the calibration spectra and the calibration responses,x is the spectrum of the sample p and Model represents the calibration action,including the preprocessing and the choice of61C.Gomez et al./Remote Sensing of Environment156(2015)58–70dimensions.Thus,each prediction relies on a chain of operations,which each adds a source of uncertainty:—The uncertainty of the spectra was assumed to be identical for the calibration and test spectra;this is mainly due to the device repeatability(Ud)and the spatial positioning(Us)—The uncertainty of the reference lab values(Uy)—The uncertainty of the model building(Um)is caused by two main factors,with Um=Uc+Ul.Uc is related to the choice made to build the calibration set,and Ul is related to the choice of model dimension.In this study,the following choices were made:Ud was considered to be negligible in comparison with Us,and Uy was ,Uc and Ul were computed by means of a bootstrap procedure(Efron,1982).Seven expressions related to the uncertainty that affected the predictions were computed and are described in the following sections.4.1.Bootstrap procedureA bootstrap procedure was performed to obtain a variance value that integrated all of the sources of uncertainty described previously.Fig.3a describes the workflows and can be summarized as:1st step:N replacement samples were drawn from the calibration dataset.2nd step:For each of the N selected samples,the associated AISA-Dual spectrum was drawn among a grid of3×3pixels that wascentered on the location of the selected sample p.The1st and2nd steps are grouped in the box called“double-drawing of the BD_Calib”,in Fig.3a.3rd step:The number of the latent variable was drawn from3to7.4th step:For each pixel p for which the estimated clay content value is searched,the associated AISA-Dual spectrum x was drawnfrom a grid of3×3pixels centered on pixel p(Fig.3c).Thisstep is the same for the validation dataset BD_Valid and forthe entire image.The1st step allows estimating a part of uncertainty of the model building(Um),caused by the choice made to build the calibration set(Uc).The2nd and4th steps allow estimating a part of uncertainty of the spectra due to spatial positioning(Us).Indeed,we assumed errors on AISA-Dual data georeferencing and collected soil samples georeferencing.Drawing randomly a pixel among a grid of3×3pixels pixels centered on the pixel p allowed to take into account these georeferencing errors in the uncertainty estimation due to the spatial positioning(Us).We used the following assumptions:—Symmetric probability of the error,centered at the central pixel p,—Maximum probability for the central pixel p,—Zero probability beyond the grid of3×3pixels centered on the pixel p.So the draw of AISA-Dual spectrum among the grid of3×3pixels follows a multinomial law,with the round probability values:0.27for the central pixel,0.09for the eight neighbor's pixels,and0for the pixels out of the grid of3×3pixels centered on the pixel p.The3rd step allows estimating a part of uncertainty of the model building(Um),caused by the choice of model dimension(Ul). Indeed,the choice of the number of latent variables is a critical step in a PLSR model building,because this choice may stronglyimpact Fig.3.Workflow of the soil property mapping associated to the uncertainty expression calculation.62 C.Gomez et al./Remote Sensing of Environment156(2015)58–70the performance of the PLSR model.To take into account this imperfect step in the PLSR model building and the bootstrap process, we choose to draw the number of latent variables following these assumptions:—Symmetric probability,centered at5,—Maximum probability for5,—Zero probability below3and above7.So the number of the latent variable is drawn from a multinomial law with the probability values:0.05for3and7,0.2for4and6,and 0.4for5.These four steps were performed R times and produced R bootstrap (training)datasets,R PLSR models,R prediction values for each new pixel and(R×K)b-coefficients.The number of iterations R was999. At each bootstrap iteration,the predicted outcomes were calculated by cross-validation,and the corresponding performance indicators R cal2and RMSEC were calculated for the calibration set.The predicted outcomes and corresponding performance indicators R val2and RMSEP were also calculated for the validation set at each of the R bootstrap iterations.4.2.Expressions of the uncertainty using the bootstrap procedureThe bootstrap procedure was used to obtain a variance value var^yðÞBS,where no assumptions were considered.At the end of the R iterations,the variance var^yðÞBS of the R predictions was calculated for each pixel of the AISA-Dual image(Fig.3a and d).When the boot-strap procedure integrates all of the sources of uncertainty(spectra, reference lab values,model building),the variance var^yðÞBS represents the sum of all of the sources of uncertainty and is considered as the “true”variance:var^yðÞBS¼UdþUsþUyþUm:ð2Þ4.3.Expressions of the uncertainty using spectral distance4.3.1.Mahalanobis distanceThe Mahalanobis distance(MD)can be used to detect outliers,which are observations located at the periphery of the data cloud that can have a stronger than average influence on thefitted model.In the framework of linear regression,the further a sample is from the center of the model, the higher its prediction uncertainty.The MD of a spectrum is calculated independently of the bootstrap procedure(Fig.3b)as the distance of this spectrum to the center of the calibration set in a PCA-reduced dimension.The MD of a VNIR/SWIR spectrum x is calculated from the calibration database as:MD xðÞ¼ffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffix−μðÞ0S−1x−μðÞqð3Þwhere x(K×1)is a VNIR/SWIR spectrum,μ(K×1)is the mean of the N calibration VNIR/SWIR spectra,and S(K×K)is the variance–covariance matrix of the N calibration spectra.The principle of the Mahalanobis distance is described in detail in Mark and Tunnell(1985).Generally, a MD value greater than3is considered to reflect an outlier to the calibration set(Mark&Tunnell,1985).The MD is related to the uncertainty of the model building(Um)with the hypothesis that the PCA space is similar to the PLSR space.4.3.2.LeverageThe leverage(H)can also be used to diagnose how atypical a new vector of a predictor is.The leverage value of a spectrum x is the distance of this spectrum to the center of the calibration set within the multivar-iate model.The leverage measures the variation within the multivariate model,so the H measurement is dependent on the model,in contrast to the Mahalanobis distance.Although the H measurement is dependent on the model,it is calculated independently of the bootstrap procedure (Fig.3b).The leverage of a VNIR/SWIR spectrum x is calculated as (Martens,1991):H xðÞ¼t0x T0TÀÁ−1t xð4Þwhere x(K×1)is a VNIR/SWIR spectrum,t x(K×1)is the score vector of x for the multivariate model,and T(N×A)is the X-score matrix of the multivariate model(see Section3).The leverage is related to the uncertainty of the model building(Um).4.4.Expressions of the uncertainty using the formula of Fernandez-Ahumada et al.(2012)4.4.1.Total variance of predictionsAs a measure of the uncertainty of the estimations made by the PLSR model,the variance model proposed by Fernandez-Ahumada et al. (2012)was applied in this study.This proposal for variance modeling is based on the errors-in-variables(EIV)model that was initially proposed by Faber and Kowalski(1997),which considers all sources of uncertainty that affect the predictors,the dependent variables and the model coeffi-cients.The difference between the classical EIV model and the variance model proposed by Fernandez-Ahumada et al.(2012)is that the latter model is constructed based on assumptions related to the predictors, which are the spectral bands.The formulation is described in detail in Fernandez-Ahumada et al.(2012)and can be written as:var^yðÞAhumada¼1þ1b0Σx bþz0Σb zþ1þ1trΣxΣbðÞþσ2labð5Þwhere^y is the prediction,z is the centered x spectrum used for the prediction,b is the K-vector of the b-coefficients of the model,N is the number of calibration samples,Σb is the variance–covariance matrix of the b-coefficients,Σx is the variance–covariance matrix associated to the spectrum x,andσlab2is the laboratory y variance.The four terms of Eq.(5),from left to right,are:T1)the hyperspectral data uncertainty,T2)the model coefficients uncertainty,T3)the depen-dency between the spectral and model uncertainties and T4)the labora-tory reference measurement uncertainty.Term T4is constant over the entire image and is small compared to the other three terms.In this study,the variance model was confined to thefirst three terms:var^yðÞAhumada¼1þ1Nb0Σx bþz0Σb zþ1þ1NtrΣxΣbðÞ:ð6ÞEach term of Eq.(6)and their calculations are described in the following sections.4.4.2.Variance of predictions due to the spectrum xThefirst term of the formula of Fernandez-Ahumada et al.(2012) (denoted T1;Fig.3d)expresses the variance of the predictions caused by the uncertainty of the hyperspectral data x corresponding to the pixel p:T1¼1þ1Nb0Σx bð7Þwhere N is the number of samples in the calibration set,b is the model coefficients(here,the mean of the R b-coefficient vectors obtained in the bootstrap procedure),andΣx is a variance–covariance matrix that describes the uncertainty of the spectrum x.In this study,the variance–covariance matrixΣx was calculated as follows:Let G be the matrix in which each line is a spectrum that belongs to the grid of3×3pixels centered on the pixel p and centered columnwiseΣx¼18G0Gð8Þ63C.Gomez et al./Remote Sensing of Environment156(2015)58–70。

