mTOR Signaling信号通路
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Direct Stimulatory Modification Direct Inhibitory Modification Multistep Stimulatory Modification Multistep Inhibitory Modification Tentative Stimulatory Modification Tentative Inhibitory Modification Transcriptional Stimulation Transcriptional Inhibition Translocation Separation of Subunits or Cleavage Products
Joining of Subunits
Nutrients Amino Acids
IRS-1
PIP3 PDK1
PIP2
PTEN
Dvl
Erk
SGK1 PKC
Akt
ຫໍສະໝຸດ Baidu
PRAS40
TSC1 TSC2
Rheb
rapamycin FKBP12
mTORC1
GL
Raptor
mTOR
DEPTOR
RSK
GSK-3 REDD1/2
AMPK Rag A/B Rag C/D
Transcription
Signaling Pathways Key
Kinase Phosphatase Transcription Factor Caspase Receptor Enzyme Cyclin, pro-apoptotic pro-survival GAP / GEF GTPase G-protein, ribosomal subunit Acetylase Deacetylase
mTOR Signaling
mTORC2
Sin1 PRR5 Rictor GL mTOR
DEPTOR
Growth Factors, Hormones,
Cytokines, etc.
PI3K
Wnt Stress Hypoxia
Frizzled
Energy AMP: ATP
AICAR metformin
p70S6K Cell Growth
ATG13
4EBP1
mRNA Translation
Autophagy Proliferation
Ribosome Biogenesis
LKB1
HIF-1 PGC-1
VEGF/ Angiogenesis
Mitochondrial Metabolism
PPAR
Adipogenesis