原发性乳腺淋巴瘤

Mammographic and sonographic findings of primary breast lymphoma

Chae Yeon Lyou,Sang Kyu Yang 4,Du Hwan Choe,Byung Hee Lee,Kie Hwan Kim

Department of Radiology,Korea Cancer Center Hospital,Seoul,Korea

Received 5December 2006;accepted 15February 2007

Abstract

The objective of this study was to describe the mammographic and sonographic appearances of primary lymphoma of the breast.We retrospectively reviewed the mammographic and ultrasonographic images of 12patients with primary lymphoma of the breast.Descriptions of imaging findings were made according to the Breast Imaging Reporting and Data System lexicon by two radiologists.Mammography was performed on 11patients.Most of the lesions were shown to be oval-shaped (72.7%)and high-density (90.9%)masses on mammography.Ultrasound examination was performed on 8patients.The lymphomas were commonly single (75%),circumscribed (50%)or microlobulated (37.5%),and oval (50%)masses on sonography.The echo pattern of the mass was hypoechoic in 7patients (87.5%)but hyperechoic in 1patient (12.5%).No mass had spiculated margins or calcifications.Ipsilateral axillary lymph node involvement was noted in 1patient.In conclusion,most primary lymphomas of the breast present as oval-shaped and high-density masses on mammography and as single and hypoechoic masses with circumscribed or microlobulated margins on sonography.D 2007Elsevier Inc.All rights reserved.

Keywords:Breast;Lymphoma;Ultrasound;Mammography

1.Introduction

The breast is an uncommon site of development for malignant lymphomas despite the relative frequency of primary extranodal non-Hodgkin lymphomas.Breast lym-phomas can be either primary or secondary.Secondary breast lymphomas more commonly occur in association with extramammary non-Hodgkin lymphomas.Primary breast lymphomas are less common,accounting for only 0.05%–0.53%of all breast malignancies [1].

There are few articles about the imaging findings of primary breast lymphoma in the radiology literature [2–7].Data on the sonographic appearance of primary breast lymphomas are even more limited than those on its mammographic appearance.We reviewed 12cases of primary lymphoma of the breast to determine the mammo-graphic and sonographic characteristics of this rare disease

with the American College of Radiology Breast Imaging Reporting and Data System (BI-RADS)lexicon [8].2.Materials and methods

A retrospective review of medical records at our institution that date between January 1993and October 2006revealed 12patients with primary breast lymphoma.All cases were diagnosed based on pathological demonstration after surgical biopsy or ultrasound (US)-guided core needle biopsy and satisfied the specific diagnostic criteria described by Wise-man and Liao [9]for primary lymphoma of the breast,including histological evidence of a close association between the mammary tissue and the lymphomatous infiltrate as well as absence of disseminated lymphoma or preceding extramammary lymphoma at the time of diagnosis.Presence of homolateral axillary node involvement is acceptable provided that both lesions developed simultaneously.

The patients’ages at the time of the diagnosis as well as their physical findings and clinical status were abstracted from the medical records.We reviewed the pathological

0899-7071/07/$–see front matter D 2007Elsevier Inc.All rights reserved.doi:10.1016/j.clinimag.2007.02.028

4Corresponding author.Department of Radiology,Korea Cancer Center Hospital,215-4Gongneung-Dong,Nowon-Gu,Seoul 139-706,Korea.Tel.:+8229701576;fax:+8229702433.

E-mail address:twoscan@ (S.K.Yang).Clinical Imaging 31(2007)234

–238