重组人γ干扰素雾化吸入治疗小儿呼吸道病毒感染100例

重组人γ干扰素雾化吸入治疗小儿呼吸道病毒感染100例

目的探讨呼吸道病毒感染患儿临床治疗中，重组人γ干扰素雾化吸入治疗方法的应用效果。方法将2014年2月～2015年2月在我院感染科治疗的200例小儿呼吸道病毒感染患者当作研究对象，采用双盲法把患者分为两组，对照组采用常规治疗方法进行治疗，观察组在此基础上采用辅助重组人γ干扰素雾化吸入方法进行治疗，两组患者用药7d后比较治疗效果，包括患者临床症状改善时间、免疫学指标以及不良反应发生情况等。结果经过观察对比，观察组患者治疗有效率为95%，对照组患者治疗有效率为86%，观察组治疗有效率明显高于对照组，差异有统计学意义（P＜0.05）；在患者咳嗽、气喘、发热、肺部湿啰音等症状改善时间上，观察组明显短于对照组，差异有统计学意义（P＜0.05）；在治疗后IgE水平上，观察组患者明显低于对照组，差异存在统计学意义（P＜0.05），而在IgA、IgG、IgM水平上，两组无明显差异，差异不存在统计学意义（P>0.05）；在IL-4及IFN-γ改善情况上，观察组明显优于对照组，差异有统计学意义（P＜0.05）；且在不良反应发生率上，两组不存在明显差异，差异不具有统计学意义（P>0.05）。结论重组人γ干扰素雾化吸入治疗小儿呼吸道病毒感染效果显著，能加速改善患者临床症状，增强患者机体免疫功能，效果显著，值得临床推广。

[Abstract] Objective To explore applicative curative effect of recombinant human Interferon-γaerosol inhalation in clinical treatment of children with respiratory virus infection. Methods 200 children with respiratory virus infection who were treated in department of infectious diseases in our hospital from February 2014 to February 2015 were selected as research objects and they were allocated to the control group and the observation group according to double-blind method. Patients in the control group were received routine treatment while patients in the observation group were received recombinant human Interferon-γaerosol inhalation treatment on the basis of routine treatment. Curative effects were compared seven days after the medication including the time of clinical symptom improvement，immunological indexes，condition of adverse reactions and so on. Results By observation，effective rate of treatment of patients in the observation group was 95% while the effective rate of treatment of patients in the control group was 86%. Effective rate of treatment of the observation group was significantly higher than that of the control group and the difference was statistically significant （P＜0.05）. The time of clinical symptom improvement includes coughing，asthma，fever，moist rales of lung and so on. The time of clinical symptom improvement of the observation group was significantly shorter than that of the control group and the difference was statistically significant （P＜0.05）. IgE levels after treatment in the observation group were significantly lower than those in the control group and the differences were statistically significant （P＜0.05）. While the IgA level，IgG level and IgM level of two groups had no significantly and the difference was not statistically significant （P>0.05）. The conditions of improvements of IL - 4 and IFN –γin the observation group were significantly better than those in the control group and the difference was statistically significant （P＜0.05）. Incidence of adverse reactions of the two groups had no