IC261_COA_18395_MedChemExpress
Bedaquiline fumarate_845533-86-0_DataSheet_MedChemExpress
Product Name:Bedaquiline fumarate CAS No.:845533-86-0Cat. No.:HY-14881A Product Data SheetMWt:671.58Formula:C36H35BrN2O6Purity :>98%Solubility:DMSOMechanisms:Biological Activity:Bedaquiline fumarate(TMC207; R207910) is an anti-tuberculosis drug which selectively inhibit the Pathways:Anti-infection; Target:Antibacterial q (;)g y mycobacterial energy metabolism i.e. ATP synthesis and found to be effective against all states ofMycobacterium tuberculosis.IC50 value:Target: anti-TB Preclinical studies have shown the efficacy of bedaquiline in terms of reduction in bacterial load and treatment duration. Phase II clinical studies have established the safety, tolerability and earliersputum conversion time in patients with MDR-TB. In 2012 FDA approved bedaquiline for treatment of MDR-TB and XDR-TB [1]. Bedaquiline possesses a unique mechanism of action that disrupts the ti it f th b t i l d i t i h h t th Cli i l t i l h b d t d References:[1]. Lakshmanan M, et al. Bedaquiline - The first ATP synthase inhibitor against multi drug resistanttuberculosis. J Young Pharm. 2013 Dec;5(4):112-115.[2]Chahine EB et al Bedaquiline:a novel diarylquinoline for multidrug-resistant tuberculosis Ann activity of the mycobacterial adenosine triphosphate synthase. Clinical trials have been conducted evaluating the use of bedaquiline in combination with a background regimen for the treatment of adults with pulmonary MDR-TB. Bedaquilin...[2]. Chahine EB, et al. Bedaquiline: a novel diarylquinoline for multidrug-resistant tuberculosis. AnnPharmacother. 2014 Jan;48(1):107-15.Caution: Not fully tested. For research purposes onlyMedchemexpress LLC18 W i l k i n s o n W a y , P r i n c e t o n , N J 08540,U S AT E m a i l : i n f o @m e d c h e m e x p r e s s .c o m W e b : w w w .m e d c h e m e x p r e s s .c o m。
FDA批准的放射性药物都有哪些？
FDA批准的放射性药物都有哪些？展开全文中华医学会核医学分会放射性药物学组整理1、药物名称：Carbon-11 choline（11C-胆碱）生产商：Mayo Clinic 商品名：—用途：前列腺癌复发诊断2、药物名称：Carbon-14 urea（14C-尿素）生产商：Kimberly-Clark 商品名：PYtest用途：胃中幽门螺杆菌感染诊断3、药物名称：Fluorine-18 florbetaben（18F-AV1）生产商：Piramal Imaging 商品名：Neuraceq™用途：阿尔茨海默（AD）患者和痴呆患者评价4、药物名称：Fluorine-18florbetapir（18F-AV45）生产商：Eli Lilly 商品名：Amyvid™用途：阿尔茨海默症诊断与治疗5、药物名称：Fluorine-18sodium fluoride（18F-氟化钠）生产商：Various 商品名：—用途：成骨能力的骨显像剂6、药物名称：Fluorine-18fludeoxyglucose（18F-FDG）生产商：Various 商品名：—用途：肿瘤、癫痫病灶糖代谢异常检测7、药物名称：Fluorine-18flutemetamol（18F-PIB）生产商：GE Healthcare 商品名：Vizamyl用途：阿尔茨海默（AD）患者和痴呆患者评价8、药物名称：Gallium-67 citrate（67Ga-柠檬酸）生产商：Lantheus MedicalImaging、Mallinckrodt商品名：—用途：霍奇金病、淋巴瘤、支气管癌以及一些急性炎症病变诊断9、药物名称：Indium-111capromab pendetide（111In-卡罗单抗喷地肽）生产商：AytuPharmaceuticals 商品名：ProstaScint®用途：前列腺癌患者、前列腺癌术后高度怀疑转移患者的检测10、药物名称：Indium-111 chloride（111In-氯化铟）生产商：GE Healthcare、Mallinckrodt 商品名：Indiclor™用途：用于放射性标记11、药物名称：Indium-111 pentetate（111In-DTPA）生产商：GE Healthcare 商品名：—用途：放射性核素脑池造影12、药物名称：Indium-111oxyquinoline（111In-羟基喹啉）生产商：GE Healthcare 商品名：—用途：用于自体白细胞标记，炎症及感染的诊断13、药物名称：Indium-111pentetreotide（111In-奥曲肽）生产商：Mallinckrodt 商品名：Octreoscan™用途：原发性和转移性内神经分泌肿瘤生长抑素受体定位14、药物名称：Iodine I-123iobenguane（123I-MIBG）生产商：GE Healthcare 商品名：AdreView™用途：原发或转移性嗜铬细胞瘤或神经母细胞瘤的辅助诊断15、药物名称：Iodine I-123 ioflupane（123I-氟潘）生产商：GE Healthcare 商品名：DaTscan™用途：对疑似帕金森症患者的评估16、药物名称：Iodine I-123sodium iodide capsules（123I-碘化钠胶囊）生产商：Cardinal Health、Mallinckrodt 商品名：—用途：甲状腺功能及形态学评价17、药物名称：Iodine I-125 humanserum albumin（125I-人血清白蛋白）生产商：IsoTex Diagnostics 商品名：Jeanatope用途：全血及血浆容量测定18、药物名称：Iodine I-125iothalamate（125I-酞酸盐）生产商：IsoT ex Diagnostics商品名：Glofil-125用途：肾小球滤过率的评价19、药物名称：Iodine I-131 humanserum albumin（131I-人血清白蛋白）生产商：IsoTex Diagnostics 商品名：Megatope用途：全血及血浆量、心脏输出、心脏及肺血容量、蛋白质周转研究、脑肿瘤定位等20、药物名称：Iodine I-131sodium iodide（131I-碘化钠）生产商：DRAXIMAGE、Mallinckrodt 商品名：HICON™用途：甲状腺疾病的诊断与治疗21、药物名称：MolybdenumMo-99 generator（钼锝发生器）生产商：GE Healthcare、Lantheus MedicalImaging、Mallinckrodt商品名：DRYTEC™、T echnelite、UltraTechneKow®DTE用途：放射性药物的制备22、药物名称：Nitrogen-13 ammonia（13N-氨水）生产商：Various 商品名：—用途：心肌灌注评价冠状动脉疾病23、药物名称：Radium-223 dichloride（223Ra-二氯化镭）生产商：Bayer HealthCarePharmaceuticalsInc. 