线粒体膜电位和精子活力

线粒体膜电位和精子活力

精子线粒体决定了生育力吗？

背景

线粒体膜电位(MMP) 是反映线粒体能量状态的指标。研究表明，降低人体MMP 值会导致人精子活力和生育能力下降。这项研究用MMP 来评估精子线粒体的完整性，以确定MMP 的基本情况是否与精子活力的不同程度有关。

∙意大利罗马大学精液学实验室收集了213 名年龄为25-38 岁男性的精液样本；进行了精液检查、精子活力检测和MMP 流式细胞分析。

∙根据活力情况将样本分为两组：A 组包含185 例具有线性活力的样本，根据活力的递增将这些样品分为13 个层级；B 组包含28 例具有非线性活力的样本，分为 5 个层级。

∙ A 组和B 组的MMP 测量值没有显著的差异（A 组FL2 平均值：46.2；

B 组：48.3）。

∙ A 组中，随着活动精子百分比的增加，MMP 值升高。

∙同样，在 B 组中可以观察到，MMP 与递增的非线性活力呈正相关关系。∙这项研究首次明确了与活动精子的不同等级相关的MMP 情况，并且首次评估了具有非线性活力的精子的MMP。

结论

作者总结道，“我们的数据揭示总活力与MMP 之间存在正相关关系，表明精子活力可能取决于线粒体的功能完整性。”

Paoli D, Gallo M, Rizzo F, et al. Mitochondrial membrane potential profile and its correlation with increasing sperm motility. Fertil Steril. 2011;95:2315-9.

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