超声增强的输送的物料进入并通过皮肤翻译

超声增强的输送的物料进入并通过皮肤翻译

超声增强的输送的物料进入并通过皮肤翻译Ultrasound-enhanced delivery of materials into and through the skinA method for enhancing the permeability of the skin or other biological membrane to a material such as a drug is disclosed. In the method, the drug is delivered in conjunction with ultrasound having a frequency of above about 10 MHz. The method may also be used in conjunction with chemical permeation enhancers and/or with iontophoresis.图片(11)权利要求(21)We claim:1. A method for enhancing the rate of permeation of a drug medium into a selected intact area of an individual's body surface, which method comprises:(a) applying ultrasound having a frequency of above 10 MHz to said selected area, at an intensity and for a period of timeeffective to enhance the permeability of said selected area;(b) contacting the selected area with the drug medium; and(c) effecting passage of said drug medium into and through said selected area by means of iontophoresis.2. The method of claim 1, wherein said ultrasound frequency is in the range of about 15 MHz to 50 MHz.3. The method of claim 2, wherein said ultrasound frequency is in the range of about 15 to 25 MHz.4. The method of claim 1, wherein said period of time is in the range of about 5 to 45 minutes.5. The method of claim 4, wherein said period of time is in the range of about 5 to 30 minutes.6. The method of claim 1, wherein said period of time is less than about 10 minutes.7. The method of claim 1, wherein said intensity of said ultrasound is less than about 5.0W/cm.sup.2.8. The method of claim 7, wherein said intensity of said ultrasound is in the range of about 0.01 to 5.0 W/cm.sup.2.9. The method of claim 8, wherein said intensity of said ultrasound is in the range of about 0.05 to 3.0 W/cm.sup.2.10. The method of claim 1, wherein said area of the stratum corneum is in the range of about 1 to 100 cm.sup.2.11. The method of claim 10, wherein said area of the stratum corneum is in the range of about 5 to 100 cm.sup.2.12. The method of claim 11, wherein said area of the stratum corneum is in the range of about 10 to 50 cm.sup.2.13. The method of claim 1 wherein said drug medium comprises a drug and a coupling agent effective to transfer said ultrasound to the body from an ultrasound source.14. The method of claim 13 wherein said coupling agent is a polymer or a gel.15. The method of claim 13 wherein said coupling agent is selected from the group consisting of glycerin, water, and propylene glycol.16. The method of claim 1 wherein said drug medium further comprises a chemical permeation enhancer.17. The method of claim 1, wherein steps (a) and (b) are carried out approximately simultaneously.18. The method of claim 1, wherein step (b) is carried out before step (a).19. The method of claim 1, wherein step (a) is carried out before step (b).20. The method of claim 1, wherein the ultrasound is applied continuously.21. The method of claim 1, wherein the ultrasound is pulsed.说明This application is a division of application Ser. No. 07/844,732 filed Mar. 2, 1992, now U.S. Pat. No. 5,231,975 which is a divisional of application Ser. No. 07/484,560, now U.S. Pat. No. 5,115,805, filed Feb. 23, 1990.TECHNICAL FIELDThis invention relates generally to the field of drug delivery. More particularly, the invention relates to a method of enhancing the rate of permeation of topically, transmucosally or transdermally applied materials using high frequency ultrasound.BACKGROUNDThe delivery of drugs through the skin ("transdermal drug delivery" or "TDD") provides many advantages; primarily, such a means of delivery is a comfortable, convenient and non-invasiveway of administering drugs. The variable rates of absorption and metabolism encountered in oral treatment are avoided, and other inherent inconveniences--e.g., gastrointestinal irritation and the like--are eliminated as well. Transdermal drug delivery also makes possible a high degree of control over blood concentrations of any particular drug.Skin is a structurally complex, relatively impermeable membrane. Molecules moving from the environment into and through intact skin must first penetrate the stratum corneum and any material on its surface. They must then penetrate the viable epidermis, the papillary dermis, and the capillary walls into the blood stream or lymph channels. To be so absorbed, molecules must overcome a different resistance to penetration in each type of tissue. Transport across the skin membrane is thus a complex phenomenon. However, it is the stratum corneum, a layer approximately 5-15 micrometers thick over most of the body, which presents the primary barrier to absorption of topical compositions or transdermally administered drugs. It is believed to be the high degree of keratinization within its cells as well as their dense packing and cementation by ordered, semicrystalline lipids which create in many cases a substantially impermeable barrier to drug penetration. Applicability of transdermal drug delivery is thus presently limited, because the skin is such an excellent barrier to the ingress of topically applied materials. For example, many of the new peptides and proteins now produced as a result of the biotechnology revolution cannot be delivered across the skin in sufficient quantities due to their naturally low rates of skin permeability.Various methods have been used to increase skin permeability, and in particular to increase the permeability of thestratum corneum (i.e., so as to achieve enhanced penetration, through the skin, of the drug to be administered transdermally). The primary focus has been on the use of chemical enhancers, i.e., wherein drug is coadministered with a penetration enhancing agent (or "permeation enhancer"). While such compounds are effective in increasing the rate at which drug is delivered through the skin, there are drawbacks with many permeation enhancers which limit their use. For example, many permeation enhancers are associated with deleterious effects on the skin (e.g., irritation). In addition, control of drug delivery with chemical enhancement can be quite difficult.Iontophoresis has also been used to increase the permeability of skin to drugs, and involves (1) the application of an external electric field, and (2) topical delivery of an ionized form of drug (or of a neutral drug carried with the water flux associated with ion transport, i.e., via "electroosmosis"). While permeation enhancement via iontophoresis has, as with chemical enhancers, been effective, there are problems with control of drug delivery and the degree of irreversible skin damage induced by the transmembrane passage of current.The presently disclosed and claimed method involves the use of ultrasound to decrease the barrier function of the stratum corneum and thus increase the rate at which a drug may be delivered through the skin. "Ultrasound" is defined as mechanical pressure waves with frequencies above 20,000 Hz (see, e.g., H. Lutz et al., Manual of Ultrasound: 1. Basic Physical and Technical Principles (Berlin: Springer-Verlag, 1984)).As discussed by P. Tyle et al. in Pharmaceutical Research 6(5):355-361 (1989), drug penetration achieved via "sonophoresis" (the movement of drugs through skin under theinfluence of an ultrasonic perturbation; see D. M. Skauen and G. M. Zentner, Int. J. Pharmaceutics 20:235-245 (1984)), is believed to result from thermal, mechanical and chemical alteration of biological tissues by the applied ultrasonic waves. Unlike iontophoresis, the risk of skin damage appears to be low.Applications of ultrasound to drug delivery have been discussed in the literature. See, for example: P. Tyle et al., supra (which provides an overview of sonophoresis); S. Miyazaki et al., J. Pharm. Pharmacol. 40:716-717 (1988) (controlled release of insulin from a polymer implant using ultrasound); J. Kost et al., Proceed. Intern. Symp. Control. Rel. Bioact. Mater.16(141):294-295 (1989) (overview of the effect of ultrasound on the permeability of human skin and synthetic membranes); H. Benson et al., Physical Therapy 69(2):113-118 (1989) (effect of ultrasound on the percutaneous absorption of benzydamine); E. Novak, Arch. Phys. Medicine & Rehab. 45:231-232 (1964) (enhanced penetration of lidocaine through intact skin using ultrasound); J. E. Griffin et al., Amer. J. Phys. Medicine 44(1):20-25 (1965) (ultrasonic penetration of cortisol into pig tissue); J. E. Griffin et al., J. Amer. Phys. Therapy Assoc.46:18-26 (1966) (overview of the use of ultrasonic energy in drug therapy); J. E. Griffin et al., Phys. Therapy 47(7):594-601 (1967) (ultrasonic penetration of hydrocortisone); J. E. Griffin et al., Phys. Therapy 48(12):1336-1344 (1968) (ultrasonic penetration of cortisol into pig tissue); J. E. Griffin et al., Amer. J. Phys. Medicine 51(2):62-72 (1972) (same); J. C. McElnay, Int. J. Pharmaceutics 40:105-110 (1987) (the effect of ultrasound on the percutaneous absorption of fluocinolone acetonide); and C. Escoffier et al., Bioeng. Skin 2:87-94 (1986) (in vitro study of the velocity of ultrasound in skin).In addition to the aforementioned art, U.S. Pat. Nos. 4,767,402 and 4,780,212 to Kost et al. relate specifically to the use of specific frequencies of ultrasound to enhance the rate of permeation of a drug through human skin or through a synthetic membrane.While the application of ultrasound in conjunction with drug delivery is thus known, results have for the most part been disappointing, i.e., enhancement of skin permeability has been relatively low.SUMMARY OF THE INVENTIONThe present invention provides a novel method for enhancing the rate of permeation of a given material through a selected intact area of an individual's body surface. The method comprises contacting the selected intact area with the material and applying ultrasound to the contacted area. The ultrasound preferably has a frequency of above about 10 MHz, and is continued at an intensity and for a period of time sufficient to enhance the rate of permeation of the material into and through the body surface. The ultrasound can also be used to pretreat the selected area of the body surface in preparation for drug delivery, or for diagnostic purposes, i.e., to enable non-invasive sampling of physiologic material beneath the skin or body surface.In addition to enhancing the rate of permeation of a material, the present invention involves increasing the permeability of a biological membrane such as the stratum corneum by applying ultrasound having a frequency of above about 10 MHz to the membrane at an intensity and for a period of time sufficient to give rise to increased permeability of the membrane. Once the permeability of the membrane has been increased, it is possible to apply a material thereto and obtain an increased rate of flowof the material through the membrane.It is accordingly a primary object of the invention to address the aforementioned deficiencies of the prior art by providing a method of enhancing the permeability of biological membranes and thus allow for an increased rate of delivery of material therethrough.It is another object of the invention to provide such a method which is effective with or without chemical permeation enhancers.It is still another object of the invention to minimize lag time in such a method and provide a relatively short total treatment time.It is yet another object of the invention to provide such a method in which drug delivery is effected using ultrasound.It is a further object of the invention to enable sampling of tissue beneath the skin or other body surface by application of high frequency (>10 MHz) ultrasound thereto.A further feature of the invention is that it preferably involves ultrasound of a frequency greater than about 10 MHz.Additional objects, advantages and novel features of the invention will be set forth in part in the description which follows, and in part will become apparent to those skilled in the art upon examination of the following, or may be learned by practice of the invention.BRIEF DESCRIPTION OF THE DRAWINGSFIGS. 1A, 1B and 1C are theoretical plots of energy dissipation within the skin barrier versus frequency of applied ultrasound.FIGS. 2, 3 and 4 are graphic representations of the amount of salicylic acid recovered from the stratum corneum after ultrasound treatment at different frequencies.FIGS. 5 and 6 represent the results of experiments similar to those summarized in FIGS. 2, 3 and 4, but with a shorter treatment time.FIGS. 7, 8, 9 and 10 are plots of enhancement versus "tape-strip number," as described in the Example.FIG. 11 illustrates the effect of ultrasound on the systemic availability of salicylic acid following topical application.DETAILED DESCRIPTION OF PREFERRED EMBODIMENTSBefore the present method of enhancing the rate of permeation of a material through a biological membrane and enhancing the permeability of membranes using ultrasound are disclosed and described, it is to be understood that this invention is not limited to the particular process steps and materials disclosed herein as such process steps and materials may, of course, vary. It is alto to be understood that the terminology used herein is used for purpose of describing particular embodiments only and is not intended to be limiting since the scope of the present invention will be limited only by the appended claims.It must be noted that as used in this specification and the appended claims, the singular forms "a", "an" and "the" include plural reference unless the context clearly dictates otherwise. Thus, for example, reference to "a drug" includes mixtures of drugs and their pharmaceutically acceptable salts, reference to "an ultrasound device" includes one or more ultrasound devices of the type necessary for carrying out the present invention, and reference to "the method of administration" includes one or more different methods of administration known to those skilled in the art or which will become known to those skilled in the art upon reading this disclosure.In one aspect of the invention a method is provided forenhancing the permeation of a given material such as a drug, pharmacologically active agent, or diagnostic agent into and/or through a biological membrane on an individual's body surface, which method comprises: (a) contacting the membrane with the chosen material in a pharmacologically acceptable carrier medium; and (b) applying ultrasound of an intensity and for a treatment time effective to produce delivery of the material through the membrane. The material is preferably a drug and it is preferable to obtain a desired blood level of the drug in the individual. The ultrasound is of a frequency and intensity effective to increase the permeability of the selected area to the applied drug over that which would be obtained without ultrasound. The ultrasound preferably has a frequency of more than 10 MHz, and may be applied either continuously or pulsed, preferably continuously. The ultrasound may be applied to the skin either before or after application of the drug medium so long as administration of the ultrasound and the drug medium is relatively simultaneous, i.e., the ultrasound is applied within about 6, more preferably within about 4, most preferably within about 2 minutes of drug application.The invention is useful for achieving transdermal permeation of pharmacologically active agents which otherwise would be quite difficult to deliver through the skin or other body surface. For example, proteinaceous drugs and other high molecular weight pharmacologically active agents are ideal candidates for transdermal, transmucosal or topical delivery using the presently disclosed method. In an alternative embodiment, agents useful for diagnostic purposes may also be delivered into and/or through the body surface using the present method.The invention is also useful as a non-invasive diagnostictechnique, i.e., in enabling the sampling of physiologic material from beneath the skin or other body surface and into a collection (and/or evaluation) chamber.The present invention will employ, unless otherwise indicated, conventional pharmaceutical methodology and more specifically conventional methodology used in connection with transdermal delivery of pharmaceutically active compounds and enhancers.In describing the present invention, the following terminology will be used in accordance with the definitions set out below.A "biological membrane" is intended to mean a membrane material present within a living organism which separates one area of the organism from another and, more specifically, which separates the organism from its outer environment. Skin and mucous membranes are thus included."Penetration enhancement" or "permeation enhancement" as used herein relates to an increase in the permeability of skin to a material such as a pharmacologically active agent, i.e., so as to increase the rate at which the material permeates into and through the skin. The present invention involves enhancement of permeation through the use of ultrasound, and, in particular, through the use of ultrasound having a frequency of greater than 10 MHz."Transdermal" (or "percutaneous") shall mean passage of a material into and through the skin to achieve effective therapeutic blood levels or deep tissue therapeutic levels. While the invention is described herein primarily in terms of "transdermal" administration, it will be appreciated by those skilled in the art that the presently disclosed and claimed methodalso encompasses the "transmucosal" and "topical" administration of drugs using ultrasound. "Transmucosal" is intended to mean passage of any given material through a mucosal membrane of a living organism and more specifically shall refer to the passage of a materialfrom the outside environment of the organism, through a mucous membrane and into the organism. "Transmucosal" administration thus includes delivery of drugs through either nasal or buccal tissue. By "topical" administration is meant local administration of a topical pharmacologically active agent to the skin as in, for example, the treatment of various skin disorders or the administration of a local anaesthetic. "Topical" delivery can involve penetration of a drug into the skin but not through it, i.e., topical administration does not involve actual passage of a drug into the bloodstream."Carriers" or "vehicles" as used herein refer to carrier materials without pharmacological activity which are suitable for administration with other pharmaceutically active materials, and include any such materials known in the art, e.g., any liquid, gel, solvent, liquid diluent, solubilizer, or the like, which is nontoxic and which does not interact with the drug to be administered in a deleterious manner. Examples of suitable carriers for use herein include water, mineral oil, silicone, inorganic gels, aqueous emulsions, liquid sugars, waxes, petroleum jelly, and a variety of other oils and polymeric materials.By the term "pharmacologically active agent" or "drug" as used herein is meant any chemical material or compound suitable for transdermal or transmucosal administration which can either (1) have a prophylactic effect on the organism and prevent an undesired biological effect such as preventing aninfection, (2) alleviates a condition caused by a disease such as alleviating pain caused as a result of a disease, or (3) either alleviates or completely eliminates the disease from the organism. The effect of the agent may be local, such as providing for a local anaesthetic effect or it may be systemic. Such substances include the broad classes of compounds normally delivered through body surfaces and membranes, including skin. In general, this includes: anti-infectives such as antibiotics and antiviral agents; analgesics and analgesic combinations; anorexics; antihelminthics; antiarthritics; antiasthmatic agents; anticonvulsants; antidepressants; antidiabetic agents; antidiarrheals; antihistamines; antiinflammatory agents; antimigraine preparations; antinauseants; antineoplastics; antiparkinsonism drugs; antipruritics; antipsychotics; antipyretics; antispasmodics; anticholinergics; sympathomimetics; xanthine derivatives; cardiovascular preparations including potassium and calcium channel blockers, beta-blockers, and antiarrhythmics; antihypertensives; diuretics; vasodilators including general coronary, peripheral and cerebral; central nervous system stimulants; cough and cold preparations, including decongestants; hormones such as estradiol and other steroids, including corticosteroids; hypnotics; immunosuppressives; muscle relaxants; parasympatholytics; psychostimulants; sedatives; and tranquilizers. By the method of the present invention, both ionized and nonionzed drugs may be delivered, as can drugs of either high or low molecular weight.Proteinaceous and polypeptide drugs represent a preferred class of drugs for use in conjunction with the presently disclosed and claimed invention. Such drugs cannot generally be administered orally in that they Are often destroyed in the G.I.tract or metabolized in the liver. Further, due to the high molecular weight of most polypeptide drugs, conventional transdermal delivery systems are not generally effective. It is also desirable to use the methodof the invention in conjunction with drugs to which the permeability of the skin is relatively low, or which give rise to a long lag-time (application of ultrasound as described herein has been found to significantly reduce the lag-time involved with the transdermal administration of most drugs).By a "therapeutically effective" amount of a pharmacologically active agent is meant a nontoxic but sufficient amount of a compound to provide the desired therapeutic effect. The desired therapeutic effect may be a prophylactic effect, in preventing a disease, an effect which alleviates a system of the disease, or a curative effect which either eliminates or aids in the elimination of the disease.As noted above, the present invention is a method for enhancing the rate of permeation of a drug through an intact area of an individual's body surface, preferably the human skin. The method involves transdermal administration of a selected drug in conjunction with ultrasound. Ultrasound causes thermal, mechanical and chemical alterations of biological tissue, thereby enhancing the rate of permeation of a given material therethrough.While not wishing to be bound by theory, applicants propose that the use of higher frequency ultrasound as disclosed herein specifically enhances the permeation of the drug through the outer layer of skin, i.e., the stratum corneum, by causing momentary and reversible perturbations within (and thus short-term, reversible reduction in the barrier function of) the layer ofthe stratum corneum. It will be appreciated by those skilled in the art of transdermal drug delivery that a number of factors related to the present method will vary with the drug to be administered, the disease or injury to be treated, the age of the selected individual, the location of the skin to which the drug is applied, and the like.As noted above, "ultrasound" is ultrasonic radiation of a frequency above 20,000 Hz. As may be deduced from the literature cited above, ultrasound used for most medical purposes typically employs frequencies ranging from 1.6 to about 10 MHz. The present invention, by contrast, employs ultrasound frequencies of greater than about 10 MHz, preferably in the range of about 15 to 50 MHz, most preferably in the range of about 15 to 25 MHz. It should be emphasized that these ranges are intended to be merely illustrative of the preferred embodiment; in some cases higher or lower frequencies may be used.The ultrasound may be pulsed or continuous, but is preferably continuous when lower frequencies are used. At very high frequencies, pulsed application will generally be preferred so as to enable dissipation of generated heat.The preferred intensity of the applied ultrasound is less than about 5.0 W/cm.sup.2, more preferably is in the range of about 0.01 to 5.0 W/cm.sup.2, and most preferably is in the range of 0.05 to 3.0 W/cm.sup.2. The total treatment time, i.e., the period over which drug and ultrasound are administered, will vary depending on the drug administered, the disease or injury treated, etc., but will generally be on the order of about 30 seconds to 60 minutes, preferably 5 to 45 minutes, more preferably 5 to 30 minutes, and most preferably 5 to 10minutes. It should be noted that the aforementioned ranges represent suggested, or preferred, treatment times, but are not in any way intended to be limiting. Longer or shorter times may be possible and in some cases desirable. Virtually any type of device may be used to administer the ultrasound, providing that the device is callable of producing the higher frequency ultrasonic waves required by the present method. A device will typically have a power source such as a small battery, a transducer, a reservoir in which the drug medium is housed (and which may or may not be refillable), and a means to attach the system to the desired skin site.As ultrasound does not transmit well in air, a liquid medium is generally needed to efficiently and rapidly transmit ultrasound between the ultrasound applicator and the skin. As explained by P. Tyle et al., cited above, the selected drug medium should contain a "coupling" or "contacting" agent typically used in conjunction with ultrasound. The coupling agent should have an absorption coefficient similar to that of water, and furthermore be nonstaining, nonirritating to the skin, and slow drying. It is clearly preferred that the coupling agent retain a paste or gel consistency during the time period of ultrasound administration so that contact is maintained between the ultrasound source and the skin. Examples of preferred coupling agents are mixtures of mineral oil and glycerine and propylene glycol, oil/water emulsions, and a water-based gel. A solid-state, non-crystalline polymeric film having the above-mentioned characteristics may also be used. The drug medium may also contain a carrier or vehicle, as defined alone.A transdermal patch as well known in the art may be used in conjunction with the present invention, i.e., to deliver the drugmedium to the skin. The "patch", however, must have the properties of the coupling agent as described in the preceding paragraph so as to enable transmission of the ultrasound from the applicator, through the patch, to the skin.As noted earlier in this section, virtually any chemical material or compound suitable for transdermal, transmucosal or topical administration may be administered using the present method. Again, the present invention is particularly useful to enhance delivery of proteinaceous and other high molecular weight drugs.The method of the invention is preferably carried out as follows. The drug medium, i.e., containing the selected drug or drugs in conjunction with the coupling agent and optionally a carrier or vehicle material, is applied to an area of intact body surface. Ultrasound preferably having a frequency greater than about 10 MHz may be applied before or after application of the drug medium, but is preferably applied immediately before application of the drug so as to "pretreat" the skin prior to drug administration.It should also be pointed out that the present method may be used in conjunction with a chemical permeation enhancer as known in the art, wherein the ultrasound enables the use of much lower concentrations of permeation enhancer--thus minimizing skin irritation and other problems frequently associated with such compounds--than would be possible in the absence of ultrasound. The permeation enhancer may be incorporated into the drug medium or it maybe applied in a conventional transdermal patch after pretreatment of the body surface with ultrasound.The present invention may also be used in conjunction with。