商品名：Xofigo®用途：去势性前列腺癌治疗24、药物名称：Rubidium-82 chloride（82Ru-氯化铷）生产商：Bracco Diagnostics 商品名：Cardiogen-82®用途：心肌灌注显像剂25、药物名称：Samarium-153lexidronam（153Sm-EDTMP）生产商：Lantheus MedicalImaging 商品名：Quadramet®用途：减轻骨转移患者的疼痛26、药物名称：Strontium-89 chloride（89Sr-氯化锶）生产商：GE Healthcare商品名：MetastronTM用途：减轻骨转移患者的疼痛27、药物名称：T echnetium-99mbicisate（99mT c-ECD）生产商：Lantheus MedicalImaging 商品名：Neurolite®用途：脑卒中患者卒中的诊断与治疗28、药物名称：Technetium-99mdisofenin（99mTc-地索芬宁）生产商：Pharmalucence 商品名：Hepatolite®用途：急性胆囊炎诊断29、药物名称：Technetium-99mexametazine（99mTc-HMPAO）生产商：GE Healthcare 商品名：C eretec™用途：脑卒中患者血脑灌注、白细胞标记显像用用于腹腔感染及肠道炎症定位30、药物名称：T echnetium-99mmacroaggregatedalbumin （99mT c-MAA）生产商：DRAXIMAGE 商品名：—用途：肺灌注评价、腹静脉分流畅通性评价31、药物名称：Technetium-99mmebrofenin（99mT c-甲溴苯宁）生产商：Bracco Diagnostics、Pharmalucence 商品名：Choletec®用途：肝胆显像剂32、药物名称：Technetium-99mmedronate（99mTc-MDP）生产商：DRAXIMAGE、GE Healthcare、Pharmalucence 商品名：MDP-25、MDP Multidose用途：骨显像剂33、药物名称：Technetium-99mmertiatide（99mTc-MAG3）生产商：Mallinckrodt 商品名：TechnescanMAG3TM用途：肾动态显像34、药物名称：Technetium-99moxidronate（99mT c-HDP）生产商：Mallinckrodt 商品名：Tec hnescan™HDP用途：骨显像剂35、药物名称：Technetium-99mpentetate（99mT c-DTPA）生产商：DRAXIMAGE 商品名：—用途：脑显像、肾显像36、药物名称：T echnetium-99mpyrophosphate（99mTc-PYP）生产商：Mallinckrodt、Pharmalucence 商品名：Technescan™、PYP™用途：骨显像、心脏显像剂、血池显像剂37、药物名称：Technetium-99m redblood cells（99mT c-红细胞）生产商：Mallinckrodt 商品名：UltraTag™用途：血池造影、消化道出血定位38、药物名称：T echnetium-99msestamibi（99mTc-MIBI）生产商：Cardinal Health、DRAXIMAGE、Lantheus MedicalImaging、Mallinckrodt、Pharmalucence商品名：Cardiolite®用途：心肌灌注，用于检测缺血、评价心机功能，乳腺成像39、药物名称：Technetium-99msodium pertechnetate （99mT c-高锝酸钠）生产商：GE Healthcare、Lantheus MedicalImaging、Mallinckrodt商品名：—用途：脑显像、甲状腺显像、胎盘定位、膀胱显像等40、药物名称：Technetium-99msuccimer（99mT c-DMSA）生产商：GE Healthcare 商品名：—用途：肾显像41、药物名称：Technetium-99msulfur colloid（99mT c-硫胶体）生产商：Pharmalucence 商品名：—用途：肝、脾、骨髓显像等42、药物名称：Technetium-99mtetrofosmin（99mTc-替曲膦）生产商：GE Healthcare 商品名：MyoviewTM用途：心肌灌注剂43、药物名称：Technetium-99mtilmanocept（99mTc-替马诺噻）生产商：NavideaBiopharmaceuticals,Inc. 商品名：Lymphoseek®用途：淋巴结定位44、药物名称：Thallium-201chloride（201Tl-氯化铊）生产商：GE Healthcare、Lantheus MedicalImaging、Mallinckrodt商品名：—用途：心肌灌注显像45、药物名称：Xenon-133 gas（133Xe气体）生产商：Lantheus MedicalImaging 商品名：—用途：肺功能评估与肺显像、脑血流评估46、药物名称：Yttrium-90chloride（90Y-氯化钇）生产商：MDS Nordion、Eckert＆ZieglerNuclitec商品名：—用途：放射性标记47、药物名称：Yttrium-90ibritumomab tiuxetan（90Y-替伊莫单抗）生产商：SpectrumPharmaceuticals商品名：Zevalin®用途：非霍奇金氏淋巴瘤治疗截止至2015年8月1日。
26291346_基于UPLC-MS
Abstract: A UPLC-MS/MS method was established to quantitatively determine the content of alliin in animal plasma to study whether alliin and alliin in garlic enteric preparations can react to produce the active ingredient allicin in the in vivo environment. Methods Reversed-phase C18 column (Waters ICQUITY UPLC BEH, 100 × 2.1 mm, 1.7μm), column temperature: 40 ℃, flow rate: 0.15 mL/min, injection volume: 2μl, Mobile phase: 0.1% formic acid (A)-acetonitrile (B), gradient elution; mass spectrometry ionization: ESI+, determination of allicin in rat plasma . Results The results of two parallel experiments of garlic enteric preparation and enzymatic garlic powder showed that in the garlic enteric preparation with allinase, the plasma concentration of alliin in the blood of rats was significantly lower. Conclusion A UPLC-MS/MS method for the quantitative determination of alliin in animal plasma has been established. Alliin and alliin in garlic enteric-coated preparations can react in vivo.Key words: Garlic enteric preparation; garbonine; UPLC-MS-MS基于UPLC-MS/MS大蒜肠溶制剂中蒜氨酸、蒜酶体内反应情况研究杨亮1，胡小霞4 ，宋百灵4，关明3，李新霞2*（1.新疆警察学院 新疆 乌鲁木齐 8300112.新疆医科大学药学院 新疆 乌鲁木齐 8300113.新疆师范大学化学化工学院 新疆 乌鲁木齐 8300544.新疆医科大学中心实验室 新疆 乌鲁木齐 830011）Study on the Reaction of Garlic and Uterine in the UPLC-MS / MS of Garlic SausolYANG Liang 1，HU Xiaoxia 4 ，SONG Bailing 4，GUAN Ming 3，LI Xinxia 2*(1. Xinjiang Police College, Urumqi 830054, Xinjiang China2.Chemistry and Chemical Engineering of Xinjiang Normal University College, Urumqi 830054, Xinjiang China3.School of Pharmacy, Xinjiang Medical University, Urumqi 830011, Xinjiang China4.Central Laboratory of Xinjiang Medical University, Urumqi 830011, Xinjiang China ）摘要：目的 建立定量测定动物血浆中蒜氨酸含量的UPLC-MS/MS 方法，研究大蒜肠溶制剂中蒜氨酸、蒜酶能否在体内环境下反应生成活性成分大蒜辣素。
