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p21 DecBiblioteka Baidueased expression (No known direct mutation)
Apoptosis
Invasion & Metastasis
PI3K
PI 4,5 P2
PI 3,4,5 P3
PTEN
Survival
uPAR
ELK1 AP1 cMyc
M G2 G1
S
Apoptosis
Steps in RNA splicing
Exon 1
Intron
Excision, Lariat formation
Exon 1
Excision, Transesterification
Exon 2
Exon 2
AT TA
G
A
T
C
C
T
A
G
T C
G A
TG CA
G A TCG A T CG A T CG C T AG C T AG C T AG C
MTA3 Mi-2
HDAC1 MTA1
Snail
Apoptosis
ECadherin
Histone acetylation and gene expression
Common Alterations in Breast Cancer (ER+)
Proliferation
EGFR
Grb2 ER
Sos
p21 Decreased expression (No known mutation)
Cell Cycle Control
Apoptosis
Invasion & Metastasis
p53
p21
CyclinD1
M G2 G1
S
PI3K
PI 4,5 P2
PI 3,4,5 P3
PTEN
Survival
K-Ras
Raf
MEK1/2 ERK1/2
Cell Cycle Control
p53
p21
CyclinD1
Ras
Activating mutation in
cancer
RasIncreased expression (no known direct mutation)
PTEN Inactivating mutation in cancer
Protein complexes in RNA splicing
Exon 1
U1
U2 U5
Exon 1
Exon 2
Intron
Exon 2
U2
U5 U1 U4
U2 U5
Common Alterations in Breast Cancer (ER-)
Proliferation
DNA Repair
Wnt
HER2
Grb2 Sos Ras Raf β-
MEK1/2 Catenin ERK1/2
BRCA1/2
ELK1 AP1 cMyc
Ras
Activating mutation in
cancer
RasIncreased expression (no known mutation)
PTEN Inactivating mutation in cancer
Apoptosis
Invasion & Metastasis
PI3K
PI 4,5 P2
PI 3,4,5 P3
PTEN
Survival
uPAR
ELK1 AP1 cMyc
M G2 G1
S
Apoptosis
Steps in RNA splicing
Exon 1
Intron
Excision, Lariat formation
Exon 1
Excision, Transesterification
Exon 2
Exon 2
AT TA
G
A
T
C
C
T
A
G
T C
G A
TG CA
G A TCG A T CG A T CG C T AG C T AG C T AG C
MTA3 Mi-2
HDAC1 MTA1
Snail
Apoptosis
ECadherin
Histone acetylation and gene expression
Common Alterations in Breast Cancer (ER+)
Proliferation
EGFR
Grb2 ER
Sos
p21 Decreased expression (No known mutation)
Cell Cycle Control
Apoptosis
Invasion & Metastasis
p53
p21
CyclinD1
M G2 G1
S
PI3K
PI 4,5 P2
PI 3,4,5 P3
PTEN
Survival
K-Ras
Raf
MEK1/2 ERK1/2
Cell Cycle Control
p53
p21
CyclinD1
Ras
Activating mutation in
cancer
RasIncreased expression (no known direct mutation)
PTEN Inactivating mutation in cancer
Protein complexes in RNA splicing
Exon 1
U1
U2 U5
Exon 1
Exon 2
Intron
Exon 2
U2
U5 U1 U4
U2 U5
Common Alterations in Breast Cancer (ER-)
Proliferation
DNA Repair
Wnt
HER2
Grb2 Sos Ras Raf β-
MEK1/2 Catenin ERK1/2
BRCA1/2
ELK1 AP1 cMyc
Ras
Activating mutation in
cancer
RasIncreased expression (no known mutation)
PTEN Inactivating mutation in cancer