资勘专业英语段落翻译

资勘专业英语段落翻译

Unit1 Cosmic Beginnings宇宙的起源1.Where and when does the history of the Earth begin? Only in the last few decades could this question be asked with any hope of a scientific answer. 地球的历史上是何时何地开始的?只有在过去的几十年里,这个问题才有了一个比较科学的回答来解释。

Certainly one good point at which to start is the time when the materials that were to become the Earth became separated in space from materials that were to become other members of the solar system. 当然存在一个较好的说法是地球的起源时间是当组成地球的物质在宇宙中开始与太空中组成太阳系其它成员的物质分离的时候.Although the story could well commence here, a great many important questions would remain unanswered.虽然故事很可能开始在这里,许多重要的问题仍悬而未决。

Something needs to be said about the materials that make up the Earth, and this pushes the question of origin to a more remote period. 一些有必要提及的物质构成了地球,这将推动更偏远的起源问题。

Earth's partners in space must also be considered. 地球在太空的合作伙伴也必须加以考虑。

大连海事大学老题库翻译 第6章

大连海事大学老题库翻译 第6章

第六章(1733---1911)1733 Your ship is solely to the damage to my crane.A. To.B.C. Of.D. On.对于起重机的损坏,你船完全。

1734 Your kind attention to the above will be much ______.A. Appreciate.B.C. Appreciating.D. Being appreciated. 你对上述的友好关注将被(给予)很多的。

(非常感谢你对上述事情的关注)1735 Your kind attention to our ship will be ______.A. B. Much appreciating. C. Many appreciated. D. Many appreciating. 你对我船的友好关注将被(给予)Much可修饰动词,而Many不能修饰动词;Be much appreciated非常感谢1736 You should not the fresh water ______ three trips.A. In.B.C. To.D. For.你不应淡水三个航次。

xxh1737 You shall ______ this letter so as to signify your acknowledgement of the responsibility.A. Make out.B. Submit.C. Produce.D.你应这个信件以便表示你责任的确认。

1738 You must ______ in this area unless you have messages about the casualty.A. Keep radio silence.B.C. Keep radio be silent.D. Keep silent the radio.你必须直到你收到有关伤亡的信息。

翻译——精选推荐

翻译——精选推荐

Modelling the grain orientation of austenitic stainless steel multipass welds to improve ultrasonic assessment of structural integrity奥氏体不锈钢的多路模拟晶粒取向改善焊缝超声评价结构完整性J. Moysan a,*, A. Apfel a, G. Corneloup a, B. Chassignole bJ.莫伊桑A.阿普费尔G.科尔内卢帕 B.沙西尼奥尔aLaboratoire de Caracte´risation Non Destructive (LCND, EA 3153), Universite´ de la Me´diterrane´e, IUT Avenue Gaston Berger,13625 Aix-en-Provence Cedex, FrancebElectricite´ De France, Direction Etudes et Recherches, Les Renardie`res, 77818 MoretsurLoing, FranceReceived 1 August 2002; revised 4 February 2003; accepted 4 February 2003 AbstractKnowledge of the grain orientation quantifies the material anisotropy which helps to ensure the good ultrasonic testing of weldedassemblies and the assessment of their mechanical integrity. The model described here concerns the weld solidification of 316L stainlesssteel. The solidification of multipass welds made with a shielded electrode raises many unsolved modelling questions as it involves heat andfluid flow modelling in addition to soluteredistribution models. To overcome these difficulties we have developed the MINA model topredict the resulting grain orientations without using a complete solidification model. This model relies upon a phenomenologicaldescriptionof grain orientations from macrograph analysis. One important advance of this model is to include data reporting in the welding notebook thatensures the generality of the model. This model allows us to accurately simulate the ultrasonic testing of welded co mponents and to propose anew tool to associate welding design with the ultrasonic assessment of structural integrity.Keywords: Welding; Anisotropy; Modelling; Ultrasound; Structural integrity文摘晶粒取向量化材料各向异性的知识,有助于确保良好的焊接程序集和评估超声检测机械的完整性。

作物生产理论

作物生产理论

一、名词解释1、优质棉:优质棉是能充分满足和适应纺织工业生产不同类型、不同品质棉织用纱所必需的质量指标,并能为纺织工业和植棉者提供最大经济效益的原棉。

2、四桃:伏前桃:指7月15日以前开花所结的棉铃,江淮流域也以7月20日作时间限。

伏桃:指7月16日(江淮流域也用7月20日)至8月15日期间开花所结的棉铃。

早秋桃:指8月16日至8月25日(江淮流域也用8月30日)期间开花所结的棉铃。

晚秋桃:指8月26日(或8月31日)至有效开花结铃终止期开花所结的棉铃。

3、成铃时空分布:棉花群体开花结铃时间长达70天(7/上-9/10)左右,以时间为主线形成的产量和品质差异规律,就是棉花单铃产量和品质的时间分布特征。

棉花不同果枝、果节位的结铃,形成铃重、衣分及纤维品质变化的规律,就是棉花产量和品质的空间分布特征。

4、优化成铃:优化成铃就是实现棉花集中成铃期(高能转化期)与高温富照期(最佳光热季节)的高度同步,达到优质铃强势果节的高成铃强度。

5、单铃经济系数:成熟棉铃风干状态下实收单铃皮棉或籽棉重量占单铃实收全部干物重的百分率。

6、圆锥体规律:棉花现蕾的顺序是:由下而上,由内而外,以第一果节为中心,呈螺旋形由内向外,由下向上逐渐推进。

7、强(弱)势果节:强势果节的空间,结铃率和铃重高、烂铃率低的强势果节量中有84.4%座落于近主茎的1、2内围果节,外围果节仅占15.6%。

8、三同步四集中:三同步是指棉花集中成铃期与成铃最佳光热季节和肥效高峰期三者的高度同步。

集中现蕾、集中开花、集中成铃、集中吐絮简称“四集中”,这是棉花优化成铃的目标之一。

9、最佳结铃期:集中成铃期与最佳光热季节相同步的时期称之为最佳结铃期。

10、“密矮早”:大群体、小个体,多结内围铃,是增产优质棉的一个途径。

密度较高、分布均匀、植株矮化、生长整齐的高产群体。

11、“小壮高”:采取扩行降密,小群体、壮个体,增加中上部铃,更易于达到高产更高产。

1、初生根:也叫胚根、种子根。

翻译

翻译

• Different comminution methods produce various particle sizes. For example, chipping and milling/grinding yield final particle sizes of 10-30 mm and 0.2-2 mm, respectively . • 不同的粉碎机生产出不同颗粒尺寸的颗粒。例如,切片机和制粉机最 后打磨出来的颗粒是分别是10—30mm或者0.2—2mm。
• Comminution of biomass can be accomplished by using milling or grinding machines, including ball, vibro,hammer, knife, two-roll, colloid, and attrition mills,as well as extruders. • 生物质的粉碎,使得在碾磨、粉碎机的时候更熟练,包括 球磨机、振捣、敲打、刀片、双轴、胶体、摩擦搅拌还有 挤压机。 • The selection of a comminution machine depends on the moisture content of the feedstock. • 粉碎机的选择取决于原料水分含量的含量。
2. Physical pretreatment 物理预处理
Physical pretreatment refers to methods that do not use chemicals or microorganisms during the pretreatment processes. 物理预处理方法涉及的方法是在预处理过程中不使用化学药品 或者微生物。

