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Idiopathic Adult Nephrotic Syndrome:
A Clinicopathological Study and Response to Steroid in a Sub-Saharan African Country
Repoerters: Zheng Wei Dai Qing Li Shuang
with azathioprine(2.5%)
Prognosis
complete remission
23.7%
patial remission
4.45%
relapse
5.1%
Discussion
Prevalence Age
Histology
progress
Prevalence of idiopathic NS
Epidemiology
Clinico-biology.
C Histology D
Therapeutics & Progression profile
Patients
Nephrology Department at Aristide Le Dantec University Hospital during 2001.01 to 2010.10
Symptoms
edema
edema was the most frequent type of presentation found in 98 patients.
63%
40%
hypertension
hypertension was found in 63 patients.
Laboratory details
•diuretics(91.5%) •antiprotein uric agents(43%) •ACE-inhibitors(100%) anticoagulation(8.4%) steroid(95.9%)
alone(85.8%)
Steroid therapy
with cyclophosphamide(7.6%)
C Remission is very low D
Early diagnosis is important
Definition
Clinical translation
50% of glomerulonephritis
podocyte injury 25%-30%glomerulonephritis in adult
chronic kidney disease
Aims of the study
A B
mean serum protein
41.7-55.3g/l
mean serum albumin mean proteinuria renal insufficiency hypertriglyceridemia
10-30g/l 2.2-11.4g/24h 44%(n=68) 52.5%(n=82)
Renal biopsy
treatment
lifestyle measures
drug treatment
• • • •
sufficent caloric diet(100%) fluid restriction(13.4%) sodium restriction(95%) a low potassium diet(5.7%)
28%
Chronic kidney disease
33% The progress towards chronic kidney disease was noted in 33%.
Conclusion
A B
NS is frequent in our country
Commom . lesion→FSGS
Introduction of NS Patients and Methods
Content
Results Discussion Conclusion
Idiopathic nephrotic syndrome(NS)
is determined by a proteinuria higher than 3g/24h associated with hypoalbuminemia, with no kidney inflammatory lesions or immune complex deposits .
77%
41.2%
12%
our study
Akpechi’s study
Deme’study
Age
our study
mean age of 29 years
Deme’s study
02
age group of 25-34years
Histology
45.6%
FSGS
5%
.
43.4%
our study
(156 out of 202 patients were primitive(77%)
Results
Population distribution
Age the mean age was 17.7-41.7 years the group of 15-25 years was the most representative with 46％ of patients Gender men represented 72％(112 patients) women represented 28％(44 patients)
teen years of age and above
Electronic questionnaire elaborated by Epi Info3.3.2version
Methods
Data collection
Analysis
Population distribution
Symptoms
Laboratory details Renal biopsy Treatments Prognosis
(局灶性节段性肾小球硬化)
MN(微小病变型)
MCD(膜性肾病)
75%Fra Baidu bibliotek
6%
12%
T
Deme’ study
The cause of difference
renal biopsy
PROGRESS
Remission
In our study the progression was favorable with remission in 57 patient .
A Clinicopathological Study and Response to Steroid in a Sub-Saharan African Country
Repoerters: Zheng Wei Dai Qing Li Shuang
with azathioprine(2.5%)
Prognosis
complete remission
23.7%
patial remission
4.45%
relapse
5.1%
Discussion
Prevalence Age
Histology
progress
Prevalence of idiopathic NS
Epidemiology
Clinico-biology.
C Histology D
Therapeutics & Progression profile
Patients
Nephrology Department at Aristide Le Dantec University Hospital during 2001.01 to 2010.10
Symptoms
edema
edema was the most frequent type of presentation found in 98 patients.
63%
40%
hypertension
hypertension was found in 63 patients.
Laboratory details
•diuretics(91.5%) •antiprotein uric agents(43%) •ACE-inhibitors(100%) anticoagulation(8.4%) steroid(95.9%)
alone(85.8%)
Steroid therapy
with cyclophosphamide(7.6%)
C Remission is very low D
Early diagnosis is important
Definition
Clinical translation
50% of glomerulonephritis
podocyte injury 25%-30%glomerulonephritis in adult
chronic kidney disease
Aims of the study
A B
mean serum protein
41.7-55.3g/l
mean serum albumin mean proteinuria renal insufficiency hypertriglyceridemia
10-30g/l 2.2-11.4g/24h 44%(n=68) 52.5%(n=82)
Renal biopsy
treatment
lifestyle measures
drug treatment
• • • •
sufficent caloric diet(100%) fluid restriction(13.4%) sodium restriction(95%) a low potassium diet(5.7%)
28%
Chronic kidney disease
33% The progress towards chronic kidney disease was noted in 33%.
Conclusion
A B
NS is frequent in our country
Commom . lesion→FSGS
Introduction of NS Patients and Methods
Content
Results Discussion Conclusion
Idiopathic nephrotic syndrome(NS)
is determined by a proteinuria higher than 3g/24h associated with hypoalbuminemia, with no kidney inflammatory lesions or immune complex deposits .
77%
41.2%
12%
our study
Akpechi’s study
Deme’study
Age
our study
mean age of 29 years
Deme’s study
02
age group of 25-34years
Histology
45.6%
FSGS
5%
.
43.4%
our study
(156 out of 202 patients were primitive(77%)
Results
Population distribution
Age the mean age was 17.7-41.7 years the group of 15-25 years was the most representative with 46％ of patients Gender men represented 72％(112 patients) women represented 28％(44 patients)
teen years of age and above
Electronic questionnaire elaborated by Epi Info3.3.2version
Methods
Data collection
Analysis
Population distribution
Symptoms
Laboratory details Renal biopsy Treatments Prognosis
(局灶性节段性肾小球硬化)
MN(微小病变型)
MCD(膜性肾病)
75%Fra Baidu bibliotek
6%
12%
T
Deme’ study
The cause of difference
renal biopsy
PROGRESS
Remission
In our study the progression was favorable with remission in 57 patient .