超声乳化白内障吸除术后角膜内皮细胞损伤和修复的研究_谢立信

#论著#

作者单位:266071青岛,山东省眼科研究所通讯作者:谢立信,Email:lixinxie@public 1qd 1sd 1cn

超声乳化白内障吸除术后角膜内皮细胞损伤和修复的研究

谢立信 姚瞻 黄钰森 应良

=摘要> 目的 探讨超声乳化白内障吸除术后角膜内皮细胞损伤和修复的特点及角膜水肿的临床分级标准。方法 对105例(105只眼)老年性白内障患者行超声乳化白内障吸除术,术后使用裂隙灯显微镜观察角膜水肿程度,并记录水肿消退时间;术前和术后3个月分别使用接触型角膜内皮显微镜观察角膜上、中、下部内皮细胞的密度变化。结果 角膜水肿程度为0~4级者的角膜内皮细胞丢失率分别为416%、1419%、4018%、6710%及8414%;1~3级者角膜水肿的消退时间分别为(211?017)、(516?119)、(2118?711)d 。术后3个月角膜上、中、下部内皮细胞平均密度分别为(2006?546)、(1979?545)、(1754?543)个/mm 2;上部与下部、中部与下部比较,差异均有显著意义(P =01025,01030);上部与中部比较,差异无显著意义(P =01921)。角膜上、中、下部内皮细胞密度的平均下降值分别为(627?496)、(656?492)、(1026?509)个/mm 2;上部与下部、中部与下部比较,差异均有显著意义(P =01017,01027);上部与中部比较,差异无显著意义(P =01867)。结论 将超声乳化白内障吸除术后角膜水肿程度分为0~4级,可明确表示角膜内皮细胞的损伤程度,为临床评估预后提供重要参考。超声乳化白内障吸除术后角膜内皮细胞的损伤部位以角膜下部为主,且术后3个月角膜内皮细胞密度无法恢复至正常水平。(中华眼科杂志,2004,40:90-93)

=关键词> 超声乳化白内障吸除术; 白内障; 内皮,角膜; 角膜水肿

C orneal endothelial damage and its repair after phacoemulsif ication XI E L i -x in ,YA O Zhan,H UA N G Yu -sen,YIN G L iang.Shandong Eye I nstitute &H osp ital ,Qingdao 266071,China Cor r esponding author :XI E L i -x in ,Email:lix inx ie @p

=Abstract > Objective T o introduce a grading system for corneal edema after phacoemulsificat ion and to study the cor neal endothelial damage and its repair after phaco emulsification.Methods One hun -dred and five senile cataracts after phacoemulsificat ion were included.Corneal edema was categorized into g rades 0to 4.Endot helial densit ies at var ious locations of the cornea w er e measur ed with specular m-i

croscopy before and three months after sur gery.Results T he corneal endothelial cell loss rate w as 416%,14.9%,40.8%,67.0%and 84.4%in eyes w ith corneal edema from grades 0to 4,r espectively.T ime r equired for resolution of corneal edema was (2.1?0.7)days (gr ade 1),(5.6? 1.9)days (g rade 2)and (21.8?7.1)days (g rade 3).T he endothelial cell densities at super ior,mid and inferior port ions of the cornea were (2006?546)cells/mm 2,(1979?545)cells/mm 2and (1754?543)cells/mm 2respectively at 3mo nths after phacoemulsification.Posto perative endothelial cell loss at superio r,mid and infer ior por -tions of the cor nea w as (627?496)cells/mm 2,(656?492)cells/mm 2and (1026?509)cells/mm 2re -spectively.T he differ ence in postoperative endothelial cell densit ies between the super ior and inferior por -tions of t he cornea was statistically significant (P =0.017),so was the difference between mid and inferior portions of the corneas (P =0.027).T here w as no statistically significant difference between t he superior and mid portions of the cornea (P =0.867).C onclusion T he gr ading system fo r corneal edema is helpful in evaluating the severity of endothelial damag e after phacoemulsificat ion and can be used to predict the out -come of the cornea.T he major ar ea of endothelial injury after phacoemulsification occurs at the inferior por -tion of the cornea.(Chin J Op hthalmol ,2004,40:90-93)

=Key words > Phacoemulsification; Cataract; Endothelium,Corneal; Corneal edema

角膜内皮细胞损伤性水肿是超声乳化白内障吸

除术后的常见并发症之一[1,2]。虽然部分手术顺利的患者术后角膜无明显水肿反应,但角膜内皮细胞的损伤在所难免。当内皮细胞损伤达到一定程度时,角膜内皮功能将失代偿,导致发生大泡性角膜病