航海英语改革版海上搜索

航海英语改革版海上搜索

Ê®Æß º£ÉÏËѾÈ14.1 º£ÉÏËÑË÷[4601]______ the survivors known more of how to cope with cold water in the sinking of MV Titanic in 1912 countless lives ______.A. Have£¯could have been savedB. Have£¯could have savedC. Had£¯could has savedD. Had£¯could have been savedKEY: D[4602]A marker pole£¬with a horseshoe buoy and a sea anchor attached£¬should be used to ______.A. mark the position of a lost mooringB. determine your vessel's sideslip underwayC. determine your speed through the waterD. indicate location of a man overboardKEY: D[4603]A rescuer can most easily determine whether or not an adult victim has a pulse by checking the pulse at the ______.A. carotid artery in the neckB. femoral artery in the groinC. brachial artery in the armD. radial artery in the wristKEY: A[4604]A seaman has a small£¬gaping laceration of the arm that is not bleeding excessively. What can be done as an alternative to suturing to close the wound?A. Wrap a tight bandage around the wound.B. Apply a compression bandage.C. Use temporary stitches of sail twine.D. Apply butterfly strips£¬then a sterile dressing.KEY: D[4605]A seaman is reported missing in the morning and was last seen after coming off the mid-watch. Which type of turn would you use to return to the trackline steamed during the night?A. WilliamsonB. RacetrackC. 180turnD. AndersonKEY: A[4606]A ship must have on board a first-aid kit that is approved by the ______.A. Minerals Management ServiceB. Occupational Safety and Health AdministrationC. Mine Safety and Health AdministrationD. American Bureau of ShippingKEY: C[4607]A shipmate chokes suddenly£¬cannot speak£¬and starts to turn blue. You should ______.A. perform the Heimlich maneuverB. make the victim lie down with the feet elevated to get blood to the brainC. immediately administer CPRD. do nothing until the victim becomes unconsciousKEY: A[4608]A shipmate suffers a heart attack and stops breathing. You must ______.A. administer oxygenB. immediately check his pulse and start CPRC. make the victim comfortable in a bunkD. immediately give a stimulant£¬by force if necesssaryKEY: B[4609]A snag or other underwater obstruction may form a ______.A. V-shaped ripple with the point of the V pointing upstreamB. V-shaped ripple with the point of the V pointing downstreamC. small patch of smooth water on a windy dayD. smoothing out of the vessel's wakeKEY: A[4610]A survival craft being used to pick up a person who has fallen overboard from a vessel should approach the person ______.A. at a high rate of speedB. under oarsC. against the windD. with the windKEY: C[4611]A tourniquet should be used to control bleeding ONLY ______.A. with puncture woundsB. when all other means have failedC. when the victim is unconsciousD. to prevent bleeding from minor woundsKEY: B[4612]A tug is approaching a broken down steamer in moderately heavy weather preparing to take it in tow. In most cases the ______.A. steamer will drift stern downwindB. tug will drift faster than the steamerC. tug should approach stern toD. tug should approach from downwindKEY: D[4613]After you activate your emergency position indicating radiobeacon£¬you should ______.A. turn it off for five minutes every half-hourB. turn it off and on at five-minute intervalsC. turn it off during daylight hoursD. leave it on continuouslyKEY: D[4614]All casualties such as personnel injuries or illness£¬oil spills£¬accidental fire£¬collision£¬stranding£¬and unusually severe weather damage£¬whether at sea£¬in port£¬or in shipyard£¬must be promptly ______to the company.A. spokenB. saidC. toldD. communicatedKEY: D[4615]AN APPOINTMENT BETWEEN VESSELS NORMALLY MADE ON RADIO TO MEET IN A CERTAIN AREA OR POSITION defines ______.A. Bona fideB. Rendez-vousC. Prima facieD. Action in personamKEY: B[4616]An emergency sea anchor may be constructed by using ______.A. a boat bucketB. an air tank filled with waterC. an oar and canvas weighted downD. All of the aboveKEY: D[4617]An immersion suit must be equipped with a(n) ______.A. air bottle for breathingB. whistle and lightC. whistle£¬light£¬and reflective tapeD. whistle£¬light£¬and sea dye markerKEY: C[4618]If you see anybody fall overboard£¬act as follows except __________.A. tell an officer/crew the person's position in the water£¬or telephone the bridge immediatelyB. throw lifebuoys overboardC. call out "Man overboard" and keep your eyes on the person in the waterD. try to find medicine for the person to use when he is rescuedKEY: D[4619]If£¬for any reason£¬it is necessary to abandon ship while far out at sea£¬it is important that the crew members should ______.A. separate from each other as this will increase the chances of being rescuedB. get away from the area because sharks will be attracted to the vesselC. immediately head for the nearest landD. remain together in the area because rescuers will start searching at the vessel's last known positionKEY: D[4620]Immediately after abandoning a vessel£¬lookouts should be posted aboard liferafts to look for ______.A. survivors in the waterB. food and waterC. landD. bad weatherKEY: A[4621]In a racetrack turn£¬to recover a man overboard£¬the vessel is steadied for the SECOND time after a turn of how many degrees from the original heading?A. 60B. 135C. 180D. 360KEY: D[4622]In relation to the turning circle of a ship£¬the term advance means the distance ______.A. gained at right angles to the original courseB. gained in the direction of the original courseC. moved sidewise from the original course when the rudder is first put overD. around the circumference of the turning circleKEY: A[4623]Information on search and rescue procedures will be found in the ______.A. World Port IndexB. International Code of SignalsC. Sailing DirectionsD. Merchant Ship Search and Rescue Manual (MERSAR)KEY: D[4624]MOVING OF AN ANCHOR OVER THE SEA BOTTOM INVOLUNTARILY BECAUSE IT IS NO LONGER PREVENTING THE MOVEMENT OF THE VESSEL defines ______.A. Dredging (of anchor)B. Dragging (of anchor)C. Weighing anchorD. Walking out anchorKEY: B[4625]One of your crew members falls overboard from the starboard side. You should IMMEDIATELY ______.A. apply left rudderB. throw the crew member a life preserverC. begin backing your enginesD. position your vessel to windward and begin recoveryKEY: B[4626]The best method to secure a towline to bitts is to ______.A. take a round turn on the bitt farthest from the pull and use figure-eightsB. take a round turn on the bitt closest to the pull and use figure-eightsC. use figure-eights and take a round turn at the top of the bittsD. use only figure-eightsKEY: B[4627]The distance a vessel moves at right angles to the original course£¬when a turn of 180has been completed£¬is called the ______.A. advanceB. pivoting pointC. tactical diameterD. kickKEY: C[4628]The distance a vessel moves parallel to the original course from the point where the rudder is put over to any point on the turning circle is called the ______.A. advanceB. drift angleC. pivoting pointD. transferKEY: A[4629]The distance gained in the direction of the original course when you are making a turn is known as ______.A. advanceB. driftC. tactical diameterD. transferKEY: A[4630]The major cause of anchor buoy pendant wire failures is ______.A. corrosionB. rough weatherC. defective socketsD. mishandlingKEY: B[4631]The most likely location for a liquid cargo fire to occur on a tanker would be ______.A. in the midships houseB. at the main deck manifoldC. at the vent headerD. in the pumproomKEY: D[4632]The only type of helicopter that may be refueled with the engine running and the blades turning is ______.A. a helicopter carrying cargo onlyB. a turbine-equipped helicopterC. a SikorskyD. a helicopter carrying injured personnel in an emergency situationKEY: B[4633]The patrolman£¬while on duty on a passenger vessel£¬must have in his possession a(n) ______.A. nightstickB. flashlightC. passenger list showing assigned berthsD. A-I fire extinguisherKEY: B[4634]The signal for fire alarm on a ship must be indicated ______.A. at each alarm bellB. at each alarm actuatorC. near all exitsD. on the station billKEY: D[4635]The survival craft is manufactured with fire retardant ______.A. foamB. marine plywoodC. steelD. fiberglassKEY: D[4636]Upon receipt of a distress message£¬a merchant vessel is bound to proceed to the scene of the distress. Under which of the following cases would this NOT be true?A. The vessel would arrive at the distress scene more than 36 hours after the receipt of the initial distress message.B. There are vessels closer to the distress scene that are proceeding to assist.C. The Master of the vessel in distress has requisitioned another vessel£¬and that vessel has accepted the requisition.D. You are on a tanker and the distress involves a major fire on board the other vessel.KEY: C[4637]What is one of the FIRST actions you should take after abandoning and clearing away from a vessel?A. Identify the person in charge.B. Gather up useful floating objects.C. Prepare for arrival of rescue units.D. Arrange watches and duties.KEY: A[4638]What should you do if you have transmitted a distress call a number of times on channel 16 and have received no reply?A. Repeat the message using any other channel on which you might attract attention.B. Key the microphone several times before transmitting again.C. Turn up the volume on the receiver before transmitting again.D. Report the problem to the head electrician.KEY: A[4639]When evacuating a seaman by helicopter lift£¬the vessel should be ______.A. stopped with the wind dead aheadB. stopped with the wind on the beamC. underway with the wind 30on the bowD. underway on a course to provide no apparent windKEY: C[4640]When evacuating a seaman by helicopter lift£¬which course should the ship take?A. Downwind so that the apparent wind is close to nil.B. A course that will keep a free flow of air£¬clear of smoke£¬over the hoist area.C. A course that will have the hoist area in the lee of the superstructure.D. With the wind dead ahead because the helicopter is more maneuverable when going into the wind.KEY: B[4641]When evacuating a seaman by helicopter lift£¬which statement is TRUE?A. The vessel should be stopped with the wind dead ahead during the hoisting operation.B. Flags should be flown to provide a visual reference as to the direction of the apparent wind.C. The drop line should be grounded first then secured as close to the hoist point as possible.D. The hoist area should be located as far aft as possible so the pilot will have a visual reference while approaching.KEY: B[4642]When joining a vessel£¬do not forget personal documents and your spectacles£¬and ______ if necessary.A. drugB. remedyC. medicineD. healerKEY: C[4643]When jumping into water upon which there is an oil-fire£¬you should ______.A. break the water surface with your hands when diving head-firstB. use your hands to hold your knees to your chestC. cover your eyes with one hand while pinching your nose shut and covering your mouth with the otherD. enter the water at the bow or stern on the windward side of the vesselKEY: D[4644]When retrieving the survival craft£¬the winch operator should stop the winch and check ______.A. that all personnel are seated in the craftB. that the cable has not jumped any grooves on the drumC. which way the wind is blowingD. the hydraulic fluid level before liftingKEY: B[4645]Which condition is necessary for a substance to burn?A. The temperature of the substance must be equal to or above its fire point.B. The air must contain oxygen in sufficient quantity.C. The mixture of vapors with air must be within the explosive range.D. All of the aboveKEY: D[4646]Which is the proper method of determining whether a portable CO2 fire extinguisher needs recharging?A. Check the tag to see when the extinguisher was last charged.B. Release a small amount of CO2; if the CO2 discharges£¬the extinguisher is acceptable.C. Weigh the extinguisher and compare the weight against that stamped on the valve.D. Recharge the extinguisher at least once each year.KEY: C[4647]Which of the following is not a maritime perils£¿ ______.A. Stranding or grounding£®B. Striking upon rocks or shoalsC. Collision between shipsD. FireKEY: D[4648]Which of the following statements regarding low expansion foam and its application is INCORRECT£¿ ______.A. Foam should not be used on electrical firesB. One kilo of low expansion foam solution produces much more foam£®C. Foam is only efficient when it covers the top of burning combustibles£®D. A stream of foam should be deflected off the deck in order to best agitate the fireKEY: D[4649]Which procedure should be followed when individuals are rescued in cold climates and suffer from hypothermia?A. Give them brandy.B. Keep them in motion.C. Immerse them in a warm bath (105F£¬40C).D. Cover them with an electric blanket set for maximum temperature.KEY: C[4650]Which statement about firefighting foam is TRUE?A. Foam conducts electricity.B. To be most effective£¬foam