育种模拟的原理和遗传模拟工具QuLine
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第四届“QTL作图和育种模拟研讨会”，2009年8月18-20日，山东泰安
育种模拟的原理和
遗传模拟工具QuLine
CIMMYT’s headquarter in Mexico
Dr. Borlaug and green revolution ¾
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Mexico City
El Batan
Toluca, 19º N, 2640 masl.
High rainfall (800-900 mm)Cd. Obregon, 27º N, 39 masl. 8-11 t/ha under irrigation; 1-2t/ha under reduced irrigation
CIMMYT’s Shuttle breeding
May to November
Breeding methods with self-pollinated crops
Breeding methods in CIMMYT’s wheat breeding program
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About 40% of
after F7
About 30% of the crosses are discarded in F1About 20% of
of yield trials
Why do we need tools in breeding?¾
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Why do we need tools in breeding?¾
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Questions that can be studied by QuLine: A genetic and breeding simulation tool 1.
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Questions that can be studied by QuLine (mainly for inbred line development) 5.
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QuLine: A simulation tool for genetics and breeding
¾QU-GENE (QUantitative GENEtics)
A simulation platform for quantitative analysis of genetic models, developed by
The University of Queensland, Australia
¾QuCim (funded by GRDC 2000-2004)
A QU-GENE application breeding simulation module, specifically designed for
CIMMYT’s wheat breeding programs
Simulate most breeding programs for developing inbred lines
Version 1.1 released on July, 2003 (Workshop in Brisbane, Australia)
More than 100 global requests for QuCim 1.1
¾Renamed as QuLine (currently funded by GCP, H+, and Research Programs of China, i.e. 973, 863, and NSF)
Landscape representation of a complex GE system (the real GE system is multi-dimensional)
What can QuLine do?¾
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In genetics
(implemented by the QU-GENE engine)¾
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In breeding (implemented by the QuLine module)
How does QuLine work?
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•(= input for QuLine
•(= input for QuLine
(= input for QuLine
Define the QMP file for the selected bulk selection method: an example
General simulation parameters
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General simulation parameters ¾
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The number of models in the GE system and the number of runs for breeding strategy
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Parameters to describe a
set of breeding strategies
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Definition of a generation ¾
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