CAS号413611-93-5_10074-G5_MedBio_物理性质
1、产品物理参数：
常用名
10074-G5
英文名
10074-G5
CAS号
413611-93-5
分子量
332.313
密度
1.4±0.1 g/cm3
沸点
538.6±60.0 °C at 760 mmHg
分子式
C18H12N4O3
熔点
无资料
闪点
279.5±32.9 °C
2、技术资料：
体外研究
10074-G5抑制Daudi Burkitt淋巴瘤细胞的生长并破坏c-Myc / Max二聚化。针对Daudi和HL-60细胞的IC50值分别为15.6和13.5μM[1]。10074-G5在区域Arg363-Ile381中结合Myc肽Myc353-437，Kd值为2.8μM。10074-G5结合在由诱导螺旋结构域（Leu370-Arg378）的N末端的扭结（Asp379-Ile381）产生的空腔中[3]。
≥98%
品牌
货号
中文名称
英文名称
CAS
包装
纯度
MedBio
MED11457
CDK inhibitor II
CDK inhibitor II
1269815-17-9
50mg
≥98%
品牌
货号
中文名称
英文名称
CAS
包装
纯度
MedBio
MED11591
(S)-CCG-1423
(S)-CCG-1423
None
体内研究
静脉注射20 mg / kg小鼠的血浆半衰期为10074-G5，为37分钟，血药浓度峰值为58μM，比肿瘤峰值浓度高10倍[1]。
3、同类产品列表：
化学类影响因子
Abbreviated JournalTitle(linked to journal information)Total CitesImpact Factor5-YearImpactFactor Immediacy Index综合1Nature 0028-0836********.59738.1599.2432Science0036-807550848931.02733.587 6.6913P Natl Acad Sci Usa 0027-84245349519.73710.583 1.893化学综合1Chem Rev 0009-266511259641.29845.79514.3351Chem Rev 0009-266511259641.29845.79514.3352Nat Mater 1476-11224634835.74942.3768.4113Nat Nanotechnol 1748-33872192031.1736.011 5.8764Chem Soc Rev 0306-00124764624.89230.1817.9975Prog Mater Sci 0079-6425592123.19422.3337.2176Nat Chem 1755-4330865221.75723.02 5.5327Accounts Chem Res 0001-48424211220.83324.633 5.2958Nano Today 1748-0132294417.68918.1920.7849Annu Rev Mater Res 1531-7331525916.17914.4950.66710Surf Sci Rep 0167-5729411515.33322.2817.7511Adv Mater 0935-96489195214.82913.86 2.55712Mat Sci Eng R 0927-796X 485013.90218.9740.66713Angew Chem Int Edit 1433-785122989413.73413.56 2.95914Annu Rev Phys Chem 0066-426X 700213.36518.121 4.13815Nano Lett 1530-69848843113.02514.132 2.47116Acs Nano 1936-0851*******.06212.524 1.9417Energ Environ Sci 1754-56921284911.65312.462 3.08718Coordin Chem Rev 0010-85452560111.01612.257 2.29419J Am Chem Soc 0002-786343128610.67710.237 2.16420Nat Prod Rep 0265-0568660910.17810.072 2.38521Adv Energy Mater 1614-6832199510.04310.05 2.11822Adv Funct Mater 1616-301X 347589.76510.342 1.81523Med Res Rev 0198-632532979.5839.978 1.81124Npg Asia Mater 1884-40493019.0428.556 2.41425Annu Rev Anal Chem 1936-132711498.612.2830.69626Top Curr Chem 0340-102255078.456 6.205 4.27327Chem Sci 2041-652048458.3148.33 2.77128Chem Mater 0897-4756746518.2387.627 1.12329J Photoch Photobio C 1389-556720268.06911.9520.7530Small 1613-6810181377.8238.084 1.42931Prog Photovoltaics 1062-799545357.7127.023 3.22332J Control Release 0168-3659297557.6338.078 1.13633Annu Rev Chem Biomol 1947-54383317.5127.5121.045JCR Data RankISSN34Int Mater Rev0950-660822557.487.149 1.188 35Chemsuschem1864-563150567.4757.951 1.189 36Prog Solid State Ch0079-678614747.429 3.3380 37Nano Res1998-012430317.3927.8010.979 38Prog Surf Sci0079-681619047.1369.140.273 39Adv Carbohyd Chem Bi0065-23188337.133 5.8460.75 40Green Chem1463-926215554 6.828 6.992 1.269 41Adv Organomet Chem0065-3055841 6.758.9410 42Curr Opin Colloid In1359-02944670 6.6297.0360.884 43J Phys Chem Lett1948-71858575 6.585 6.651 1.301 44Top Organometal Chem1436-60021152 6.384 1.762 45Chem Commun1359-7345122728 6.378 6.226 1.53 46Catal Rev0161-49402529 6.37510.1750.889 47Trac-Trend Anal Chem0165-99367327 6.351 6.7610.92 48Nanoscale2040-33647835 6.233 6.262 1.167 49Adv Colloid Interfac0001-86867115 6.1698.01 1.32 50Org Lett1523-706073440 6.142 5.563 1.572 51Mater Today1369-70213769 6.0718.677 1.977 52Prog Nucl Mag Res Sp0079-65651993 6.022 6.065 1.389 53Crit Rev Solid State1040-8436744 5.9477.3681 54Carbon0008-622332742 5.868 6.35 1.197 55Chem-Eur J0947-653960788 5.831 5.623 1.241 56Appl Catal B-Environ0926-337323011 5.825 6.0310.965 57J Catal0021-951734516 5.787 6.249 1.025 58Wires Comput Mol Sci1759-0876570 5.738 5.738 3.518 59Lab Chip1473-019716485 5.697 6.136 1.256 60Anal Chem0003-270096794 5.695 5.7690.948 61J Med Chem0022-262359227 5.614 5.383 1.225 62Adv Synth Catal1615-415015502 5.535 5.323 1.109 63Curr Opin Solid St M1359-02862508 5.4387.3290.913 64Biosens Bioelectron0956-566322068 