2012生物信息学试卷(英文)

中南大学研究生《生物信息学》考试试题（2012.10.27）

No: name:Tel：

Classify the nouns by bioinformation, and to briefly explain they respectively. （20 Points）

Problem #1Pairwise sequence alignment（10 Points）

（1）match ＋2 Points，mismatch －1 Points，

gap open －11 Points ，gap extened －1 Points

（2）match and mismatch by BLOSUM62

gap open －11 Points ，gap extened －1 Points

（3）What's the difference between (1) and (2)?Which is more appropriate？Why？

表1 BLOSUM62矩阵

Problem #2 HMM （10 Points ）

A possible hidden Markov model for the protein ACCY .

（1） Scoring a Sequence with an HMM along this path:

[mach A] [insert C] [mach C] [mach Y]

（2） There are three kinds of states represented by three different shapes.

What do they all mean?

0.1 0.3 0.3 0.4 0.2

0.6 0.3 0.2 0.5 0.1 0.9 0.1 0.1 0.1

0.5 0.4 0.1 0.6 0.2 0.2 0.6 0.2 0.4 0.7 0.2 0.4 0.7 0.4 0.6

0.7 A 0.3 C 0.5 Y 0.8

Problem #3 The circuits in Single Genes （10 Points ）

How much regulatory modules in Endo16 ? Briefly explain the relationship between them.

Homework （50 Points ）

(1) Serach Uniprot ,GO,KEGG (2) NCBI blast (3) swiss mdel 邮箱：rlf126@ 截止日期：2012.11.04

0.2

A 0.5

C

0.3 C