should be directed at the base of the fire.C. Foam is most effective on burning liquids which are flowing.D. Foam can ONLY be used to extinguish class A fires.KEY: A14.2 º£ÉϾÈÖú[4651]As a vessel sinks to a depth of 15 feet£¬the hydrostatic trip releases the liferaft container from its cradle by ______.A. breaking the weak linkB. releasing the tie-down strapC. pulling the operating cordD. releasing the CO2 canisterKEY: B[4652]An inflatable liferaft should be manually released from its cradle by ______.A. cutting the straps that enclose the containerB. removing the rubber sealing strip from the containerC. loosening the turnbuckle on the securing strapD. pushing the button on the hydrostatic releaseKEY: D[4653]An inflatable liferaft is hand-launched by ______.A. pulling a cordB. cutting the wire restraining bandsC. removing the rubber packing stripD. throwing the entire container overboardKEY: D[4654]An inflatable liferaft can be launched by ______.A. the float-free method ONLYB. breaking the weak link on the painterC. throwing the entire container overboard and then pulling on the operating cord to inflate the raftD. removing the securing strapsKEY: C[4655]Progressive flooding may be indicated by ______.A. ballast control alarmsB. excessive draftC. excessive list or trimD. a continual worsening of list or trimKEY: D[4656]You are proceeding to a distress site and expect large numbers of people in the water. Which statement is TRUE?A. You should stop to windward of the survivors in the water and only use the ship's boats to recover the survivors.B. If the survivors are in inflatable rafts you should approach from windward to create a lee for the survivors.C. An inflatable liferaft secured alongside can be an effective boarding station for transfer of survivors from the boats.D. Survivors in the water should never be permitted alongside due to the possibility of injury from the vessel.KEY: C[4657]A breeches buoy is being rigged from the shore to a stranded vessel. The initial shot line passed to the vessel is normally made fast to a ______.A. hawser which is used to pass a tail-block and whip to the vesselB. hawser with breeches buoy and harness attachedC. hawser which should be made fast to the vessel below the intended location of the tail-blockD. tail-block and whip which may be used to pass a hawser to the vesselKEY: D[4658]A cable used by helicopters for lifting or lowering persons in a pick-up operation is a ______.A. HoistB. RopeC. CableD. LineKEY: A[4659]A capsized small sail vessel is best righted when what part of the vessel is downwind?A. SternB. BowC. CenterboardD. MastKEY: D[4660]A floating ship with an initial negative metacentric height ______.A. will capsizeB. will incline furtherC. may lie at an angle of lollD. may be initially levelKEY: C[4661]A helicopter making a round trip from a helideck with refueling capabilities to an unmanned platform will take 45 minutes each way. The helicopter should be carrying enough fuel to last ______.A. 45 minutesB. 1 hour and 15 minutesC. 1 hour and 30 minutesD. 2 hoursKEY: D[4662]A mechanical davit is designed to automatically ______.A. position the boat at the embarkation stationB. lift the boat off the inboard chocksC. energize the winch for the fallsD. set the brake on the winchKEY: B[4663]A minor heat burn of the eye should be treated by ______.A. gently flooding with waterB. warming the eye with moist warm packsC. laying the person flat on his backD. mineral oil drops directly on the eyeKEY: A[4664]A negative metacentric height ______.A. will always cause a vessel to capsizeB. should always be immediately correctedC. always results from off-center weightsD. All of the above are correctKEY: B[4665]A person has fallen overboard and is being picked up with a lifeboat. If the person appears in danger of drowning£¬the lifeboat should make ______.A. an approach from leewardB. an approach from windwardC. the most direct approachD. an approach across the windKEY: C[4666]A person has suffered a laceration of the arm. Severe bleeding has been controlled by using a sterile dressing and direct pressure. What should you do next?A. Apply a tourniquet to prevent the bleeding from restarting.B. Apply a pressure bandage over the dressing.C. Remove any small foreign matter and apply antiseptic.D. Administer fluids to assist the body in replacing the lost blood.KEY: B[4667]A person may operate an air compressor in which of the following areas on board a tank barge?A. PumproomB. Generator roomC. A space adjacent to a cargo tankD. A space two meters from a cargo valveKEY: B[4668]A person who gets battery acid in an eye should IMMEDIATELY wash the eye with ______.A. boric acid solutionB. waterC. baking soda solutionD. ammoniaKEY: B[4669]A person with diabetes has received a minor leg injured. The symptoms of the onset of a diabetic coma include ______.A. reduced appetite and thirstB. sneezing and coughingC. only a low grade feverD. slurred speech and loss of coordinationKEY: D[4670]A racetrack turn would be better than a Williamson turn in recovering a man overboard if ______.A. the man has been missing for a period of timeB. the sea water is very cold and the man is visibleC. there is thick fogD. the wind was from astern on the original courseKEY: B[4671]A rescuer can most easily determine whether or not an adult victim has a pulse by checking the pulse at the ______.A. carotid artery in the neckB. femoral artery in the groinC. brachial artery in the armD. radial artery in the wristKEY: A[4672]A right-handed propeller will cause the survival craft to ______.A. walk the stern to starboard in reverseB. walk the stern to port in reverseC. run faster than a left-handed propellerD. right itself if capsizedKEY: B[4673]A shipmate chokes suddenly£¬cannot speak£¬and starts to turn blue. You should ______.A. perform the Heimlich maneuverB. make the victim lie down with the feet elevated to get blood to the brainC. immediately administer CPRD. do nothing until the victim becomes unconsciousKEY: A[4674]A towline should be fastened to ______.A. the chocks at the bow of a towed vesselB. the most forward£¬centermost point of a towed vessel such asa sturdy bow railC. the mast of a towed sailboatD. a secure fitting near the bow of the towed vesselKEY: D[4675]Aboard a survival craft£¬ether can be used to ______.A. start the engine in cold weatherB. aid in helping personnel breatheC. prime the sprinkler systemD. prime the air supplyKEY: A[4676]AN ILLNESS PREFERABLY OF AN INFECTIOUS NATURE SEIZING MORE THAN TWO PERSONS ON BOARD AT THE SAME TIME defines ______.A. Disease of CrewB. Crew illnessC. Group illnessD. Mass diseaseKEY: D[4677]An obstruction on a helideck is any object that might present a hazard to the______.A. rotor blades and landing gearB. unloading of passengersC. loading of cargoD. pilot's visibilityKEY: A[4678]Any vessel in need of carrying out deck washing must be ______ by the department concerned beforehand£®A. requestedB. allowedC. approvedD. inquiredKEY: C[4679]For a ship not on an international voyage£¬an approved substitute for an impulse projected rocket-type line throwing appliance is a ______.A. spring loaded line throwerB. hand thrown buoyant lineC. shoulder-type line throwing gunD. heaving lineKEY: C[4680]If the coxswain of your lifeboat gives the command HOLD WATER you should ______.A. complete the stroke£¬raise your oar slightly£¬swinging the oar slightly forward£¬and place it in the boatB. lift the oar in a vertical positionC. complete the stroke and hold the oar out of the waterD. dip the blade of your oar into the water vertically and hold it perpendicular to the keel lineKEY: D[4681]If you have to jump in the water when abandoning a vessel£¬your legs should be ______.A. spread apart as far as possibleB. held as tightly against your chest as possibleC. in a kneeling positionD. extended straight down and crossed at the anklesKEY: D[4682]If you must land on a beach with an oar-propelled lifeboat through a heavy surf£¬the recommended method is to ______.A. keep the bow directly in toward the beach£¬and tow the sea anchor off the sternB. ride in on the back of a large breakerC. keep the bow into the seas with the sea anchor out over the bow£¬and row to meet the breaking wavesD. head directly into the beach by staying between the crests of the waves KEY: C[4683]In an open lifeboat£¬the lifeboat compass is usually ______.A. placed in a fixed bracket when being usedB. clamped to any position convenient for the coxswain to see itC. permanently mounted on the lifeboat's centerlineD. mounted in the center of the boat to eliminate deviationKEY: A[4684]In heavy seas the helmsman should steer the motor lifeboat ______.A. into the seasB. broadside to the seasC. in the same direction as the seasD. in a series of figure-eightsKEY: A[4685]In heavy seas you decide to heave to. The lifeboat should be ______.A. brought to a position with the stern into the seasB. allowed to take its own headC. brought to lay in the troughD. brought bow into the seasKEY: D[4686]In which situation could a vessel most easily capsize?A. Running into head seasB. Running in the troughC. Running with following seasD. Anchored with your bow into the seasKEY: B[4687]Inflatable liferafts are less maneuverable than lifeboats due to their ______.A. shapeB. shallow draftC. large sail areaD. All of the aboveKEY: D[4688]Large volumes of carbon dioxide are safe and effective for fighting fires in enclosed spaces£¬such as in a pumproom£¬provided that the ______.A. persons in the space wear gas masksB. persons in the space wear damp cloths over their mouths and nostrilsC. ventilation system is secured and all persons leave the spaceD. ventilation system is kept operatingKEY: C[4689]Multiple fire pumps may be used for other purposes provided that one pump is ______.A. on line to the fire mainB. kept available for use on the fire main at all timesC. capable of being connected to the fire mainD. rated at or above 125 psiKEY: B[4690]Oil fires are best extinguished by ______.A. cutting off the supply of oxygenB. removing the fuelC. cooling below the ignition temperatureD. spraying with waterKEY: A[4691]On a rigid liferaft which is equipped with all of the required equipment you may NOT find a ______.A. boathookB. fishing kitC. lifeline or grab railD. sea painterKEY: B[4692]On a ship£¬a fire pump may be used for other purposes if ______.A. the other services are run off a reducing station with a pressure gageB. a separate fire pump is available for use on the fire mainC. all other services are operated by a manifold near the pumpD. All of the aboveKEY: B[4693]On a vessel£¬if someone fell overboard and you did not know over which side the person fell£¬you should ______.A. immediately reverse the enginesB. stop the propellers from turning and throw a ring buoy over the sideC. increase speed to full to get the vessel away from the personD. first put the rudder hard over in either directionKEY: B[4694]Releasing oil from the sea anchor of a lifeboat may ______.A. keep the propeller from being fouledB. increase propeller speedC. help calm the waves in the vicinity of the craftD. increase the holding power of the sea anchorKEY: C[4695]Seasickness is caused by rolling or rocking motions which affect fluids in the ______.A. stomachB. lower intestinesC. inner earD. bladderKEY: C[4696]Separation cloths may be used to ______.A. absorb moisture from hygroscopic cargoesB. fill gaps between layers of cargoC. wrap cargo that leaks from packagingD. keep bagged cargo leakage from contacting the deckKEY: D[4697]Severe exposure to chlorine gas can be fatal. Chlorine gas is primarily a ______.A. respiratory irritantB. skin burning agentC. blood poisoning agentD. nerve paralyzing irritantKEY: A[4698]Steering a motor lifeboat broadside to the sea could cause it to ______.A. capsizeB. run smootherC. run fasterD. sinkKEY: A[4699]Steering a survival craft broadside to the sea could cause it to ______.A. capsizeB. run smootherC. run fasterD. sinkKEY: A[4700]Survival practice in the mooring system is to slack off the tensions on the leeward side and ______.A. deballast the unit to transit draftB. adjust as evenly as practical the windward tensionsC. release the anchors on the windward sideD. tighten the anchor buoys on the leeward side anchorsKEY: BÊ®°Ë º£ÉÏÏû·À18.1 ȼÉÕÓ뱬ը[4701]The emergency signal for fires is sounded on the ship's whistle and general alarm as ______ £®A. a continuous ringing for 10 secondsB. one short ring followed by one long ringC. two long rings of at least 20 secondsD. a continuous ringing until the fire is extinguishedKEY: A[4702]A carbon dioxide fire extinguisher should be recharged ______.A. at least annuallyB. whenever it is below its required weightC. only if the extinguisher has been usedD. before every safety inspectionKEY: B[4703]A carburetor is required to have a safety device called a(n) ______.A. pressure releaseB. backfire flame arrestorC. automatic shut off。

