香砂养胃丸联合雷贝拉唑治疗慢性萎缩性胃炎的临床观察
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World Latest Medicine Information (Electronic Version) 2019 Vo1.19 No.26
·临床研究·
香砂养胃丸联合雷贝拉唑治疗慢性萎缩性胃炎的临床观察
李锦
（河南中医药大学第三附属医院，南 郑州）
摘要：目的 观察香砂养胃丸联合雷贝拉唑治疗慢性萎缩性胃炎的临床疗效。方法 80 例慢性牙周炎患者随机分为治疗组 (40 例 ) 和对照组 (40 例 )。治疗组采用香砂养胃丸联合雷贝拉唑治疗，对照组采用雷贝拉唑进行治疗。观察两组患者治疗前后胃脘胀痛和气短乏力；治疗前后分别 检测血清 IL-33 和 IFN-γ 含量；比较两组总有效率。结果 治疗组患者治疗后总有效率 95.0%，显著高于对照组的 82.5%（P<0.05）。治疗组胃 脘胀痛和气短乏力评分明显优于对照组（P<0.05）。治疗组 IL-33 和 IFN-γ 含量明显优于对照组（P<0.05）。结论 香砂养胃丸联合雷贝拉唑 可有效改善慢性萎缩性胃炎患者的临床症状和实验室指标，值得临床推广应用。 关键词：香砂养胃丸；雷贝拉唑；慢性萎缩性胃炎；临床观察 中图分类号：R57 文献标识码：A DOI: 10.19613/ki.1671-3141.2019.26.081
LI Jin
(The Third Hospital Affiliated of Henan University of Traditional Chinese Medicine, Zhengzhou Henan)
ABSTRACT: Objective To observe the clinical effect of xiangsha yangwei pill combined with rabeprazole in the treatment of chronic atrophic gastritis. Methods 80 patients with chronic periodontitis were randomLy divided into treatment group (40 cases) and control group (40 cases). The treatment group was treated with xiangsha yangwei pill combined with rabeprazole, while the control group was treated with rabeprazole. Epigastric distension pain and shortness of breath were observed before and after treatment. The contents of clear IL-33 and IFN- were detected before and after treatment. Compare the two groups of total efficiency. Results The total effective rate was 95.0% in the treatment group, significantly higher than 82.5% in the control group (P<0.05). The scores of epigastric distension and shortness of breath in the treatment group were significantly better than those in the control group (P<0.05). The levels of il-33 and IFN- in the treatment group were significantly higher than those in the control group (P<0.05).Conclusion Xiangsha yangwei pill combined with rabeprazole can effectively improve the clinical symptoms and laboratory indicators of patients with chronic atrophic gastritis, which is worthy of clinical application. KEY WORDS: Xiangsha yangwei pill; Rabeprazole; Chronic atrophic gastritis; Clinical observation
1 资料与方法
1.1 一般资料 选取河南中医药大学第三附属医院 2018 年 1 月 -2018 年 12
月的慢性萎缩性胃炎患者 80 例，按就诊先后顺序分为治疗组 (40 例 ) 和对照组 (40 例 )。治疗组男 17 例，女 23 例；年龄 42-65 岁， 平均年龄（49.3±8.4）岁；病程 5-12 年，平均病程（7.6±1.2）年。 对照组男 19 例，女 21 例；年龄 43-64 岁，平均年龄（48.6±8.1）岁； 病程 5-11 年，平均病程（7.7±1.3）个月。两组患者一般资料比较 不具有统计学意义（P>0.05）。 1.2 纳入标准
0 引言
慢性萎缩性胃炎萎缩性胃炎也称慢性萎缩性胃炎，以胃黏膜 上皮和腺体萎缩，数目减少 [1]，胃黏膜变薄，黏膜基层增厚，或伴幽 门腺化生和肠腺化生，或有不典型增生为特征的慢性消化系统疾 病 [2]。常表现为上腹部隐痛、胀满、嗳气，食欲不振，或消瘦、贫血 等，无特异性，是一种多致病因素性疾病及癌前病变 [3]。
本文引用格式：李锦 . 香砂养胃丸联合雷贝拉唑治疗慢性萎缩性胃炎的临床观察 [J]. 世界最新医学信息文摘 ,2019,19(26):152,154.
