免疫学5固有免疫的组成细胞

TLR
TLR TLR
1
TLRPAMP NF-B mRNAIL-1IL-6IL-8IL-12TNF-IFN-
TLRPAMP TLRTLR
2
LPS TLR2 CD83 MHCCD80CD86CD54CD58DC DC
源自文库3
TLR4
4
(LBP)TLR2 Caspase-8TLR2
�
�
� DC NK NKTTB1
IgG Fc C3b
� � �
�
�
�
�
1.PRR
2. IgG Fc
1.
PAMP( )
TollNOD
PAMP DNARNA 1 2 3Toll
MR
8C
(SR)
G-G+
TollTLR
T
� 1 � 2MIP-1,M CP-1,IL-
8) � 3IL-1IL-6,TNF-
� 4IFN-
� (1) LPSIFN-GM-CSF � (2) / � (3) ROI,RNI,
� (4) TNF- � (5) ADCC
� 1MHC/CD4+/
CD8+TTCR-CD3-CD4/CD8 MHC/
MyD88TLRB IgG
5 NO
6 TLR
TLRPAMPTLR6 TLR2G+
2.
1IgGFc Fab Ig Fc
Fc
2 C3bC4b
+
+
� 1. � 2. � 3.
1.
1ROI)
2(RNI)
iNOS
+
L-
NO,
2 .
(1)PH 2G 3
3.
MHC
NKT
CD4-CD8-T NK1.1TCR-CD3
TCR NKT TCR CD1 MHC
1.FasL 2. IL-12IFN- IL- 4
3.MCP-1a
T B1
� 1-3% 6-8 8-12
�
0.2% 10~15
I
1 2NK
1.TLRTLR1-10
TLR550-980
TLR 18-31 (LRR) CD14
TLRs200 IL-1R Toll/IL-1R (TIR)TIRTLR
TLR
TLR1 TLR2TLR4TLR5 TBNKTLR3
TLR(TLR1)(TLR2TLR4TLR5) (TLR3)
TLR4 TLR2 TLR2TLR4(HEK293) (HDMEC)THP-1
� 2B7ICAM-1TC
D28LFA-1T
� 1IL-1TB
� 2TNF-T (CTL) � 3IL-6BT
� 4IL-1,IL-18TNK � 5IL-10
DC
� 1
� DCCD1aCD11cCD 83MHC/ B7ICAM-1
� 1.
2.IL-12IL-10TGF IFN
CD94/NKG2A R CD94/NKG2C: R
NKG2A/2C
HLA
NCR NKG2D
1 .NKG2D
NK
DAP-1
0
+
MICA,M
ICB(MHC I
A/B)
2.NCR( NKNKp46 NKp30 NK
p44
NKp46,NKp30CD3ITAM NKp444DAP-12(ITAM);
� NKTB
� CD3- CD16+ CD56+N K
� NKCD16 CD56
� NKNK ---- NK----
� NK
NK
MHC-I
HLA
1.KIR(
� IgKI R2DKIR3D
� KIRDL R;
KIRDS R
+
-
CD94
2.KLR( CD94NKG2A C
NK
1./
2.FasFasL
3.TNF-TNFR-:
TNF-TNFR-I
TNF-R
NK
/
Dead tumor cell
NK
FasL Fas
DD
TNF
TNFR
Inactive procaspase
FasL-Fas
Actived caspase
Dead tumor cell
NK 1. 2.IL-2TNFIFN-