5.437 5.389 1.105 65J Chem Theory Comput1549-961811067 5.389 5.936 1.067 66Biomacromolecules1525-779724209 5.371 5.750.721 67Acs Catal2155-54351461 5.265 5.265 1.222 68Adv Catal0360-05641399 5.25 5.2860 69Chemcatchem1867-38802718 5.181 5.3070.941 70Mrs Bull0883-******** 5.024 5.590.569 71Acs Appl Mater Inter1944-82448635 5.008 5.040.683 72Electroanal Chem0070-977837757.50.25 73J Comb Chem1520-47662925 4.933 3.10274Int Rev Phys Chem0144-235X1524 4.92 5.595 2.231 75J Phys Chem C1932-744778595 4.814 5.1520.738 76Pharm Res-Dordr0724-874119035 4.742 5.0460.735 77Cryst Growth Des1528-748322310 4.689 4.8730.869 78Sol Energ Mat Sol C0927-024818447 4.63 5.205 1.21579J Chromatogr A0021-967363419 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Struct0964-17267120 2.024 2.3770.289 265Inorg Chem Commun1387-70036416 2.016 1.8810.434 266Appl Organomet Chem0268-26052866 2.011 1.9220.272 267Electrochem Solid St1099-00628883 2.01 2.0260.596 268J Chem Eng Data0021-956815169 2.004 2.1150.295 269Comb Chem High T Scr1386-207314532 1.9750.268 269J Organomet Chem0022-328X217932 1.9920.527 271Thermochim Acta0040-603111408 1.989 2.0460.327 272J Mol Model1610-29403157 1.984 2.3010.378 273J Therm Anal Calorim1388-61509934 1.982 1.7420.243 274Int J Fatigue0142-11235248 1.976 1.9740.352 275J Vib Control1077-54631649 1.966 1.7360.672 276Chem Phys0301-010412935 1.957 2.0590.592 277J Mater Process Tech0924-013618426 1.953 2.1760.332 277Sensors-Basel1424-82207082 1.953 2.3950.321 279Biomed Chromatogr0269-38792861 1.945 1.8150.385 280J Fluorine Chem0022-11394998 1.939 1.9490.465ArticlesCited Half-life Eigenfactor ®Metrics ScoreArticleInfluenc e® Score8699.6 1.5750820.8448329.7 1.3598717.71238018 1.55663 4.8921768.20.2266114.2941768.20.2266114.294141 5.20.2278819.481121 3.70.1543615.607390 3.50.178418.8542370.015018.643126 2.40.054018.927207 6.50.108177.90837 3.20.01489 5.62318>10.00.013647.55389.40.008828.821867 5.10.27819 4.24368.40.00872 6.542227 5.50.53637 3.497299.90.01888.1211078 4.40.37491 5.1891191 2.40.20333 4.012473 1.80.05534 3.461368.20.03818 3.07130997.70.83183 2.99465 5.90.01757 3.141169 1.40.00944 3.344569 4.20.12336 3.006377.20.00647 2.73229 1.90.00155 3.27323 3.90.00716 4.441557.70.01045 2.068458 1.40.02121 2.833576 6.70.15215 2.032167.90.00342 3.148457 3.60.07856 2.503112 4.60.01202 1.97501 6.90.05008 1.9062220.001972.739Eigenfactor®Metrics16>10.00.00328 2.792 286 2.60.0208 2.0046>10.00.00142 1.13896 2.80.01517 2.301119.20.00397 3.974>10.00.00086 1.894 44940.03848 1.5233>10.00.00076 2.537437.60.01013 2.301 63220.04884 2.393 2150.003483173 4.80.28954 1.5629>10.00.00211 3.009 138 5.80.01695 1.794 1015 1.70.02966 1.597 508.20.01226 2.37 160850.18182 1.40244 5.40.01448 3.213188.30.00431 2.295 107.10.00156 2.34 674 6.40.06437 1.6 1916 4.10.1766 1.469 480 5.40.05059 1.419 284>10.00.04014 1.60356 1.20.00194 1.703 617 3.70.05475 1.603 14797.80.17236 1.533 8907.80.09182 1.35 404 4.40.04405 1.352 239.20.00403 2.705 448 4.10.05929 1.252 507 3.50.04948 1.865 480 5.30.05919 1.416 315 1.30.00585 1.6362>10.00.00057 1.543 255 2.10.01222 1.495 116 6.20.01779 2.376 953 2.30.03563 1.2844>10.00.00016 2.2160 5.10.006940.708137.90.00319 2.303 3283 3.40.34957 1.353 2798.70.02859 1.299 773 3.90.057280.943 493 5.30.04212 1.30411447.10.090460.921 15617.50.124780.98 259 5.70.03346 1.295 372 2.80.02555 1.219 1289>10.00.12482 1.03 7277.10.06585 1.03830 5.80.00343 1.39794 6.80.01439 1.685 303 6.60.019140.892 2119 6.70.21487 1.164 9987.10.059110.76263 3.40.002370.436140.000190.962 475 5.50.03101 1.1898.60.00225 1.225 194 2.50.00680.908 817 6.60.031350.985 68170.09849 1.714 1358 2.50.073 1.334 1194 2.60.032550.749 10720.00309 1.26 1021 4.40.12987 1.194 459 3.20.02416 1.192 2618.90.03446 1.396 1804 3.70.15067 1.296 1418.60.01298 1.609 1709 4.50.08330.842 327 1.30.00320.94181 4.90.00904 1.23 327 4.70.03579 1.258 17750.0131 1.044 2597.10.02119 1.078 877 4.30.068460.99799 1.40.001410.915 449 6.30.028910.786 16157.50.18356 1.081 22860.020170.96535 1.90.00176 1.224 1160 3.80.055440.914 201 6.30.017610.949 426 4.10.025740.772 2120 