抗磷脂综合征诊断标准

抗最新标准

标准

1.血管栓塞:至少有一次经影像学、超声多普勒或组织学证实的任何脏器或器官的动脉、静脉或小血管血栓形成发作

2.怀孕异常

(1)至少1次不能解释的孕10周或10周以上的胎儿死亡，或

(2)至少1次因先兆子痫、子痫或严重胎盘功能不全导致孕34周或34周以上的早产（新生儿形态正常），或

(3)3次或3次以上的孕10周前自发流产

实验室标准

1.抗心磷脂抗体：2次中高滴度的IgG或/和IgM型抗体阳性（间隔至少12周）

2.狼疮抗凝物：2次阳性（间隔至少12周）

3.抗β2GPI抗体：2次高滴度IgM或IgG型抗体阳性（间隔至少12周）

至少1条临床标准和至少1条实验室标准即可确诊

附原文：

Diagnostic Criteria for APS

Clinical criteria

1．Vascular thrombosis：At least one episode of arterial, venous, or small-vessel

thrombosis in any tissue or organ confirmed by imaging, Doppler ultrasound, or histopathology

2．Pregnancy morbidity

(1)At least one unexplained fetal death at or beyond 10 wk, or

(2)At least one premature birth of morphologically normal neonate at or beyond 34 wk due to preeclampsia, eclampsia, or severe placental insufficiency, or (3)Three or more spontaneous pregnancy losses before 10 wk of gestation

Laboratory criteria

antibodies: medium- or high-titer IgG and/or IgM on two occasions at least 12 wk apart

anticoagulant: on two occasions at least 12 wk apart

of anti-β2GPI antibodies: high-titer IgM or IgG on two occasions at least 12 wk apart

* Definite APS is confirmed when at least one clinical criterion and at least one laboratory criterion are present.

摘自：Lockshin MS, Atsumi T, et al. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome. J Thromb Haemost,2006, 4:295-306.