参考文献改错

参考文献改错：

王彪等研究发现多个常见肿瘤胞浆Slit2高表达，部分恶性肿瘤细胞表达Robo1，其肿瘤血管内皮细胞呈高表达，并首次报道该信号在肿瘤血管形成中的重要作用，同时制备出该信号的特异性阻断抗体R5[1]。在对恶性神经胶质瘤的研究也显示该肿瘤细胞Slit2高表达[2]；Ito等[3]在肺癌细胞中发现Slit2及Robo1均有表达，Nasarre等[4]发现Robo1在肝癌组织中高表达，其表达强度与分化程度有一定的相关性。Slit和Robo家族基因可能是癌基因，它们对肿瘤的发生发展具有促进作用，可能具有肿瘤治疗的靶点作用[5，6，7，8]。

参考文献：

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induced by chemotactic factors[J]. Nature, 2001, 410(6831): 948-952.

[2]Yiin JJ, Hu B, Jarzynka MJ, et al. Slit2 inhibits glioma cell invasion in the brain by

suppression of Cdc42 activity[C]. J Neurooncol, 2009, 779-89.

[3]Nasarre Polo, et al. Guidance molecules in lung cancer[M]. J Cell Adhesion Migration, 2009,

4(1): 130-45.

[4]Ito H, Funahashi S, Yamauchi N, et al. Identification of ROBO1 as a novel hepatocellular

carcinoma antigen and a potential therapeutic and diagnostic target[J]. Clin Cancer Res, 2006, 12(11 Pt 1): 3257-64.

[5] 李明, 王保国, 李兴昌. 癌基因研究[J]. 北京: 科学出版社, 2006, 111-2.

[6]Xiaojun Huang, Aiguo Chen, Juanjuan Wu, et al. Inadequate lung development and bronchial

hyperplasia in mice with a targeted deletion in the Dutt1/Robo1 gene[J]. Proc Natl Acad Sci U S A, 2001, 98(26): 15062-6.

[7]Xian J, Aitchison A, Bobrow L, et al. Targeted disruption of the 3p12 gene, Dutt1/Robo1,

predisposes mice to lung adenocarcinomas and lymphomas with methylation of the gene promoter[J]. Cancer Research, 2004, September, 64(18): 6432-6437.