第17章 细胞应激 厦门大学分子生物学课程
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hypothalmus-pituitary-adrenal axis (HPA) excitatory下 丘脑-垂体-肾上腺皮质系统反应
Other hormonal responses to stress其他激素系统反应
Zona glomerulosa Zona fasciculata
球状带
束状带
■ Distress: if the stress response is excessive or prolonged, it may eventually result in diseases, such as ulcers, et al.
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Stress
Classification of stress response
Physical, chemical
Stress response
Physical stress
Psychological stress
PsyΒιβλιοθήκη Baiduhological or socio-cultural
Significance of stress
Catecholamine (CA) 儿茶酚胺secretion↑ hypothalmus-pituitary-adrenal axis (HPA) excitatory
Glucocorticoid (GC)糖皮质激素 secretion↑ Other hormonal responses to stress
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Stress
Stress
Stress is defined as a state of tension that can lead to disharmony or threaten the homeostasis of body.
Homeostasis, Acid-base disturbances, shock, cancer. 内环境紊乱，休克，癌症
Psychological or socio-cultural
Threat to self esteem, relationships with other people. 心理创伤，人际关系
■ rapid response system while stress occurs the key to start the HPA stress axis
Effects of peripheral 外周系统效应
■ CA (include Ad、NE、Dopamine) concentration increase
■ Eustress: Normal stress is necessary for an active, healthy life, increase mental and physical alertness and can enhance certain abilities. (Fight or flight).
not directly related to the
nature of stimulus
Increased heart rate Redistributio n of blood
fear
anxiety
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Stressor
Stress Stressor
The same stimuli， The stimuli or agents that induce stress are termed
Nervous System
Endocrine System
Neuroendocrine responses
[Neuroendocrine responses to stress]
Stress
Locus coeruleus (LC) 蓝斑核- norepinephrine neurons(NE)去甲肾上腺素神经元-sympathetic/adrenal medulla axis （LC-NE）excitatory交感-肾上腺髓质系统 反应
骨 髓 胸 腺
脾 脏
免 疫 细 胞
淋 巴 结
巨噬细胞
Locus coeruleus - Norepinephrine （LC-NE E）ffects of CNS 中枢系统效应
■ induce excitement, alertness, anxiety and other emotional reactions
stressor.
the same response？
External environment（Physical, chemical, biological）
Cold, heat, toxins, drugs, bacteria. 冷热，毒品，药物，细菌
Intrinsic factor of body
Stress
stress response and pathogenesis
stressor
neuroendocrine
response 神经内分泌应答
Cellular stress
Effects of stress on the body
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neuroendocrine response
Burn 烧伤 Operation 手术 Infection 感染 Hypoxia 缺氧 Injury 受伤 Noise 噪音
stimulate
Necrosis
Specific response
fester
acidosis
nonspecific and common response
Stress response
Adrenal cortex 肾上腺皮质
Zona reticularis
网状带
adrenal
Medulla
肾上腺髓质
Neuroendocrine responses
[Neuroendocrine responses to stress]
Stress
Locus coeruleus (LC) - norepinephrine neurons(NE)sympathetic/adrenal medulla axis （LC-NE）excitatory
Other hormonal responses to stress其他激素系统反应
Zona glomerulosa Zona fasciculata
球状带
束状带
■ Distress: if the stress response is excessive or prolonged, it may eventually result in diseases, such as ulcers, et al.
返回主页 返回目录
返回主页 返回目录
返回主页 返回目录
Stress
Classification of stress response
Physical, chemical
Stress response
Physical stress
Psychological stress
PsyΒιβλιοθήκη Baiduhological or socio-cultural
Significance of stress
Catecholamine (CA) 儿茶酚胺secretion↑ hypothalmus-pituitary-adrenal axis (HPA) excitatory
Glucocorticoid (GC)糖皮质激素 secretion↑ Other hormonal responses to stress
返回主页 返回目录 上一页
返回主页 返回目录
返回主页 返回目录
Stress
Stress
Stress is defined as a state of tension that can lead to disharmony or threaten the homeostasis of body.
Homeostasis, Acid-base disturbances, shock, cancer. 内环境紊乱，休克，癌症
Psychological or socio-cultural
Threat to self esteem, relationships with other people. 心理创伤，人际关系
■ rapid response system while stress occurs the key to start the HPA stress axis
Effects of peripheral 外周系统效应
■ CA (include Ad、NE、Dopamine) concentration increase
■ Eustress: Normal stress is necessary for an active, healthy life, increase mental and physical alertness and can enhance certain abilities. (Fight or flight).
not directly related to the
nature of stimulus
Increased heart rate Redistributio n of blood
fear
anxiety
返回主页 返回目录
Stressor
Stress Stressor
The same stimuli， The stimuli or agents that induce stress are termed
Nervous System
Endocrine System
Neuroendocrine responses
[Neuroendocrine responses to stress]
Stress
Locus coeruleus (LC) 蓝斑核- norepinephrine neurons(NE)去甲肾上腺素神经元-sympathetic/adrenal medulla axis （LC-NE）excitatory交感-肾上腺髓质系统 反应
骨 髓 胸 腺
脾 脏
免 疫 细 胞
淋 巴 结
巨噬细胞
Locus coeruleus - Norepinephrine （LC-NE E）ffects of CNS 中枢系统效应
■ induce excitement, alertness, anxiety and other emotional reactions
stressor.
the same response？
External environment（Physical, chemical, biological）
Cold, heat, toxins, drugs, bacteria. 冷热，毒品，药物，细菌
Intrinsic factor of body
Stress
stress response and pathogenesis
stressor
neuroendocrine
response 神经内分泌应答
Cellular stress
Effects of stress on the body
返回主页 返回目录
neuroendocrine response
Burn 烧伤 Operation 手术 Infection 感染 Hypoxia 缺氧 Injury 受伤 Noise 噪音
stimulate
Necrosis
Specific response
fester
acidosis
nonspecific and common response
Stress response
Adrenal cortex 肾上腺皮质
Zona reticularis
网状带
adrenal
Medulla
肾上腺髓质
Neuroendocrine responses
[Neuroendocrine responses to stress]
Stress
Locus coeruleus (LC) - norepinephrine neurons(NE)sympathetic/adrenal medulla axis （LC-NE）excitatory