上海交大外科学外科学与免疫学

B Cell
Secondary lymphoid organs and tissues
Spleen
lymph nodes and lymphatic system
Mucosa-associated lymphoid tissue (MALT)
Cells of the Innate Immune System
●TCR ● complement ● cytokines ● adhesion molecules ● MHC
TCR
上海交大外科学外科学与免疫学
The αβ TCR heterodimer forms the recognition unit of the receptor
CD3 complex associates with the αβand γδforms of the TCR
天然免疫
上海交大外科学外科学与免疫学
Innate immunity
● 机体与生具有的抵抗
Body defenses come from birth Against all kinds of pathogens,
外来病原的防御系统
百度文库
Not specific
无特异性, 包括
Including barriers Basic barrier: skin, mucosa Physical barrier: body temp, ph Phagocytes Inflammation
MHC
MHC I molecules consist of an MHC-encoded heavy chain bound to β2-microglobalin
β2-M is essential for上海e交x大p外r科e学s外s科i学o与n免疫o学f MHC I molecules
Heavy chainα1 &α2 domains form the Ag-binding groove
Surface Molecules Expressed on DC
抗原递呈细胞的表面标志
上海交大外科学外科学与免疫学
T B 细胞表面标志的主要差别
上海交大外科学外科学与免疫学
Molecules of immune sys
● immunoglobulin / BCR 上海交大外科学外科学与免疫学
Phagocytes
上海交大外科学外科学与免疫学
Mononuclear phagocytes
Polymorphs
Neutrophils
Eosinophils
Basophils and mast cells
Platelets
Natural killer (NK) cells
Cells of the Adaptive Immune System
● 免疫:
Immune: protect from pathogens
● 免疫性
上海交大外科学外科学与免疫学
Immunity: Capacity of defense infection ● 免疫应答
Immune response : response of recognition and elimination antigenicity foreign material
上海交大外科学外科学与免疫学
外科学与免疫学 Surgery & Immunology
Bing-ya Liu, M.D., Ph. D. , Shanghai Institute of Digestive Surgery
上海交大外科学外科学与免疫学
基本概念
Basic Principles
概念 Concepts
Variations in aa sequence change the shape of the binding groove
MHC II blinding groove accommodate longer peptides than class I
获得性免疫应答上海交大外科A学外d科a学p与ti免v疫e学or Specific Immune
具有高度病原特异性
response
特异性 多样性 记忆性
Highly specific for a particular pathogen
可转移性
● Specific
● Muti-type
● Remember/ memory
● 免疫学
Immunology: The science study on the structure & function of the immune system
Science of self-nonself discrimination
天然免疫与获得性免疫 Adaptive and Innate immunity
效应相
● Response: Lymphocytes coordinate an immune response that eliminates the source of the Ag
免疫系统 Immune System
●Organs of th上e海交Im大外m科u学n外e科学S与y免s疫te学m 免疫器官
● Cells of the Immune System 免疫细胞
● Molecule of the Immune System 免疫分子
Lymphoid Tissues
Primary lymphoid organs
上海交大外科学外科学与免疫学
Thymus——T cell mature
fetal liver Bone marrow
● Transferable
上海交大外科学外科学与免疫学
免疫应答的三个时相 Three phases of immune response
上海交大外科学外科学与免疫学
识别相
● Recognition: Ag recognized by lymphocytes
激活相
● Activation: lymphocytes activation
上海交大外科学外科学与免疫学
Lympho cytes T cells αβT γδT Suppressor T B cells
Antigen-presenting cells (APCs)
上海交大外科学外科学与免疫学
上海交大外科学外科学与免疫学
上海交大外科学外科学与免疫学
上海交大外科学外科学与免疫学