CDAS-Clean Dry Air System CDAS HL 050 - CDAS HL 08

CDAS-Clean Dry Air System CDAS HL 050 - CDAS HL 08

CDAS – Clean Dry Air System CDAS HL 050 - CDAS HL 085 Adsorption DryersWhether a compressed air user wants tocontrol the growth of micro-organisms(essential for direct and in-direct contactapplications in the food, beverage &pharmaceutical industries), ensureair used for critical applications /instrumentation is free from watercontamination or has external pipingwhere low ambient temperature cancause condensation, adsorption dryersare the go to dryer technology.There are many different adsorptiondryer technologies available andwhilst they all reduce water from thecompressed air in the same way, theydiffer in the way they regenerate thedesiccant material.Heatless Adsorption DryersThe simplest and most common methodused to regenerate the adsorbentdesiccant material is the ‘heatless’method (so called as it does not useheat for desiccant regeneration).Using a proportion of the clean, dryprocess air for regeneration, heatlessdryers typically have the lowest capitalcosts of all adsorption dryer types (dueto the simplicity of the heatless design).Being very robust and having fewercomponents, they typically have thelowest maintenance cost of all theadsorption technologies.Heatless dryers are available to suit allcompressed air flow rates from small tolarge, whereas the more complicatedregeneration methods are often onlyavailable for higher flow rates due tocost and complexity of the designs.Advantages• Parker CDAS dryers provide a constant outlet dewpoint in accordance with ISO8573-1 classes 1, 2 or 3 for water vapour• Parker CDAS dryers provide an outlet dewpoint which inhibits the growth of micro-organisms (allowing their efficient reduction using filtration)• Parker CDAS dryers use clean, dry purge air for regeneration, eliminating any risk of damage to the adsorption bed or re-contamination of the downstream compressed air• Parker CDAS dryer performance has been tested in accordance with ISO7183, the international standard for compressed air dryer testing• The dewpoint performance of Parker CDAS dryers has been 3rd party validated by Lloyds Register to ISO8573-1 air purity classifications• No heat is used for regeneration; therefore, no insulation is required and loss of dewpoint on column changeover due to inefficient cool down is eliminated• Parker CDAS dryers include Parker OIL-X General Purpose & High Efficiency Coalescing pre-filtration and General Purpose Dry Particulate post filtration as standard• Full feature electronic control with dewpoint display and Energy SavingTechnology fitted as standardStated flows are for operation at 7 bar (g) (102 psi g) with reference to 20°C, 1 bar (a), 0% relative water vapourpressure. For flows at other pressures, apply the correctionfactors shown below.Product Selection & Correction FactorsFor correct operation, compressed air dryers must be sized using for the maximum (summer) inlet temperature, maximum (summer) ambient temperature, minimum inlet pressure, required outlet dewpoint and maximum flow rate of the installation.To select a dryer, first calculate the MDC (Minimum Drying Capacity) using the formula below then select a dryer from the flow rate table above with a flow rate equal to or above the MDC.Minimum Drying Capacity = System Flow x CFIT x CFAT x CFMIP x CFODISO8573-1 Classifications when used with Parker domnick hunter OIL-X pre / post filtrationW D Pressure vessel approved for fluid group 2 in accordance with the Pressure Equipment Directive 2014/68/EU©2019 Parker Hannifin Corporation. All rights reserved.PISCDASHL50-85-00-ENEurope, Middle East, AfricaAE – United Arab Emirates, DubaiTel: +971 4 8127100 ********************AT – Austria, St. Florian Tel: +43 (0)7224 66201 *************************AZ – Azerbaijan, Baku Tel: +994 50 2233 458****************************BE/NL/LU – Benelux, Hendrik Ido Ambacht Tel: +31 (0)541 585 000 ********************BG – Bulgaria, Sofia Tel: +359 2 980 1344**************************BY – Belarus, Minsk Tel: +48 (0)22 573 24 00 ************************CH – Switzerland, Etoy Tel: +41 (0)21 821 87 00*****************************CZ – Czech Republic, Klecany Tel: +420 284 083 111*******************************DE – Germany, Kaarst Tel: +49 (0)2131 4016 0*************************DK – Denmark, Ballerup Tel: +45 43 56 04 00*************************ES – Spain, Madrid Tel: +34 902 330 001 ***********************FI – Finland, Vantaa Tel: +358 (0)20 753 2500 *************************FR – France, Contamine s/Arve Tel: +33 (0)4 50 25 80 25 ************************GR – Greece, Piraeus Tel: +30 210 933 6450 ************************HU – Hungary, Budaörs Tel: +36 23 885 470*************************IE – Ireland, Dublin Tel: +353 (0)1 466 6370 *************************IL – IsraelTel: +39 02 45 19 21************************IT – Italy, Corsico (MI) Tel: +39 02 45 19 21 ***********************KZ – Kazakhstan, Almaty Tel: +7 7273 561 000****************************NO – Norway, Asker Tel: +47 66 75 34 00************************PL – Poland, Warsaw Tel: +48 (0)22 573 24 00 ************************PT – PortugalTel: +351 22 999 7360**************************RO – Romania, Bucharest Tel: +40 21 252 1382*************************RU – Russia, Moscow Tel: +7 495 645-2156************************SE – Sweden, Spånga Tel: +46 (0)8 59 79 50 00 ************************SK – Slovakia, Banská Bystrica Tel: +421 484 162 252**************************SL – Slovenia, Novo Mesto Tel: +386 7 337 6650**************************TR – Turkey, Istanbul Tel: +90 216 4997081 ************************UA – Ukraine, Kiev Tel: +48 (0)22 573 24 00 ************************UK – United Kingdom, Warwick Tel: +44 (0)1926 317 878 ********************ZA – South Africa, Kempton Park Tel: +27 (0)11 961 0700*****************************Parker WorldwideNorth AmericaCA – Canada, Milton, Ontario Tel: +1 905 693 3000US – USA, Cleveland Tel: +1 216 896 3000Asia PacificAU – Australia, Castle Hill Tel: +61 (0)2-9634 7777CN – China, Shanghai Tel: +86 21 2899 5000HK – Hong Kong Tel: +852 2428 8008IN – India, MumbaiTel: +91 22 6513 7081-85JP – Japan, Tokyo Tel: +81 (0)3 6408 3901KR – South Korea, Seoul Tel: +82 2 559 0400MY – Malaysia, Shah Alam Tel: +60 3 7849 0800NZ – New Zealand, Mt Wellington Tel: +64 9 574 1744SG – Singapore Tel: +65 6887 6300TH – Thailand, Bangkok Tel: +662 186 7000TW – Taiwan, Taipei Tel: +886 2 2298 8987South AmericaAR – Argentina, Buenos Aires Tel: +54 3327 44 4129BR – Brazil, Sao Jose dos Campos Tel: +55 800 727 5374 CL – Chile, Santiago Tel: +56 2 623 1216MX – Mexico, Toluca Tel: +52 72 2275 4200EMEA Product Information Centre Free phone: 00 800 27 27 5374(from AT , BE, CH, CZ, DE, DK, EE, ES, FI, FR, IE, IL, IS, IT , LU, MT , NL, NO, PL, PT , RU, SE, SK, UK, ZA) US Product Information Centre Toll-free number: 1-800-27 27 537/gsfe。

材料科学与工程专业英语第三版-翻译以及答案

材料科学与工程专业英语第三版-翻译以及答案

UNIT 1一、材料根深蒂固于我们生活的程度可能远远的超过了我们的想象,交通、装修、制衣、通信、娱乐(recreation)和食品生产,事实上(virtually),我们生活中的方方面面或多或少受到了材料的影响。

历史上,社会的发展和进步和生产材料的能力以及操纵材料来实现他们的需求密切(intimately)相关,事实上,早期的文明就是通过材料发展的能力来命名的(石器时代、青铜时代、铁器时代)。

二、早期的人类仅仅使用(access)了非常有限数量的材料,比如自然的石头、木头、粘土(clay)、兽皮等等。

随着时间的发展,通过使用技术来生产获得的材料比自然的材料具有更加优秀的性能。

这些性材料包括了陶瓷(pottery)以及各种各样的金属,而且他们还发现通过添加其他物质和改变加热温度可以改变材料的性能。

此时,材料的应用(utilization)完全就是一个选择的过程,也就是说,在一系列有限的材料中,根据材料的优点来选择最合适的材料,直到最近的时间内,科学家才理解了材料的基本结构以及它们的性能的关系。

在过去的100年间对这些知识的获得,使对材料性质的研究变得非常时髦起来。

因此,为了满足我们现代而且复杂的社会,成千上万具有不同性质的材料被研发出来,包括了金属、塑料、玻璃和纤维。

三、由于很多新的技术的发展,使我们获得了合适的材料并且使得我们的存在变得更为舒适。

对一种材料性质的理解的进步往往是技术的发展的先兆,例如:如果没有合适并且没有不昂贵的钢材,或者没有其他可以替代(substitute)的东西,汽车就不可能被生产,在现代、复杂的(sophisticated)电子设备依赖于半导体(semiconducting)材料四、有时,将材料科学与工程划分为材料科学和材料工程这两个副学科(subdiscipline)是非常有用的,严格的来说,材料科学是研究材料的性能以及结构的关系,与此相反,材料工程则是基于材料结构和性能的关系,来设计和生产具有预定性能的材料,基于预期的性能。

