浙江大学医学免疫学押题

尤其是填空题。

首先antigen，antibody必须知道，Ag和Ab嗯

记住外源性对于MHC-II类途径，也称溶酶体途径，CD8+ 就是foreign Ag→MHC2→lysosome →CD8

内源性是MHC-I类途径，也称胞质溶胶途径，CD4+ 就是endogenous Ag→MHC1→cytosol→CD4

淋巴细胞是lymphocyte；单核细胞是monocyte ；巨噬细胞是macrophage，树突状细胞就是DC，什么T-cell啊B-cell不说了

对了，体液免疫应答/细胞免疫应答，分别是humoral和cellular的immune response

中枢和外周分别是central和peripheral，能用到的地方就是什么中枢和外周的immune organ和torelance了

抗独特型抗体不知道考不考，就是Anti-Id

激活和抑制分别是activated和inhibitory之类

抗原性和免疫原性，antigenicity和immunogenicity 就是什么什么genicity（原性……）血液循环和淋巴循环，circulation，嗯，blood和lymph的circulation

免疫应答分固有（innate）和适应（adaptive）性免疫应答

免疫系统三功能：immune defense/surveillance/homeostasis 就是防御、监视、自稳定似乎还有个胸腺依赖性的问题，thymus 的（in）dependent，所以是TI-Ag和TD-Ag

途径一律翻译成pathway吧，什么经典途径classic pathway啊，旁路途径alternative pathway……

差不多了，对了复合体是complex啊，MHC里的C就是这个意思

先这些吧，打完字我也基本上记住了，拼写多练练，好歹10分英文填空，写中文不如不写……

嗯，05级恒源祥学长的记忆中是有这样几道题目的：

问答题:

1:CD4阳性T细胞有哪些亚群,各自的功能是什么?

2:简述Ⅲ超敏反应发生的机制,并列举两种疾病.

3:人工主动免疫和人工被动免疫各有哪些特点?

名词解释:

cam

胸腺细胞的阴性选择(概念和意义)

APC(概念和种类)

交叉提呈

可溶性细胞因子受体(概念和作用)

TI-AG

最后他来了一句：建议大家选夏老师的课，给分相对高。

以下是老师给的英文题:

Concepts:

Hapten

Complementarity determining region (CDR)

Complement

MHC

Leukocyte differentiation antigen

APC

Somatic hypermutation

Negative selection

Anergy

Regulatory T cell

AICD

Questions:

1. Please describe the concepts of TD-Ag and TI-Ag respectively and compare the differences between TD-Ag and TI-Ag.

2. Please describe the general properties of cytokine.

3. What are the rules of antibody production in vivo? (What are the general features of antibody responses in vivo?)

4. Please describe the general process of CD4+ T cell mediated immune response.

5. Please describe the components and pathogenic mechanism involved in type

Ⅰhypersensitivity.

6. What’s the difference between Artificial Active Immunization and Artificial Passive Immunization? Please give 2-3 examples for each.

Hapten

A hapten is a small molecule which can elicit an immune response only when attached to a large carrier such as a protein; the carrier may be one which also does not elicit an immune response by itself.

Complementarity determining region (CDR)

A complementarity determining region (CDR) is a short amino acid sequence found in the variable domains of antigen receptor (e.g. immunoglobulin and T cell receptor) proteins that complements an antigen and therefore provides the receptor with its specificity for that particular antigen.

Complement