组会讲文献 PPT

• figure 9 the metastasis promoting effect of CLDN4 could be regulated in vivo
• figure 10 the mechanism graph of the regulatory network and function of CLDN4
ceRNA
表达调节： ↓ 结合
沉默
microRNA------→mRNA
figure 1 cldn-4 is identified as a target of miR-596 and miR-3620-3p
• figure 2 CLDN-4 reinforces the proliferative and invasive capacity of GC cells in vitro
组会讲文献
• CLDN4 属于claudin（密闭蛋白）家族 是一组细胞间紧密连接的骨架蛋白，
在98年第一次在鸡肝脏中被发现。
ceRNA(competing endogenous RNAs) 竞争性內源RNA 假说揭示了一种RNA间相互作用的
新机制。已知microRNA可以通过结合mRNA导致基因沉默，而ceRNA可以通过竞争性地结合microRNA来调节 基因表达。ceRNA可以通过应答元件与microRNA结合从而影响microRNA导致的基因沉默，这揭示了一条 RNA->microRNA调节通路的存在，具有重大生物意义。
• figure 6 LncRNA-KRTAP5-AS1 and LncRNA-TUBB2A act as ceRNAs
• CLDN4 promotes proliferation in vivo
figure 8 the effect of CLDN4 and ncRNAs on tumor growth
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• figure 3 CLDN-4 induces EMT in vitro
• figure 4 LncRNAs can crosstalk with miRNAs through direHale Waihona Puke Baidut binding
• figure 5 LncRNA-KRTAP5-AS1 and LncRNA-TUBB2A enhance the proliferative and invasive capacity of GC cells in vitro