3.70.074070.708 1016 5.80.054290.757 321 5.50.013530.63690 3.30.006210.726184 4.80.010070.73123>10.00.00228 1.513 610 3.80.032170.72 842 5.40.057730.829 213 5.40.01270.77439 2.40.001731002 4.80.033670.729 208 4.30.00930.537 5247.60.043570.93 116>10.00.02104 1.812 173>10.00.013330.936 589 5.30.032210.807 108 6.10.009190.931 487 4.70.03951 1.142 76450.047770.779 1666 5.20.091160.854 193 1.80.004620.921 120 2.20.004670.894 3338.70.027140.756 4327.10.027040.625 19520.003610.533 194 6.90.011710.909 2597.30.013360.716 266 6.80.026850.752 87080.070140.869 2187.70.01310.75610 5.60.00062 1.012 4189.20.026590.815 622 5.20.034970.666 1709.90.01712 1.222 178 5.80.009120.836 907.70.00320.65258>10.00.01221 1.371 4877.30.041850.896 187 5.60.009820.662 338 6.50.019280.711 443 6.30.026840.651 20850.01330.806 409 4.50.027060.735 774 3.20.034350.762 15287.90.107180.745 739 5.40.053960.715 227.60.001180.774 105 5.10.007480.647 129 4.90.00780.74475 3.50.002990.639 212 3.70.013920.784 201 5.60.009290.599 500 6.30.06138 1.238 >10.00.00042 1.049 290 6.10.019640.625 251 5.60.017330.895 12498.40.075460.68 241 2.20.005560.628 1341 6.70.120620.829 651 6.90.026690.572 224 5.10.010210.672 290 5.30.013220.702 194 1.60.002660.7278>10.00.000620.792 314>10.00.019270.649 32830.001390.381 520 6.30.034550.62153 5.20.004350.904 200 1.30.002460.856 109 3.70.00563143 5.80.013670.825 439 4.20.025470.66 441>10.00.03210.853 17290.80.002020.494 1527.40.009010.741 624 2.40.016810.714 337 6.40.02850.71 173 1.90.002010.614 124 6.30.008010.593 2207.60.010810.602 4708.20.028730.596 221 5.20.00853 1.29 4957.50.036490.714 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Calcipotriol_SDS_MedChemExpress
Inhibitors, Agonists, Screening LibrariesSafety Data Sheet Revision Date:Sep.-13-2017Print Date:Sep.-13-20171. PRODUCT AND COMPANY IDENTIFICATION1.1 Product identifierProduct name :CalcipotriolCatalog No. :HY-10001CAS No. :112965-21-61.2 Relevant identified uses of the substance or mixture and uses advised againstIdentified uses :Laboratory chemicals, manufacture of substances.1.3 Details of the supplier of the safety data sheetCompany:MedChemExpress USATel:609-228-6898Fax:609-228-5909E-mail:sales@1.4 Emergency telephone numberEmergency Phone #:609-228-68982. HAZARDS IDENTIFICATION2.1 Classification of the substance or mixtureNot a hazardous substance or mixture.2.2 GHS Label elements, including precautionary statementsNot a hazardous substance or mixture.2.3 Other hazardsNone.3. COMPOSITION/INFORMATION ON INGREDIENTS3.1 SubstancesSynonyms:MC 903; CalcipotrieneFormula:C27H40O3Molecular Weight:412.60CAS No. :112965-21-64. FIRST AID MEASURES4.1 Description of first aid measuresEye contactRemove any contact lenses, locate eye-wash station, and flush eyes immediately with large amounts of water. Separate eyelids with fingers to ensure adequate flushing. Promptly call a physician.Skin contactRinse skin thoroughly with large amounts of water. Remove contaminated clothing and shoes and call a physician.InhalationImmediately relocate self or casualty to fresh air. If breathing is difficult, give cardiopulmonary resuscitation (CPR). Avoid mouth-to-mouth resuscitation.IngestionWash out mouth with water; Do NOT induce vomiting; call a physician.4.2 Most important symptoms and effects, both acute and delayedThe most important known symptoms and effects are described in the labelling (see section 2.2).4.3 Indication of any immediate medical attention and special treatment neededTreat symptomatically.5. FIRE FIGHTING MEASURES5.1 Extinguishing mediaSuitable extinguishing mediaUse water spray, dry chemical, foam, and carbon dioxide fire extinguisher.5.2 Special hazards arising from the substance or mixtureDuring combustion, may emit irritant fumes.5.3 Advice for firefightersWear self-contained breathing apparatus and protective clothing.6. ACCIDENTAL RELEASE MEASURES6.1 Personal precautions, protective equipment and emergency proceduresUse full personal protective equipment. Avoid breathing vapors, mist, dust or gas. Ensure adequate ventilation. Evacuate personnel