袁宗辉简介

袁宗辉简介
袁宗辉，男，1958年2月生，湖北天门人，农学博士。

华中农业大学二级教授，博士生导师，基础兽医学系主任，
国家兽药残留基准实验室(HZAU)主任，国家兽药安全评价
实验室主任，农业部食品安全评价重点开放实验室主任，国
家“973”项目首席科学家。

1981年在华中农业大学兽医专业毕业，1987年在华南
农业大学获得博士学位，成为我国第一位兽医药理学及毒理学博士。

1997年在美国肯塔基大学动物科学系、2002年在美国罗德岛大学药学院从事合作研究。

主要学术兼职：国家农产品质量安全风险评估专家委员会委员，中国国际食品法典委员会(CAC)农业专家工作组成员，中国兽药典委员会委员，全国兽药残留专家委员会委员，农业部兽药审评委员会委员。

J Vet Pharmacol Therap，Asian J Pharmacod Pharmacok等6个杂志的编委，J Chromatog. A & B, Anal Bioanal Chem等多个杂志的审稿人，全球避免食品动物残留数据系统(gFARAD)中方联系人。

全国多个学会的副理事长、常务理事或理事。

主要研究方向：药代动力学、兽药残留与食品安全、抗菌药耐药性。

主持国家重点基础研究发展计划(973计划)项目、国家自然科学基金项目、国家支撑计划(攻关计划)课题等20多项，制定兽药残留检测方法国家标准37项，研制残留标志物(兽药代谢产物)标准品7种，研发兽药残留快速检测试剂盒备案产品12种，获得国家发明专利授权7项，另申报国家发明专利16项，在Drug Metabol Rev，J Chromat A、Anal Chim Acta、Food Chem Toxicol, J Agri Food Chem等国内外杂志发表论文200多篇，主编专著3部，参编8部，审稿3部，获教育部和湖北省科技进步奖4项。

