PREPARATION AND APPLICATION OF BIODEGRADABLE-MATER
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专利名称：PREPARATION AND APPLICATION OF
BIODEGRADABLE-MATERIAL-MADE
MICROSPHERE VASCULAR EMBOLUS
CONTAINING LIPOSOME-ENCAPSULATED
CYTOKINES
发明人：Li Xiaoping,Cui Heng,Wei Lihui,Feng Jie,Hong Hong,Li Xinjian,Qi Xianrong
申请号：US11955490
申请日：20071213
公开号：US20090155344A1
公开日：
20090618
专利内容由知识产权出版社提供
摘要：The present invention discloses preparation and application of a kind of biodegradable-material-made microsphere vascular embolus that contains liposome-encapsulated cytokines. The present invention is technologically characterized by encapsulation of liposome-wrapped immunocytokines such as IL-2, TNF and interferon by sodium polysaccharide or gelatin, which is extracted from natural alga and is good at biodegradability and biocompatibility. Owing to the encapsulation procedures, cytokine microspheres can take shape measuring 50-75 μm, 75-150 μm, 100-200 μm, 200-300 μm, 200-450 μm, 100-300 μm, 300-500 μm, 500-700 μm, and 700-900 μm. The microsphere preparations are good targeting medication for embolism treatment and immunochemotherapy of animals loaded with human hepatocarcinoma and cervical cancer, as well as human suffering from late-stage or recurrent liver cancer, renal tumors, bladder cancer, colon carcinoma and rectal cancer.
申请人：Li Xiaoping,Cui Heng,Wei Lihui,Feng Jie,Hong Hong,Li Xinjian,Qi Xianrong 地址：Beijing CN,Beijing CN,Beijing CN,Beijing CN,Beijing CN,Beijing CN,Beijing CN 国籍：CN,CN,CN,CN,CN,CN,CN
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