AD危险因素及干预因素
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Hg) at midlife had a significantly higher risk of AD later in life----Midlife vascular risk factors and Alzheimer's disease in later life:
longitudinal, population based study. Brit Med J. 2001;322:1447-51.
2021/2/21
4
• regular leisure exercise may decrease the risk of developing dementia in late-life---
APOE ε4 allele, cognitive dysfunction, and obstructive sleep • apnea in children. Neurology. 2007;69(3):243-9.
ischemia in Alzheimer’s disease.Neurobiol Aging. 2000;21:321-30.
• Cerebral hypoxia accruing from sleep apnea has been linked toAD---Midlife respiratory function and incidence of Alzheimer's
• late-life cognitive decline123,124, MCI, AD, and conversion from MCI to AD---Mediterranean diet and mild cognitive impairment. Arch
2021/2/21
3
• The program was designed to be implemented 5 times per week by a nursing assistant or family member under the supervision of a physical therapist.
2021/2/21
5
Vascular Factors与AD
• 高血压: • There is fairly robust evidence linking midlife
hypertension to the development of dementia in later life. • individuals with raised systolic blood pressure (>160 mm
• 方式：An activity specific exercise program was compared to a walking program and to an attention control.
• 评估方法：assessed using the subscales of the Acute Care Index of Function; functional mobility was measured using the 6-Minute Walk test.
Controlled Trial of an Activity Specific Exercise Program for Individuals With Alzheimer Disease in Long-term Care Settings.J Geriatr Phys Ther 2011;34:50-56.
AD危险因素及干预因素
1
2021/2/21
AD的危险因素与干预
2021/2/21
2
运动锻炼与AD关系
• 目的：whether an activity specific exercise program could improve ability to perform basic mobility activities in long-term care residents with AD.
• this study suggest that walking programs may not be sufficient to improve mobility limitations in individuals who are dependent in transfers and support the benefit of a targeted, simple exercise program in reducing mobility limitations in institutionalized patients with moderate to severe cognitive impairment.----A Randomized
• cerebrovascular atherosclerosis and increased burden of • subcortical white matter lesions commonly found in AD.
Hale Waihona Puke Baidu
2021/2/21
6
• 卒中或TIA增加发生AD：
• The risk of developing AD, and not merely vascular dementia, is significantly increased in individuals with stroke or transient ischemic attacks---The role of cerebral
disease:A29-year longitudinal study in women. Neurobiol Aging. 2007;28(3):343-50.
2021/2/21
7
营养、饮食与AD
• “Mediterranean” diet:
• The diet has recently been linked to a reduced risk of
longitudinal, population based study. Brit Med J. 2001;322:1447-51.
2021/2/21
4
• regular leisure exercise may decrease the risk of developing dementia in late-life---
APOE ε4 allele, cognitive dysfunction, and obstructive sleep • apnea in children. Neurology. 2007;69(3):243-9.
ischemia in Alzheimer’s disease.Neurobiol Aging. 2000;21:321-30.
• Cerebral hypoxia accruing from sleep apnea has been linked toAD---Midlife respiratory function and incidence of Alzheimer's
• late-life cognitive decline123,124, MCI, AD, and conversion from MCI to AD---Mediterranean diet and mild cognitive impairment. Arch
2021/2/21
3
• The program was designed to be implemented 5 times per week by a nursing assistant or family member under the supervision of a physical therapist.
2021/2/21
5
Vascular Factors与AD
• 高血压: • There is fairly robust evidence linking midlife
hypertension to the development of dementia in later life. • individuals with raised systolic blood pressure (>160 mm
• 方式：An activity specific exercise program was compared to a walking program and to an attention control.
• 评估方法：assessed using the subscales of the Acute Care Index of Function; functional mobility was measured using the 6-Minute Walk test.
Controlled Trial of an Activity Specific Exercise Program for Individuals With Alzheimer Disease in Long-term Care Settings.J Geriatr Phys Ther 2011;34:50-56.
AD危险因素及干预因素
1
2021/2/21
AD的危险因素与干预
2021/2/21
2
运动锻炼与AD关系
• 目的：whether an activity specific exercise program could improve ability to perform basic mobility activities in long-term care residents with AD.
• this study suggest that walking programs may not be sufficient to improve mobility limitations in individuals who are dependent in transfers and support the benefit of a targeted, simple exercise program in reducing mobility limitations in institutionalized patients with moderate to severe cognitive impairment.----A Randomized
• cerebrovascular atherosclerosis and increased burden of • subcortical white matter lesions commonly found in AD.
Hale Waihona Puke Baidu
2021/2/21
6
• 卒中或TIA增加发生AD：
• The risk of developing AD, and not merely vascular dementia, is significantly increased in individuals with stroke or transient ischemic attacks---The role of cerebral
disease:A29-year longitudinal study in women. Neurobiol Aging. 2007;28(3):343-50.
2021/2/21
7
营养、饮食与AD
• “Mediterranean” diet:
• The diet has recently been linked to a reduced risk of