to safe areas.Refer to protective measures listed in sections 8.6.2 Environmental precautionsTry to prevent further leakage or spillage. Keep the product away from drains or water courses.6.3 Methods and materials for containment and cleaning upAbsorb solutions with finely-powdered liquid-binding material (diatomite, universal binders); Decontaminate surfaces and equipment by scrubbing with alcohol; Dispose of contaminated material according to Section 13.7. HANDLING AND STORAGE7.1 Precautions for safe handlingAvoid inhalation, contact with eyes and skin. Avoid dust and aerosol formation. Use only in areas with appropriate exhaust ventilation.7.2 Conditions for safe storage, including any incompatibilitiesKeep container tightly sealed in cool, well-ventilated area. Keep away from direct sunlight and sources of ignition.Recommended storage temperature: 4°C, protect from light, stored under nitrogenShipping at room temperature if less than 2 weeks.7.3 Specific end use(s)No data available.8. EXPOSURE CONTROLS/PERSONAL PROTECTION8.1 Control parametersComponents with workplace control parametersThis product contains no substances with occupational exposure limit values.8.2 Exposure controlsEngineering controlsEnsure adequate ventilation. Provide accessible safety shower and eye wash station.Personal protective equipmentEye protection Safety goggles with side-shields.Hand protection Protective gloves.Skin and body protection Impervious clothing.Respiratory protection Suitable respirator.Environmental exposure controls Keep the product away from drains, water courses or the soil. Cleanspillages in a safe way as soon as possible.9. PHYSICAL AND CHEMICAL PROPERTIES9.1 Information on basic physical and chemical propertiesAppearance White to off-white (Solid)Odor No data availableOdor threshold No data availablepH No data availableMelting/freezing point No data availableBoiling point/range No data availableFlash point No data availableEvaporation rate No data availableFlammability (solid, gas)No data availableUpper/lower flammability or explosive limits No data availableVapor pressure No data availableVapor density No data availableRelative density No data availableWater Solubility No data availablePartition coefficient No data availableAuto-ignition temperature No data availableDecomposition temperature No data availableViscosity No data availableExplosive properties No data availableOxidizing properties No data available9.2 Other safety informationNo data available.10. STABILITY AND REACTIVITY10.1 ReactivityNo data available.10.2 Chemical stabilityStable under recommended storage conditions.10.3 Possibility of hazardous reactionsNo data available.10.4 Conditions to avoidNo data available.10.5 Incompatible materialsStrong acids/alkalis, strong oxidising/reducing agents.10.6 Hazardous decomposition productsUnder fire conditions, may decompose and emit toxic fumes.Other decomposition products - no data available.11.TOXICOLOGICAL INFORMATION11.1 Information on toxicological effectsAcute toxicityClassified based on available data. For more details, see section 2Skin corrosion/irritationClassified based on available data. For more details, see section 2Serious eye damage/irritationClassified based on available data. For more details, see section 2Respiratory or skin sensitizationClassified based on available data. For more details, see section 2Germ cell mutagenicityClassified based on available data. For more details, see section 2CarcinogenicityIARC: No component of this product present at a level equal to or greater than 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.ACGIH: No component of this product present at a level equal to or greater than 0.1% is identified as a potential or confirmed carcinogen by ACGIH.NTP: No component of this product present at a level equal to or greater than 0.1% is identified as a anticipated or confirmed carcinogen by NTP.OSHA: No component of this product present at a level equal to or greater than 0.1% is identified as a potential or confirmed carcinogen by