MAPK信号通路
合集下载
相关主题
- 1、下载文档前请自行甄别文档内容的完整性,平台不提供额外的编辑、内容补充、找答案等附加服务。
- 2、"仅部分预览"的文档,不可在线预览部分如存在完整性等问题,可反馈申请退款(可完整预览的文档不适用该条件!)。
- 3、如文档侵犯您的权益,请联系客服反馈,我们会尽快为您处理(人工客服工作时间:9:00-18:30)。
• PKB/Akt: protein kinase B
• RTKs: receptor tyrosine kinases
Thank you!
MAP Kinase Pathways
• MAPK:Mitogen-activated protein kinase
• MAPKK: MAPK kinase
• MAPKKK: MAPKK kinases
ERK1,ERK2
ERKs
Larger ERKs MAPK JNKs P38/SAPKs
ERKs: extracellular-signal-regulated kinases JNKs: Jun amino-terminal kinases P38/SAPKs: stess-activated protein kinases
ERKs
• TEY motif • TPY motif • TGY motif
JNKs
P38/SAPKs
Biblioteka Baidu
MAPK Pathways
ERK MAPK Pathway
JNK MAPK Pathway
P38 MAPK Pathway
PI3K-PKB/Akt Pathway
• PI3K: phosphoinositide-3-kinase