Clinical Observation of xiangsha yangwei Pill Combined with Rabeprazole in the Treatment of Chronic Atrophic Gastritis
World Latest Medicine Information (Electronic Version) 2019 Vo1.19 No.26
·临床研究·
香砂养胃丸联合雷贝拉唑治疗慢性萎缩性胃炎的临床观察
李锦
（河南中医药大学第三附属医院，南 郑州）
摘要：目的 观察香砂养胃丸联合雷贝拉唑治疗慢性萎缩性胃炎的临床疗效。方法 80 例慢性牙周炎患者随机分为治疗组 (40 例 ) 和对照组 (40 例 )。治疗组采用香砂养胃丸联合雷贝拉唑治疗，对照组采用雷贝拉唑进行治疗。观察两组患者治疗前后胃脘胀痛和气短乏力；治疗前后分别 检测血清 IL-33 和 IFN-γ 含量；比较两组总有效率。结果 治疗组患者治疗后总有效率 95.0%，显著高于对照组的 82.5%（P<0.05）。治疗组胃 脘胀痛和气短乏力评分明显优于对照组（P<0.05）。治疗组 IL-33 和 IFN-γ 含量明显优于对照组（P<0.05）。结论 香砂养胃丸联合雷贝拉唑 可有效改善慢性萎缩性胃炎患者的临床症状和实验室指标，值得临床推广应用。 关键词：香砂养胃丸；雷贝拉唑；慢性萎缩性胃炎；临床观察 中图分类号：R57 文献标识码：A DOI: 10.19613/ki.1671-3141.2019.26.081
LI Jin
(The Third Hospital Affiliated of Henan University of Traditional Chinese Medicine, Zhengzhou Henan)
ABSTRACT: Objective To observe the clinical effect of xiangsha yangwei pill combined with rabeprazole in the treatment of chronic atrophic gastritis. Methods 80 patients with chronic periodontitis were randomLy divided into treatment group (40 cases) and control group (40 cases). The treatment group was treated with xiangsha yangwei pill combined with rabeprazole, while the control group was treated with rabeprazole. Epigastric distension pain and shortness of breath were observed before and after treatment. The contents of clear IL-33 and IFN- were detected before and after treatment. Compare the two groups of total efficiency. Results The total effective rate was 95.0% in the treatment group, significantly higher than 82.5% in the control group (P<0.05). The scores of epigastric distension and shortness of breath in the treatment group were significantly better than those in the control group (P<0.05). The levels of il-33 and IFN- in the treatment group were significantly higher than those in the control group (P<0.05).Conclusion Xiangsha yangwei pill combined with rabeprazole can effectively improve the clinical symptoms and laboratory indicators of patients with chronic atrophic gastritis, which is worthy of clinical application. KEY WORDS: Xiangsha yangwei pill; Rabeprazole; Chronic atrophic gastritis; Clinical observation
1 资料与方法
1.1 一般资料 选取河南中医药大学第三附属医院 2018 年 1 月 -2018 年 12
月的慢性萎缩性胃炎患者 80 例，按就诊先后顺序分为治疗组 (40 例 ) 和对照组 (40 例 )。治疗组男 17 例，女 23 例；年龄 42-65 岁， 平均年龄（49.3±8.4）岁；病程 5-12 年，平均病程（7.6±1.2）年。 对照组男 19 例，女 21 例；年龄 43-64 岁，平均年龄（48.6±8.1）岁； 病程 5-11 年，平均病程（7.7±1.3）个月。两组患者一般资料比较 不具有统计学意义（P>0.05）。 1.2 纳入标准
0 引言
慢性萎缩性胃炎萎缩性胃炎也称慢性萎缩性胃炎，以胃黏膜 上皮和腺体萎缩，数目减少 [1]，胃黏膜变薄，黏膜基层增厚，或伴幽 门腺化生和肠腺化生，或有不典型增生为特征的慢性消化系统疾 病 [2]。常表现为上腹部隐痛、胀满、嗳气，食欲不振，或消瘦、贫血 等，无特异性，是一种多致病因素性疾病及癌前病变 [3]。
本文引用格式：李锦 . 香砂养胃丸联合雷贝拉唑治疗慢性萎缩性胃炎的临床观察 [J]. 世界最新医学信息文摘 ,2019,19(26):152,154.
Clinical Observation of xiangsha yangwei Pill Combined with Rabeprazole in the Treatment of Chronic Atrophic Gastritis