先后培养博士后2名，博士生30名(18名已毕业)，硕士生100多名(已毕业77名)。

今年发表的主要论文如下：
Awais Ihsan, Xu Wang, Xianju Huang, Yu Liu, Qin Liu, Wen Zhou, Zonghui Yuan*. Acute and Subchronic Toxicological Evaluation of Mequindox in Wistar Rats. Revised
Zhao-Ying Liu, Ling-Li Huang, Dong-Mei Chen, Meng-Hong Dai, Yan-Fei Tao, Yu-Lian Wang, Zonghui Yuan*. Application of electrospray ionization hybrid ion trap/time-of-flight mass spectrometry in the rapid characterization of quinocetone metabolites formed in vitro.
Analytical and Bioanalytical Chemistry; Accepted
Bo Yang, Lingli Huang, Yulian Wang, Yu Liu, Yanfei Tao, Dongmei Chen, Zhenli Liu, Ke Fang,
Yueping Chen, Zonghui Yuan∗. Residue depletion and tissue-plasma correlation of methyl-3-quinoxaline-2-carboxylic acid after dietary administration of olaquindox in pigs.
Journal of Agricultural and Food Chemistry. Accepted
Hao Haihong, Dai Menghong, Wang Yulian, Chen Dongemi, Yuan Zonghui*. Quantification of Mutated alleles of 23s rRNA in Macrolide Resistant Campylobacterby TaqMan real-time PCR. Foodborne Pathogens and Disease Accepted
Guo Qianji, Huang Lingli, Fang Ke, Wang Yulian, Chen Dongmei, Tao, Yanfei, Dai Menghong, Liu Zhenli, Peng Dapeng, Yuan Zonghui*. Population pharmacokinetics of enrofloxacin and its metabolite ciprofloxacin in chicken based on retrospective data, incorporating first-pass metabolism. Journal of Veterinary Pharmacology and Therapeutics doi: 1111/j.1365-2885.2009.01106. x
Min Yao; Zhaoying Liu; Menghong Dai; Lingli Huang; Dongmei Chen; Yulian Wang; Yanfei Tao;
Xu Wang; Zhenli Liu; Zonghui Yuan*. Transcriptional Profile of CYP3As and Functional Expression of CYP3A29 from Piglets. Bioinformatics and Biomedical Engineering 2009;
10.1109/ICBBE.2009. 5163697
Qinghua Wu, Vlastimil Dohnal, Lingli Huang, Kamil Kuca, Zonghui Yuan. Metabolic Pathway of Trichothecenes. Drug Metabolism Reviews 2009; 41: 1-18
Hao Haihong, Dai Menghong, Wang Yulian, Peng Dapeng, Liu Zhenli, Yuan Zonghui*. 23S rRNA Mutation A2074C conferring high-lecel Macrolide Resistance and fitness cost in Campylobacter jejuni. Microbial Drug Resistance 2009; 15(4): 239- 244
Xianju Huang, Awais Ihsan, Xu Wang, Menghong Dai, Yulian Wang, Shijia Su, Xijuan Xue, Zonghui Yuan*. Long-term dose-dependent response of mequindox aldosterone, corticosterone and five steroidogenic enzyme mRNAs in the adrenal of male rats. Toxicology Letters 2009; 191(2-3): 167-173
Zhaoying Liu, Lingli Huang, Menghong Dai, Dongmei Chen, Yanfei Tao, Yulian Wang, Zonghui Yuan*. Metabolism of cyadox in rat, chicken and pig liver microsomes and identification of metabolites by accurate mass measurements using electrospray ionization hybrid ion trap/time-of-flight mass spectrometry. Rapid Communication in Mass Spectrometry 2009;
23(13): 2026~2034
Qinghua Wu, Alena Jezkova, Zonghui Yuan*, Lucie Pavlikova, Vlastimil Dohnal, Kamil Kuca.
Biological degradation of aflatoxins. Drug Metabolism Reviews, 2009: 41(1): 1~7
Z Yuan, Z Liu, L Huang, D Chen, Y Wang, M Dai and Z Liu. Metabolism of olaquindox in rats, chicken and pigs. Journal of Veterinary Pharmacology and Therapeutics 2009; 32: 178~179 Lingli Huang, Yulian Wang, Yanfei Tao, Dongmei Chen, Zonghui Yuan*. Development of high performance liquid chromatographic methods for the determination of cyadox and its metabolites in plasma and tissues of chicken. Journal of Chromatography B 2008; 874: 7~14 Zhao Cunbao, Peng Dapeng, Wang Yulian, Huang Lingli, Chen Dongmei, Tao Yanfei and Yuan Zonghui*. Preparation and validation of the polyclonal antibodies for detection of chlortetracycline residues. Food and Agricultural Immunology 2008; 19(2): 163~174
Chang Chao, Dapeng Peng, Jine Wu, Yulian Wang, Zonghui Yuan*.Developmentof an indirect competitive ELISA for detecting furazolidone marke residue in animal edible tissues.
Journal of Agriculturae and Food Chemistry 2008; 56(5): 1525~1531
Zhaoying Liu, Lingli Huang, Menghong Dai, Dongmei Chen, Yulian Wang, Yanfei Tao, Zonghui Yuan*. Characterization of olaquindox metabolites in rat liver microsomes by high-performance liquid chromatography combined with ion trap/time -of-flight mass spectrometry. Drug Metabolism Reviews 2008; 40: 131.
Zaoying Liu，Lingli Huang, Menghong Dai, Dongmei Chen, Yulian Wang, Yanfei Tao and
