神经系统肿瘤分子病理学研究进展

一些经典的分子病理分析对高级别胶质瘤诊断、治疗 和预后的贡献
1p/19q缺失预测胶质瘤亚型以及预后
van den Bent, M. J., et al. (2003). "Chromosomal anomalies in oligodendroglial tumors are correlated with clinical features." Cancer 97(5): 1276-1284.
第三版：Kleihues P, Cavenee WK (eds) (2000) World Health Organization Classification of Tumours. Pathology and genetics of tumours of the nervous sy开st始em加.入IA了R遗C P传re学sps,roLfyiloens
神经系统肿瘤分子病 理学研究进展
分子病理学（Molecular Pathology）定义
Molecular pathology is an emerging discipline within pathology which is focused in the study and diagnosis of disease through the examination of molecules within organs, tissues or bodily fluids. Molecular pathology shares some aspects of practice with both anatomic pathology and clinical pathology, molecular biology, biochemistry, proteomics and genetics, and is sometimes considered a "crossover" discipline. It is multi-disciplinary in nature and focuses mainly on the sub-microscopic aspects of disease. A key consideration is that more accurate diagnosis is possible when the diagnosis is based on both the morphologic changes in tissues (traditional anatomic pathology) and on molecular testing.
of the central nervous system. World Health Organization,
Geneva
单纯解剖形态
第二版：Kleihues P, Burger PC, Scheithauer BW (eds) (1993) Histological typing of tumours of the central nervous system. World Health Organization international histological classification of tumours. Springer, Heide加lb入er了g 免疫组化分析
Cited from Wikipedia
分子病理学的定义的延伸
现代分子病理学的研究范畴超越分子层面本身，已经包含细胞 和组织层面的范畴：
细胞身份（Cell identity）： 肿瘤干细胞， 细胞起源….
细胞-细胞间相互作用（cell-cell interaction）： 肿瘤微环境， 免疫识别…..
目前关于中枢神经系统肿瘤的分型与分级（WHO第四版） 主要还是以解剖形态分类为主
传统分类与分级：基于形态
Huse, J. T. and E. C. Holland (2010). "Targeting brain cancer: advances in the molecular pathology of malignant glioma and medulloblastoma." Nat Rev Cancer 10(5): 319-331.
Cancer Cell. 2010 Jan 19;17(1):98-110.
一些经典的分子病理分析对高级别胶质瘤诊断、 治疗和预后的贡献
MGMT启动子甲基化决定放化疗敏感性
Gerson, S. L. (2004). "MGMT: its role in cancer aetiology and cancer therapeutics." Nat Rev Cancer 4(4): 296-307
一些分子病理分析对高级别胶质瘤诊断、治疗 和预后的贡献
MGMT启动子甲基化决定放化疗敏感性
"MGMT Gene Silencing and Benefit from Temozolomide in Glioblastoma.“N Engl J Med 352;10
Nature. 2008 Oct 23;455(7216):1061-8.
背后的本质： 分子行为必须放在特定的细胞背景下加以研究和分析
来自百度文库
Molecular Pathology Plays More Important Roles in the Diagnosis in Neuro-oncology
第一版：Zülch KJ (ed) (1979) Histological typing of tumours
第四版： Louis DN, Ohgaki H, Wiestler OD, Cavenee WK (eds) (2007) WHO Classification of tumours of the central nervous system. IARC, Lyon
第五版： is coming.
目前关于中枢神经系统肿瘤的分型与分级（WHO第四版） 主要还是以解剖形态分类为主