OSHA.Reproductive toxicityClassified based on available data. For more details, see section 2Specific target organ toxicity - single exposureClassified based on available data. For more details, see section 2Specific target organ toxicity - repeated exposureClassified based on available data. For more details, see section 2Aspiration hazardClassified based on available data. For more details, see section 212. ECOLOGICAL INFORMATION12.1 ToxicityNo data available.12.2 Persistence and degradabilityNo data available.12.3 Bioaccumlative potentialNo data available.12.4 Mobility in soilNo data available.12.5 Results of PBT and vPvB assessmentPBT/vPvB assessment unavailable as chemical safety assessment not required or not conducted.12.6 Other adverse effectsNo data available.13. DISPOSAL CONSIDERATIONS13.1 Waste treatment methodsProductDispose substance in accordance with prevailing country, federal, state and local regulations.Contaminated packagingConduct recycling or disposal in accordance with prevailing country, federal, state and local regulations.14. TRANSPORT INFORMATIONDOT (US)This substance is considered to be non-hazardous for transport.IMDGThis substance is considered to be non-hazardous for transport.IATAThis substance is considered to be non-hazardous for transport.15. REGULATORY INFORMATIONSARA 302 Components:No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302.SARA 313 Components:This material does not contain any chemical components with known CAS numbers that exceed the threshold (De Minimis) reporting levels established by SARA Title III, Section 313.SARA 311/312 Hazards:No SARA Hazards.Massachusetts Right To Know Components:No components are subject to the Massachusetts Right to Know Act.Pennsylvania Right To Know Components:No components are subject to the Pennsylvania Right to Know Act.New Jersey Right To Know Components:No components are subject to the New Jersey Right to Know Act.California Prop. 65 Components:This product does not contain any chemicals known to State of California to cause cancer, birth defects, or anyother reproductive harm.16. OTHER INFORMATIONCopyright 2017 MedChemExpress. The above information is correct to the best of our present knowledge but does not purport to be all inclusive and should be used only as a guide. The product is for research use only and for experienced personnel. It must only be handled by suitably qualified experienced scientists in appropriately equipped and authorized facilities. The burden of safe use of this material rests entirely with the user. MedChemExpress disclaims all liability for any damage resulting from handling or from contact with this product.Caution: Product has not been fully validated for medical applications. For research use only.Tel: 609-228-6898 Fax: 609-228-5909 E-mail: tech@Address: 1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USA。
高效液相色谱法测定硫酸氢氯吡格雷片有关物质
高效液相色谱法测定硫酸氢氯吡格雷片有关物质作者：李飞张黎娟孟祥松等来源：《中国医药导报》2012年第08期硫酸氢氯吡格雷是一种新型血小板聚集抑制剂，临床上用于治疗中风、心肌梗死、外周动脉疾病等[1]，市场需求量较大，但国内对其制剂有关物质检测报道较少，为了更有效地控制本品质量，本文参照美国药典[2]建立测定硫酸氢氯吡格雷片有关物质的HPLC法，方法专属、灵敏、可靠，有效地控制了本品的质量。
1 仪器与试药1.1 仪器岛津高效液相色谱仪，紫外检测器（型号：SPD-20AD），泵（型号：LC-20AD），色谱工作站（LC Solution色谱工作站），电子天平（METTLER TOLOD XS105电子天平），紫外-可见分光光度仪（型号：Agilent 8453）。
1.2 试药硫酸氢氯吡格雷片（合肥医工医药有限公司，规格：75 mg/片，批号：20081226），波立维（法国赛诺菲，规格：75 mg/片，批号：2613），泰嘉（深圳信立泰，规格25 mg/片，批号：20090312），硫酸氢氯吡格雷对照品（中国药品生物制品检定所，批号：100819-200601），氯吡格雷杂质A对照品（USP，批号：G0H250），氯吡格雷杂质B对照品（USP，批号：G1H047），氯吡格雷杂质C对照品（USP，批号：F2H215），起始原料、中间体及空白辅料（合肥医工医药有限公司提供）。
1.3 试剂乙腈（色谱纯），磷酸二氢钾（国药集团化学试剂有限公司），甲醇（分析纯），水（纯化水）。
2 方法与结果2.1 色谱条件色谱柱为ULTRON ES-OVM（4.6 mm×150.0 mm，5 μm），流动相为0.01 mol/L磷酸二氢钾溶液-乙腈（75∶25），流速为1.0 mL/min，检测波长为220 nm，柱温为25℃，进样量为20 μL。
2.2 溶液的配制2.2.1 供试品溶液配制本品细粉适量（约相当于硫酸氢氯吡格雷25 mg），精密称定，置100 mL量瓶中，加甲醇适量使溶解，再加流动相稀释至刻度，摇匀，滤过，作为供试品溶液。
非洛地平纳米脂质载体在大鼠体内的药动学与药效学研究
非洛地平纳米脂质载体在大鼠体内的药动学与药效学研究曹桑博;王敏;谢鹏【期刊名称】《西北药学杂志》【年(卷),期】2022(37)4【摘要】目的研究非洛地平(FLD)纳米脂质载体(FLD-NLCs)在大鼠体内的药动学特征以及对高血压模型大鼠的血压控制效果。
方法以山嵛酸甘油酯(Compritol 888 ATO)作为固体脂质,聚乙二醇-15羟基硬脂酸酯(Solutol HS 15)作为液体脂质,泊洛沙姆188(Poloxamer 188)作为表面活性剂,使用高压均质技术制备FLD-NLCs,并对FLD-NLCs的理化性质进行评价,考察FLD-NLCs在不同pH介质溶液中的稀释稳定性以及体外释药特性;研究FLD原料药和FLD-NLCs的细胞跨膜转运性质;比较FLD混悬剂和FLD-NLCs经大鼠口服给药后的体内药动学及药效学。