Zonghui Yuan*. Metabolism of olaquindox in rat liver microsomes: structural elucidation of metabolites by high-performance liquid chromatography combined with ion trap/time-of-flight mass spectrometry. Rapid Communications in Mass Spectrometry 2008;
22: 1009~1016
Dai XH*, Chen WW*, Wang Xu*, Zhu QH, Li C, Li L，Liu MG, Wang QK, Liu JY. A novel genetic locus for familial febrile seizures and epilepsy on chromosome 3q26.2 -q26.33.
Human Genetics 2008; 124(4): 423~429
Ling Cao，Weiming Wang, Yi Yang, Chengtai Yang, Zonghui Yuan, Shanbo Xiong and Jiames Diana. Environmental Impact of Aquaculture and Countermeasures to Aquaculture Pollution in China. Environment Science and Pollution Research 2007; 14(7): 452~462
Xueli Wu, Gong Zhang, Yongning Wu, Xiaolin Hou, Zonghui Yuan*. Simultaneous determination of malachite green, gentian violet and their leuco-metabolites in aquatic products by high-performance liquid chromatography-linear ion trap mass spectrometry.
Journal of Chromatography A 2007; 1172(2): 121~126
Yujie Wu, Huan Yu, Yulian Wang, Lingli Huang, Yanfei Tao, Dongmei Chen, Dapeng Peng, Zhenli Liu, Zonghui Yuan*. Development of an HPLC-UV method for the simultaneous quantification of Quinoxaline-2-carboxylic acid and methyl-3- quinoxaline-2-carboxylic acid in animal tissues. Journal of Chromatography A 2007; 1146(1)：1~7
M.X. Ding, Y. L. Wang, H.L. Zhu, Z.H. Yuan*. Effects of cyadox and olaquindox on intestinal mucosal immunity and on fecal sedding of Escherichia coli in piglets. Journal of Animal Science 2006; 84(9): 2367~2373
ZH Yuan*, YJ Wu, YL Wang, LL Huang, DM Chen and YF Tao. Development of an HPLC-UV method for simultaneous quantification of quinoxaline-2-carboxylic acid and 3-methyl-quinoxiline-2-caboxylic acid in muscle and liver of swine, chicken and fish.
Journal of Veterinay Pharmacology and Therapeutics 2006; 29: 142~143
Yujie Wu, Yulian Wang, Lingli Huang, Yanfei Tao, Zonghui Yuan* and Dongmei Chen.
Simultaneous determination of five quinoxiline 1,4-dioxides in animal feeds using ultrasonic solvent extraction and high-performance liquid chromatography. Analytica Chimica Acta 2006; 569(1-2): 97~102
Mingxing Ding, Zonghui Yuan*, Yulian Wang, Huiling Zhu and Shengxian Fan. Olaquindox and cyadox stimulate growth and decrease mucosal immunity in piglets orally inoculated with Escherichia coli. Journal of Animal Physiology and Animal Nutrition 2006；90(5-6): 238~243
Qinghua He, Guijie Fang, Yulian Wang, Zhichao Wei, Daju Wang, Shiqi Zhou, Shengxian Fan, Zonghui Yuan*. Experimental Evaluation of Cyadox Phototoxicity to Balb/c mouse skin.
Photodermatology, Photoimmunology and Photomedicine 2006; 22(2):100~104
HL Zhu, ZH Yuan*，YL Wang, YS Qiu, SX Fan. The Effect of Cyadox Supplementa- tion on Metabolic Hormones and Epidermal Growth Factor in Swine. Animal Science 2006; 82(3): 345~350
Guijie Fang, Qinghua He, Shiqi Zhou, Daju Wang, Yanling Zhang, Zonghui Yuan*. Subchronic Oral Toxicity study with Cyadox in Wistar Rats. Food and Chemical Toxicology 2006; 44(1): 36~41
Yanling Zhang, Lingli Huang, Dongmei Chen, Shengxian Fan, Yulian Wang, Yanfei Tao, Zonghui Yuan*. Development of HPLC Methods for Determination of Cyadox and Its Main
Metabolites in Goat Tissues. Analytical Sciences 2005; 21(12): 1495~1499
Zhang Yinling, Wang Yulian, Huang Lingli, Chen Dongmei, Tao Yanfei, Yuan Zonghui*. Effects of cooking and storage on cyadox residues in chicken muscle. Journal of Agricultural and Food Chemistry 2005; 53: 9737-9741
Mingxing Ding, Zonghui Yuan*, Yulian Wang, Huiling Zhu and Shengxian Fan. Effects of olaquindox and cyadox on immunity of piglets orally inoculated with Escherichia coli.
Asian-Astralaian Animal Science 2005; 18(9): 1320~1325
Y. Wang, Z. Yuan*, H. Zhu, M. Ding, S. Fan. Effect of cyadox on growth and nutrient digentibility in wealing pigs. South African Journal of Animal science 2005; 35(2): 117~125 Lingli Huang, Aiguo Xiao, Shengxian Fan, Juyi Yin, Pin Chen, Dengcai Liu, Yingsheng Qiu, Yulian Wang, Zonghui Yuan*. Development of HPLC Methods for Determination of Quinocetone and its metabolites in edible tissues of swine and chicken. Journal of AOAC International 2005; 88(2): 472-478。