条件空气机使用说明书

条件空气机使用说明书

123456Emptying condensationAfter each drying cycle, empty the condensate container; otherwise the next drying programme may be cancelled as a result of the condensate container being full.1.Pull out condensate container keeping it horizontal.2.Pour out condensation.3.Always push container in fully until it clicks into place.If Í Container flashes in the display panel a What to do if..., Page 10.Cleaning the fluff filterClean the fluff filter after each drying operation.1.Open the door, remove fluff from door/door area.2.Pull out and fold open the fluff filter.3.Remove the fluff (by wiping the filter with your hand).If the fluff filter is very dirty or blocked, rinse with warm water and dry thoroughly.4.Close and reinsert the fluff filter.Switching off the dryerTurn the programme selector to Off .Do not leave laundry in the dryer.Removing the laundryThe automatic anti-crease function causes the drum to move at specific intervals, the washing remains loose and fluffy for an hour (two hours if the additional S Reduced Ironing function is also selected-depending on model ).... and adapt to individualNever start the dryer if it is damaged!Inform your after-sales service.Inspecting thedryer Sorting and loading laundryRemove all items from pockets.Check for cigarette lighters.The drum must be empty prior to loading.See programme overview on page 7.See also separate instructions for “Woollens basket” (depending on model)Your new dryerCongratulations - You have chosen a modern, high-quality Bosch Intended usePreparing for installation, see Page 8Selecting and adjusting the programmeDryingCondensate container Control panelʋfor domestic use only,ʋonly to be used for drying fabrics that have beenwashed with water.Keep children younger than 3 years old away from the dryer.Do not let children make the cleaning andmaintenance work on the dryer without supervision.Do not leave children unsupervised near the dryer.Keep pets away from the dryer.The dryer can be operated by children 8 years old and older, by persons with reduced physical, sensory or mental abilities and by persons with insufficient experience or knowledge if they are supervised or have been instructed in its use by a responsible adult.This appliance is intended for use up to a maximum height of 4000 metres above sea level.Select the drying programme ...123Make sure your hands are dry. Hold the plug only.Connecting themains plugDryingInformation on laundry ...Labelling of fabricsFollow the manufacturer's care information.(c Drying at normal temperature.'c Drying at low temperature a also select V Low Heat .)c Do not machine dry.Observe safety instructions without fail a Page 11!Do not tumble-dry the following fabrics for example:–Impermeable fabrics (e.g. rubber-coated fabrics).–Delicate materials (silk or curtains made from synthetic material) a they may crease.–Laundry contaminated with oil.Drying tips–To ensure a consistent result, sort the laundry by fabric type and drying programme.–Always dry very small items (e.g. baby socks) together with large items of laundry (e.g. hand towel).–Close zips, hooks and eyelets, and button up covers. Tie fabric belts, apron strings, etc. together.–Do not over-dry easy-care laundry a risk of creasing! Allow laundry to finish drying in the air.–Do not dry woolens in the dryer, only use to freshen them up a Page 7, Woollens finish Programme (depending on model).–Do not iron laundry immediately after drying, fold items up and leave for a while a the remaining moisture will then be distributed evenly.–The drying result depends on the type of water used during washing. a Fine adjustment of the drying result a Page 5/6.–Machine-knitted fabrics (e.g. T-shirts or jerseys) often shrink the first time they are dried a do not use the Cupboard Dry Plus programme.–Starched laundry is not always suitable for dryers a starch leaves behind a coating that adversely affects the drying operation.–Use the correct dosage of fabric softener as per the manufacturer's instructions when washing the laundry to be dried.–Use the timer programme for small loads a this improves the drying result.Environmental protection / Energy-saving tips–Before drying, spin the laundry thoroughly in the washing machine a the higher the spin speed the shorter the drying time will be (consumes less energy), also spin easy-care laundry.–Put in, but do not exceed, the maximum recommended quantity of laundry a programme overview a Page 7.–Make sure the room is well ventilated during drying.–Do not obstruct or seal up the air inlet.–Keep the air cooler clean a Page 6 “Care and cleaning”.Fine adjustment of the drying resultAdjustment of the levels of dryness1 x to the rightPress and hold V Low Heat and turn 5 x to the rightPress V Low Heat until the required level is reached Turn to OffTurn to OffDrumAll buttons are sensitive and only need to be touched lightly.Only operate the dryerAir inletFluff filterDrum interior light (depending on model)Maintenance flapProgramme end once lights up in the display. Interrupt programme removing or adding laundry.The drying cycle can be interrupted for a brief period so that laundry may be added or removed. The programme selected must then be resumed and completed.Never switch the dryer off before the drying process has ended.Drum and door may be hot!1.Open door, the drying process is interrupted.2.Load or remove laundry and close door.3.If required, select a new programme and additional functions.4.Press the Start/Stop button.Programme selectorDisplay panelService indicatorsÍ Container n FilterClean the fluff filter and/or air cooler under running water. a Page 4/6.Fineadjustment of the drying resultThe drying result (e.g. Cupboard Dry) can be adjusted over three levels (1 - max. 3) and A Super Quick 40’ programmes a presetting = 0. After one of these programmes has been finely adjusted, the setting is retained for the Page 5/6.0, 1, 2, 3 Fine adjustment of the drying resultCare and cleaningDryer housing, control panel, air cooler, moisture sensors–Wipe with a soft, damp cloth.–Do not use harsh cleaning agents and solvents.–Remove detergent and cleaning agent residue immediately.Clean the protective filter 5 - 6 times a year or if n Filter flashes after cleaning the fluff filter.Air cooler / Protective filterWhen cleaning, only remove the protective filter. Clean the air cooler behind the protective filter once a year.–Allow the dryer to cool.–Residual water may leak out, so place an absorbent towel underneath the maintenance door.1.Unlock the maintenance door.2.Open the maintenance door fully.3.Turn both locking levers towards each another.4.Pull out the protective filter/air cooler.Do not damage the protective filter or air cooler.Clean with warm water only. Do not use any hard or sharp-edged objects.5.Clean the protective filter/air cooler thoroughly,Allow to drip dry.6.Clean the seals.7.Re-insert the protective filter/air cooler,with the handle facing down.8.Turn back both locking levers.9.Close the maintenance door until the lock clicks into place.Moisture sensorsThe dryer is fitted with stainless steel moisture sensors. The sensors measure the level of moisture in the laundry. After a long period of operation, a fine layer of limescale may form on the sensors.1.Open the door and clean the moisture sensors with a damp spongewhich has a rough surface.Do not use steel wool or abrasive materials.Drying H , Iron Dry |, Cupboard Dry +,Anti-crease/End R / are displayed in sequence.Short signal when changing from level 3 to 0, otherwise long signal.Only when switched off!Press the Start/Stop button*D r y n e s s l e v e l s c a n b e s e l e c t e d i n d i v i d u a l l y a C u p b o a r d D r y P l u s ,c + C u p b o a r d D r y a n d | I r o n D r y (d e p e n d i n g o n t h e m o d e l ).D e g r e e o f d r y n e s s c a n b e f i n e l y a d j u s t e d ; m u l t i -l a y e r e d t e x t i l e s r e q u i r e a l o n g e r d r y i n g t i m e t h a n s i n g l e -l a y e r e d i t e m s o f c l o t h i n g . R e c o m m e n d a t i o n : D r y s e p a r a t e l y .Page 11.Connect to an AC earthed socket. If in doubt have the socket checked by an expert.The mains voltage and the voltage shown on the rating plate (a Page 9) must correspond.The connected load and necessary fuse protection are specified on the rating plate.Note the fuse protection of the socket.The values for the energy label are determined using a circuit breaker/fuse rating of 16 A. If the circuit breaker/fuse rating is changed to 10 A, the drying time and energy consumption will be higher. You can find details on this in the consumption values table. a Page 9Make sure that the air inlet remains unobstructedClean and levelpress and hold selection then turn 3 x to the right turn to Offsetamperage off flashesDo not operate the dryer if there is a danger of frost.en Instruction manualDryerWTE84106ZA12Remove all items from pockets.Check for cigarette lighters.The drum must be empty prior to loading.See programme overview on page 7.See also separate instructions for “Woollens ba (depending on model)domestic appliance.The condensation dryer is distinguished by its economical energy consumption.Every dryer which leaves our factory is carefully checked to ensure that it functions correctly and is in perfect condition.Should you have any questions, our after-sales service will be pleased to help.Disposal in an environmentally-responsible manner This appliance is labelled in accordance with European Directive 2012/19/EU concerning used electrical and electronic appliances (waste electrical and electronic equipment - WEEE). The guideline determines the framework for the return and recycling of used appliances as applicable throughout the EU.For further information about our products, accessories, spare parts and services, please visit: All buttons are need to be touProgramme selector34Emptying condensationAfter each drying cycle, empty the condensate container; otherwise the next drying programme may be cancelled as a result of the condensate container being full.1.Pull out condensate container keeping it horizontal.2.Pour out condensation.3.Always push container in fully until it clicks into place.If Í Container flashes in the display panel a What to do if..., Page 10.Cleaning the fluff filterClean the fluff filter after each drying operation.1.Open the door, remove fluff from door/door area.2.Pull out and fold open the fluff filter.3.Remove the fluff (by wiping the filter with your hand).If the fluff filter is very dirty or blocked, rinse with warm water and dry thoroughly.4.Close and reinsert the fluff filter.Switching off the dryerTurn the programme selector to Off .Do not leave laundry in the dryer.Removing the laundryThe automatic anti-crease function causes the drum to move at specific intervals, the washing remains loose and fluffy for an hour (two hours if the additional S Reduced Ironing function is also selected-depending on model ).adapt to individualspecting thedryeroading laundryasket”he programmeDryingCondensate container Control paneldrying programme ...123nnecting the mains plugDryingDrume sensitive and only uched lightly.Air inletFluff filterDrum interior light (depending on model)Maintenance flapProgramme end once lights up in the display. Interrupt programme removing or adding laundry.The drying cycle can be interrupted for a brief period so that laundry may be added or removed. The programme selected must then be resumed and completed.Never switch the dryer off before the drying process has ended.Drum and door may be hot!1.Open door, the drying process is interrupted.2.Load or remove laundry and close door.Start/Stop buttonInformation on laundry ...Labelling of fabricsFollow the manufacturer's care information.(c Drying at normal temperature.'c Drying at low temperature a also select V Low Heat.)c Do not machine dry.Observe safety instructions without fail a Page 11!Do not tumble-dry the following fabrics for example:–Impermeable fabrics (e.g. rubber-coated fabrics).–Delicate materials (silk or curtains made from synthetic material) a they may crease.–Laundry contaminated with oil.Drying tips–To ensure a consistent result, sort the laundry by fabric type and drying programme.–Always dry very small items (e.g. baby socks) together with large items of laundry(e.g. hand towel).–Close zips, hooks and eyelets, and button up covers. Tie fabric belts, apron strings, etc.together.–Do not over-dry easy-care laundry a risk of creasing! Allow laundry to finish drying inthe air.–Do not dry woolens in the dryer, only use to freshen them up a Page 7, Woollens finish Programme (depending on model).–Do not iron laundry immediately after drying, fold items up and leave for a whilea the remaining moisture will then be distributed evenly.–The drying result depends on the type of water used during washing. a Fine adjustment of the drying result a Page 5/6.–Machine-knitted fabrics (e.g. T-shirts or jerseys) often shrink the first time they are drieda do not use the Cupboard Dry Plus programme.–Starched laundry is not always suitable for dryers a starch leaves behind a coating that adversely affects the drying operation.–Use the correct dosage of fabric softener as per the manufacturer's instructions whenwashing the laundry to be dried.–Use the timer programme for small loads a this improves the drying result.Environmental protection / Energy-saving tips–Before drying, spin the laundry thoroughly in the washing machine a the higher the spin speed the shorter the drying time will be (consumes less energy), also spin easy-carelaundry.–Put in, but do not exceed, the maximum recommended quantity of laundry a programme overview a Page 7.–Make sure the room is well ventilated during drying.–Do not obstruct or seal up the air inlet.–Keep the air cooler clean a Page 6 “Care and cleaning”.Fine adjustment of the drying resultAdjustment of the levels of dryness1 x to the right Press and hold V Low Heatand turn 5 x to the right Press V Low Heat until the required level is reachedTurn to Off Turn toOffFine adjustment of the drying resultCare and cleaningDryer housing, control panel, air cooler, moisture sensors–Wipe with a soft, damp cloth.–Do not use harsh cleaning agents and solvents.–Remove detergent and cleaning agent residue immediately.Clean the protective filter 5 - 6 times a yearor if n Filter flashes after cleaning the fluff filter.Air cooler / Protective filterWhen cleaning, only remove the protective filter. Clean the air coolerbehind the protective filter once a year.–Allow the dryer to cool.–Residual water may leak out, so place an absorbent towelunderneath the maintenance door.1.Unlock the maintenance door.2.Open the maintenance door fully.3.Turn both locking levers towards each another.4.Pull out the protective filter/air cooler.Do not damage the protective filter or air cooler.Clean with warm water only. Do not use any hard or sharp-edgedobjects.5.Clean the protective filter/air cooler thoroughly,Allow to drip dry.6.Clean the seals.7.Re-insert the protective filter/air cooler,with the handle facing down.8.Turn back both locking levers.9.Close the maintenance door until the lock clicks into place.Moisture sensorsThe dryer is fitted with stainless steel moisture sensors. The sensorsmeasure the level of moisture in the laundry. After a long period ofoperation, a fine layer of limescale may form on the sensors.1.Open the door and clean the moisture sensors with a damp spongewhich has a rough surface.Do not use steel wool or abrasive materials.Drying H, Iron Dry |, Cupboard Dry +,Anti-crease/End R / are displayed in sequence.Short signal when changing from level 3 to 0,otherwise long signal.Only when switched off!56*D r y n e s s l e v e l s c a n b e s e l e c t e d i n d i v i d u a l l y a C u p b o a r d D r y P l u s ,c + C u p b o a r d D r y a n d | I r o n D r y (d e p e n d i n g o n t h e m o d e l ).D e g r e e o f d r y n e s s c a n b e f i n e l y a d j u s t e d ; m u l t i -l a y e r e d t e x t i l e s r e q u i r e a l o n g e r d r y i n g t i m e t h a n s i n g l e -l a y e r e d i t e m s o f c l o t h i n g . R e c o m m e n d a t i o n : D r y s e p a r a t e l y .Page 11.Connect to an AC earthed socket. If in doubt have the socket checked by an expert.The mains voltage and the voltage shown on the rating plate (a Page 9) must correspond.The connected load and necessary fuse protection are specified on the rating plate.Note the fuse protection of the socket. The values for the energy label are determined using a circuit breaker/fuse rating of 16 A. If the circuit breaker/fuse rating is changed to 10 A, the drying time and energy consumption will be higher. You can find details on this in the consumption values table. a Page 9Make sure that the air inlet remains unobstructedClean and levelpress and hold selection then turn 3 x to the right turn to Offsetamperage off flashesDo not operate the dryer if there is a danger of frost.en Instruction manualDryerWTE84106ZA。