结果FLD-NLCs的平均粒径为(126.8±3.3)nm,多聚分散系数(PDI)为(0.184±0.005),Zeta电位为(-26.3±0.6)mV,在透射电镜下可观察到FLD-NLCs呈球形,均匀分散;FLD-NLCs经不同pH介质溶液稀释后稳定性良好,在不同pH介质溶液中均表现为双相释药特征,且药物释放速率无明显差异;FLD-NLCs能有效提高药物的跨膜转运能力;与FLD混悬剂相比,大鼠口服给予FLD-NLCs后显著提高了药物生物利用度,可长时间有效控制血压。
结论FLD-NLCs能显著提高药物的生物利用度,有效控制血压,对非洛地平的临床应用具有重要价值。
【总页数】5页(P93-97)【作者】曹桑博;王敏;谢鹏【作者单位】唐山市协和医院药剂科;唐山职业技术学院【正文语种】中文【中图分类】R94【相关文献】1.UPLC-MS/MS法考察多西他赛纳米脂质载体的大鼠体内药代动力学研究2.鱼藤酮纳米脂质载体及其修饰物在大鼠体内的分布3.莪术油纳米脂质载体在大鼠体内的药动学研究4.马钱子碱及其纳米结构脂质载体在大鼠体内的药动学比较研究因版权原因，仅展示原文概要，查看原文内容请购买。
乙酰胆碱酯酶抑制剂
上海应用技术学院研究生课程《高等天然产物化学》试卷2014 / 2015 学年第1 学期课程代码：NX0702013论文题目：乙酰胆碱酯酶抑制剂的研究进展姓名：芮银146061414康满满146061409专业：制药工程学院：化工学院乙酰胆碱酯酶抑制剂的研究进展芮银，陈祎桐，康满满摘要：本文阐述了乙酰胆碱酯酶抑制剂(AChEI)的研究进展，介绍了用于药物治疗的乙酰胆碱酯酶抑制剂的各种来源如植物、微生物等，及其抑制乙酰胆碱的活性物质。
在此基础上，总结了几种现代分析技术，对AChEIs进行筛选，大大加快AD药物资源的开发利用进程。
这些方法主要有基于比色法的Ellman's法及相关的改进方法、薄层显色法、荧光显色法、电喷雾质谱法等。
但是，到目前为止，现代分析技术在AD药物资源中的应用还处在起步阶段。
关键词：乙酰胆碱酯酶抑制剂，筛选方法，薄层显色法，荧光显色法The progress of acetylcholinesteraseinhibitorsRui Yin, Chen Yitong, Kang ManmanAbstract：In this artical, the research elaborates progress of acetylcholinesterase inhibitors (AChEI), and introduces a variety of sources for drug treatment acetylcholinesterase inhibitors such as plants, microorganisms, and its active ingredients. On this basis, the review summarizes several modern analytic techniques such as Ellman's method which based on the colorimetric method, TLC chromogenic method, fluorescent color method, Electrospray ionization mass spectrometry and so on. However, at present, the application of modern analytic techniques in AD drug resources is still in infancy.Key word: Acetylcholinesterase inhibitors, Screening Methods, TLC chromogenic method, Fluorescent color method目录摘要.................................................................................................错误!未定义书签。
15523666_迷迭香酸对哮喘小鼠氧化性肺损伤的保护作用
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一种同时测定血浆中脂蛋白磷脂酶A2与C反应蛋白含量的检测方法及试
专利名称：一种同时测定血浆中脂蛋白磷脂酶A2与C反应蛋白含量的检测方法及试剂盒
专利类型：发明专利
发明人：杨子学
申请号：CN201410605080.3
申请日：20141031
公开号：CN104280556A
公开日：
20150114
专利内容由知识产权出版社提供
摘要：本发明公开了一种同时测定血浆中脂蛋白磷脂酶A2与C反应蛋白含量的检测方法及试剂盒，可用于缺血性脑卒中发生后评价神经功能损伤程度和梗死体积的双指标联合检测。
该试剂盒是以血浆脂蛋白磷脂酶A2(Lp-PLA2)与C反应蛋白(CRP)为检测指标，基于多孔板的双抗体夹心法，标记物为荧光物质，例如荧光染料、镧系元素或者量子点，可以实现双指标的同时分析。
申请人：杨子学
地址：210018 江苏省南京市玄武区长江后街6号东大科技园5-107
国籍：CN
代理机构：北京天平专利商标代理有限公司
代理人：缪友菊
更多信息请下载全文后查看。
靶向CD133载sPD1微泡的制备方法及在制备抑制宫颈癌的药物上的应用[
专利名称：靶向CD133载sPD1微泡的制备方法及在制备抑制宫颈癌的药物上的应用
专利类型：发明专利
发明人：赵云,刘朝奇,郑智唯
申请号：CN201910636105.9
申请日：20190715
公开号：CN110339371A
公开日：
20191018
专利内容由知识产权出版社提供
摘要：本发明涉及一种超声联合靶向CD133载sPD1微泡的制备方法，具体是将生物素化脂质微泡滴加PE标记链酶亲和素孵育，加入再加入生物素化的CD133抗体，经孵育后离心得到靶向CD133微泡。
将所得的靶向CD133微泡和sPD1质粒室温下孵育后，再用PBS冲洗，离心，即可得到靶向
CD133载sPD1脂质微泡。
本发明将靶向CD133载sPD1脂质微泡应用于制备抑制宫颈癌移植瘤的药物上，结果表明靶向CD133载sPD1脂质微泡具体更高的抑瘤效果，靶向CD133载sPD1脂质微泡的体积抑制率和体重抑制率分别为78.01％和72.25％。
申请人：三峡大学
地址：443002 湖北省宜昌市西陵区大学路8号
国籍：CN
代理机构：宜昌市三峡专利事务所
代理人：成钢
更多信息请下载全文后查看。
新型抗PD-1抗体[发明专利]
![新型抗PD-1抗体[发明专利]](https://img.taocdn.com/s3/m/1bb640d60912a216157929bf.png)
专利名称：新型抗PD-1抗体专利类型：发明专利
发明人：陈蕴颖,李竞
申请号：CN201980020380.6申请日：20190318
公开号：CN112236454A
公开日：
20210115
专利内容由知识产权出版社提供
摘要：提供了与细胞表面PD‑1特异性结合的新型抗PD‑1抗体。
还提供了编码抗PD‑1抗体的核酸分子，用于表达抗PD‑1抗体的表达载体和宿主细胞。
本发明进一步提供了产生抗PD‑1抗体的方法及其用途。
申请人：上海药明生物技术有限公司
地址：200131 上海市浦东新区富特中路299号
国籍：CN
代理机构：中国贸促会专利商标事务所有限公司
代理人：李程达
更多信息请下载全文后查看。
高效液相色谱法测定复方亚油酸乙酯胶丸中橙皮苷的含量
高效液相色谱法测定复方亚油酸乙酯胶丸中橙皮苷的含量曹桂侠;汪秀月;焦坤
【期刊名称】《海峡药学》
【年(卷),期】2013(025)006
【摘要】目的建立复方亚油酸乙酯胶丸中橙皮苷的含量测定方法.方法液相色谱法.色谱柱:Kromasil C18柱(4.6mm×250mm,5μm)；流动相:甲醇-0.5％冰醋酸溶液(40:60)；流速1.0mL·min-1；柱温:40℃；检测波长:283nm.结果橙皮苷在0.07505～0.3752μg范围内呈线性关系(r =0.9997,n=5),平均加样回收率为99.16％,RSD为1.7％(n=6).结论该方法操作简便,结果可靠,可用于复方亚油酸乙酯胶丸中橙皮苷的含量测定.
【总页数】2页(P34-35)
【作者】曹桂侠;汪秀月;焦坤
【作者单位】安徽省阜阳市第四人民医院阜阳236000;安徽省阜阳市食品药品检验所阜阳236015;安徽省阜阳市食品药品检验所阜阳236015
【正文语种】中文
【中图分类】R927.2
【相关文献】
1.HPLC法测定复方三维亚油酸胶丸Ⅰ中维生素C、B6的含量 [J], 刘艳丽
2.高效液相色谱法测定复方三维亚油酸胶丸Ⅰ中维生素E含量 [J], 刘艳丽
3.高效液相色谱法同时测定复方亚油酸乙酯胶丸中维生素C和烟酸含量 [J], 沈黎;
刘玉春
4.高效液相色谱法测定复方止咳胶丸中茶碱和愈创术甘油醚的含量 [J], 刘珍;朱炳辉
5.毛细管电泳法测定复方三维亚油酸胶丸I中甲基橙皮苷的含量 [J], 杨轲;孙晓东;唐蕾;薛雅云;汪睿捷;季一兵
因版权原因，仅展示原文概要，查看原文内容请购买。