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12Dryer Section Optimisation of the Air Conditionsin the Dryer SectionGeorgi Slawtschew (Dipl.-Ing.), Application and Technical Services, Heimbach GmbH & Co.KGgeorgi.slawtschew@OVERVIEW OF CONTENTSIntroduction1. Energy requirement for heating and evaporating the water from the sheet2. Removal of evaporated water – optimisation of hood ventilation3. Air flows in the pockets4. Optimisation of pocket ventilation4.1 Case studies: Pocket ventilation with blow boxes4.2 Pocket ventilation with air doctors4.2.1 Case study: Pocket ventilation with optimally functioning air doctors4.2.2 Case study: Pocket ventilation with non-optimally functioning air doctors4.3 Case study: Optimisation of a newsprint machine4.4 Zero point – air leakage4.4.1 Case study: Leakage – small “holes”, large effect5. Energy potential of exhaust airConclusionCaption “Measuring conditions”TASKINFO/46GB·97IntroductionIncreasing energy costs and demands on the envi-ronment require to an ever greater extent reduced energy consumption in the paper industry. Where else can the most energy be saved, if not where the most energy is consumed: in the dryer section.Paper drying in the dryer section can be divided into two parts of the process:1. Heating and evaporating the water, primarilyby means of steam-heated cylinders2. Removal of the evaporated water from thepockets and from the dryer hoodThe following contribution deals mainly with the often ignored second part of the process, the removal of the moisture from the sheet and from the machine.Previous TASK Information Booklets have consid-ered the significance of ventilation and heat exchanger systems for the functioning of the whole dryer section.Badly adjusted volumes and quality of supplyair and exhaust air (temperature / moisture) and inadequate energy recovery can lead to enormous losses of energy and / or production capacity as well as deterioration in paper quality.With the aid of case studies the following contri-bution highlights possibilities of how the air conditions in the dryer section can be optimised at relatively low cost.1. Energy requirement for heating andevaporating the water from the sheetIn order to warm (from 50 to 100 °C) and subse-quently evaporate 1 kg of water under ideal con-ditions ca. 2,400 kJ are required. That amounts to a condensation energy of ca. 1.1 kg steam at 1 bar pressure (or 1.2 kg steam at 7.0 bar pressure). Therefore the steam consumption can simply be reduced to 1.1 t steam / t evaporated water. In practice 1.2-1.6 t steam is needed for the heat-ing of the cylinders (not to be confused with the specific steam consumption per tonne of paper which depends on the dry content before / after the dryer section, paper grade etc.).These figures have come from examinations carried out by Heimbach in recent years.The required condensation energy for low pressure steam is higher than that for high pressure steam. The pressure of the steam determines the tempera-ture difference between the paper sheet and the cylinder surface and also the speed of heat transfer. Therefore, the bigger the temperature difference, the faster is the transfer of heat energy from the cylinder surface into the sheet.This temperature difference can, in the case of most board and packaging grades, be increased by raising the steam pressure – but with the disad-vantage of a higher specific steam consumption.On more sensitive grades such as writings and printings the higher cylinder temperatures can have negative effects on the sheet characteristics. In this case another route can be followed. In the open draws between the cylinders the sheet cools through vaporisation. The greater the vaporisation in this area, the greater will be the temperature difference between the paper sheet and the following cylinder. In this way heat transfer can be accelerated. The vaporisation is also augmented by a more effective pocket ventilation.2. Removal of evaporated water –optimisation of hood ventilation Immediately after the sheet leaves the hot cylinder surface the vaporisation of the water commences. For a rapid take-up of the resulting moisture into the surrounding air in the pockets between the cyl-inders, this air must be hot and dry. Experience has shown that a difference of 20 °C between the dry air temperature and the dew point temperaturewill ensure a rapid and complete take-up of the evaporated water from the sheet – the prerequisite being an appropriate temperature level. In order to ensure this process, dry air of at least 90-100°C is blown into the pockets. The initial moisture content of the supply air introduced is mostly that of the outside air and is on average 10-20 g water / kg dry air. The temperature of the supply air should be 110-120 °C so that it is no lower than 90-100 °C when blown into the pockets.Between the cylinders of conventional running sec-tions, the distance for augmented vaporisation of the water from the sheet is shorter than in Slalom sections. That is why the moisture in the pockets of conventional sections has to be removed in a shorter time.The exhaust air volume required for the removal of the evaporated water depends on the dew point in the hood. Conversely this means that the exhaust air can be carrying differing water volumes. In practice air consumption between8 and 20 kg dry air / kg evaporated water have been measured.The following table (Fig.1) shows the differences between the maximum possible absolute moisture content of the exhaust air in relation to the dew point of the hood.Example: A dew point temperature of 55 °C equates to a maximum absolute exhaust air mois-ture content of 120 g water / kg air. If the supply air content of 20 g water / kg air is subtracted, the result is a maximum water carrying capacity of the exhaust air of 100 g water / kg air. This means that the specific air consumption for the removal of the evaporated water is 10 kg air / kg water.An increase of the dew point temperature from 55 °C to 60 °C would increase the maximum absolute moisture content of the exhaust air from 120 g to 155 g water / kg air. Simultaneously the specific air requirement would reduce from 10 kg to 7.4 kg air / kg water – that means about 25 %. This reduced air consumption can lead to signifi-cant energy savings – subject to all air supply ven-tilators being frequency controlled. Alternatively the air volumes made available can be used to increase production.The figures in table 1 impressively confirm the above claims. At the same time they highlight the energy saving potential in the optimisationof the dew point by, for example, closing-up and insulating the hood.A further advantage of such optimisation can be found in the increased effectiveness of the heat exchangers. Briefly: the wetter the exhaust air, the greater is the gain from the heat exchangers.3. Air flows in the pocketsWith a number of examples it can be shown that large air supply and exhaust volumes alone are not sufficient for effective hood ventilation. It is important that not only air quality and quantityFig.1 Dewpoint –> Air moisture content –> Air consumptionare taken into consideration but also the manner in which it is introduced into the dryer section. In the following suggestions for improving air control are described.After the separation of the sheet and cylinder an underpressure occurs in the wedge-shaped separation zone – shown here in Figure 2 on a conventional dryer section. The result is that the air is drawn into the pockets on both sides, mainly affecting the edge zones. The result is dryer paper edges and a bowed moisture profile with a wetter middle. This air movement can be made visible in many dryer sections by means of smoke, as already described in earlier TASK Infor-mation booklets.at the exit from a cylinder in a Slalom section. The air flows in from the side and against the running direction into the separation wedge. After creating vortices within the wedge it is then taken from the paper surface – now in the running direction – to the outside. Similar conditions also apply in conventional sections.4. Optimisation of pocket ventilation From the above it can be seen that in order to even out the underpressure which occurs in the wedge between the exiting sheet and the cylinder, The air in the pockets moves evenly from the middle of the machine in the direction of front and drive sides (Fig.5). In this way a moisture block in the middle of the machine is prevented. The sheet is stabilised and sheet flutter signifi-cantly reduced.Fig.3 Air flow in a Slalom sectionAirFabricFig.4Optimal blowpipe positioning4.1 Case studies: Pocket ventilationwith blow boxes(Caption "Measuring conditions" see page 14)The possible effects of unevenly distributed pocket ventilation are documented in the following case study. It can be seen in Figure 6 that in the dryer sections measured, blow boxes are installed only in the pockets under cylinders 30, 33, 36 and 38. Result: The absolute moisture in these pockets is about 38 % lower than in the non-ventilated pockets. The water take-up capacity of the air in the ventilated pockets is appropriately higher,and lower in the non-ventilated pockets.The possible effects on the moisture profile have already been mentioned.In a comparable dryer section all the pockets were equipped with blow boxes (Fig.7).Result: Air flow from the middle of the machine in all pockets to front and drive side, lower mois-ture content of the air in all pockets and therefore higher water take-up capacity. In total a very even removal of the evaporated water from all pockets.Fig.6 Uneven moisture removal through uneven pocket ventilation[°C] 100 90 80 70 60 50 40 30 20 10 0800 700 600 500 400 300 200 100 0[g w a t e r / k g a i r ]28293031323334353637383940Cylinder temperature Dry air temperatureDewpointAbsolute moisture content pocket airWater take-up capacity pocket airFig.5 Optimal air flow out of the pockets4.2 Pocket ventilation with air doctors In the existing pocket ventilation in conventional sections the supply air must be blown through the dryer fabric. Depending on its condition (air permeability, degree of contamination etc) and also the positioning of the blow boxes, the pocket ventilation can be seriously impaired. Additionally, with increasing speed, by the dryer fabrics will be more air dragged along, which cannot be fullythe blow box.supply air – just as with Slalom sections – getsunhindered into the wedge between the exiting sheet and the cylinder (Fig.8). The underpressure created by the separation of sheet and cylinder is evened out. The very high moisture from the evaporation at this point is taken up significantly better by the air blown in.Besides higher drying capacity and lower specific air consumption the optimised pocket ventilation Fig.7 Even moisture removal through even pocket ventilation[°C] 100 90 80 70 60 50 40 30 20 10 0111213141516171819202122800 700 600 500 400 300 200 100 0[g w a t e r / k g a i r ]Cylinder temperature Dry air temperatureWater take-up capacity pocket airDewpointAbsolute moisture content pocket airFig.8Optimal functioning of air doctorsObviously Slalom sections can also be fitted with air doctors as is the case in some of the newer machines.Additionally sheet flutter in conventional sections can be reduced by repositioning the felt rolls in the direction of the headbox, so that the exiting sheet lies against the dryer fabric and is supported by it (Fig.8 to 10).4.2.1 Case study: Pocket ventilationwith optimally functioning air doctors (Caption "Measuring conditions" see page 14) Based on the above results a doctor beam was drilled across its width and connected to the air supply. Comparison between Figures 9 and 10 shows the significant reduction in sheet flutter as the supply air from this “air doctor” presses the sheet against the dryer fabric. The two measuring diagrams indicate the non-visible effects in each photo with closed air supply (Fig.9A) and with open air supply (Fig.10A) via an optimally functioning air doctor. The air conditions in the pocket are as follows:Figure 9A: Air supply closed:• Cold outside air flows laterally into the pocket • Moisture in the machine middle higher than at the edges• Lower dry air temperature in the pocket, particularly in the edge zones• Therefore lower water take-up capacity of the pocket air• Big temperature differences betweenmiddle and edges• Therefore bowed moisture profile• Severe sheet flutter2325 222426Figure 10A: Air supply open:• Hot air flows out of the pocket• More even moisture across the width (lower in machine middle than at the edges) • Significantly higher dry air temperature in the pocket• Resulting immense increase in water take-up capacity of the pocket air 4.2.2 Case study: Pocket ventilation withnon-optimally functioning air doctors (Caption "Measuring conditions" see page 14) On a machine with Slalom sections this example highlights the fact that air doctors do not always function optimally. Figure 11 shows the schematic sketch of an air doctor applicable to all cylinders on this machine, in which the supply air is blown100908070605040302010111213141516171819is equipped with such an air doctor. The air condi-tions were measured at both the inlet and outlet of each cylinder. The absolute moisture measured at the cylinder outlet is almost always double that measured at the inlet, and in fact at a relatively high level for Slalom sections. It is striking how precisely the absolute moisture and the water take-up capacity mirrors the function of the air doctors in consistent zig-zags.The following calculation shows the saving poten-tial of a relatively easily achievable improvement in the moisture profile – as described under 4.2.1. The figures apply to an 8 m wide machine running at 1300 m/min. An increase in the end moisture of 1 % (from 7.5 % to 8.5 %) at the same 2-Sigma values was the result of a more even moisture profile.Energy saving potential from profile improvementEnd moisture with “bad” profile 7.5 % End moisture with “good” profile 8.5 % Steam saving 1.5 t / h Steam costs30 EUR / tSaving potential in EUR per hour45 EURper day1,080 EUR per year (330 days) 356,400 EUR4.3 Case study:Optimisation of a newsprint machine(Caption "Measuring conditions" see page 14)Even quite small mechanical modifications can achieve energy saving and process relevant improvements, as shown in the example of a small newsprint machine with trim width of 3.2 m and a running speed of 920 m/min. Figure 13 shows the situation before optimisation. Figure 14 shows the measures carried out and documents the energy improvements. The energy savings are shown in the following calculation. A further stage of optimi-sation for cylinders from No.22 is planned. Measures carried out:1. The bottom cylinders of the2. and3. sections were separated from the steam and condensate systems (the 1. section had already been separated in the first stage of the optimisation).Fig.13 Before optimisation[°C] 120110100 90 80 70 60 50 40 30 20 10 0[g w a t e r / k g a i r ]800 700 600 500 400 300 200 100 0135791113151719212325Cylinder temperature Dry air temperatureDryer fabric temperature Sheet temperatureWater take-up capacity pocket airDewpointAbsolute moisture content pocket air2.1 The bottom cylinder blow boxes were repo- sitioned under the pockets so that the supply air could enter the pockets more easily. 2.2 Blow pipes were were installed in the pockets under cylinders 1 and3.3. The ventilators of the sheet stabilisers were replaced.Advantages of measures carried out: 1. The bottom cylinders of the 2. and 3. sections were no longer heated, with an appropriate energy saving. The dryer fabrics of the 2. and 3. sections were heated no more than necessary, reducing the risk of hydrolysis.2. Better pocket ventilation from machine middle to edges together with increased water take-up capacity of the pocket air3. Improved runnability – no sheet lifting and no edge creasingSaving from machine optimisation Steam saving 0.6 t / h Steam costs30 EUR / tEnergy saving in EUR per hour18 EURper day432 EURper year (330 days) 142,560 EUR 4.4 Zero point – air leakageThe “zero point” can be described as an imaginary surface within the hood which forms the barrier between underpressure and overpressure. The zero point should be at the same height at front and drive side in order to prevent a lateral air flow in the hood.Frequently a zero point height of about 2 m above machine floor, approximately at the level of the middle of the top cylinders, is recommended. This is substantiated that the pockets are in the underpressure zone from which the air can better escape. This only applies when the necessary ven-tilation of the pockets is lacking or is not function-ing adequately.The current contribution will show why the pock-ets should not be “evacuated” but positivelyFig.14 After optimisationCylinder temperature Dry air temperatureDryer fabric temperature Sheet temperatureWater take-up capacity pocket airDewpointAbsolute moisture content pocket air [°C] 120110100 90 80 70 60 50 40 30 20 10 0[g w a t e r / k g a i r ]800 700 600 500 400 300 200 100 0135791113151719212325be operated with a low zero point, which could be about the level of the bottom of the suction rolls or of the bottom cylinders.As a result almost the complete hood would be in overpressure which would be more favourable from an energy point of view. It also means that the lower the zero point, the less is the leakage that can penetrate the hood.This situation would have the result that the rela-tionship between exhaust air and supply air could be adjusted in the direction of 1:1 and thereby op-timised. The reduction of an incalculable amount of leakage would improve control of the total air conditions in the hood.The exhaust air should be dew point controlled and the supply air zero point controlled. This means that the exhaust air can be carrying a maxi-mum load of moisture so that the moisture can be transported from the pockets with a minimum exhaust volume.It also means that there is an optimal energy ad-vantage can be obtained by the heat exchangers (see chapter 2, final paragraph). through the wall there was sufficient space for the continuous inflow of cold outside air (see Fig.15).The air pulled in flowed onto the drive side, then through the rusty steel floor of the hood and later-ally to the sheet. Despite only moderate warming relative to the air in the hood, this flow of leakage air overdried the drive side edge zone of the sheet (see Fig.15).At the same time moist air built up towards the front side leading to a wetter front edge. In addition the zero point was way above the top cylinders which further encouraged the ingress of the cold outside leakage air.After closing the openings in the basement and sealing the rusted hood supports the 2-Sigma value fell from 0.33 (see Fig.15) to 0.11 (Fig.16).5. Energy potential of exhaust airIn optimising the dry end, measures for reducing energy consumption play a decisive part. The fol-lowing calculation indicates the volume of energy reserves to be found in the exhaust air (Fig.17A and 17B).ConclusionThe growing demands for economies on the whole paper machine require a higher effective-ness in the dryer section. Therefore a significantly more subtle approach to the question of “hot air” is needed than was the case in previous years. The air plays a very important role in paper drying. It is not just a question of how much air is available, but much more where and how itis applied. By the optimal use of supply air and exhaust air the specific air consumption can be much reduced and the speed of drying increased. Energy savings and also production increases can be achieved while bottlenecks in the dryers can be avoided or eliminated.In this case a part of the exhaust air from an 8 m wide machine was led direct to atmosphere – without any energy recovery by a heat exchanger (Fig.17A). The measurements showed residual heat in the exhaust air of 8,890 kW which can be utilised as demonstrated in Fig.17B. Energy saving potential of heat recovery Residual heat in exhaust8,890 kWResult with heat exchanger efficiency of 15 % 1,333 kW Price per kW 0.04 EUR Potential saving in EURper hour53 EURper day1,280 EUR per year (330 days)422,400 EURFig.15 Before optimisation:Effects of cold air ingress on drive side and blocked moist air at front sideFig.16 After optimisationFig.17A Existing situation:Energy loss Fig.17B Ideal situation:Using energy potential of exhaust airCaption "Measuring conditions"In the dryer section analyses the following para-meters were measured:Position 1. Cylinder temperaturePosition 2. Paper sheet temperaturePosition 3. Dry air and moist air temperature Position 4. Clothing temperatureThe measuring positions are shown in Figure 18. All measuring positions are located on the front side of the machine approx. 50 cm towards the machine middle from the front side of the sheet. The measurement of pocket air conditions is carried out with the hood closed to exclude the influence of the machine house climate. The dew point and absolute moisture figures are obtained from the dry air and moist air temperatures.The difference between dry air temperature and dew point temperature documents the water take-up capacity of the pocket air and is shown hatched within the measuring diagrams.Fig.18 Measuring positions。

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